Local Reflex Research Articles

ANY DUAL OPERATOR SPACE IS WEAKLY LOCALLY REFLEXIVE

Abstract We introduce the notion of weakly local reflexivity in operator space theory and prove that any dual operator space is weakly locally reflexive.

Finite approximation properties of $C^{*}$-modules II

We study quasidiagonality and local reflexivity for C^{*} -algebras which are C^{*} -module over another C^{*} -algebra with compatible actions. We introduce and study a notion of amenability for vector valued traces.

Human pain ratings to electrical sinusoids increase with cooling through a cold-induced increase in C-fibre excitability.

Low-frequency sinusoidal current applied to human skin evokes local axon reflex flare and burning pain, indicative of C-fibre activation. Because topical cooling works well as a local analgesic, we examined the effect of cooling on human pain ratings to sinusoidal and rectangular profiles of constant current stimulation. Unexpectedly, pain ratings increased upon cooling the skin from 32 to 18°C. To explore this paradoxical observation, the effects of cooling on C-fibre responses to stimulation with sinusoidal and rectangular current profiles were determined in ex vivo segments of mouse sural and pig saphenous nerve. As expected by thermodynamics, the absolute value of electrical charge required to activate C-fibre axons increased with cooling from 32°C to 20°C, irrespective of the stimulus profile used. However, for sinusoidal stimulus profiles, cooling enabled a more effective integration of low-intensity currents over tens of milliseconds resulting in a delayed initiation of action potentials. Our findings indicate that the paradoxical cooling-induced enhancement of electrically evoked pain in people can be explained by an enhancement of C-fibre responsiveness to slow depolarization at lower temperatures. This property may contribute to symptoms of enhanced cold sensitivity, especially cold allodynia, associated with many forms of neuropathic pain.

Reverse Triggering during Controlled Ventilation: From Physiology to Clinical Management.

Reverse triggering dyssynchrony is a frequent phenomenon recently recognized in sedated critically ill patients under controlled ventilation. It occurs in at least 30-55% of these patients and often occurs in the transition from fully passive to assisted mechanical ventilation. During reverse triggering, patient inspiratory efforts start after the passive insufflation by mechanical breaths. The most often referred mechanism is the entrainment of the patient's intrinsic respiratory rhythm from the brainstem respiratory centers to periodic mechanical insufflations from the ventilator. However, reverse triggering might also occur because of local reflexes without involving the respiratory rhythm generator in the brainstem. Reverse triggering is observed during the acute phase of the disease, when patients may be susceptible to potential deleterious consequences of injurious or asynchronous efforts. Diagnosing reverse triggering might be challenging and can easily be missed. Inspection of ventilator waveforms or more sophisticated methods, such as the electrical activity of the diaphragm or esophageal pressure, can be used for diagnosis. The occurrence of reverse triggering might have clinical consequences. On the basis of physiological data, reverse triggering might be beneficial or injurious for the diaphragm and the lung, depending on the magnitude of the inspiratory effort. Reverse triggering can cause breath-stacking and loss of protective lung ventilation when triggering a second cycle. Little is known about how to manage patients with reverse triggering; however, available evidence can guide management on the basis of physiological principles.

NeuroWalknet, a controller for hexapod walking allowing for context dependent behavior.

Decentralized control has been established as a key control principle in insect walking and has been successfully leveraged to account for a wide range of walking behaviors in the proposed neuroWalknet architecture. This controller allows for walking patterns at different velocities in both, forward and backward direction-quite similar to the behavior shown in stick insects-, for negotiation of curves, and for robustly dealing with various disturbances. While these simulations focus on the cooperation of different, decentrally controlled legs, here we consider a set of biological experiments not yet been tested by neuroWalknet, that focus on the function of the individual leg and are context dependent. These intraleg studies deal with four groups of interjoint reflexes. The reflexes are elicited by stimulation of the femoral chordotonal organ (fCO) or groups of campaniform sensilla (CS). Motor output signals are recorded from the alpha-joint, the beta-joint or the gamma-joint of the leg. Furthermore, the influence of these sensory inputs to artificially induced oscillations by application of pilocarpine has been studied. Although these biological data represent results obtained from different local reflexes in different contexts, they fit with and are embedded into the behavior shown by the global structure of neuroWalknet. In particular, a specific and intensively studied behavior, active reaction, has since long been assumed to represent a separate behavioral element, from which it is not clear why it occurs in some situations, but not in others. This question could now be explained as an emergent property of the holistic structure of neuroWalknet which has shown to be able to produce artificially elicited pilocarpine-driven oscillation that can be controlled by sensory input without the need of explicit innate CPG structures. As the simulation data result from a holistic system, further results were obtained that could be used as predictions to be tested in further biological experiments.

