Local Effects Research Articles

GARLIC: Nature's potent antifungal and antibacterial ally - cream formulation and evaluation

In the pursuit of effective and safe treatments for infectious diseases, herbal remedies have garnered significant attention due to their diverse phytochemical composition and potential therapeutic properties. This study aimed to explore the phytochemical profile and evaluate the antibacterial and antifungal properties of herbal garlic extracts. Traditional natural products continue to be sought after for their bioactive compounds, which offer promising avenues for therapeutic intervention in both human and veterinary medicine. Our investigation not only sheds light on the regional variation of stomach disease occurrence, highlighting the role of dietary factors, but also underscores the importance of herbal preparations in medicinal practice. By combining various plant classes, herbal formulations can exert localized effects upon application, penetrating the skin or mucous membranes to target underlying conditions. The effectiveness of these combined medications may lie in their synergistic mechanisms, offering a comprehensive therapeutic approach. This research contributes valuable insights into the potential of herbal remedies as adjuncts or alternatives to conventional treatments, paving the way for further exploration in infectious disease management and prevention strategies.

Mechanism and growth kinetics of Al3Ti phase in fifteen-layered Ti Gr.1/A1050 clads produced with the explosive welding technique

This study was dedicated to the detailed characterization of the microstructural changes and the phase analysis of the interfaces formed in explosive welding of multilayered Ti Gr.1/A1050 clads. The significant effect of the detonation source localization on the microstructure of the welded materials interfaces after collision, and consequently on the diffusion processes induced by the elevated temperature was showed. Annealing process at 550 °C for series of time intervals of the Ti/Al clad allowed to determine the growth mechanism of the Al3Ti phase formed along particular interfaces. Moreover, the microstructure observations and calculations evidenced different growth mechanisms related to the localization of the Ti/Al interface in respect to the detonation source.

Review on treatment of pleural metastasis and malignant pleural effusion with Pressurized IntraThoracic Aerosol Chemotherapy (PITAC)

Abstract Background Malignant pleural effusion (MPE) is a common and debilitating condition seen in advanced cancer disease, and life-expectancy is short. Symptoms include pain and severe shortness of breath. Current first-line treatment options include pleural drainage using catheters as well as pleurodesis. However, these treatment modalities are often inefficient and patients need repeated procedures. Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) is a minimally invasive procedure, where antineoplastic agents are nebulized under pressure into the pleural space. Content We present the preliminary safety, feasibility, and response assessment data for PITAC based on a comprehensive literature review. Summary Five retrospective studies reported data on 38 PITACs in 21 patients. Data were heterogeneous and incomplete on several important aspects such as procedure, safety, local effect and long-term outcomes. PITAC seems technically feasible with a low risk of complications and may provide some reduction in MPE in selected cases. Outlook PITAC seems feasible, but prospective phase I and II studies are needed to define safety, indications, and efficacy.

Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms

BackgroundSignificant variations exist in the forms of ZnO, making it impossible to test all forms in in vivo inhalation studies. Hence, grouping and read-across is a common approach under REACH to evaluate the toxicological profile of familiar substances. The objective of this paper is to investigate the potential role of dissolution, size, or coating in grouping ZnO (nano)forms for the purpose of hazard assessment. We performed a 90-day inhalation study (OECD test guideline no. (TG) 413) in rats combined with a reproduction/developmental (neuro)toxicity screening test (TG 421/424/426) with coated and uncoated ZnO nanoforms in comparison with microscale ZnO particles and soluble zinc sulfate. In addition, genotoxicity in the nasal cavity, lungs, liver, and bone marrow was examined via comet assay (TG 489) after 14-day inhalation exposure.ResultsZnO nanoparticles caused local toxicity in the respiratory tract. Systemic effects that were not related to the local irritation were not observed. There was no indication of impaired fertility, developmental toxicity, or developmental neurotoxicity. No indication for genotoxicity of any of the test substances was observed. Local effects were similar across the different ZnO test substances and were reversible after the end of the exposure.ConclusionWith exception of local toxicity, this study could not confirm the occasional findings in some of the previous studies regarding the above-mentioned toxicological endpoints. The two representative ZnO nanoforms and the microscale particles showed similar local effects. The ZnO nanoforms most likely exhibit their effects by zinc ions as no particles could be detected after the end of the exposure, and exposure to rapidly soluble zinc sulfate had similar effects. Obviously, material differences between the ZnO particles do not substantially alter their toxicokinetics and toxicodynamics. The grouping of ZnO nanoforms into a set of similar nanoforms is justified by these observations.

