Loading Phase Research Articles

Grasp context-dependent uncertainty alters the relative contribution of anticipatory and feedback-based mechanisms in object manipulation

Predictive control within dexterous object manipulation while allowing for the choice of contact points has been shown to employ a predominantly feedback-based force modulation. The anticipation is thought to be facilitated through the internal representation of the object dynamics being integrated and updated on a trial-to-trial basis with the feedback of contact locations on the object. This is as opposed to the classically studied memory representation-based fingertip force control for grasping with pre-selected contact locations. We designed a study to examine this grasp context-dependent asymmetry in sensorimotor integration by introducing binary uncertainty about the grasp type before movement initiation within the framework of motor planning. An inverted T-shaped instrumented object was presented to 24 participants as the manipulandum, and they were asked to reach, grasp, and lift it while minimising the peak roll. We dissociated the planning and the execution phases by pseudo-randomly manipulating the availability of visual contact cues on the object after movement onset. We analysed both derived as well as direct kinetic and kinematic measures of the grasp during the loading phase to understand the anticipatory coordination. Our findings suggest that uncertainty about the grasp context during movement preparation resulted in a shift towards feedback-based mechanisms for grasp force modulation despite the persistence of visual cues.

Mechanical properties and restoring force model of Squeezing Rub-type Particle Damper

The sliding effect of isolation bearings has been proven to effectively mitigate the seismic effects on large-span bridges. However, it also results in excessive relative displacement between the main girder and piers during earthquakes. In this study, a pioneering Squeezing Rub-type Particle Damper (SRPD) is developed to address this issue. In order to verify the damping characteristics of SRPDs and investigate the working principle of squeezing friction energy dissipation, five quasi-static tests were conducted on SRPDs using two particle damping materials with different compactness levels. In order to compare the energy dissipation performance, comparative tests were conducted on Non-Squeezing-type Particle Dampers (NSPDs) and SRPDs. Utilizing regression analysis, two skeletal curve models for SRPDs were proposed, alongside a detailed restoring force model that incorporates considerations for both the pinching effect and stiffness degradation phenomena observed during the loading and unloading phases. The experimental results demonstrate that the maximum damping force of SRPDs can reach 16 times that of NSPDs, and the energy dissipation of each loading cycle can reach 21.06 times that of NSPDs. SRPDs exhibits improved energy dissipation performance when using high-density blended quartz sand. After sand replenishment repairs,damping force and energy dissipation per cycle of SRPDs were significantly enhanced. The proposed restoring force models of SRPDs aligns well with the experimental curves, underscoring its efficacy in accurately characterizing the hysteresis performance of SRPDs.

Predictive factors for Submacular Hemorrhage in Age-related Macular Degeneration: A Retrospective Study.

Little is known about the major risk factors for submacular hemorrhage (SMH). This study aimed to evaluate the factors associated with SMH in patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) receiving three consecutive loading doses of intravitreal aflibercept or ranibizumab injections. This retrospective cross-sectional study included 48 patients diagnosed with wAMD and PCV who completed three loading doses under a treat-and-extend regimen. Patients were divided into the SMH group (n=24) and the non-SMH group (age- and sex-matched without SMH). Intravitreal injections, agents, and optical coherence tomography (OCT) features were compared. In the SMH group, SMH occurred approximately 3.29 years after post-nAMD diagnosis. The non-SMH group received more intravitreal injections of aflibercept and brolucizumab during the follow-up period after the initial loading phase. The SMH group exhibited a higher prevalence of serous/hemorrhagic pigment epithelial detachments (PEDs) at the last visit before SMH occurrence compared to the non-SMH group. Patients with a PED increase in the past two visits showed a higher tendency in the SMH group. No other OCT features significantly correlated with SMH development. The presence of serous/hemorrhagic PEDs may indicate a higher risk of SMH, and eyes with these features should be closely monitored to prevent sudden and devastating visual loss caused by SMH.