Chapter 2 - Upper and lower motor neuron neurophysiology and motor control

This chapter considers the principles that underlie neurophysiological studies of upper motor neuron or lower motor neuron lesions, based on an understanding of the normal structure and function of the motor system. Human motor neurophysiology consists of an evaluation of the active components of the motor system that are relevant to volitional movements. Relatively primitive motor skills include locomotion, much dependent on the spinal cord central pattern generator, reaching, involving proximal and distal muscles activation, and grasping. Humans are well prepared to perform complex movements like writing. The role of motor cortex is critical for the motor activity, very dependent on the continuous sensory feedback, and this is essential for adapting the force and speed control, which contributes to motor learning. Most corticospinal neurons in the brain project to brainstem and spinal cord, many with polysynaptic inhibitory rather than excitatory connections. The monosynaptic connections observed in humans and primates constitute a specialized pathway implicated in fractional finger movements. Spinal cord has a complex physiology, and local reflexes and sensory feedback are essential to control adapted muscular contraction during movement. The cerebellum has a major role in motor coordination, but also consistent roles in sensory activities, speech, and language, in motor and spatial memory, and in psychological activity. The motor unit is the final effector of the motor drive. The complex interplay between the lower motor neuron, its axon, motor end-plates, and muscle fibers allows a relevant plasticity in the movement output.

Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats

BackgroundThe role of cholinergic receptors in the regulation of duodenal mucosal permeability in vivo is currently not fully described.AimsTo elucidate the impact of nicotinic and muscarinic acetylcholine receptor signaling in response to luminal hypotonicity (50 mM NaCl) in the proximal small intestine of rat.MethodsThe effect on duodenal blood-to-lumen clearance of 51Cr-EDTA (i.e., mucosal permeability) and motility was studied in the absence and presence of nicotinic and muscarinic receptor agonists and antagonists, a sodium channel blocker (tetrodotoxin), and after bilateral cervical vagotomy.ResultsRats with duodenal contractions responded to luminal hypotonicity by substantial increase in intestinal permeability. This response was absent in animals given a non-selective nicotinic receptor antagonist (mecamylamine) or agonist (epibatidine). Pretreatment with tetrodotoxin reduced the increase in mucosal permeability in response to luminal hypotonicity. Further, the non-selective muscarinic receptor antagonist (atropine) and agonist (bethanechol) reduced the hypotonicity-induced increase in mucosal permeability, while vagotomy was without an effect, suggesting that local enteric reflexes dominate. Finally, neither stimulating nor blocking the α7-nicotinic receptor had any significant effects on duodenal permeability in response to luminal hypotonicity, suggesting that this receptor is not involved in regulation of duodenal permeability. The effect of the different drugs on mucosal permeability was similar to the effect observed for duodenal motility.ConclusionsA complex enteric intramural excitatory neural reflex involving both nicotinic and muscarinic receptor subtypes mediates an increase in mucosal permeability induced by luminal hypotonicity.

Reflexes of exponent movement in inflectional morphology

Seemingly non-local phonological operations triggered by inflectional exponents have been observed in a number of languages. Focussing on de-spirantization in Barwar Aramaic, accent shift in Lithuanian, ni-insertion in Quechua, ruki rule application in Sanskrit, and vowel harmony in Kazakh, we argue that these phenomena should be analyzed as strictly local phonological reflexes of movement in a pre-syntactic autonomous morphological component. Such morphological movement is shown to arise without further assumptions under the approach to inflectional morphology based on Harmonic Serialism (McCarthy 2016) developed in Müller 2020. Here, each morphological operation immediately gives rise to an optimization procedure, morphological structure-building is subject to simple alignment constraints, and counter-cyclic operations are precluded. Against this background, phonological reflexes of movement are predicted to show up when a potentially complete word triggers a phonological cycle, which is then followed by morphological movement. Finally, we argue that constraint-driven morphological movement is superior to alternative accounts based on (i) non-local phonology, (ii) base-derivative faithfulness, (iii) phonological movement, (iv) counter-cyclic operations (interfixation, lowering, local dislocation), (v) syntactic movement, and (vi) strata.

Menthol-induced activation of TRPM8 receptors increases cutaneous blood flow across the dermatome.

