Load Area Research Articles

Optimization of low-velocity impact behavior of FML structures at different environmental temperatures using taguchi method and grey relational analysis

Carbon fiber-reinforced Aluminum Laminate (CARALL) is a new generation of Fibre Metal Laminate (FML) material. This study investigates the low-velocity impact behavior of CARALL structures at different environmental temperatures (−40°C, 23°C, and 80°C). Two different groups of CARALL composite structures with varying fiber orientations were produced by hot pressing in a 3/2 arrangement: C1 (Al/0°90°/Al/90°0°/Al) and C2 (Al/0°0°/Al/0°0°/Al). Low-velocity impact tests were conducted at 23 J, 33 J, and 48 J energy levels using a Ø20 mm spherical impactor tip. The area of damage was detected by ultrasonic C-Scan. In addition, analysis of variance (ANOVA) was applied to reveal the influential parameters and their effect levels. After conducting experiments using the Taguchi L18 test set, it was observed that the C2-coded specimen yielded better results in terms of maximum peak load, maximum displacement, and damage area. While the decrease in temperature increased the damage and maximum peak load, the increase in temperature did not cause a significant change in the maximum peak load. The primary damage mechanisms observed in damage investigations were matrix cracks and delamination between composite layers. Although delamination is present between the Al/CFRP layer, it is not significant. According to ANOVA results, impact energy was the most effective parameter for maximum impact force, maximum displacement, and damage area, with contribution rates of 81%, 74%, and 76%, respectively. The optimal experimental conditions (23°C temperature and 23 J impact energy with the C1-coded sample) were determined using grey relational analysis based on principal component analysis.

AFM Nanoindentation of Stiff Inhomogeneous Layer onPolymeric Substrate.

Analysis of indentation data of heterogeneous material, in particular, layer on an elastic substrate requires information about the contact area that is essential for calculating mechanical properties. The actual shape of the AFM-tip is not described by simple body of revolution. In this work, the indentation of a stiff layer on a hyperelastic substrate by a truncated conical tip is studied using finite element methods. The size of the tip, elastic modulus, and thickness of the layer are varied. The obtained model dependences of loading and contact area versus the depth of indentation are used in analysis of the experimental data of AFM indentation of stiff inhomogeneous nanolayers of polyurethane surface. Thickness and elastic modulus of the layers, fracture properties of the surface are studied. The obtained results can find application in the study of mechanical properties and fracture toughness of thin flexible films on an elastic substrate.

Influence depth of highway subgrade under heavy vehicle loads based on a theoretical model

A three-dimensional dynamic model of vehicle-road-unsaturated subgrade coupling is established. The semi-analytical and numerical solutions of three-dimensional dynamic response of highway subgrade under vehicle load are presented for the first time. Then, the accuracy of the theoretical model is verified by the field measurement data. Finally, the spatial distribution of dynamic stress and depth of working zone under different influencing factors are studied, and the calculation model of depth of working zone of highway subgrade is proposed. The results show that the dynamic stresses, σx, σy, σz, and τxz increase significantly with the increase of vehicle axle load and decrease significantly with the increase of road thickness under the same subgrade depth. In addition, with the increase of axle load and the decrease of road thickness, the peak values of dynamic stress σx, σy, σz, and τxz decrease more obviously along the depth of roadbed. In the process of vehicle movement, the traditional subgrade working area can be divided into a sensitive area and an influence area of dynamic load. The depth of these two areas is positively correlated with the axle load of the vehicle and negatively correlated with the thickness of the road surface. The advantage of the model in this paper is that the semi-analytical solution of the total stress component of the soil element in the course of traffic load is given.