Ethyl levulinate regulates traditional sulfolane biphasic absorbent for energy-efficient CO2 capture

Traditional CO2 biphasic absorbents currently suffer from problems such as high initial phase separation loading, poor product distribution selectivity, and weak dynamic phase separation ability, which limit their potential for industrial applications. This study developed a biphasic absorbent regulated by dual physical solvents by introducing partial ethyl levulinate (EL) into a sulfolane biphasic system. The optimal composition of this system was 30 wt% 1-amino-2-propanol (MIPA), 20 wt% sulfolane and 30 wt% EL. Under dual physical solvent conditions, strong electrostatic attraction between MIPA and CO2 promoted generation of MIPA zwitterions and carbamate. Analysis of the interactions between different product components through electrostatic potentials and with an independent gradient model based on Hirshfeld's partitioning revealed only extremely weak van der Waals force-driven interactions between the reaction products and EL. These interactions substantially reduced the initial phase separation loading and offered precise control over phase transition behavior. Compared with MIPA/sulfolane system, the MIPA/sulfolane/EL system achieved a 48.9 % lower initial phase separation loading, an 11.6 % lower proportion of saturated rich phase volume, a 10.1 % higher CO2-rich phase loading, and a 6.7 % lower viscosity. The excellent dynamic phase separation performance was verified using a customized device and the energy consumption for CO2 regeneration decreased to 2.2 GJ/t CO2.

The Relationship Between the Burpee Movement Program and Strength and Endurance Performance Measures in Active Young Adults: A Cross-Sectional Analysis.

This paper aimed to assess the motor performance in the Burpee Movement Program through the acceleration recorded by the Phyphox mobile app and define its relationship to strength and endurance parameters. Altogether, 15 students in physical education teaching completed the 3 × 3 min Burpee Movement Program, consisting of the repeated execution of a single burpee with maximum effort at regular intervals triggered by a sound signal. During the load phase, the intensity of the burpee and the fatigue index expressed in percentages were evaluated by means of the acceleration recorded through a mobile phone. In the second part of testing, we evaluated the performance parameters during a bench press and squat where the intensity was measured using a linear displacement transducer (Tendo Power Analyzer) and aerobic endurance was assessed with a 20 m shuttle run test (20 mSR). The average intensity of the burpee ranged from 3.12 to 11.12 ms-2. The fatigue index ranged from -21.95% (which represented an increase in performance) to 33.63% (which represented a decrease in performance). The performances in the bench presses ranged from 58 to 480 W and from 175 to 696 W during the squats. The distance in the 20 m shuttle run test (20 mSR) ranged from 540 to 2000 m. The intensity of the burpee showed a significant correlation to the performances achieved in the bench presses and squats r = 0.82 and 0.79. The fatigue index showed a significant correlation to the 20 m shuttle run test (20 mSR) r = -0.67. These findings indicate that in, our case, the results from the Burpee Movement Program are significantly associated with the participants' strength and endurance abilities. We recommend using BMP for the development of strength-endurance abilities, but further exploration is needed regarding the potential use of BMP as a diagnostic test.

Study on bending performance of prefabricated glulam-cross laminated timber composite floor

Abstract The glulam-cross laminated timber (CLT) composite floor is a type of prefabricated composite floor that integrates glulam beams and CLT slab into a unified structure using shear connectors. To investigate the bending performance of the glulam-CLT composite floor, the bending test was conducted on a full-scale composite floor under static load. The study comprehensively analyzed the failure mechanism, load–deflection behavior, interface slip and strain distribution of the glulam-CLT composite floor. The test results of the composite floor indicated that the failure mode was tensile fracture of the wood beam at the bottom. As the load increased, the deflection deformation of the mid-span beam exceeded that of the edge beam. When the load reached its ultimate limit, the deflection deformation of the mid-span beam increased by 14.4% compared to the edge beam. In the early loading phase, the strain distribution of the composite section satisfied the assumption of a plane section. However, the strain distribution deviated from this assumption with the increased load due to the relative slips between the glulam beam and CLT flange. To calculate the bending performance of the composite floor, the M-shaped section of the glulam-CLT composite floor was simplified as T-section composite beams. The linear-elastic method for determining the flexural rigidity and ultimate bearing capacity of the glulam-CLT composite floors was proved to be accurate and reliable. The findings provided valuable insights into the bending behavior of the CLT flange under load and emphasized the non-uniform stress distribution caused by shear lag effects.

