Rheumatoid Arthritis is a chronic inflammatory systemic autoimmune disease.This Autoimmune disease characterized by inflammatory arthritis & extra articular involvement.It is caused in many cases by the interaction between genes & environmental factores,including tobacco,that primararily involves synovial joints.It is typically starts in small peripheral joints,is usually symmentric & progressess to involve proximal joints if left untreated.Joint inflmmation over time leads to the destruction of the joint with loss of cartilage & bone erosions.RA with a symptom duration of fewer than six months is defines as early RA, & when the symptoms have been present for more than six months is defines as established RA.The main aim for Comparing the Effectiveness of Centesimal Potency and LM Potency in cases of Rheumatoid Arthritis is to Minimize Use of Immunosuppressive Drugs, NSAIDS,Corticosteroids and its side effects with its prevalance in all over india.