Three-dimensional finite element analysis of occlusal stress on maxillary first molars with different marginal morphologies restored with occlusal veneers

BackgroundThere are differences in the research results regarding which edge design of occlusal veneers can achieve the best long-term success rate as a relatively new fixed prosthesis restoration method. Further research is needed. The three-dimensional finite element method was used to conduct stress analysis on occlusal veneers of maxillary first permanent molars with different thicknesses and margin preparation designs. The aim of this study was to provide mechanical research evidence and a reference for exploring standardized clinical protocols for the design of occlusal veneer restorations of maxillary first molars.MethodA 3Shape (Intraoral Scanner) was used to scan the maxillary first molar teeth in vitro, after which 3D printing was carried out. Three different edge designs were applied to identical teeth: straight-beveled finishing line(SFL), chamfer finishing line(CFL), and standard cuspal inclination(SCI). Preparation was carried out with a thickness of 0.5 mm. Using the surface deformation feature, the occlusal veneer was thickened to 0.5 mm and 1.0 mm, and periodontal ligaments were added. They were then placed into the upper and lower jaws and dental arches. Finite element analysis was performed after applying bite force dispersion to the loading area on the mandible following dynamic contact.Results(1) As the thickness increased, the maximum Von Mises stress in the occlusal veneers SFL and CFL also increased, while the SCI exhibited the opposite trend. (2). The trend of the maximum Von Mises stress in the adhesive layer decrease gradually with increasing thickness of the occlusal veneer. The stresses of the SFL and CFL is concentrated primarily at the edge position below the functional cusp, resulting in relatively low adhesive stress. However, in the SCI group, the maximum stress at the edge of the adhesive layer exceeds the maximum shear strength of commonly used adhesives.ConclusionsUnder the experimental conditions, the mechanical properties of the maximum Von Mises stress in the SFL, CFL, and SCI occlusal veneers meet clinical needs. Incorporating the minimally invasive concept of tooth preservation, a thickness of 1.0 mm are optimal for glass ceramic occlusal veneers on maxillary first molars.

Whole body vibration and rider comfort determination of an electric two-wheeler test rig

Background Two-wheeled vehicles are the major mode of transportation in India. Such vehicles are exposed to excessive vibration on the road when compared to four-wheeled vehicles. However, the research on the reduction of whole body vibration in the case of two-wheelers is not explored in detail. The present study predicts rider comfort in the case of an electric two-wheeler as per ISO 2631-1, by obtaining the finding the weighted acceleration at the strategic locations of vibration at the test rig. Methods An electric two-wheeler test rig is used in the study. The values of acceleration from the test rig in running conditions are obtained by using NI LabVIEW 2019. The drive cycle of the electric vehicle (EV) test rig is controlled by Sync sols’ EV lab software. Obtaining the weighted root mean square (RMS) acceleration from running the test setup, it is compared with the ISO 2631-1 standard to obtain the rider comfort. Results Loading area, traction motor, base mount, and suspension were found to be the strategic points of vibration. Frequency weighted RMS acceleration of 0.3 to 0.4 m/s2 obtained at these points are prone to cause discomfort for the rider. Vehicle speed, road profile, and duration of exposure were found to be important parameters affecting the rider’s comfort. A maximum of 4.6 m/s2 amplitude was observed. The loading area, which corresponds to a rider’s seat in actual vehicle, is important and reduction of these vibrations make the ride comfortable for the rider. Suspension and base mount of the test rig are found to be uncomfortable observing the weighted RMS acceleration. Conclusions A suitable damping technique design is very much essential in reducing these vibrations and improve the rider comfort, as many more non-deterministic vibrations are prone to cause dis-comfort in case of actual on road riding conditions.

Behind Amor Blunt Trauma Lung and Liver Strains from Indenter Loading via Finite Element Modeling

Abstract To determine behind armor blunt trauma injury criteria, experiments have been conducted to launch projectiles at live swine at velocities ranging up to 65 m/s using one type of indenter design. To ensure the generalizability of the developed injury criteria, tests are needed with other indenter designs. The objectives of this study were to evaluate the kinematics and injury parameters from two indenter designs using human body finite element modeling. The simulation matrix consisted of indenter designs of chord and cylindrical shape, and 150 and 230 grams (g) mass, with impacts to liver and lung regions at 30 and 60 m/s. Rib and lung strains from lung impacts, and rib strains and liver strain energy densities from liver impacts were used to evaluate the design variables of mass and shape. Both designs played a role in skeletal and organ injury parameters. Analysis revealed the increased susceptibility for skeletal and organ traumas with the high mass indenter at high velocity impacts. The cylindrical indenter may be protective for organ injuries due to the larger area of loading on the ribcage compared to the chord indenter. Results from the chord indenter may serve as a conservative estimate of injury criteria.