Deep soil seismic hazard assessment: analyzing the impact of local site effects by stochastic site response analysis—a comparative approach

Deep soil seismic hazard assessment: analyzing the impact of local site effects by stochastic site response analysis—a comparative approach

Synthesis and Characterization of Lignin-Silver Nanoparticles

Metal nanoparticle synthesis via environmentally friendly methods is gaining interest for their potential advantages over conventional physico-chemical approaches. Herein, we propose a robust green synthesis route for lignin-modified silver nanoparticles, utilizing the recovery of lignin as a renewable raw material and exploring its application in valuable areas. Through a systematic approach combining UV-Vis spectroscopy with AAS and DLS, we identified repeatable and scalable reaction conditions in an aqueous solution at pH 11 for homogeneous silver nanoparticles with high uniformity. The TEM median sizes ranged from 12 to 15 nm with circularity between 0.985 and 0.993. The silver nanoparticles yield exceeded 0.010 mol L−1, comparable with traditional physico-chemical methods, with a minimal loss of silver precursor ranging between 0.5 and 3.9%. Characterization by XRD and XPS revealed the presence of Ag-O bonding involving lignin functional groups on the pure face-centered cubic structure of metallic silver. Moreover, the lignin-modified silver nanoparticles generated a localized thermal effect upon near-infrared laser irradiation (808 nm), potentially allowing for targeted applications in the biomedical field. Our study showcases the potential of lignin as a renewable reducing and capping agent for silver nanoparticle synthesis, addressing some shortcomings of green synthesis approaches and contributing to the development of suitable nanomaterials.

Estimation of the Local Conditional Tail Average Treatment Effect*

The conditional tail average treatment effect (CTATE) is defined as a difference between the conditional tail expectations (CTE’s) of potential outcomes, which can capture heterogeneity and deliver aggregated local information on treatment effects over different quantile levels and is closely related to the notion of second-order stochastic dominance and the Lorenz curve. These properties render it a valuable tool for policy evaluation. In this paper, we study estimation of the CTATE locally for a group of compliers (local CTATE or LCTATE) under the two-sided noncompliance framework. We consider a semiparametric treatment effect framework under endogeneity for the LCTATE estimation using a newly introduced class of consistent loss functions jointly for the CTE and quantile. We establish the asymptotic theory of our proposed LCTATE estimator and provide an efficient algorithm for its implementation. We then apply the method to evaluate the effects of participating in programs under the Job Training Partnership Act in the US.

Three-dimensional flow around and through a porous screen

We investigate the three-dimensional (3-D) flow around and through a porous screen for various porosities at high Reynolds number $Re = {O}(10^4)$ . Historically, the study of this problem has been focused on two-dimensional cases and for screens spanning completely or partially a channel. Since many recent problems have involved a porous object in a 3-D free flow, we present a 3-D model initially based on Koo & James (J. Fluid Mech., vol. 60, 1973, pp. 513–538) and Steiros & Hultmark (J. Fluid Mech., vol. 853, 2018 pp. 1–11) for screens of arbitrary shapes. In addition, we include an empirical viscous correction factor accounting for viscous effects in the vicinity of the screen. We characterize experimentally the aerodynamic drag coefficient for a porous square screen composed of fibres, immersed in a laminar air flow with various solidities and different angles of attack. We test various fibre diameters to explore the effect of the space between the pores on the drag force. Using PIV and hot wire probe measurements, we visualize the flow around and through the screen, and in particular measure the proportion of fluid that is deviated around the screen. The predictions from the model for drag coefficient, flow velocities and streamlines are in good agreement with our experimental results. In particular, we show that local viscous effects are important: at the same solidity and with the same air flow, the drag coefficient and the flow deviations strongly depend on the Reynolds number based on the fibre diameter. The model, taking into account 3-D effects and the shape of the porous screen, and including an empirical viscous correction factor that is valid for fibrous screens may have many applications including the prediction of water collection efficiency for fog harvesters.

