Local Reorganization Research Articles

Structure of face-centred icosahedral quasicrystals with cluster close packing.

A 6D structure model for face-centred icosahedral quasicrystals consisting of so-called pseudo-Mackay and mini-Bergman-type atomic clusters is proposed based on the structure model of the Al69.1Pd22Cr2.1Fe6.8 3/2 cubic approximant crystal (with space group Pa3, a = 40.5 Å) [Fujita et al. (2013). Acta Cryst. A69, 322-340]. The cluster centres form an icosahedral close sphere packing generated by the occupation domains similar to those in the model proposed by Katz & Gratias [J. Non-Cryst. Solids (1993), 153-154, 187-195], but their size is smaller by a factor τ2 [τ = (1 + (5)1/2)/2]. The clusters cover approximately 99.46% of the atomic structure, and the cluster arrangement exhibits 15 and 19 different local configurations, respectively, for the pseudo-Mackay and mini-Bergman-type clusters. The occupation domains that generate cluster shells are modelled and discussed in terms of structural disorder and local reorganization of the cluster arrangements (phason flip).

Neuroelectrophysiology-compatible electrolytic lesioning.

Lesion studies have historically been instrumental for establishing causal connections between brain and behavior. They stand to provide additional insight if integrated with multielectrode techniques common in systems neuroscience. Here, we present and test a platform for creating electrolytic lesions through chronically implanted, intracortical multielectrode probes without compromising the ability to acquire neuroelectrophysiology. A custom-built current source provides stable current and allows for controlled, repeatable lesions in awake-behaving animals. Performance of this novel lesioning technique was validated using histology from ex vivo and in vivo testing, current and voltage traces from the device, and measurements of spiking activity before and after lesioning. This electrolytic lesioning method avoids disruptive procedures, provides millimeter precision over the extent and submillimeter precision over the location of the injury, and permits electrophysiological recording of single-unit activity from the remaining neuronal population after lesioning. This technique can be used in many areas of cortex, in several species, and theoretically with any multielectrode probe. The low-cost, external lesioning device can also easily be adopted into an existing electrophysiology recording setup. This technique is expected to enable future causal investigations of the recorded neuronal population's role in neuronal circuit function, while simultaneously providing new insight into local reorganization after neuron loss.

From Ultrafast Photoinduced Small Polarons to Cooperative and Macroscopic Charge-Transfer Phase Transition.

We study by femtosecond infrared spectroscopy the ultrafast and persistent photoinduced phase transition of the Rb0.94Mn0.94Co0.06[Fe(CN)6]0.98 ⋅ 0.2H2O material, induced at room temperature by a single laser shot. This system exhibits a charge-transfer based phase transition with a 75 K wide thermal hysteresis, centred at room temperature, from the low temperature Mn3+-N-C-Fe2+ tetragonal phase to the high temperature Mn2+-N-C-Fe3+ cubic phase. At room temperature, the photoinduced phase transition is persistent. However, the out-of-equilibrium dynamics leading to this phase is multi-scale. Femtosecond infrared spectroscopy, particularly sensitive to local reorganizations through the evolution of the frequency of the N-C vibration modes with the different characteristic electronic states, reveals that at low laser fluence and on short time scale, the photoexcitation of the Mn3+-N-C-Fe2+ phase creates small charge-transfer polarons [Mn2+-N-C-Fe3+]* within ≃250 fs. The local trapping of photoinduced intermetallic charge-transfer is characterized by the appearance of a polaronic infrared band, due to the surrounding Mn2+-N-C-Fe2+ species. Above a threshold fluence, when a critical fraction of small CT-polarons is reached, the macroscopic phase transition to the persistent Mn2+-N-C-Fe3+ cubic phase occurs within ≃ 100 ps. This non-linear photo-response results from elastic cooperativity, intrinsic to a switchable lattice and reminiscent of a feedback mechanism.

