Local Magnetic Field Gradients Research Articles

An atomic-scale multi-qubit platform.

Individual electron spins in solids are promising candidates for quantum science and technology, where bottom-up assembly of a quantum device with atomically precise couplings has long been envisioned. Here, we realized atom-by-atom construction, coherent operations, and readout of coupled electron-spin qubits using a scanning tunneling microscope. To enable the coherent control of "remote" qubits that are outside of the tunnel junction, we complemented each electron spin with a local magnetic field gradient from a nearby single-atom magnet. Readout was achieved by using a sensor qubit in the tunnel junction and implementing pulsed double electron spin resonance. Fast single-, two-, and three-qubit operations were thereby demonstrated in an all-electrical fashion. Our angstrom-scale qubit platform may enable quantum functionalities using electron spin arrays built atom by atom on a surface.

Computational Assessment of Unsteady Flow Effects on Magnetic Nanoparticle Targeting Efficiency in a Magnetic Stented Carotid Bifurcation Artery.

Worldwide, cardiovascular disease is the leading cause of hospitalization and death. Recently, the use of magnetizable nanoparticles for medical drug delivery has received much attention for potential treatment of both cancer and cardiovascular disease. However, proper understanding of the interacting magnetic field forces and the hydrodynamics of blood flow is needed for effective implementation. This paper presents the computational results of simulated implant assisted medical drug targeting (IA-MDT) via induced magnetism intended for administering patient specific doses of therapeutic agents to specific sites in the cardiovascular system. The drug delivery scheme presented in this paper functions via placement of a faintly magnetizable stent at a diseased location in the carotid artery, followed by delivery of magnetically susceptible drug carriers guided by the local magnetic field. Using this method, the magnetic stent can apply high localized magnetic field gradients within the diseased artery, while only exposing the neighboring tissues, arteries, and organs to a modest magnetic field. The localized field gradients also produce the forces needed to attract and hold drug-containing magnetic nanoparticles at the implant site for delivering therapeutic agents to treat in-stent restenosis. The multi-physics computational model used in this work is from our previous work and has been slightly modified for the case scenario presented in this paper. The computational model is used to analyze pulsatile blood flow, particle motion, and particle capture efficiency in a magnetic stented region using the magnetic properties of magnetite (Fe3O4) and equations describing the magnetic forces acting on particles produced by an external cylindrical electromagnetic coil. The electromagnetic coil produces a uniform magnetic field in the computational arterial flow model domain, while both the particles and the implanted stent are paramagnetic. A Eulerian-Lagrangian technique is adopted to resolve the hemodynamic flow and the motion of particles under the influence of a range of magnetic field strengths (Br = 2T, 4T, 6T, and 8T). Particle diameter sizes of 10nm-4µm in diameter were evaluated. Two dimensionless numbers were evaluated in this work to characterize relative effects of Brownian motion (BM), magnetic force induced particle motion, and convective blood flow on particle motion. The computational simulations demonstrate that the greatest particle capture efficiency results for particle diameters within the micron range of 0.7-4µm, specifically in regions where flow separation and vortices are at a minimum. Similar to our previous work (which did not involve the use of a magnetic stent), it was also observed that the capture efficiency of particles decreases substantially with particle diameter, especially in the superparamagnetic regime. Contrary to our previous work, using a magnetic stent tripled the capture efficiency of superparamagnetic particles. The highest capture efficiency observed for superparamagnetic particles was 78% with an 8T magnetic field strength and 65% with a 2T magnetic field strength when analyzing 100nm particles. For 10nm particles and an 8T magnetic field strength, the particle capture efficiency was 55% and for a 2T magnetic field strength the particle capture efficiency was observed to be 43%. Furthermore, it was found that larger magnetic field strengths, large particle diameter sizes (1µm and above), and slower blood flow velocity improves the particle capture efficiency. The distribution of captured particles on the vessel wall along the axial and azimuthal directions is also discussed. Results for captured particles on the vessel wall along the axial flow direction showed that the particle density decreased along the axial direction, especially after the stented region. For the entrance section of the stented region, the captured particle density distribution along the axial direction is large, corresponding to the center-symmetrical distribution of the magnetic force in that section. The simulation results presented in this work have shown to yield favorable capture efficiencies for micron range particles and superparamagnetic particles using magnetized implants such as the stent discussed in this work. The results presented in this work justify further investigation of MDT as a treatment technique for cardiovascular disease.