Topical menthol-based analgesics increase skin blood flow (SkBF) through transient receptor potential melastatin 8 (TRPM8) receptor-dependent activation of sensory nerves and endothelium-derived hyperpolarization factors. It is unclear if menthol-induced TRPM8 activation mediates a reflex change in SkBF across the dermatome in an area not directly treated with menthol. The purpose of this study was to determine the effects of localized topical menthol application on SkBF across a common dermatome. We hypothesized that SkBF would be increased with menthol at the site of application and across the dermatome (contralateral limb) through a spinal reflex mechanism. In a double blind, placebo controlled, cross-over design, 15 healthy participants (7 men; age=22±1yrs) were treated with direct application (3ml over 8×13cm) of 5% menthol gel (Biofreeze™) or placebo gel on the L4 dermatome, separated by 48h. Red blood cell flux was measured using laser Doppler flowmetry over the area of application, on the contralateral leg of the same dermatome, and in a separate dermatome (L5/S1) to serve as control. Cutaneous vascular conductance was calculated for each measurement site (CVC=flux/MAP). At baseline there were no differences in CVC between menthol and placebo gels, or among sites (all p>0.05). After 30±6min, CVC increased at the treated site with menthol (0.12±0.02 vs. 1.36±0.19flux/mmHg, p<0.01) but not the placebo (0.10±0.01 vs. 0.18±0.04flux/mmHg, p=0.91). There was a modest increase in CVC at the contralateral L4 dermatome with menthol gel (0.16±0.04 vs. 0.29±0.06flux/mmHg, p<0.01), but not placebo (0.11±0.02 vs. 0.15±0.03flux/mmHg, p=0.41). There was no effect on SkBF from either treatments at the L5/S1 control dermatome (both, p>0.05), suggesting the lack of a systemic response. In conclusion, menthol containing topical analgesic gels increased SkBF at the treated site, and modestly throughout the dermatome. These data suggest menthol-induced activation of the TRPM8 receptors induces an increase in SkBF across the area of common innervation through a localized spinal reflex mechanism.

Fibroblast Growth Factor 19 Increases the Excitability of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice.

Intracerebroventricular administration of the protein hormone fibroblast growth factor 19 (FGF19) to the hindbrain produces potent antidiabetic effects in hyperglycemic mice that are likely mediated through a vagal parasympathetic mechanism. FGF19 increases the synaptic excitability of parasympathetic motor neurons in the dorsal motor nucleus of the vagus (DMV) from hyperglycemic, but not normoglycemic, mice but the source of this synaptic input is unknown. Neurons in the area postrema (AP) and nucleus tractus solitarius (NTS) express high levels of FGF receptors and exert glutamatergic control over the DMV. This study tested the hypothesis that FGF19 increases glutamate release in the DMV by increasing the activity of glutamatergic AP and NTS neurons in hyperglycemic mice. Glutamate photoactivation experiments confirmed that FGF19 increases synaptic glutamate release from AP and NTS neurons that connect to the DMV in hyperglycemic, but not normoglycemic mice. Contrary to expectations, FGF19 produced a mixed effect on intrinsic membrane properties in the NTS with a trend towards inhibition, suggesting that another mechanism was responsible for the observed effects on glutamate release in the DMV. Consistent with the hypothesis, FGF19 increased action potential-dependent glutamate release in the NTS in hyperglycemic mice only. Finally, glutamate photoactivation experiments confirmed that FGF19 increases the activity of glutamatergic AP neurons that project to the NTS in hyperglycemic mice. Together, these results support the hypothesis that FGF19 increases glutamate release from AP and NTS neurons that project to the DMV in hyperglycemic mice. FGF19 therefore modifies the local vago-vagal reflex circuitry at several points. Additionally, since the AP and NTS communicate with several other metabolic regulatory nuclei in the brain, FGF19 in the hindbrain may alter neuroendocrine and behavioral aspects of metabolism, in addition to changes in parasympathetic output.

A case of red nucleus and hillock syndrome

Th. Dosuzkov in Revue v neurologii i psychiatrii, 1928, no. In addition to the presence of semi-paresis, sensory disturbances, pain, intentional tremor, the author indicates cerebellar disorders on the same side, changes in local setting reflexes on both sides, and on the part of the psyche, euphoria and mild dementia.