From Ultrafast Photoinduced Small Polarons to Cooperative and Macroscopic Charge‐Transfer Phase Transition

AbstractWe study by femtosecond infrared spectroscopy the ultrafast and persistent photoinduced phase transition of the Rb0.94Mn0.94Co0.06[Fe(CN)6]0.98 ⋅ 0.2H2O material, induced at room temperature by a single laser shot. This system exhibits a charge‐transfer based phase transition with a 75 K wide thermal hysteresis, centred at room temperature, from the low temperature Mn3+−N−C−Fe2+ tetragonal phase to the high temperature Mn2+−N−C−Fe3+ cubic phase. At room temperature, the photoinduced phase transition is persistent. However, the out‐of‐equilibrium dynamics leading to this phase is multi‐scale. Femtosecond infrared spectroscopy, particularly sensitive to local reorganizations through the evolution of the frequency of the N−C vibration modes with the different characteristic electronic states, reveals that at low laser fluence and on short time scale, the photoexcitation of the Mn3+−N−C−Fe2+ phase creates small charge‐transfer polarons [Mn2+−N−C−Fe3+]* within ≃250 fs. The local trapping of photoinduced intermetallic charge‐transfer is characterized by the appearance of a polaronic infrared band, due to the surrounding Mn2+−N−C−Fe2+ species. Above a threshold fluence, when a critical fraction of small CT‐polarons is reached, the macroscopic phase transition to the persistent Mn2+−N−C−Fe3+ cubic phase occurs within ≃ 100 ps. This non‐linear photo‐response results from elastic cooperativity, intrinsic to a switchable lattice and reminiscent of a feedback mechanism.

Insertion and Anchoring of HIV-1 Fusion Peptide into Complex Membrane Mimicking Human T-cell.

A fundamental understanding of how HIV-1 envelope (Env) protein facilitates fusion is still lacking. The HIV-1 fusion peptide, consisting of 15 to 22 residues, is the N-terminus of the gp41 subunit of the Env protein. Further, this peptide, a promising vaccine candidate, initiates viral entry into target cells by inserting and anchoring into human immune cells. The influence of membrane lipid reorganization and the conformational changes of the fusion peptide during the membrane insertion and anchoring processes, which can significantly affect HIV-1 cell entry, remains largely unexplored due to the limitations of experimental measurements. In this work, we investigate the insertion of the fusion peptide into an immune cell membrane mimic through multiscale molecular dynamics simulations. We mimic the native T-cell by constructing a 9-lipid asymmetric membrane, along with geometrical restraints accounting for insertion in the context of gp41. To account for the slow timescale of lipid mixing while enabling conformational changes, we implement a protocol to go back and forth between atomistic and coarse-grained simulations. Our study provides a molecular understanding of the interactions between the HIV-1 fusion peptide and the T-cell membrane, highlighting the importance of conformational flexibility of fusion peptides and local lipid reorganization in stabilizing the anchoring of gp41 into the targeted host membrane during the early events of HIV-1 cell entry. Importantly, we identify a motif within the fusion peptide critical for fusion that can be further manipulated in future immunological studies.

Cortical plasticity is associated with blood-brain barrier modulation.

Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated leakage of serum albumin to the neuropil have been shown to induce pathological plasticity, neuronal hyper-excitability, and seizures. The effect of neuronal activity on BBB function and whether it plays a role in plasticity in the healthy brain remain unclear. Here we show that neuronal activity induces modulation of microvascular permeability in the healthy brain and that it has a role in local network reorganization. Combining simultaneous electrophysiological recording and vascular imaging with transcriptomic analysis in rats, and functional and BBB-mapping MRI in human subjects, we show that prolonged stimulation of the limb induces a focal increase in BBB permeability in the corresponding somatosensory cortex that is associated with long-term synaptic plasticity. We further show that the increased microvascular permeability depends on neuronal activity and involves caveolae-mediated transcytosis and transforming growth factor β signaling. Our results reveal a role of BBB modulation in cortical plasticity in the healthy brain, highlighting the importance of neurovascular interactions for sensory experience and learning.