Preparation of core-shell Si/C/graphene composite for high-performance lithium-ion battery anodes

One of the important objectives for the development of enhanced lithium-ion batteries is developing high-performance silicon-based anodes with durable operational capability. Herein, a three-dimensional graphene-decorated core-shell Si/C composite is fabricated by the in-situ polymerization of organic pyrrole molecule and pyrolysis process, in which the melamine formaldehyde resin is subtly used as three-dimensional porous framework to offer abundant loading area for the uniform dispersion of active silicon nanoparticles. Meanwhile, the core-shell structure deriving from polypyrrole in the composite can effectively buffer the volume change of silicon ingredient and avoid the direct contact with the electrolyte during the cycling process, leading to the improved structural stability and electrochemical performance. The outermost layer of graphene nanosheets is designed to enhance the electrical conductivity of the electrode. As a result, the synthesized Si/C/graphene composite exhibits a high capacity and excellent cycling performance. This work reveals that combining a three-dimensional carbon substrate with a core-shell structure might be a promising solution for anode materials with obvious volume transformation.

Experimental analysis of quasi‐static indentation in composite sandwich multilayers with corrugated core

AbstractThis study examines the effects of multilayering in sandwich panel composite structures with different corrugated core configurations under quasi‐static indentation loading. The panels were fabricated using woven glass fibers and epoxy resin via the Vacuum Infusion Process. Experiments were conducted using two hemispherical cylindrical indenters with a diameter of 20 mm (ID = 20 mm) and 10 mm (ID = 10 mm) and the behavior of the composite structure in terms of contact force and fracture mechanisms for different core corrugations (square and butterfly) were investigated in two ways with foam and without foam. The experimental results demonstrate that, among corrugated core geometries without foam, butterfly cores outperform square cores in terms of structural strength, maximum force, moment force, energy absorption, specific energy absorption, and displacement until full indentation. Moreover, the butterfly core shows a higher peak load and different failure mechanisms compared to the square core. Under loading with a 10 mm indenter, the butterfly core without foam only experienced perforation in the loading area, without fracture completely. Also, adding foam did not change failure mechanisms and mechanical behavior in the butterfly geometry. However, in the square geometry, foam filled gaps between the core, preventing fracture completely and leading to only perforation in the loading area, unlike the specimen without foam. The visual analysis during the quasi‐static indentation process revealed several significant damage mechanisms, including matrix cracking, fiber breakage, delamination, buckling and crushing of cell walls, damage to top sheets, core separation, and complete indentation of the samples.Highlights Delamination and indentation failure mechanisms were seen on the butterfly core. Skin indentation and rib fracture failure mechanisms were seen on the square core. Butterfly corrugated cores revealed the best performance without/with foam. The core shape was more effective on the strength than the foam addition.

Study on the extension mechanism of fissures in expansive soil based on fracture mechanics test method

Expansive soil, characterized by widespread fissures, is a special type of soil prone to localized fissure propagation, leading to failure and instability, often resulting in landslides. Numerous studies have applied fracture mechanics theory to analyze soil failure along fissures, but no standardized testing method has been established. This paper reviews existing soil fracture toughness testing methods, designs an integrated system combining digital image correlation(DIC) technique and electrical resistance testing, and employs the Cracked Chevron-Notched Brazilian Disc (CCNBD) method to assess the fracture toughness of expansive soil. The deformation and internal damage accumulation processes of the specimens were monitored. The KΙc and KΙΙc of expansive soil were tested at moisture contents of 15 %, 20 %, and 25 % using specimens with three different crack length ratios (a/R). The role of water was explored by injecting water into the fissures. The results showed that KΙc of expansive soil ranged from 10 to 36 kPa·m0.5, with a linear negative correlation to moisture content and a proportional relationship to tensile strength, having a proportionality coefficient of 0.331. The KΙΙc ranged from 20 to 70 kPa·m0.5,and it is greater than KΙc under the same conditions. Based on the load, internal damage, strain, and fissure area during the tests, the failure process of expansive soil along fissures was divided into four stages: initial deformation stage(I), quasi-elastic deformation stage(II), fissure extension stage(III), and failure stage(IV). Water injection into the fissures reduced the soil's fracture toughness, with a more significant reduction as a/R increased and the failure showed progressive behavior. The CCNBD method, combined with DIC technique and electrical resistance testing, effectively measures the fracture toughness of soil, aiding in understanding the failure mechanism along fissures and providing a basis for preventing and controlling landslides and other hazards in expansive soils.