Are there kinematic and kinetic parameters correlated with racket velocity during the tennis serve? A preliminary comparison between a slow and a fast serve for performance improvement.

The tennis serve is a complex motion with numerous rotations which are important to manage for performance. The main aim of this study was to investigate kinematic parameters, including the evolution of the center of gravity, and kinetic parameters correlated with racket velocity over all phases of the tennis serve. The secondary objective was to find out which of the correlated parameters differed between a slow and a fast serve. The advantage of such an approach would be to propose biomechanical parameters that coaches and teachers could use to optimize performance or learn how to serve. Quantitative analysis was carried out on 5 flat serves performed by four ranked players using an optoelectronic system (82 markers located on whole body and racket) composed of 10 infrared cameras (150 Hz) and two force platforms (750 Hz). A descriptive statistical analysis highlighted 11 very large and almost perfect correlations with racket velocity: vertical ground reaction force of back foot in release backward, trunk axial rotation during loading phase, back and front knee flexions, dominant shoulder and hip mediolateral rotation during cocking phase, and center of gravity vertical velocity, dominant shoulder medial rotation velocity, dominant elbow flexion, trunk flexion/extension and axial rotation during acceleration phase. Differences were observed for some of the correlated parameters between slow and fast serve. Consequently, all these correlated kinematic and kinetics parameters constitute information that coaches, instructors and athletes can use to improve, optimize or teach the tennis serve.

A loading dose of clofazimine to rapidly achieve steady-state-like concentrations in patients with nontuberculous mycobacterial disease.

Clofazimine is a promising drug for the treatment of nontuberculous mycobacterial (NTM) diseases. Accumulation of clofazimine to reach steady-state plasma concentrations takes months. A loading dose may reduce the time to steady-state-like concentrations. We evaluated the pharmacokinetics (PK), safety and tolerability of a loading dose regimen in patients with NTM disease. Adult participants received a 4-week loading dose regimen of 300 mg clofazimine once daily, followed by a maintenance dose of 100 mg once daily (combined with other antimycobacterial drugs). Blood samples for PK analysis were collected on three occasions. A population PK model for clofazimine was developed and simulations were performed to assess the time to reach steady-state-like (target) concentrations for different dosing regimens. Twelve participants were included. The geometric mean peak and trough clofazimine concentrations after the 4-week loading phase were 0.87 and 0.50 mg/L, respectively. Adverse events were common, but mostly mild and none led to discontinuation of clofazimine. Our loading dose regimen reduced the predicted median time to target concentrations by 1.5 months compared to no loading dose (3.8 versus 5.3 months). Further time benefit was predicted with a 6-week loading dose regimen (1.4 versus 5.3 months). A 4-week loading dose regimen of 300 mg once daily reduced the time to target clofazimine concentrations and was safe and well-tolerated. Extending the loading phase to 6 weeks could further decrease the time to target concentrations. Using a loading dose of clofazimine is a feasible strategy to optimize treatment of NTM disease. NCT05294146.

The Coefficient of Earth Pressure at Rest K0 of Sands up to Very High Stresses

The mechanical behaviour of soils subjected to any stress path in which deviatoric stresses are present is heavily characterised by non-linearity, irreversibility and is strongly dependent on the initial state of stress. The latter, for the majority of geotechnical applications, is normally determined by the at-rest earth pressure coefficient K0, even though this state is valid, strictly speaking, for axisymmetric conditions and for zero-lateral deformations only. Many expressions are available in the literature for the determination of this coefficient for cohesive and granular materials both for normal consolidated and over-consolidated conditions. These relations are available for low to medium stress levels. Results of an extensive experimental investigation on two sands of different mineralogy up to very high stress (120 MPa) are reported in the paper. For reach very high vertical stresses, a special oedometer has been realised. In the loading phase (normal consolidated sands), the coefficient K0n depends on the stress level. It passes from values of about 0.8 to values of about 0.45 in the range of effective vertical stress σ′v = 0.5–4 MPa. Subsequently, K0n is about constant and varies between 0.45 to 0.55 up to very high vertical effective stresses (120 MPa). For the sands employed in the tests, Jaki’s relation did not lead to reliable results at relatively low pressures, while at high pressures, the same relationship seems to lead to reliable predictions if it refers to the constant volume angle of shear strength. For the over-consolidated sands, K0C strongly depends on the OCR, and for very high values of OCR, K0C could be greater than Rankine’s passive coefficient of earth pressure, Kp. This result is due to the very locked structure of the sands caused by the grain crushing, with intergranular contact of sutured and sigmoidal, concavo-convex and inter-penetrating type, that confer to the sand a sort of apparent cohesion and make it similar to weak sandstone.