Sensing of Magnetic-Field Gradients with Nanodiamonds on Optical Glass-Fiber Facets.

We demonstrate a photonic sensor of the magnetic field and its gradients with remote readout. The sensor is based on optically detected magnetic resonance (ODMR) in nanodiamonds with nitrogen-vacancy color centers that are covalently attached as a thin film on one facet of an optical fiber bundle. By measuring ODMR signals from a group of individual fibers in an ∼0.5-mm-wide imaging bundle, differences of local magnetic field strengths and magnetic field gradients are determined across the plane of the bundle facet. The measured gradients are created by direct electric currents flowing in a wire placed near the nanodiamond film. The measurement enabled the determination of the net magnetic field corresponding to various current directions and their corresponding magnetic field gradients. This demonstration opens up a perspective for compact fiber-based endoscopy, with additional avenues for remote and sensitive magnetic field detection with submicrometer spatial resolution under ambient conditions.

Manipulation of New Fluorescent Magnetic Nanoparticles with an Electromagnetic Needle, Allowed Determining the Viscosity of the Cytoplasm of M-HeLa Cells.

Magnetic nanoparticles (MNPs) have recently begun to be actively used in biomedicine applications, for example, for targeted drug delivery, in tissue engineering, and in magnetic resonance imaging. The study of the magnetic field effect on MNPs internalized into living cells is of particular importance since it allows a non-invasive influence on cellular activity. There is data stating the possibility to manipulate and control individual MNPs utilizing the local magnetic field gradient created by electromagnetic needles (EN). The present work aimed to demonstrate the methodological and technical approach for manipulating the local magnetic field gradient, generated by EN, novel luminescent MNPs internalized in HeLa cancer cells. The controlling of the magnetic field intensity and estimation of the attractive force of EN was demonstrated. Both designs of EN and their main characteristics are also described. Depending on the distance and applied voltage, the attractive force ENs ranged from 0.056 ± 0.002 to 37.85 ± 3.40 pN. As a practical application of the presented, the evaluation of viscous properties of the HeLa cell's cytoplasm, based on the measurement of the movement rate of MNPs inside cells under impact of a known magnetic force, was carried out; the viscosity was 1.45 ± 0.04 Pa·s.

Artificial skyrmion in magnetic multilayers

A magnetic skyrmion is a promising candidate for information carrier in future logic functional devices, ultra-density storage devices, and neuromorphic computing. The presence of interfacial Dzyaloshinskii–Moriya interaction in magnetron sputtered multilayers results in the spontaneous nucleation of magnetic skyrmion. However, the precise control of position and arrangement of magnetic skyrmion spontaneously nucleated in multilayers is still a significant challenge. Artificial skyrmion, generated by various external stimuli, shows high promise for manipulating the spatially ordered arrangement on demand. In this review, we summarize the progress of artificial skyrmion with various formation mechanisms. After introducing the concept of artificial skyrmion, we will focus on several methods of producing artificial skyrmion in magnetic multilayers using spin texture imprinting, integrated bias magnet, local magnetic field gradient, optical irradiation, and nanolithography. In the end, we give a perspective of the potential applications of artificial skyrmions for cavity magnonics and quantum spintronics.

Electron Surfing Acceleration at Rippled Reconnection Fronts

The reconnection front (RF), one of the most efficient accelerators of particles in the terrestrial magnetosphere, is a sharp plasma boundary resulting from transient magnetic reconnection. It has been both theoretically predicted and observationally confirmed that electron-scale substructures can develop at the RFs. How such electron-scale structures modulate the electron energization and transport has not been fully explored. Based on high-resolution data from MMS spacecraft and particle tracing simulations, we investigate and compare the electron acceleration across two typical RFs with or without rippled electron-scale structures. Both observations and simulations reveal that high-energy electron flux behind the RF increases more dramatically if the electrons encounter a rippled RF surface, as compared to a smooth RF surface. The main acceleration mechanism is electron surfing acceleration, in which electrons are trapped by the ripples, due to the large local magnetic field gradient, and therefore undergo surfing motion along the motional electric field.