Flexoelectronics of a centrosymmetric semiconductor cylindrical nanoshell

Cylindrical shell-type semiconductors are essential for sensing and energy harvesting when integrated into surfaces of certain equipment, such as spacecraft, marine devices, and portable electronics, where mechanical forces play a significant impact on charge transport. Traditionally, such functionalities are only manifested in piezoelectric or pyroelectric crystals that possess non-centrosymmetry. Here, we theoretically investigate electronic behaviors driven by strain gradient-induced flexoelectric polarization in a centrosymmetric semiconductor cylindrical nanoshell, expanding the flexoelectronics in shell structures. The governing equations and accompanying boundary conditions are formulated simultaneously using the principle of virtual work and the fundamental lemma of the calculus of variation. Electromechanical interactions through static bending and forced vibration analyses of the newly developed model are systematically investigated. Under localized force excitation, the distribution of mobile charges is manipulated by tuning loading magnitudes and areas. The effects of doping levels on electric potentials and mobile charges are explored to show the interaction mechanism between flexoelectric and semiconducting properties. Moreover, the natural frequencies and modes of all mechanical displacements, electric potentials, and carrier concentration perturbations within the shell are identified. This paper provides a new approach for designing shell-shaped sensors and energy harvesters specifically for centrosymmetric semiconductors.

Evolution Mechanism of Blast Furnace Cooling Plate Slag‐Hanging Behavior with Different Cooling System Structure

Based on the 3D heat transfer numerical simulation model, the evolution mechanism of blast furnace cooling plate slag‐hanging behavior with different cooling system structures is analyzed. Cooling plate reduced by 20 mm will not affect its slag‐hanging behavior. Copper cooling plate is best suited for high heat load areas. The vertical spacing of cooling plate is extended by 200 mm, the uniformity of the slag layer decreases by 5%, and the temperature of cooling plate and refractory material increases by 11 and 50 °C. Cooling plate vertical spacing of 510 mm or less can ensure stable slag hanging in the blast furnace. When using a single refractory material, the average uniformity of the slag layer is 95%, 86%, and 79% for graphite brick, semigraphite brick, and sialon‐SiC brick, respectively. Si3N4‐SiC brick cannot operate properly in high heat load areas. The factory can consider setting 125 mm sialon‐SiC brick in the furnace; graphite brick is used outside the furnace lining. The slag layer is well distributed, and the average value of uniformity is about 90%. Even if the slag layer is fully dislodged, the hot surface temperature of the furnace lining is 785 °C, and it can be quickly reslag hanging.

Multi-area short-term load forecasting based on spatiotemporal graph neural network

Short term power load forecasting can accurately evaluate the overall power load changes and provide accurate reference for power system operation decision-making. To address the limitations of traditional load forecasting methods, which are unable to capture spatial correlations and simultaneously predict load changes in multiple areas, this paper proposes a load forecasting model based on the spatiotemporal attention convolutional mechanism. The proposed model is composed of two key components: a spatiotemporal attention module and a spatiotemporal convolution module. First, the dynamic spatiotemporal correlations between different electricity load areas are captured and analyzed by using the spatiotemporal attention mechanism. Secondly, the spatial pattern and temporal features of the load data sequence are effectively obtained by spatiotemporal convolutional layers. Finally, this paper verifies the accuracy and effectiveness of the proposed method through a real electricity consumption load dataset. The experimental results demonstrate that, in comparison to various benchmark prediction methods, the proposed method can fully explore and utilize the spatiotemporal correlation between different electricity load areas, thereby improving the accuracy of load prediction.