Multi-omics analysis reveals the dynamic interplay between Vero host chromatin structure and function during vaccinia virus infection

The genome folds into complex configurations and structures thought to profoundly impact its function. The intricacies of this dynamic structure-function relationship are not well understood particularly in the context of viral infection. To unravel this interplay, here we provide a comprehensive investigation of simultaneous host chromatin structural (via Hi-C and ATAC-seq) and functional changes (via RNA-seq) in response to vaccinia virus infection. Over time, infection significantly impacts global and local chromatin structure by increasing long-range intra-chromosomal interactions and B compartmentalization and by decreasing chromatin accessibility and inter-chromosomal interactions. Local accessibility changes are independent of broad-scale chromatin compartment exchange (~12% of the genome), underscoring potential independent mechanisms for global and local chromatin reorganization. While infection structurally condenses the host genome, there is nearly equal bidirectional differential gene expression. Despite global weakening of intra-TAD interactions, functional changes including downregulated immunity genes are associated with alterations in local accessibility and loop domain restructuring. Therefore, chromatin accessibility and local structure profiling provide impactful predictions for host responses and may improve development of efficacious anti-viral counter measures including the optimization of vaccine design.

Hydrogen charging can relax compressive residual stresses caused by shot peening

Surface engineering to generate compressive stresses via processes such as shot peening is commonly employed to mitigate fracture or fatigue failures in metallic systems. Localized plastic deformation is used to generate the generally biaxial compressive elastic stresses. This study examined the residual stress conditions and local mechanical performance of medium carbon steel in a quenched and tempered state. Electrolytic hydrogen charging of peened samples led to a permanent reduction in the compressive surface stress while concurrently hardening the surface. Slight changes in elastic modulus when solute hydrogen was present could not explain the resulting change in the measured residual stress; a reduction in X-ray peak breadth suggests that the combined effects of elastic stresses and solute hydrogen caused local dislocation annihilation and re-organization of the dislocation structure in the severe plastically deformed layer, leading to a lower magnitude and shallower depth of compressive residual stress on the peened surface after hydrogen charging.

Destabilization of Oxidized Lattice Oxygen in Layered Oxide Cathode.

Integrating anion-redox capacity with orthodox cation-redox capacity is deemed as a promising solution for high-energy-density battery cathodes surmounting the present technical bottlenecks. However, the evolution of oxidized oxygen species during the electrochemical or chemical process easily jeopardizes the reversibility of oxygen redox and remains poorly understood. Herein, we showcase the gradual conversion of the π-interacting oxygen (localized hole states on O) to the σ-interacting oxygen upon resting at a high voltage for P3-type Na0.6Li0.2Mn0.8O2 with nominally stable ribbon-like superstructure, accompanied by the O-O dimerization and the local structural reorganization. We further pinpoint an abnormal Li+ migration process from the alkali-metal layer to the transition-metal layer for desodiated P3-Na0.6Li0.2Mn0.8O2, thereby leading to a partial reconstruction of the ribbon superstructure. The high-voltage plateau of oxygen-redox cathodes is concluded to be exclusively controlled by the oxygen stabilization mechanism rather than the superstructure ordering. In addition, there exists a kinetic competition between π and σ interaction during the uninterrupted electrochemical process.

Dynamic Nanoindentation and Short-Range Order in Equiatomic NiCoCr Medium-Entropy Alloy Lead to Novel Density Wave Ordering.