The External Validity of College Remediation Effects: Caveats about Compliers in Fuzzy-discontinuity Designs

Abstract Fuzzy regression-discontinuity evaluations of college remediation often find negative and null estimates of local average treatments effects (LATEs), but with substantial heterogeneity. We find that a remedial quantitative skills course at Wellesley College has a modestly positive LATE on participation in mathematically intensive fields of study—including the sciences, mathematics, and economics courses. Yet, LATEs are a weighted average of average causal effects (at the passing cutoff) in two principal strata: students who voluntarily comply with remediation, and those who are coerced to comply after scoring below the cutoff on an optional retest. In the retest sample, we show that average causal effects are close to zero among (1) coerced compliers, and (2) never-takers. By implication, there are even larger effects among a smaller group of voluntary compliers at the cutoff. The results help interpret the mixed findings in the literature, in which compliance varies widely, and demonstrate methods for assessing external validity in fuzzy-discontinuity designs.

High-Detectivity and Broadband MoS2 Phototransistor Array by Coupling Negative Capacitance and Local Surface Plasmon Resonance Effects

High-Detectivity and Broadband MoS₂ Phototransistor Array by Coupling Negative Capacitance and Local Surface Plasmon Resonance Effects

Violent Crime and the Long Shadow of Immigration Enforcement

This research highlights a neglected paradox of migration policies: whereas narratives on migrants as a security threat in their countries of destination find little support in empirical studies, forcing migrants to return may increase violence and crime back home. Using migrants’ exposure to deportation threats at destination as an exogenous source of identification, this paper traces the long shadow of immigration enforcement on violent crime in Mexico, recipient of more than 3.5 million deportees from the US over the period 2000–2015. Enforced return is associated with more homicides and a stronger presence of cartels in migrants’ municipalities of origin, as well as a higher sense of insecurity among the population and a higher probability of being assaulted. Identifying these local effects of enforced return are a first step towards unpacking the various direct and indirect channels through which immigration enforcement generates unintended negative outcomes in migrants’ communities of origin.

On the Features of Numerical Simulation of Hydrogen Self-Ignition under High-Pressure Release

The paper is devoted to the comparative analysis of different CFD techniques used to solve the problem of high-pressure hydrogen release into the air. Three variations of a contemporary low-dissipation numerical technique (CABARET) are compared with each other and a conventional first-order numerical scheme. It is shown that low dissipation of the numerical scheme defines better resolution of the contact surface between released hydrogen and ambient air. As a result, the spatial structures of the jet and the reaction wave that arise during self-ignition are better resolved, which is useful for predicting the local effects of high-pressure hydrogen release. At the same time, the dissipation has little effect on the induction delay, so critical conditions of self-ignition can be reliably reproduced even via conventional numerical schemes. The test problem setups formulated in the paper can be used as benchmarks for compressible CFD solvers.

Theoretico-experimental analysis of bistability in the oscillatory response of a TaOx ReRAM to pulse train stimuli

Fading memory is the capability of a physical system to approach a unique asymptotic behaviour, irrespective of the initial conditions, when stimulated by an input from a certain class. Standard stimuli from the AC periodic class typically induce fading memory effects in non-volatile memristors, as uncovered for the first time back in 2016. Very recently, a deep investigation of resistance switching phenomena in a TaOx resistive random access memory cell revealed the capability of the nano-device to exhibit one of two possible oscillatory behaviours, depending upon the initial condition, when subject to a particular periodic excitation. This interesting finding was, however, left unexplained. Bistability is the simplest form of local fading memory. In a system, endowed with local fading memory under a given stimulus, the initial condition does not affect the long-term behaviour of the state as long as it is drawn from the basin of attraction of either of the distinct coexisting state-space attractors (two limit cycles for the periodically forced memristor acting as a bistable oscillator). Here, the history of the system, encoded in the initial condition, is, thus, erasable only locally through ad hoc stimulation. Motivated by the discovery of local history erase effects in our resistive random access memory cell, this study applies a powerful system-theoretic tool, enabling the analysis of the response of first-order systems to square pulse train-based periodic stimuli, known as the time-average state dynamic route, to an accurate physics-based mathematical model, earlier fitted to the nano-device, to determine a strategy for specifying the parameters of an excitation signal, consisting of the sequence of two square pulses of opposite polarity per period so as to induce various forms of monostability or multistability in the non-volatile memristor. In particular, as an absolute novelty in the literature, experimental measurements validate the theoretical prediction on the capability of the device to operate as one of two distinct oscillators, depending upon the initial condition, under a specific pulse train excitation signal. The coexistence of multiple oscillatory operating modes in the periodically forced resistive random access memory cell, an example par excellence of their unique non-linear dynamics, may inspire the development and circuit implementation of novel sensing and mem-computing paradigms.