Comparative study on shape memory, mechanical, and thermomechanical properties of multi‐walled carbon nanotubes and graphene nanoplatelets modified bidirectional (twill) carbon fiber polymer composites

AbstractThe research conducts a comparative analysis of epoxy/bi‐directional (twill) carbon fiber three‐phase shape memory hybrid composites modified with MWCNT and GnP, examining their mechanical, thermomechanical, and shape memory properties. Fabrication involves preparing nanoparticle‐modified epoxy nanocomposites through ultrasonication followed by hand layup technique. The findings revealed that the modified composites achieved their optimal performance at a 0.6 wt% concentration of nanoparticle, with the tensile strength and modulus increasing by 33.59% and 23.47% for 0.6 wt% MWCNT composite and by 45.94% and 25.61% for 0.6 wt% GnP composite. GnP‐modified composites outperformed MWCNT ones due to GnP's sheet structure aligning parallel to the load and larger surface area facilitating enhanced interaction with the matrix. Despite polymer modification, the shape recovery ratio values remained high, with 98.92% for unmodified composite, 97.72% for 0.6 wt% MWCNT composites, and 97.12% for 0.6 wt% GnP modified composites, all exceeding 90%, indicating no compromise in performance.

PH-responsive mupirocin-loaded hybrid nanoparticles in hydrogel and film forming spray against resistant bacterial wound infections

The aim of this work was to fabricate smart Mupirocin loaded Lipid Polymeric Hybrid Nanoparticles (MUP-LPHNs) based hydrogel and Film forming spray (FFS) for targeted release of MUP in response to wound pH. The MUP-LPHNs were optimized through design expert v.12. The optimized MUP-LPHNs had a particle size of 270.7 ± 3.20 nm with zeta potential of 17.05 ± 1.20 mV and entrapment efficiency of 88.0 ± 0.35 %. MUP-LPHNs showed no major chemical interaction, spherical morphology and amorphous nature as confirmed by FTIR, SEM and XRD, respectively. MUP-LPHNs were loaded to MUP-LPHNs based hydrogel (MUP-LPHNs-HG) and MUP-LPHNs based film forming spray (MUP-LPHNs-FFS) with successful characterization. In vitro release data confirmed sustained and pH dependent release from both MUP-LPHNs-HG and MUP-LPHNs-FFS as higher release was observed at pH 7.4. MUP-LPHNs-HG and MUP-LPHNs-FFS showed high efficiency and long-term inhibition of Staphylococcus aureus (SA), Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) with 4–6 fold increase in the antibacterial activity compared to MUP solution. MUP-LPHNs-HG and MUP-LPHNs-FFS exhibited both in vitro and in vivo wound pH contingent, sustained drug release. Moreover, the prepared nanocarriers systems flaunted significant therapeutic efficacy against MRSA infected wound model by significant reduction in bacterial load and wound area, increased hydroxy proline level and antioxidant enzymes and reduced proinflammatory cytokines. Similarly, immunohistochemistry, histopathological and trichrome assessment showed significant reduction in level of inflammatory markers, accelerated and enhanced re-epithelization, improved connective tissue remodeling and effectively promote collagen deposition with effective wound regeneration, respectively. It can be concluded that LPHNs could be a potential carrier system for enhancing the therapeutic efficacy of MUP against resistant bacterial wound infections.