Chemical short-range order is believed to be a key contributor to the exceptional properties of multicomponent alloys. However, its direct validation and confirmation has been highly elusive in most compounds. Recent studies for equiatomic NiCoCr alloys have shown that thermal treatments (i.e., annealing and aging) may facilitate and manipulate such ordering. In this work, by using molecular simulations, we show that nanomechanical probes, such as nanoindentation, may be utilized toward further manipulation of chemical short-range order, providing explicit validation pathways. By using well established interatomic potentials, we perform hybrid molecular-dynamics-MonteCarlo at room temperature to demonstrate that particular dwell nanoindentation protocols can lead, through thermal MonteCarlo equilibration, to local reorganization under the indenter tip, toward a density-wave stripe pattern. We characterize the novel density-wave structures, which are highly anisotropic and dependent on local, nanoindentation-induced stress concentrations, and we show how they deeply originate from intrinsic features of interelemental interactions. Furthermore, we show that these novel patterns consistently scale with the incipient plastic zone, under the indenter tip, justifying their observation at experimentally feasible nanoindentation depths.

지방정부 조직개편 유형과 시기적 특징 분석 : 경기도를 중심으로

지방정부 조직개편 유형과 시기적 특징 분석 : 경기도를 중심으로

High-density electroencephalographic functional networks in genetic generalized epilepsy: Preserved whole-brain topology hides local reorganization.

Genetic generalized epilepsy (GGE) accounts for approximately 20% of adult epilepsy cases and is considered a disorder of large brain networks, involving both hemispheres. Most studies have not shown any difference in functional whole-brain network topology when compared to healthy controls. Our objective was to examine whether this preserved global network topology could hide local reorganizations that balance out at the global network level. We recorded high-density electroencephalograms from 20 patients and 20 controls, and reconstructed the activity of 118 regions. We computed functional connectivity in windows free of interictal epileptiform discharges in broad, delta, theta, alpha, and beta frequency bands, characterized the network topology, and used the Hub Disruption Index (HDI) to quantify the topological reorganization. We examined the generalizability of our results by reproducing a 25-electrode clinical system. Our study did not reveal any significant change in whole-brain network topology among GGE patients. However, the HDI was significantly different between patients and controls in all frequency bands except alpha (p < .01, false discovery rate [FDR] corrected, d < -1), and accompanied by an increase in connectivity in the prefrontal regions and default mode network. This reorganization suggests that regions that are important in transferring the information in controls were less so in patients. Inversely, the crucial regions in patients are less so in controls. These findings were also found in delta and theta frequency bands when using 25 electrodes (p < .001, FDR corrected, d < -1). In GGE patients, the overall network topology is similar to that of healthy controls but presents a balanced local topological reorganization. This reorganization causes the prefrontal areas and default mode network to be more integrated and segregated, which may explain executive impairment associated with GGE. Additionally, the reorganization distinguishes patients from controls even when using 25 electrodes, suggesting its potential use as a diagnostic tool.

Tracing mechanistic pathways and reaction kinetics toward equilibrium in reactive molten salts.

In the dynamic environment of multi-component reactive molten salts, speciation unfolds as a complex process, involving multiple competing reaction pathways that are likely to face free energy barriers before reaching the reaction equilibria. Herein, we unravel intricate speciation in the AlCl3-KCl melt compositions with rate theory and ab initio molecular dynamics simulations. We find that the compositions with 100 and 50 mol% AlCl3 exclusively comprise neutral Al2Cl6 dimers and charged AlCl4- monomers, respectively. In intermediate AlCl3-KCl compositions, the chemical speciation proves to be a very complex process, requiring over 0.5 nanosecond to reach an equilibrium distribution of multiple species. It is a consequence of the competitive formation and dissociation of additional species, including charged Al dimers, trimers, and tetramers. Here, the species formation occurs through ion exchange events, which we explain by computing free energy landscapes and employing a Marcus-like rate theory. We show that both interspecies and intraspecies ion exchanges are probable and are dictated by the local structural reorganization reflected in the change of local coulombic fields. The species distributions are validated by comparing computed Raman spectra and neutron structure factors with the available experimental data. We find an excellent simulation-experiment agreement in both cases. Nevertheless, Raman spectroscopy turns out to be particularly advantageous for distinguishing between unique species distributions because of the distinct vibrational signatures of different species. The mechanistic insight into reaction dynamics gained in this study will be essential for the advancement of molten salts as reactive media in high-temperature energy applications.