Identifying the source of spurious signals caused by B0 inhomogeneities in single-voxel 1 H MRS.

PurposeSingle‐voxel MRS (SV MRS) requires robust volume localization as well as optimized crusher and phase‐cycling schemes to reduce artifacts arising from signal outside the volume of interest. However, due to local magnetic field gradients (B0 inhomogeneities), signal that was dephased by the crusher gradients during acquisition might rephase, leading to artifacts in the spectrum. Here, we analyzed this mechanism, aiming to identify the source of signals arising from unwanted coherence pathways (spurious signals) in SV MRS from a B0 map.MethodsWe investigated all possible coherence pathways associated with imperfect localization in a semi‐localized by adiabatic selective refocusing (semi‐LASER) sequence for potential rephasing of signals arising from unwanted coherence pathways by a local magnetic field gradient. We searched for locations in the B0 map where the signal dephasing due to external (crusher) and internal (B0) field gradients canceled out. To confirm the mechanism, SV‐MR spectra (TE = 31 ms) and 3D‐CSI data with the same volume localization as the SV experiments were acquired from a phantom and 2 healthy volunteers.ResultsOur analysis revealed that potential sources of spurious signals were scattered over multiple locations throughout the brain. This was confirmed by 3D‐CSI data. Moreover, we showed that the number of potential locations where spurious signals could originate from monotonically decreases with crusher strength.ConclusionWe proposed a method to identify the source of spurious signals in SV 1H MRS using a B0 map. This can facilitate MRS sequence design to be less sensitive to experimental artifacts.

Detection of magnetic tracers with Mx atomic magnetometer for application to blood velocimetry

In the new generation of blood velocimeter systems, considerable attention has been paid to atomic magnetometers due to their high resolution and high sensitivity for detection of magnetic tracers. Passing the magnetic tracers adjacent to the atomic magnetometer produces a spike-like signal, the shape of which depends on the position of the tracer, as well as its velocity and orientation. The present study aimed to evaluate the effect of abrupt variations in the instantaneous velocity of the magnetic tracer on the magnetometer response compare to constant velocity. Modeling the magnetic tracer as a dipole moment indicated that the velocity dependence of the magnetic field and local magnetic field gradient associated with moving magnetic tracer cause the spike-like signal to go out of symmetry in the case of variable velocity. Based on the experimental results, any instantaneous variation in tracer velocity leads to shrinkage in the signal width. The behavior has been studied for both magnetic microwire with variable instantaneous velocity and magnetic droplets in stenosis artery phantom. In addition, the position of the tracer could be detected by following the shrinkage behavior which may occur on the peak, valley, or both. These advantageous outcomes can be applied for high sensitivity diagnosis of arterial stenosis.

Self-Assembled Hexagonal Superparamagnetic Cone Structures for Fabrication of Cell Cluster Arrays.

In this study, we demonstrated that arrays of cell clusters can be fabricated by self-assembled hexagonal superparamagnetic cone structures. When a strong out-of-plane magnetic field was applied to the ferrofluid on a glass substrate, it will induce the magnetic poles on the upper/lower surfaces of the continuous ferrofluid to increase the magnetostatic energy. The ferrofluid will then experience hydrodynamic instability and be split into small droplets with cone structures because of the compromising surface tension energy and magnetostatic energy to minimize the system's total energy. Furthermore, the ferrofluid cones were orderly self-assembled into hexagonal arrays to reach the lowest energy state. After dehydration of these liquid cones to form solid cones, polydimethylsiloxane was cast to fix the arrangement of hexagonal superparamagnetic cone structures and prevent the leakage of magnetic nanoparticles. The U-343 human neuronal glioblastoma cells were labeled with magnetic nanoparticles through endocytosis in co-culture with a ferrofluid. The number of magnetic nanoparticles internalized was (4.2 ± 0.84) × 106 per cell by the cell magnetophoresis analysis. These magnetically labeled cells were attracted and captured by hexagonal superparamagnetic cone structures to form cell cluster arrays. As a function of the solid cone size, the number of cells captured by each hexagonal superparamagnetic cone structure was increased from 48 to 126 under a 2000 G out-of-plane magnetic field. The local magnetic field gradient of the hexagonal superparamagnetic cone was 117.0-140.9 G/mm from the cell magnetophoresis. When an external magnetic field was applied, we observed that the number of protrusions of the cell edge decreased from the fluorescence images. It showed that the local magnetic field gradient caused by the hexagonal superparamagnetic cones restricted the cell growth and migration.