MP08-15 HIGH-RESOLUTION EPIDURAL SPINAL CORD STIMULATION (HR-SCS) EVOKES SELECTIVE MICTURITION AND CONTINENCE REFLEXES THROUGH A FREQUENCY-DEPENDENT EFFECT GOVERNED BY DISTINCT NEURAL CIRCUITS

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology (MP08)1 Sep 2021MP08-15 HIGH-RESOLUTION EPIDURAL SPINAL CORD STIMULATION (HR-SCS) EVOKES SELECTIVE MICTURITION AND CONTINENCE REFLEXES THROUGH A FREQUENCY-DEPENDENT EFFECT GOVERNED BY DISTINCT NEURAL CIRCUITS Chaitanya Gopinath, Maria K. Jantz, Ritesh Kumar, Bryan L. McLaughlin, and Robert A. Gaunt Chaitanya GopinathChaitanya Gopinath More articles by this author , Maria K. JantzMaria K. Jantz More articles by this author , Ritesh KumarRitesh Kumar More articles by this author , Bryan L. McLaughlinBryan L. McLaughlin More articles by this author , and Robert A. GauntRobert A. Gaunt More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001981.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Spinal cord stimulation (SCS) has been explored for controlling lower urinary tract function in experimental and clinical settings. However, there are no mechanistic and reproducible approaches to evoke both micturition and continence reflexes. Here, we demonstrate that epidural SCS can selectively evoke micturition and continence behaviors in both isovolumetric and cystometric studies in feline anesthetized animal model. Our results indicate the existence of two distinct frequency-dependent neural circuits mediating continence and micturition evoked by varying stimulus frequencies. METHODS: Three male and three female cats (n=6) were anesthetized with α-chloralose after initial surgical preparations under isoflurane anesthesia. Nerve cuffs were placed unilaterally on the pelvic nerve, pudendal nerve and its branches (sensory, deep perineal and caudal rectal nerves). HR-SCS electrodes (Ripple Neuro, Micro-Leads Medical) were placed on the epidural surface of sacral cord and cauda equina. Stimulation pulse trains with amplitudes between 200-800 µA were delivered through SCS electrodes while recording bladder pressure and compound action potentials in the peripheral nerve cuffs. Electromyograms from the pelvic floor and urethral sphincter, as well as bladder pressure data were collected, first under isovolumetric bladder conditions and later during filling cystometries. RESULTS: Epidural SCS through many electrodes was able to elicit functional changes in the bladder and urethra. We also identified bipolar electrode pairs that evoked a frequency-dependent effect. Stimulation at 3 Hz stimulation evoked a continence reflex, while the same electrodes evoked a voiding reflex when the stimulation frequency was changed to 33 Hz. Inhibition through 3 Hz stimulation was particularly robust and resulted in abolishing all non-voiding contractions (NVCs) and decreasing the bladder pressure to its baseline value. Voiding under 33 Hz was incomplete and varied between 20-50% of the infused volume. In 3 animals, an acute spinalization at T10 abolished all 33 Hz-evoked responses suggesting that this neural circuit requires an intact spino-bulbo-spinal reflex. The 3 Hz continence reflex remained unaffected by spinalization suggesting a local reflex in the lumbosacral spinal cord. CONCLUSIONS: HR-SCS can selectively evoke continence and micturition reflexes through a unique frequency-dependent effect. Source of Funding: NIH OT2OD024908 and Craig H. Neilsen Foundation—476681 © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e155-e156 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chaitanya Gopinath More articles by this author Maria K. Jantz More articles by this author Ritesh Kumar More articles by this author Bryan L. McLaughlin More articles by this author Robert A. Gaunt More articles by this author Expand All Advertisement Loading ...

Neurogenic Flare Response following Image-Guided Focused Ultrasound in the Mouse Peripheral Nervous System in Vivo

Focused ultrasound (FUS) has been used to non-invasively elicit or inhibit motor neuronal activity in the mouse peripheral nervous system in vivo. However, less is known about whether FUS elicits immune system responses associated with peripheral sensory neuronal activity. In this study, we sought to determine that non-invasive ultrasound image-guided FUS can elicit the neurogenic axon reflex of peripheral nerves in the mouse sciatic nerve. The local vasodilation in the plantar view of the hind paw detected with a high-resolution laser Doppler imager indicated neurogenic flare responses after FUS stimulation. The effects of FUS were compared with control groups, where a distinct pattern of blood flow changes was observed only in FUS-elicited neurogenic flare responses. The findings indicate that image-guided FUS elicits local axon reflexes in vivo with a high degree of specificity and penetration depth.

Acupuncture modulates immunity in sepsis: Toward a science-based protocol.