Estrogen restores disordered lipid metabolism in visceral fat of prediabetic mice.

Visceral obesity is increasingly prevalent among adolescents and young adults and is commonly recognized as a risk factor for type 2 diabetes. Estrogen [17β-estradiol (E2)] is known to offer protection against obesity via diverse me-chanisms, while its specific effects on visceral adipose tissue (VAT) remain to be fully elucidated. To investigate the impact of E2 on the gene expression profile within VAT of a mouse model of prediabetes. Metabolic parameters were collected, encompassing body weight, weights of visceral and subcutaneous adipose tissues (VAT and SAT), random blood glucose levels, glucose tolerance, insulin tolerance, and overall body composition. The gene expression profiles of VAT were quantified utilizing the Whole Mouse Genome Oligo Microarray and subsequently analyzed through Agilent Feature Extraction software. Functional and pathway analyses were conducted employing Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses, respectively. Feeding a high-fat diet (HFD) moderately increased the weights of both VAT and SAT, but this increase was mitigated by the protective effect of endogenous E2. Conversely, ovariectomy (OVX) led to a significant increase in VAT weight and the VAT/SAT weight ratio, and this increase was also reversed with E2 treatment. Notably, OVX diminished the expression of genes involved in lipid metabolism compared to HFD feeding alone, signaling a widespread reduction in lipid metabolic activity, which was completely counteracted by E2 administration. This study provides a comprehensive insight into E2's local and direct protective effects against visceral adiposity in VAT at the gene level. In conclusion, the present study demonstrated that the HFD-induced over-nutritional challenge disrupted the gene expression profile of visceral fat, leading to a universally decreased lipid metabolic status in E2 deficient mice. E2 treatment effectively reversed this condition, shedding light on the mechanistic role and therapeutic potential of E2 in combating visceral obesity.

Design and Evaluation of Gastro-Retentive Floating Tablets of Ibandronic acid

The objective of this study is Preparation and evaluation of gastro-retentive floating tablets of Ibandronic acid by direct compression method polymers or combination. In this study, Ibandronic acid, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastro retentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDDs are an approach to prolong gastric residence time, there by targeting site-specific drug release in the upper GIT for local or systemic effect. GRDF tablets of Ibandronic acid (200 mg) were characterized with the effects of Carbopol 934P, HPMC 4KM and Na-CMC at various ratios on swelling, floating, physical integrity. A prolonged dissolution profile of Ibandronic acid GRDF tablets developed in this study was observed for its thickness, friability, hardness, drug content and in-vitro drug release. Formulated Floating tablets of Ibandronic acid gave satisfactory results for various physicochemical parameters like hardness, friability, thickness, weight variation and content uniformity. Sodium bicarbonate has predominant effect on the buoyancy lag time, while HPMC K4M has predominant effect on total floating time and drug release. From the study it is evident that a promising controlled release floating tablets of Ibandronic acid can be developed to increase gastric residence time and thereby increasing its bioavailability. Both doses significantly reduced the occurrence risk of new vertebral fractures by 50–52 percent when compared to the effects of the placebo drug. Keywords: Gastro retention, Ibandronic acid, floating tablet, Carbopol, GRDF, GRFT.

Mechanism of Speed Loss Reduction and Propulsion Efficiency Improvement of ONR Tumblehome with Active-Controlled Stern Flaps in Resonance Waves

The stern flap is a practical hull appendage equipment that enhances ship navigation performance and saves energy. The existing studies mainly focus on the fixed stern flap, other than an actively controlled one, so it is worth further exploring its effect and mechanism. By implanting the PID controller to the stern flap, this paper proposed a free-running CFD model on the ONRT (the Office of Naval Research Tumblehome) ship coupled with the active-controlled stern flap to investigate the hydrodynamic performance in resonance waves. The free-running performance in calm water and regular waves is numerically researched and verified versus the experimental and referenced results. Then, the effect of different PID coefficients and control strategies of the stern flap on the traveling speed, attitudes, and propulsion performance under the resonance wave condition is conducted, and the influence mechanism is explored. The results show that adopting a fixed flap controller and PID controller can reduce the original speed loss by 4.2% and 6.9%, respectively, and increase the average propulsive efficiency of the propeller by 1.0% and 1.4%, respectively. Further analysis reveals that the global effect of the suppressed motion attitudes due to the installation of the fixed flap effectively contributes to the resistance reduction. However, the local effect of the stern flap increases the resistance due to interaction with the propeller and stern. The PID-controlled stern flap exhibits similar average attitudes compared to the fixed one, which means the resistance reduction of the global effect is kept the same, and the active stern flap further improves the stern flow field, where the resistance increment of the local effect is weakened, enhancing the traveling speed and improving the propulsion efficiency.