Effect of elastic gradients on the fracture resistance of tri-layer restorative systems

ObjectivesTo assess the impact of elastic gradients formed among restorative material, cement, and substrate on the fracture resistance of tri-layer restorative systems. MethodsFour CAD/CAM materials were utilized, two glass-ceramics (IPS e.max CAD, Vita Suprinity) and two resin-ceramic hybrids (Vita Enamic, Lava Ultimate). Their fracture resistance was examined by biaxial flexure (n = 8) and Hertzian indentation (n = 10) tests. Statistical analysis was conducted using ANOVA and Tukey tests (p = 5 %). Finite element analysis (FEA) was employed to simulate the Hertzian indentation test and elucidate the stress-fields formed on the intaglio surface below the loading area. ResultsThe biaxial flexural strength (MPa) of glass-ceramics exceeded the hybrid materials (e.max 417a, Suprinity 230b, Enamic 138c, and Lava Ultimate 183bc). Conversely, the load-bearing capacity (N) of the materials bonded to dentin analog demonstrated the opposite trend, with the hybrid materials achieving superior results (e.max 830 C, Suprinity 660D, Enamic 1822B, and Lava Ultimate 2593 A). The stress-fields observed by FEA were coherent with the experimental results for Hertzian flexural stresses (MPa): e.max 501 A, Suprinity 342 C, Enamic 406B, whereas no tensile stress was observed at the intaglio surface of Lava Ultimate. SignificanceDetailed analysis of the fracture resistance of the tri-layer restorative systems showed that the elastic gradients play a more significant role than the flexural strength of the restorative materials. The coherence of the elastic moduli between the restorative material and supporting structures results in reduced tensile stress concentration at the intaglio surface beneath the loading area and enhances the ability to withstand load.

Study on the atomic scale deformation mechanism of the h-BN coating nickel matrix composites

In this paper, molecular dynamics (MD) simulations are applied to study the contact mechanical behavior of hexagonal boron nitride (h-BN) coating/Ni matrix composites during nanoindentation, revealing the material deformation mechanism. A systematic study is carried out on the load-depth curve, temperature response curve, defect morphology, and dislocation density in indentation. The results show that the presence of h-BN coating increases the actual loading area of the matrix, effectively reduces the contact stress between the tip of the indenter and the specimen, and also induces the generation of high-density Shockley dislocations, which increases the dislocation entanglement and leads to the localized hardening of the composites, thus reducing the matrix damage. During the loading process, the temperature of the specimen before the destruction of the h-BN coating is significantly lower than that after the destruction, indicating that the coating tends to block the transfer of temperature to the interior of the specimen, preventing the occurrence of temperature-induced tissue phase changes inside the specimen, and providing good protection for the interior of the specimen.

Microneedle patch casting using a micromachined carbon master for enhanced drug delivery

For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loading and analytics sampling and improve drug penetration while maintaining painless administration, patch-type microneedle arrays were designed and fabricated using polymer casting from a conical cavity mold. Microcavities were formed on a carbon plate via micromechanical machining. A porous polymer layer was coated on a microneedle patch (MNP). The pores of the porous polymer layer provided space and channels for drug delivery. A pH-sensitive polymer layer was employed to cap the porous polymer layer, which prevented drug leakage during storage and provided a stimulus drug release in response to body pH conditions. The drug can be delivered through holes connected to both sides of the patch. The drug release of the MNP was investigated in vitro and in vivo and showed conceptual proof that these MNs have the potential to enhance treatment protocols for various diseases with the flexibility of coating and therapeutic materials and offer significant scope for further variations and advancement.

Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration.