Tracking Mn and Zn in Rechargeable Aqueous Zn-MnO2 Batteries By Operando X-Ray Absorption

Zn-MnO2 batteries with mildly acidic electrolytes are a promising chemistry for large scale storage thanks to their remarkable energy density, low cost, and high safety. This is mainly obtained thanks to the high capacity of the Zn metal anode, and the nonflammable character of the aqueous electrolyte. MnO2 is one of the most common cathode of choice, not only for being Earth-abundant, but also because it can undergo a two-electron mechanism, which is however complex and still not fully understood. There is currently agreement in considering for discharge a MnO2 dissolution, leading to soluble Mn2+ and simultaneous precipitation of Zinc Hydroxide Sulfate (ZHS, ZnSO4[Zn(OH2)]3·xH2O). When charging the process is not simply reverted. In fact, a distinct electrochemical profile is observed, with at least two distinct plateaus and a third, apparently pseudocapacitive stage (Figure 1a). A similar multistage profile is observed during the second discharge. Although such profile is characteristic and observed with different MnO2 phases and architectures, the underlying mechanism remains elusive, as it seems to involve mainly poorly crystallized phases.We studied the mechanism by operando X-ray absorption (XAS) at the Mn and Zn K-edges to follow speciation simultaneously and quantitatively in the cathode and in the electrolyte via principal component analysis. Beam intensity needed appropriate regulation to avoid interference with the experiment.Simultaneous X-ray diffraction allowed precise correlation with the MnO2 dissolution and ZHS formation. We found evidence of Mn(III) intermediate occurring during local bond reorganization, which is inferred by the significant evolution of the absorption fine structure region (EXAFS) of the Mn K-edge (Figure 1b). In contrast, minor Zn spectral changes reflect primarily processes of precipitation and dissolution, suggesting that no Zn-Mn mixed phases form during cycling. Figure 1

감사원 직무감찰의 개선에 관한 연구

Recently, the Civil Rights Commission Collisions between the election management committee and auditors, and adverse effects due to duplicate audits with auditing organizations, With the enactment of the “Public Audit Law” and the “Special Law on Local Autonomy Decentralization and Regional Balanced Development”. Due to the rapid changes in the audit and administrative environment, the reform of the existing audit system can no longer be postponed. The Board of Audit and Inspection's job inspection establishes discipline in public office by eliminating control over state power and corruption. It plays an important role in national audit activities. In terms of job inspection, In addition to the legality audit, there is a suitability audit. “Special Act on Decentralization of Local Autonomy and Reorganization of Local Administrative System” With the enactment of, the administrative affairs of local governments have been abolished, and only the administrative affairs of local governments have been abolished.&#x0D; As for self-government affairs, there is a possibility of infringing the essence of autonomy, so a purposeful audit of the central administrative agency should be conducted. Denial is reasonable. Of job inspections, interpersonal inspections are used to ensure democratic control and responsibility.&#x0D; Expanding the scope of job inspections, the purpose of administrative affairs inspections will be closely related to auditing results of audits. Therefore, it is desirable to combine administrative audits with accounting audits.&#x0D; In order to ensure the effectiveness of the results, it is necessary to overcome the functional, political, ceremonial and scope limitations of the duty inspection.&#x0D; And financial application rights, indictment jury rights, investigative rights, etc. should be considered. Also includes self-audit, Auditing bodies ensure unrestricted access to information and audit findings and reports and audits to Congress and the general public.&#x0D; It is necessary to set up institutional devices such as checking the status of result disposition and audit monitoring.&#x0D; Meanwhile, while strengthening the position of the Audit &amp; Supervisory Board Members as the highest auditing body, we will strengthen the self-audit system, which is an internal control system.&#x0D; Auditors are encouraged to switch to a guardianship audit. I would like to see the legislative reform so that the employees can discuss and coordinate as the highest auditing body. Inspection by Audit &amp; Supervisory Board Members.&#x0D; but, If the independence of the Board of Audit and Supervisory Board is not guaranteed, the establishment and effectiveness of the guardianship audit system of the Board.&#x0D; It will not be able to secure it and will not be able to smoothly perform its functions of cooperation and coordination as the Supreme Oversight Body.