The relative orientation between the magnetic field and gas density structures in non-gravitating turbulent media

ABSTRACT Magnetic fields are a dynamically important agent for regulating structure formation in the interstellar medium. The study of the relative orientation between the local magnetic field and gas (column-) density gradient has become a powerful tool to analyse the magnetic field’s impact on the dense gas formation in the Galaxy. In this study, we perform numerical simulations of a non-gravitating, isothermal gas, where the turbulence is driven either solenoidally or compressively. We find that only simulations with an initially strong magnetic field (plasma-β < 1) show a change in the preferential orientation between the magnetic field and isodensity contours, from mostly parallel at low densities to mostly perpendicular at higher densities. Hence, compressive turbulence alone is not capable of inducing the transition observed towards nearby molecular clouds. At the same high initial magnetization, we find that solenoidal modes produce a sharper transition in the relative orientation with increasing density than compressive modes. We further study the time evolution of the relative orientation and find that it remains unchanged by the turbulent forcing after one dynamical time-scale.

Technique for magnetic moment reconstruction of laser-cooled atoms using direct imaging and prospects for measuring magnetic sublevel distributions

We describe a simple time-of-flight technique for measuring the magnetic moment of an optically pumped magneto-optical trap. The technique relies on free-expansion imaging of a cold atom cloud in a small magnetic field gradient without the need to detect spatial separation between magnetic sublevels. We find that the effective acceleration of the cloud can be used to characterize extreme state optical pumping. In the general case, we show that the integrated displacement of the falling cloud can be accurately modeled using rate equation simulations of magnetic sublevel populations, and knowledge of local magnetic fields, field gradients, and light intensities. The agreement between the model and the data allows the reconstruction of magnetic moments and suggests that this technique may be suitable for the measurement of population distributions over a range of optical pumping conditions.

Position and Direction Tracking of a Magnetic Object Based on an Mx-Atomic Magnetometer

Remote and non-invasive tracking of a moving magnetic object based on an atomic magnetometer has been developed recently. The sensitivity of atomic magnetometers is limited by mechanisms that relax the spin precession of alkali atoms. Meanwhile, some of these mechanisms such as magnetic field gradient are applicable in magnetic object tracking. Correspondingly, we have illustrated a way of operating an Mx atomic magnetometer to measure the magnetic field and its gradient simultaneously for a moving magnetic microwire, which resulted in recording a spike-like signal. We described the dependency of the signal on the position, velocity, and direction of the microwire. According to the results, the measurement of the inhomogeneous local magnetic field gradient opens new ways for obtaining the direction of the velocity of magnetic objects accessible in cells with large sizes. Furthermore, the accuracy of the velocimetry was found as 40 µm/s which could be an important means for assessing the microvascular blood flow.

Optimal dispersive readout of a spin qubit with a microwave resonator

Strong coupling of semiconductor spin qubits to superconducting microwave resonators was recently demonstrated. These breakthroughs pave the way for quantum information processing that combines the long coherence times of solid-state spin qubits with the long-distance connectivity, fast control, and fast high-fidelity quantum-non-demolition readout of existing superconducting qubit implementations. Here, we theoretically analyze and optimize the dispersive readout of a single spin in a semiconductor double quantum dot (DQD) coupled to a microwave resonator via its electric dipole moment. The strong spin-photon coupling arises from the motion of the electron spin in a local magnetic field gradient. We calculate the signal-to-noise ratio (SNR) of the readout accounting for both Purcell spin relaxation and spin relaxation arising from intrinsic electric noise within the semiconductor. We express the maximum achievable SNR in terms of the cooperativity associated with these two dissipation processes. We find that while the cooperativity increases with the strength of the dipole coupling between the DQD and the resonator, it does not depend on the strength of the magnetic field gradient. We then optimize the SNR as a function of experimentally tunable DQD parameters. We identify wide regions of parameter space where the unwanted backaction of the resonator photons on the qubit is small. Moreover, we find that the coupling of the resonator to other DQD transitions can enhance the SNR by at least a factor of two, a ``straddling'' effect that occurs only at nonzero energy detuning of the DQD double-well potential. We estimate that with current technology, single-shot readout fidelities in the range $82-95\%$ can be achieved within a few $\mu\textrm{s}$ of readout time without requiring the use of Purcell filters.