Sepsis is a serious medical condition in which immune dysfunction plays a key role. Previous treatments focused on chemotherapy to control immune function; however, a recognized effective compound or treatment has yet to be developed. Recent advances indicate that a neuromodulation approach with nerve stimulation allows developing a therapeutic strategy to control inflammation and improve organ functions in sepsis. As a quick, non-invasive technique of peripheral nerve stimulation, acupuncture has emerged as a promising therapy to provide significant advantages for immunomodulation in acute inflammation. Acupuncture obtains its regulatory effect by activating the somatic-autonomic-immune reflexes, including the somatic-sympathetic-splenic reflex, the somatic-sympathetic-adrenal reflex, the somatic-vagal-splenic reflex and the somatic-vagal-adrenal reflex, which produces a systemic effect. The peripheral nerve stimulation also induces local reflexes such as the somatic-sympathetic-lung-reflex, which then produces local effects. These mechanisms offer scientific guidance to design acupuncture protocols for immunomodulation and inflammation control, leading to an evidence-based comprehensive therapy recommendation.

The Enteric Nervous System and Its Emerging Role as a Therapeutic Target.

The gastrointestinal (GI) tract is innervated by the enteric nervous system (ENS), an extensive neuronal network that traverses along its walls. Due to local reflex circuits, the ENS is capable of functioning with and without input from the central nervous system. The functions of the ENS range from the propulsion of food to nutrient handling, blood flow regulation, and immunological defense. Records of it first being studied emerged in the early 19th century when the submucosal and myenteric plexuses were discovered. This was followed by extensive research and further delineation of its development, anatomy, and function during the next two centuries. The morbidity and mortality associated with the underdevelopment, infection, or inflammation of the ENS highlight its importance and the need for us to completely understand its normal function. This review will provide a general overview of the ENS to date and connect specific GI diseases including short bowel syndrome with neuronal pathophysiology and current therapies. Exciting opportunities in which the ENS could be used as a therapeutic target for common GI diseases will also be highlighted, as the further unlocking of such mechanisms could open the door to more therapy-related advances and ultimately change our treatment approach.

Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris.

PurposeIn mammals, pupil constriction and dilation form the pupillary light reflex (PLR), which is mediated by both brain-regulated (parasympathetic) and local iris-driven reflexes. To better understand the cellular mechanisms that regulate pupil physiological dynamics via central and local photoreception, we have examined the regulation of the PLR via parasympathetic and local activation, respectively.MethodsIn this study, the PLR was examined in mouse enucleated eyes ex vivo in real-time under different ionic conditions in response to acetylcholine and/or blue light (480 nm). The use of pupillometry recordings captured the relaxation, contraction, and pupil escape (redilation) processes for 10 minutes up to 1 hour.ResultsAmong others, our results show that ryanodine receptor channels are the main driver for iridal stimulation–contraction coupling, in which extracellular influx of Ca2+ is required for amplification of pupil constriction. Both local and parasympathetic iridal activations are necessary, but not sufficient for sustained pupil constriction. Moreover, the degree of membrane potential repolarization in the dark is correlated with the latency and velocity of iridal constriction. Furthermore, pupil escape is driven by membrane potential hyperpolarization where voltage-gated potassium channels play a crucial role.ConclusionsTogether, this study presents new mechanisms regulating synchronized pupil dilation and contraction, sustained pupil constriction, iridal stimulation-contraction coupling, and pupil escape.

Why is temperature sensitivity important for the success of common respiratory viruses?

SummaryThis review explores the idea that temperature sensitivity is an important factor in determining the success of respiratory viruses as human parasites. The review discusses several questions. What is viral temperature sensitivity? At what range of temperatures are common respiratory viruses sensitive? What is the mechanism for their temperature sensitivity? What is the range of temperature along the human airway? What is it that makes respiratory viruses such successful parasites of the human airway? What is the role of temperature sensitivity in respiratory zoonoses? A definition of temperature sensitivity is proposed, as “the property of a virus to replicate poorly or not at all, at the normal body temperature of the host (restrictive temperature), but to replicate well at the lower temperatures found in the upper airway of the host (permissive temperature).” Temperature sensitivity may influence the success of a respiratory virus in several ways. Firstly; by restricting the infection to the upper airways and reducing the chance of systemic infection that may reduce host mobility and increase mortality, and thus limit the spread of the virus. Secondly; by causing a mild upper airway illness with a limited immune response compared to systemic infection, which means that persistent herd immunity does not develop to the same extent as with systemic infections, and re‐infection may occur later. Thirdly; infection of the upper airway triggers local reflex rhinorrhea, coughing and sneezing which aid the exit of the virus from the host and the spread of infection in the community.