Detecting depression based on facial cues elicited by emotional stimuli in video

Recently, depression research has received considerable attention and there is an urgent need for objective and validated methods to detect depression. Depression detection based on facial expressions may be a promising adjunct to depression detection due to its non-contact nature. Stimulated facial expressions may contain more information that is useful in detecting depression than natural facial expressions. To explore facial cues in healthy controls and depressed patients in response to different emotional stimuli, facial expressions of 62 subjects were collected while watching video stimuli, and a local face reorganization method for depression detection is proposed. The method extracts the local phase pattern features, facial action unit (AU) features and head motion features of a local face reconstructed according to facial proportions, and then fed into the classifier for classification. The classification accuracy was 76.25%, with a recall of 80.44% and a specificity of 83.21%. The results demonstrated that the negative video stimuli in the single-attribute stimulus analysis were more effective in eliciting changes in facial expressions in both healthy controls and depressed patients. Fusion of facial features under both neutral and negative stimuli was found to be useful in discriminating between healthy controls and depressed individuals. The Pearson correlation coefficient (PCC) showed that changes in the emotional stimulus paradigm were more strongly correlated with changes in subjects’ facial AU when exposed to negative stimuli compared to stimuli of other attributes. These results demonstrate the feasibility of our proposed method and provide a framework for future work in assisting diagnosis.

High-pressure response of vibrational properties of b-As x P1–x : in situ Raman studies

The structural evolution of black arsenic-phosphorous (b-As x P1–x ) alloys with varying arsenic concentrations was investigated under hydrostatic pressure using in situ Raman spectroscopy. High-pressure experiments were conducted using a diamond anvil cell, which revealed pressure-induced shifts in vibrational modes associated with P–P bonds (A 1 g , A 2 g , ), As–As bonds (A 1 g , A 2 g , ), and As–P bonds in b-As x P1–x alloys. Two distinct pressure regimes were observed. In the first regime (region I), all vibrational modes exhibited a monotonic upshift, indicating phonon hardening due to hydrostatic pressure. In the second regime (region II), As0.4P0.6 and As0.6P0.4 alloys displayed a linear blueshift (or negligible change in some modes) at a reduced rate, suggesting local structural reorganization with less compression on the bonds. Notably, the alloy with the highest As concentration, As0.8P0.2, exhibited anomalous behavior in the second pressure regime, with a downward shift observed in all As–As and As–P Raman modes (and some P–P modes). Interestingly, the emergence of new peaks corresponding to the Eg mode and A 1g mode of the gray-As phase was observed in this pressure range, indicating compressive strain-induced structural changes. The anomalous change in region II confirms the formation of a new local structure, characterized by elongation of the P–P, As–As, and As–P bonds along the zigzag direction within the b-As x P1–x phase, possibly near the grain boundary. Additionally, a gray-As phase undergoes compressive structural changes. This study underscores the significance of pressure in inducing structural transformations and exploring novel phases in two-dimensional materials, including b-As x P1–x alloys.

New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex.