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain and spinal cord. Fatigue is a common disabling symptom from MS onset, however the mechanisms by which underlying disease processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments for MS-related fatigue. MRI provides insights into in vivo neuroinflammatory activity and neurodegeneration, although existing evidence for imaging correlates of MS fatigue is mixed. We explore associations between fatigue and MRI measures in the brain and spinal cord to identify neuroinflammatory and regional neurodegenerative substrates of fatigue in early relapsing-remitting MS (RRMS). Recently diagnosed (<6 months), treatment-naive people with RRMS (n = 440) were recruited to a longitudinal multi-centre nationally representative cohort study. Participants underwent 3-Tesla brain MRI at baseline and one year. We calculated global and regional white and grey matter volumes, white matter lesion (WML) load and upper cervical spinal cord cross-sectional area levels C2-3, and assessed new/enlarging WMLs visually. Participants were classed as fatigued or non-fatigued at baseline according to the Fatigue Severity Scale (>/≤36). Disability and depression were assessed with the expanded-disability status scale and Patient Health Questionnaire, respectively. MRI measures were compared between fatigue groups, both cross-sectionally and longitudinally, using regression analyses. Higher disability and depression scores were observed for participants with fatigue, with a higher number of fatigued participants receiving disease-modifying treatments at follow-up. Structural MRI data for brain were available for n = 313 (45% fatigued) and for spinal cord for n = 324 (46% fatigued). Cervical spinal cord cross-sectional area 2-3, white and grey matter volumes decreased, and WML volume increased, over time for both groups (q < 0.05). However, no significant between-group differences in these measures were found either cross-sectionally or longitudinally (q > 0.05). The presence of new/enlarging WMLs (49% in fatigued; 51% in non-fatigued) at follow-up also did not differ between groups (q > 0.05). Our results suggest that fatigue is not driven by neuroinflammation or neurodegeneration measurable by current structural MRI in early RRMS. This novel negative finding in a large multi-centre cohort of people with recently diagnosed RRMS helps to resolve uncertainty in existing literature. Notably, we showed that fatigue is prevalent in patients without brain radiological relapse, who may be considered to have inactive disease. This suggests that symptom detection and treatment should remain a clinical priority regardless of neuroinflammatory disease activity. More sensitive objective biomarkers are needed to elucidate fatigue mechanisms in RRMS, and ultimately facilitate development of effective targeted treatments for this important 'hidden disability'.

A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment

In chronic wound treatment, the debridement of devitalized tissue and the eradication of the biofilm must balance aggressiveness with care to protect regenerating tissues. In this study, urea, a potent chaotropic molecule, was modulated through the formation of a Natural Deep Eutectic Solvent (NADES) with betaine to develop a new debriding material (BU) suitable for application into injured dermal tissues. To evaluate BU’s debriding capacity, along with its antibiofilm effect and biocompatibility, pre-clinical to clinical methods were employed. In vitro determinations using artificial and clinical slough samples indicate that BU has a high debriding capacity. Additionally, BU’s de-structuring effects lead to a strong antibiofilm capability, demonstrated by a reduced bacterial load compared to the antiseptic PHMB-Betaine or medical honey, evaluated in artificial slough and ex vivo human skin. Furthermore, BU’s efficacy was evaluated in a murine model of diabetic wound, demonstrating significant effects on debriding and antibiofilm capacity, similar to those observed in PHMB-Betaine and medical honey-treated animals. Finally, BU was clinically evaluated in leg ulcers, showing superiority in reduction of bacterial load and wound area compared to honey, with no adverse effects. Thus, BU represents a simple and non-biocidal option that could contributes to chronic wound care.

Ti3C2Tz Supported Pulse‐Electrodeposited Pt Nanostructures for Enhanced Acidic Electrochemical Hydrogen Evolution

Platinum (Pt)‐based electrocatalysts are considered benchmark materials for the hydrogen evolution reaction (HER) in acidic solution. However, widespread use is limited by the high price of Pt. Tuning the Pt morphology to increase the catalytic surface area for the same mass loading is therefore essential to increase its utilization. Herein, single Ti3C2Tz flakes were deposited by electrophoresis onto a carbon‐fiber gas diffusion layer, after which Pt nanostructures were selectively deposited onto the Ti3C2Tz flakes by pulse electrodeposition. It was observed that the pulse on‐time (ton) and duration had a significant effect on the morphology and activity of the composite electrode towards HER. Flower‐like and spherical morphologies were produced at long and short values of ton, respectively. As‐synthesized electrocatalysts were studied for HER in 0.5 M sulfuric acid (H2SO4). The catalyst with the lowest Pt loading (10 mg/cm2), exhibited outstanding HER performance. It attained a current density of 10 mA/cm2 at an overpotential of 38 mV, close to that of commercial carbon supported platinum (Pt/C, Vulcan XC). This catalyst exhibited a high turnover frequency (23.9 H2 s‐1 @ 100 mV), small Tafel slope (41 mV/dec), and high mass‐specific activity (2.45 A/mgPt @ 100 mV).