Data-driven insights into the properties of liquisolid systems based on machine learning algorithms

Liquisolid systems (LS) represent a formulation approach where liquid drug or its dispersion is transformed into a powder with good flowability and compactibility, leading to enhanced drug dissolution and bioavailability. Many research groups have focused on the preparation and investigation of LS, leading to a higher need for comprehensive evaluation of factors impacting LS characteristics. The aim of this work was to investigate the applicability of machine learning algorithms in the LS evaluation, using data mined from published literature, and provide an insight into critical factors governing the liquisolid system performance.The dataset was prepared using publication search engines and relevant keywords, with a total of 425 formulations included in the database. The database focused on preparation methods, formulation parameters, and liquisolid system characteristics. Subsequently, critical properties of the liquisolid system, i.e. flowability, compact hardness, and drug dissolution, were analyzed using machine learning algorithms, including Gradient Boosting, Adaptive Boosting and Random Forest.In addition to conventional preparation methods and excipients, novel technologies (fluid bed preparation, extrusion/spheronization) and materials (Neusilin®, Fujicalin®, and Syloid®) enhanced the properties of liquisolid systems. The analysis revealed that formulation factors, such as carrier and coating agent type and content, liquid phase load, model drug type and content, as well as preparation method, significantly influenced liquisolid system characteristics. The models developed exhibited high prediction accuracy when applied on test data (higher than 80 %). This indicates that the machine learning models may provide an insight into the critical attributes affecting the LS performance and may be used as a valuable tool in the development and optimization of these samples.

Recovering Nitrogen from Anaerobic Membrane Bioreactor Permeate Using a Natural Zeolite Ion Exchange Column

In the framework of a circular economy, wastewater treatment should be oriented toward processes that allow the recovery of the resources present in the wastewater while ensuring good effluent quality. Nitrogen recovery is usually carried out in streams concentrated in this nutrient because these high concentrations facilitate nitrogen valorization. On the other hand, the mainstream of a wastewater treatment plant (WWTP) has a high potential for nitrogen recovery, but it is not usually considered because it is hard to manage due to its low nitrogen concentration. To solve this problem and facilitate the recovery of nitrogen in the mainstream, this work proposes ion exchange with zeolites as a stage of ammonium concentration, to provide a nitrogen-concentrated stream that could be valorized by another technology, while obtaining a nitrogen-free effluent. The working stream, the permeate of an AnMBR process in the mainstream, has suitable characteristics to be treated in an ion exchange column (free of suspended solids and with very low organic matter content). To this end, the effect of the working flow rate (17.5 to 4.4 BV/h) and the ammonium concentration (54 to 17 mg NH4-N/L) on the adsorption capacity of the zeolite in the loading phase was evaluated. The adsorption curves were fitted to three mathematical models: Thomas, Bohart–Adams, and Yoon–Nelson. The effect of the regeneration flow rate (from 8.7 to 2.2 BV/h) and the regenerant concentration (NaOH at 0.2, 0.1, and 0.05 M) on regeneration capacity and efficiency were also studied. A novel control strategy based on effluent conductivity was used in both phases to control the duration of the adsorption and regeneration phases.

Impact of treat and extend criteria on proportions that can be extended after loading phase of 2 mg aflibercept therapy for neovascular age related macular degeneration: PRECISE Report 5.