Anisotropic composite polymer for high magnetic force in microfluidic systems

Anisotropic carbonyl iron–polydimethylsiloxane (PDMS) composites were developed and implemented in microfluidic devices to serve as magnetic flux concentrators. These original materials provide technological solutions for heterogeneous integration with PDMS. Besides microfabrication advantages, they offer interesting modular magnetic properties. Applying an external magnetic field during the PDMS reticulation leads to the formation of 1D agglomerates of magnetic particles, organized in the non-magnetic polymer matrix. This induces an increase in susceptibility as compared to composites with randomly dispersed particles. In this report, we explored the gain in reachable magnetophoretic forces in operating microfluidic devices, from the study of magnetic microbeads motion injected in the microchannel. We show that even at relatively large distances from the magnetically functionalized channel wall, the anisotropic composite leads to a factor two increase in the magnetophoretic force. Finally, further investigations based on finite element description suggest that the measured benefit of anisotropic composite polymers does not only rely on the global susceptibility increase but also on the local magnetic field gradients originating from the microstructure.

Nuclear Magnetic Resonance Relaxation Studies in Shale

The present work involves a comprehensive experimental study of proton (1 H) nuclear magnetic resonance (NMR) transversal relaxation in shale. The sample studied belongs to the “Vaca Muerta” formation of the Neuquen basin, Argentina. The results show that the relaxation process is governed by anomalous diffusion processes in micro-pores. These processes result from the combination of interactions between the liquid molecules and the pore walls, whose structure is characterized by both large tortuosity and abundance of paramagnetic impurities, giving rise to local strong time-dependent magnetic field gradients. In addition, a simultaneous experimental method of data fitting is presented which allows processing all the relaxation profiles within a single time domain. Thus, yielding results univocally related to the complete set of relaxation data.

Multiphase ferrofluid flows for micro-particle focusing and separation.

Ferrofluids have demonstrated great potential for a variety of manipulations of diamagnetic (or non-magnetic) micro-particles/cells in microfluidics, including sorting, focusing, and enriching. By utilizing size dependent magnetophoresis velocity, most of the existing techniques employ single phase ferrofluids to push the particles towards the channel walls. In this work, we demonstrate a novel strategy for focusing and separating diamagnetic micro-particles by using the laminar fluid interface of two co-flowing fluids-a ferrofluid and a non-magnetic fluid. Next to the microfluidic channel, microscale magnets are fabricated to generate strong localized magnetic field gradients and forces. Due to the magnetic force, diamagnetic particles suspended in the ferrofluid phase migrate across the ferrofluid stream at the size-dependent velocities. Because of the low Reynolds number and high Péclet number associated with the flow, the fluid interface is sharp and stable. When the micro-particles migrate to the interface, they are accumulated near the interface, resulting in effective focusing and separation of particles. We investigated several factors that affect the focusing and separation efficiency, including susceptibility of the ferrofluid, distance between the microfluidic channel and microscale magnet, and width of the microfluidic channel. This concept can be extended to multiple fluid interfaces. For example, a complete separation of micro-particles was demonstrated by using a three-stream multiphase flow configuration.

Microfluidic separation of magnetic particles with soft magnetic microstructures

This paper demonstrates simple and cost-effective microfluidic devices for enhanced separation of magnetic particles by using soft magnetic microstructures. By injecting a mixture of iron powder and polydimethylsiloxane (PDMS) into a prefabricated channel, an iron–PDMS microstructure was fabricated next to a microfluidic channel. Placed between two external permanent magnets, the magnetized iron–PDMS microstructure induces localized and strong forces on the magnetic particles in the direction perpendicular to the fluid flow. Due to the small distance between the microstructure and the fluid channel, the localized large magnetic field gradients result a vertical force on the magnetic particles, leading to enhanced separation of the particles. Numerical simulations were developed to compute the particle trajectories and agreed well with experimental data. Systematic experiments and numerical simulation were conducted to study the effect of relevant factors on the transport of superparamagnetic particles, including the shape of iron–PDMS microstructure, mass ratio of iron–PDMS composite, width of the microfluidic channel, and average flow velocity.