All enveloped viruses enter cells by fusing their envelope with a target cell membrane while avoiding premature fusion with membranes of the producer cell-the latter being particularly important for viruses that bud at internal membranes. Flaviviruses bud in the endoplasmic reticulum, are transported through the TGN to reach the external milieu, and enter other cells via receptor-mediated endocytosis. The trigger for membrane fusion is the acidic environment of early endosomes, which has a similar pH to the TGN of the producer cell. The viral particles therefore become activated to react to mildly acidic pH only after their release into the neutral pH extracellular environment. Our study shows that for yellow fever virus (YFV), the mechanism of activation involves actively knocking out the fusion brake (protein pr) through a localized conformational change of the envelope protein upon exposure to the neutral pH external environment. Our study has important implications for understanding the molecular mechanism of flavivirus fusion activation in general and points to an alternative way of interfering with this process as an antiviral treatment.

Simulation-Based Optimization of the Urban Thermal Environment through Local Climate Zones Reorganization in Changsha City, China with the FLUS Model

Urbanization leads to changes in surface landscapes, such as the increase in built-up areas and the decrease in natural elements, resulting in local changes in land surface temperature, which often create unusually hot weather and affect livability, especially for mid- and low-latitude cities. Therefore, optimizing urban landscapes and adjusting the thermal environment is especially important to improve comfort and to achieve sustainable urban development. Existing studies on optimizing landscapes have considered mainly horizontal land uses/land covers but ignored their elevation. This study considered local climate zones as basic units to describe three-dimensional landscapes; we measured the relationship between local climate zones and land surface temperature, based on which the research further used a genetic algorithm and future land-use simulation models to optimize the spatial layouts of local climate zones in Changsha, China, considering multiple objectives including adjusting land surface temperature without affecting population carrying capacity, economic development, watershed protection, and forest and grass protection. According to the optimization results, the area of open low-rise buildings increased by 5.98% after optimization, and dense trees decreased by 7.64%; open low-rise buildings were suggested to be newly built in the city center and sparsely buildings should be developed in the surrounding administrative district far away from the city center. The optimization results contributed to a −5.2 °C reduction of average land surface temperature, which could significantly improve the thermal environment under the premise of ensuring the population and economic development levels and thus serves as a novel solution for improving urban landscapes to implement sustainable city development.

The role of functional and structural properties of the nucleus accumbens subregions in eating behavior regulation of bulimia nervosa.

Although studies have demonstrated the involvement of the nucleus accumbens (NAc) in the neurobiology of eating disorders, its alterations in bulimia nervosa (BN) remain largely unknown. This study investigated the structural and functional properties of NAc in patients with BN. Based on the resting-state functional MRI and high-resolution anatomical T1-weighted imaging data acquired from 43 right-handed BN patients and 40 sex-, age- and education-matched right-handed healthy controls (HCs), the group differences in gray matter volume (GMV) and fractional amplitude of low-frequency fluctuation (fALFF) in slow-4 and -5 bands and functional connectivity (FC) of NAc subregions (core and shell) were compared. The relationships between MRI and clinical data were explored in the BN group. Compared with HCs, BN patients showed preserved GMV, decreased fALFF in slow-5 band of the left NAc core and shell, decreased FC between left NAc core and right caudate, and increased FC between all NAc subregions and frontal regions, between all NAc subregions (except the right NAc core) and the supramarginal gyrus (SMG), and between right NAc shell and left middle temporal gyrus. FC between the NAc and SMG was correlated with emotional eating behaviors. Our study revealed preserved GMV, local neuronal activity reduction and functional network reorganization of the NAc in BN. The functional network reorganization of the NAc mainly occurred in the frontal cortex and was correlated with emotional eating behavior. These findings may provide novel insights into the BN using NAc as an entry point. Although studies have demonstrated the involvement of the nucleus accumbens (NAc) in the neurobiology of eating disorders, its alterations in bulimia nervosa (BN) remain largely unknown. We used a multimodal MRI technique to systematically investigate structural and functional alterations in NAc subregions of BN patients and explored the associations between such alterations and maladaptive eating behaviors, hoping to provide novel insights into BN.