To study the impact of definitions of various treatment extension criteria on the proportion of patients who could be extended at their first visit after the loading phase of 2 mg aflibercept therapy for neovascular age related macular degeneration (nAMD). Patients with nAMD initiated on the loading phase of three intravitreal doses of 2 mg aflibercept in routine clinical practice were recruited from December 2019 to August 2021. The response to the loading phase was assessed at approximately 8 weeks post-loading (up to 140 days from first injection) based on different definitions of response. The proportion of patients that qualify for interval extension based on different clinical trial criteria was also evaluated. A total of 722 patients with visual acuity (VA) and optical coherence tomography (OCT) scans done at all 4 visits were included. Of these 32.4% of eyes responded with complete macular fluid resolution after the first injection with no recurrence through the loading phase (super-responders) while 26.9% had persistent macular fluid in all 4 visits (true non-responders). The rest were considered suboptimal responders. Change in VA showed marked variations within each of these categories of fluid resolution. For extension of next treatment interval, if presence of any macular fluid at the post-loading visit is the only criteria considered, about 50% could be extended to 8 weeks. If both VA worsening by ≥5 letters and a > 25 μm increase in central sub-field thickness (CST)are considered, 90% will be eligible for interval extension. Clinical trial designs and pre-defined treatment extension/shortening criteria determine the proportion of patients requiring treatment in the post-loading visit. The short and long-term impact of interval extension immediate post-loading on visual outcome in clinical practice is unknown.

3D printed steel monoliths for CO2 methanation: A feasibility study

Steel honeycomb monoliths have been manufactured by Fused Deposition Modelling-FDM 3D printing technology using 90 % 17–4 PH steel nanoparticles-loaded polymer filament. Pure steel monoliths were obtained after thermal removal of the polymer and steel sintering. NiO-CeO2 active phase nanoparticles were loaded on powder steel and on the steel monoliths, and the supported catalysts were tested in the hydrogenation of CO2 to CH4, paying special attention to the steel pretreatment before active phase loading. The catalytic experiments confirm that totally functional catalysts have been prepared, showing 100 % selective conversion of CO2 to CH4 above 225 ºC and stability in long-term experiments (18 hours at 325 ºC). The catalytic behaviour is improved by H2O2-pretreatment of the steel honeycomb monoliths before the active phase loading. XPS characterization confirms that the surface of the catalysts is oxidised on the fresh catalysts and gets even more oxidised after the catalytic tests. The H2O2-pretreatment of the steel support partially avoids the additional oxidation under reaction conditions, keeping chromium and cerium cations less oxidised than on the catalyst prepared with untreated steel. In addition, evidence about the electronic interaction between the steel support and the NiO-CeO2 (np) active phase are obtained.

The impact of using prestressed CFRP bars on the development of flexural strength

Abstract The load-carrying capacity and ductility of conventional steel reinforcement may be greatly increased by using ordinary and prestressed carbon fiber-reinforced polymer (CFRP) bars, resulting in reinforced concrete structures with greater sturdiness. This research investigates the flexural behavior of CFRP-prestressed beams with bonded tendons as opposed to conventional steel-prestressed beams. This article examines a less explored topic that often fails because post-tensioned beams with unbonded CFRP tendons are crushed by concrete. The linear-elastic behavior of CFRP accounts for much of the experimentally observed considerable variations in flexural characteristics between CFRP and steel-prestressed beams. Compared to unbonded CFRP specimens, bonded CFRP specimens are much stronger. Our knowledge of CFRP reinforcement in concrete infrastructure is advanced by this work, which highlights the need for better design techniques to increase strength and ductility. It is recommended that CFRP bars be bonded with epoxy resin to restrict fast energy dissipation and avoid concrete failure. As a result, CFRP-reinforced concrete beams will react less linearly and more ductilely. CFRP may improve prestressed concrete beam performance and lifespan in a number of scenarios, as shown by comparative research with traditional steel reinforcement. Six 1,800–mm-long RC beams with a 200 × 300 mm cross-section were examined and divided into three groups, analyzing important loading phases (i.e., cracked, ultimate, and mid-span deflection) using CFRP bars as prestressed tendons to replace the bottom steel rebars. The load-carrying capabilities and ductility of CFRP-reinforced beams were much greater than those of the reference beam. A single beam using normal CFRP bars for reinforcement showed a 21.2 mm mid-span deflection and an ultimate load of 157.2 kN, with a 57.7-kN fractured load. Another beam with normal CFRP bars also showed enhanced performance, with a mid-span deflection of 21.2 mm, an ultimate load of 160.6 kN, and a cracking load of 57.5 kN.