Electric-dipole-induced spin resonance in a lateral double quantum dot incorporating two single-domain nanomagnets

On-chip magnets can be used to implement relatively large local magnetic field gradients in nanoelectronic circuits. Such field gradients provide possibilities for all-electrical control of electron spin qubits where important coupling constants depend crucially on the detailed field distribution. We present a double quantum dot (QD) hybrid device laterally defined in a GaAs/AlGaAs heterostructure which incorporates two single-domain nanomagnets. They have appreciably different coercive fields which allows us to realize four distinct configurations of the local inhomogeneous field distribution. We perform dc transport spectroscopy in the Pauli-spin blockade regime as well as electric-dipole-induced spin resonance (EDSR) measurements to explore our hybrid nanodevice. Characterizing the two nanomagnets we find excellent agreement with numerical simulations. By comparing the EDSR measurements with a second double QD incorporating just one nanomagnet we reveal an important advantage of having one magnet per QD: It facilitates strong field gradients in each QD and allows us to control the electron spins individually for instance in an EDSR experiment. With just one single-domain nanomagnet and common QD geometries EDSR can likely be performed only in one QD.

Sudden motility reversal indicates sensing of magnetic field gradients in Magnetospirillum magneticum AMB-1 strain.

Many motile unicellular organisms have evolved specialized behaviors for detecting and responding to environmental cues such as chemical gradients (chemotaxis) and oxygen gradients (aerotaxis). Magnetotaxis is found in magnetotactic bacteria and it is defined as the passive alignment of these cells to the geomagnetic field along with active swimming. Herein we show that Magnetospirillum magneticum (AMB-1) show a unique set of responses that indicates they sense and respond not only to the direction of magnetic fields by aligning and swimming, but also to changes in the magnetic field or magnetic field gradients. We present data showing that AMB-1 cells exhibit sudden motility reversals when we impose them to local magnetic field gradients. Our system employs permalloy (Ni(80)Fe(20)) islands to curve and diverge the magnetic field lines emanating from our custom-designed Helmholtz coils in the vicinity of the islands (creating a drop in the field across the islands). The three distinct movements we have observed as they approach the permalloy islands are: unidirectional, single reverse and double reverse. Our findings indicate that these reverse movements occur in response to magnetic field gradients. In addition, using a permanent magnet we found further evidence that supports this claim. Motile AMB-1 cells swim away from the north and south poles of a permanent magnet when the magnet is positioned less than ∼30 mm from the droplet of cells. All together, these results indicate previously unknown response capabilities arising from the magnetic sensing systems of AMB-1 cells. These responses could enable them to cope with magnetic disturbances that could in turn potentially inhibit their efficient search for nutrients.

Quantification of iron in the non-human primate brain with diffusion-weighted magnetic resonance imaging

Pathological iron deposits in the brain, especially within basal ganglia, are linked to severe neurodegenerative disorders like Parkinson's disease. As iron induces local changes in magnetic susceptibility, its presence can be visualized with magnetic resonance imaging (MRI). The usual approach, based on iron induced changes in magnetic relaxation (T2/T2′), is often prone, however, to confounding artifacts and lacks specificity. Here, we propose a new method to quantify and map iron deposits using water diffusion MRI. This method is based on the differential sensitivity of two image acquisition schemes to the local magnetic field gradients induced by iron deposits and their cross-term with gradient pulses used for diffusion encoding. Iron concentration could be imaged and estimated with high accuracy in the brain cortex, the thalamus, the substantia nigra and the globus pallidus of macaques, showing iron distributions in agreement with literature. Additionally, iron maps could clearly show a dramatic increase in iron content upon injection of an UltraSmall Particle Iron Oxide (USPIO) contrast agent, notably in the cortex and the thalamus, reflecting regional differences in blood volume. The method will benefit clinical investigations on the effect of iron deposits in the brain or other organs, as iron deposits are increasingly seen as a biomarker for a wide range of diseases, notably, neurodegenerative diseases in the pre-symptomatic stage. It also has the potential for quantifying variations in blood volume induced by brain activation in fMRI studies using USPIOs.