While most critical heat flux (CHF) studies focus on relatively straightforward geometries, actual equipment applications are complex. This paper summarizes literature which provides insights into the effects of selected inlet conditions on CHF and the occurrence of upstream CHF. Vertical smooth bore tube CHF tests found that the concept of “local conditions hypothesis”, though not universally defensible, provides an adequate basis for applying CHF data to design. Upstream CHF indications have been found to be associated with a minimum in the CHF versus quality curve which has been attributed to the transition from intermediate flow regimes to annular flow regimes. Design implications are discussed including: 1) for vertical smooth bore tubes, upstream CHF is generally not observed except at very high masses where specific data are required - at lower mass fluxes, special design procedures are needed where nonuiform circumferential heating is present, 2) for inclined smooth bore tubes, design specific data are needed as upstream CHF observations are more prevalent, 3) for vertical and inclined multi-lead ribbed bore tubes (common in the power industry), minimum mass fluxes are specified to avoid upstream CHF, and 4) coiled and serpentine tubes are discussed.