Influence of microstructural and loading direction on the ductility and anisotropy of Ni-based superalloys

The influences of phase coarsening and loading direction on the ductility of Ni-based superalloys with phase coarsening are investigated, and the relationship between their microstructural and macroscopic mechanical properties is also explored in detail. It is found that the precipitation phase and the corresponding phase coarsening significantly influence the ductility of alloys. Furthermore, anisotropic features in ductility are observed after phase coarsening. Generally, as the volume fraction of precipitation particles or the degree of phase coarsening increases, the ductility of alloys gradually decreases; and it initially increases and then decreases gradually with the increase of loading angle, presenting an inverted ‘V’ shape. Comparatively, for the alloys with lower volume fraction of precipitation particles and higher degree of phase coarsening, the ductility shows different variation trends with the degree of phase coarsening and loading angle compared with that in materials with other microstructure features, taking the minimum value at the loading angle of 45°. The variations of ductility are closely connected to the characteristics of precipitate shape, size and distribution. The microstructure evolution and the loading direction significantly affect the initiation and movement of dislocations within the material, and result in various macroscopic ductility characteristics in the Ni-based superalloys.

Experimental Study on Acoustic Emission Features and Energy Dissipation Properties during Rock Shear-Slip Process.

The features of rock shear-slip fracturing are closely related to the stability of rock mass engineering. Granite, white sandstone, red sandstone, and yellow sandstone specimens were selected in this study. The loading phase of "shear failure > slow slip > fast slip" was set up to explore the correlation between fracture type, acoustic emission (AE) features, and energy dissipation during the rock fracturing process. The results show that there is a strong correlation between fracture type, energy dissipation, and AE features. The energy dissipation ratio of tension-shear (T-S) composite, shear, and tensile types is 10:100:1. The fracture types in the shear failure phase are mainly tensile and TS composite types. The differential mechanism of energy dissipation of different rocks during the shear-slip process is revealed from the physical property perspectives of mineral composition, particle size, and diagenetic mode. These results provide a necessary research basis for energy dissipation research in rock failure and offer an important scientific foundation for analyzing the fracture propagation problem in the shear-slip process. They also provide a research basis for further understanding the acoustic emission characteristics and crack type evolution during rock shear and slip processes, which helps to better understand the shear failure mechanism of natural joints and provides a reference for the identification of precursors of shear disasters in geotechnical engineering.

Multimodal assessment of mechanically induced transformation and damage in TRIP steels using X-ray nanotomography and pencil-beam diffraction tomography

A comprehensive multimodal measurement environment integrating X-ray computed tomography (CT) and special X-ray diffraction (XRD) using a collimated beam has been developed and was applied for the first time to investigate martensitic transformation and damage behaviour in transformation-induced plasticity (TRIP) steels. The transformation and damage behaviour of numerous γ grains were analysed individually to understand the behaviours and to identify the factors controlling these processes.A transition was observed from a stress-assisted transformation in the early loading phase, controlled by mechanical driving forces, to a strain-induced transformation controlled by dislocation density. A characteristic reversal in the transformation rate was observed whereby γ grains with a crystallographic orientation that initially undergo rapid transformation due to high mechanical driving force underwent a sudden deceleration of transformation. Conversely, γ grains with an orientation that initially underwent gradual transformation rapidly completed transformation. The preceding hard phase inhibited the transformation of neighbouring γ grains through the triple effects of reducing stress triaxiality, relaxing stresses and constraining plastic deformation.The growth of pre-existing voids was modest, and material damage was dominated by voids that were newly formed during deformation from α′ grains. The initiation and progress of damage were influenced by the combined effects of the γ grain morphology and their interaction with surrounding α′ grains. The complexity of the local morphology governed the martensitic transformation and damage behaviour, and geometrical parameters were identified as highly sensitive indicators for describing this phenomenon. Finally, industrial measures to design damage-resistant TRIP steels based on these research findings are discussed.