Kirchberg’s conjecture in the system of Hilbert space factorable mapping spaces

This study aims to introduce the notions of injectivity, local reflexivity, exactness, and nuclearity in the system ( $$\left( {{\rm{\Gamma }}_2^c\left( { \cdot , \cdot } \right),{\rm{\gamma }}_2^c\left( \cdot \right)} \right)$$ ). We find that every dual operator space is injective in the system ( $$\left( {{\rm{\Gamma }}_2^c\left( { \cdot , \cdot } \right),{\rm{\gamma }}_2^c\left( \cdot \right)} \right)$$ ) and nuclearity is equivalent to exactness in this system. As a corollary, we prove that Kirchberg’s conjecture on the equivalence of exactness and local reflexivity for C* -algebras is false in this system, i.e., there exists a C*-algebra $${\cal A}$$ that is locally reflexive in this system but is not exact in this system.

Finite‐dimensional approximation properties for uniform Roe algebras

We study property A for metric spaces $X$ with bounded geometry introduced by Guoliang Yu. Property A is an amenability-type condition, which is less restrictive than amenability for groups. The property has a connection with finite-dimensional approximation properties in the theory of operator algebras. It has been already known that property A of a metric space $X$ with bounded geometry is equivalent to nuclearity of the uniform Roe algebra C$^*_u(X)$. We prove that exactness and local reflexivity of C$^*_u(X)$ also characterize property A of $X$.

The image characteristics of multispectral scanning laser imaging and optical coherence tomography in patients with pregnancy induced hypertension syndrome

Objective To observe the image characteristics of multispectral scanning laser imaging (MSLI) and OCT in patients with pregnancy induced hypertension syndrome (PIHS). Methods A total of 112 patients (224 eyes) of PIHS patients diagnosed in Obstetrics Department of Tianjin First Central Hospital from May 2016 to May 2017 were included in this study. The average age of the patients was 27.00±2.14 years. The average course of the disease was 15.00±8.27 days. There were 174 eyes in 87 patients of blurred vision, dazzling and visual fatigue consciously. All patients performed BCVA, direct ophthalmoscope, B ultrasound, confocal scanning laser Ophthalmoscope (cSLO) and spectral-domain OCT (SD-OCT). SD-OCT was performed with Spectralis HRA+OCT from Heidelberg Company in Germany to acquire tomographic images. Using Herdelberg's colorful program (MultiColor) based on cSLO and operating in accordance with standard methods, one scan simultaneously obtained blue light reflection based on 488 nm, green light reflection based on 515 nm, and infrared reflection based on 820 nm, synthesis to MSLI. Fundus abnormalities were classified into arterial spasm (stage Ⅰ), arteriosclerosis (stage Ⅱ), and retinopathy (stage Ⅲ). OCT examination was divided into normal and abnormal cases according to the abnormality of retinal morphology and thickness. Results Of the 224 eyes, 68 eyes (30.36%) showed normal fundus examination and 156 eyes (69.64%) showed abnormal fundus performance. Among them, 28 eyes were stage Ⅰ (17.95%); 40 eyes were stage Ⅱ (25.64%); 88 eyes were stageⅢ (56.41%). Thirty-six eyes (16.07%) showed normal fundus and 188 eyes (83.93%) showed abnormal performance with OCT. Of the 188 eyes with abnormal fundus performance, 86 eyes (45.74%) had retinal neuroepithelial serous detachment; 56 eyes (29.79%) had RPE detachment; optic disc edema, bulge, and local reflexes in the retinal nerve fiber layer were enhanced and/or the thickness increased in 46 eyes (24.47%). In MSLI, 48 eyes (21.43%) showed normal fundus; 176 eyes (78.57%) showed abnormal performance. Retinal edema was showed in green on MSLI, serous retinal neuroepithelial layer detachment, RPE layer detachment, retinal nerve fiber layer thickening, accompanied by changes in local retinal structure. The higher the degree of bulge, the darker the color. Consistent with the range of retinal edema revealed by SD-OCT. Conclusions MSLI and SD-OCT images show highly consistent lesions in PIHS patients. MSLI can more clearly show superficial and deep retinal lesions. Key words: Hypertension, pregnancy-induced; Hypertensive retinopathy/diagnosis; Tomography, optical coherence