Effect of concave‐wall jets with circumferential multi‐inlet on liquid–solid separation

AbstractThis study combined numerical simulation and experiment to explore the influence of the concave‐wall jets with uniformly distributed tangential inlets in the cyclone separator on the liquid–solid separation characteristics and equipment. The results show that as the number of tangential inlets increases, the superposition effect of particle trajectories and flow fields becomes more significant. The superimposed flow field enhances the circumferential flow velocity of the fluid, causing the distribution of the jet along the radial and spanwise directions to shrink, greatly improving the uniformity of particle distribution and turbulent kinetic energy along the circumference, and effectively reducing the impact of particles on local areas near the jet inlet. Since the superposition of circumferential multi‐inlet jets enhances the swirling flow, the local disturbance and wall erosion effects near the jet inlet were reduced. Compared with double inlets, the flow rates of three inlets and four inlets were increased by 50% and 100%, respectively, the maximum turbulent kinetic energy increased by 14.5% and 56.2%, and the maximum escape time of particles was shortened by 3.2 and 3.3 s, respectively, the maximum erosion rates were reduced by 38.4% and 23.6%, respectively, and the separation efficiency and material handling capacity were significantly improved. This study supplemented the theory of concave‐wall jets' superposition characteristics and provided a theoretical basis for applying circumferential multi‐inlet devices in liquid–solid separation equipment.

Composite RGO/Ag/Nanosponge Materials for the Photodegradation of Emerging Pollutants from Wastewaters

Composite RGO/Ag/Nanosponge Materials for the Photodegradation of Emerging Pollutants from Wastewaters

Multi-functional metasurface: ultra-wideband/multi-band absorption switching by adjusting guided-mode resonance and local surface plasmon resonance effects

This study introduces an innovative dual-tunable absorption film with the capability to switch between ultra-wideband and narrowband absorption. By manipulating the temperature, the film can achieve multi-band absorption within the 30–45 THz range or ultra-wideband absorption spanning 30–130 THz, with an absorption rate exceeding 0.9. Furthermore, the structural parameters of the absorption film are optimized using the particle swarm optimization (PSO) algorithm to ensure the optimal absorption response. The absorption response of the film is primarily attributed to the coupling of guided-mode resonance and local surface plasmon resonance effects. The film’s symmetric structure enables polarization incoherence and allows for tuning through various means such as doping/voltage, temperature and structural parameters. In the case of a multi-band absorption response, the film exhibits good sensitivity to refractive index changes in multiple absorption modes. Additionally, the absorption spectrum of the film remains effective even at large incidence angles, making it highly promising for applications in fields such as biosensing and infrared stealth.

Research on the Accounting and Spatial Effects of Emergy Ecological Footprint and Industrial Green GDP--The Case of Yangtze River Economic Belt

The booming development of industrial enterprises at the cost of ecological resource consumption has inevitably harmed the ecological environment, especially since the phenomenon of water resource pollution is more serious. Exploring the relationship between the ecological environment and the industrial economy is crucial to the green and sustainable development of the region. This study uses the Spatial Durbin Model (SDM) to investigate the impact of emergy ecological footprint on the industrial green of gross domestic product (GDP) under the perspective of water resources, based on the panel data of 11 provinces in Chinas Yangtze River Economic Belt (YREB) from 2012 to 2021. The results show that first, the overall industrial green GDP of the YREB has increased year by year, and the effect of water resource protection is outstanding. Second, the emergy ecological footprint has a significant positive effect on industrial green GDP, and the spillover effect is also significant. Third, heterogeneity analysis shows that the spatial relationship between emergy ecological footprint and industrial green GDP is different in different regions, and the local effect and neighborhood effect of the high industrial green economic development areas are consistent with those of the YREB, while the relationship between the low industrial green economic development areas is not obvious. This paper is of great significance for the green development of industrial enterprises in the YREB and guides the formulation of sustainable development policies.