Deconstructing the Retained Austenite Stability: In Situ Observations on the Austenite Stability in One- and Two-Phase Bulk Microstructures During Uniaxial Tensile Tests

Given the critical role that metastable retained austenite (RA) plays in advanced high-strength steel (AHSS), there is significant interest in obtaining a comprehensive understanding of its stability, to achieve excellent mechanical properties. Despite considerable attention and numerous studies, the significance of individual contributions of various microstructural factors (size, crystallographic orientation, surrounding phases, etc.) on the stability of RA remain unclear, partly due to the difficulty of isolating the direct effects of these factors. In this study, we examined the influence of microstructural factors while minimizing the effect of chemical composition on the mechanical stability of RA. We accomplished this by comparing the austenite (γ) stability in two distinct microstructures: a two-phase RA/martensite microstructure and a one-phase γ microstructure, both with nearly identical γ compositions. We employed in situ high-energy X-ray diffraction during uniaxial tensile testing conducted at both room temperature and 100 °C, facilitating the continuous monitoring of microstructural changes during the deformation process. By establishing a direct correlation between the macroscopic tensile load, phase load partitioning, and the γ/RA transformation, we aimed to understand the significance of the microstructural factors on the mechanical stability of the RA. The results indicate that very fine RA size and the surrounding hard martensitic matrix (aside from contributing to load partitioning) contribute less significantly to RA stability during deformation than expected. The findings of this study emphasize the critical and distinct influence of microstructure on γ/RA stability.

Comparison of Muscular Activity During Running with New and Used Military Boots and Running Footwears in Healthy Individuals: A Clinical Trial Study

Background: The type of footwear worn by military personnel and others could increase the risk of overuse injuries. Objectives: This study aimed to compare muscular activity during running with new and used military boots and running footwear in healthy individuals. Methods: Thirty healthy males were given a new pair of running footwear (n = 15) and thermoplastic polyurethane military boots (n = 15). Participants in each group were asked to wear these shoes for 6 months. Electromyographic activity of the dominant limb muscles was recorded during running at a speed of 3.3 m/s before and after 6 months. Results: The results indicated significant differences in muscle activity based on the type of footwear worn during various phases of running. Specifically, muscles such as the tibialis anterior, vastus lateralis, rectus femoris, biceps femoris, and semitendinosus showed varied activity during phases such as loading, mid-stance, and push-off. Additionally, there were significant effects of time on certain muscles, including the tibialis anterior and gastrocnemius medialis during the push-off phase. Interactions between footwear type and time were observed for the semitendinosus and gluteus medius during the loading phase, and the gastrocnemius medialis during the push-off phase. Conclusions: The results of this study indicate a decrease in muscle activity for most lower limb muscles in the military boots group compared to the running footwear group during the stance phase of running. The magnitude of gastrocnemius medialis activity increased in the military boots group (but not in the running footwear group) from pre-test to post-test during the push-off phase.

Efficacy and Durability of Faricimab in Naïve Eyes with Neovascular Age-Related Macular Degeneration

Introduction: The aim of the study was to evaluate functional and anatomical changes in patients with neovascular age-related macular degeneration (nAMD) treated with a loading dose of faricimab intravitreal injections (IVIs). Methods: Eighteen eyes of 18 patients with active macular neovascularization and nAMD were enrolled at the Ophthalmology Clinic of University G. D’Annunzio, Chieti-Pescara, Italy. All patients were scheduled for faricimab IVI as per label. Enrolled patients underwent complete ophthalmic evaluation, including optical coherence tomography, fluorescein angiography, and indocyanine green angiography. All measurements were evaluated at baseline (T0) and then monthly up to week 20 (T4). Main outcome measures were changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), pigment epithelial detachments (PEDs) presence and maximum height (PED-MH), intraretinal fluid (IRF) presence, subfoveal subretinal fluid (SSRF) presence and thickness. Results: BCVA improved and CMT reduced significantly during follow-up (p < 0.001). In addition, SFCT decreased significantly (p = 0.031). Between T0 and T4, SSRF presence reduced from 55.6 to 16.7% (p = 0.045); IRF presence changed from 50 to 22.2%, respectively (p = 0.074). PED-MH was reduced in 58.8% of patients at T4. At week 20, 72.3% of patients were in the q12/q16 interval. Conclusion: Faricimab showed efficacy in the treatment of naïve nAMD patients with an improvement of anatomical and functional parameters and a treatment interval after the loading phase equal or greater than 12 weeks in the majority of patients.