Life Of Sufferers Research Articles

The Effect of Mindfulness and Spiritual Combination Breathing Exercises towards Anxiety, Depression and Blood Pressure of Ischemic Stroke Patients

Background: Ischemic stroke causes serious ongoing problems in the lives of sufferers, including biological, psychological and spiritual changes so that comprehensive and multidisciplinary nursing care is necessary. Purpose: The purpose of this research is to analyze the effect of Mindfulness and Spiritual Combination Breathing Exercises towards anxiety, depression and blood pressure of ischemic stroke patients. Methods: This research is a quantitative research that uses a quasy experimental research design with a pretest - posttest control group design approach. The population of all ischemic stroke patients at RSAU dr. M.Munir Lanud Abdulrachman Saleh Malang as many as 108 people. The sample size is 50 respondents. The sampling technique is purposive sampling. The intervention group was given a combination of Mindfulness and SpiritualityBreathing Exerciseswithin 10-15 minutes 2 times a day for 5 days and the control group was given intervention according to hospital standards. Analysis used the Manova test with a significant p value <0.05. Results: The results of the study using the Manova test showed that there was a significant effect between anxiety, depression and blood pressure after giving the Combination of Spiritual Mindfulness and Breathing Exercise sshowed that p value = 0.000, with the highest partial Eta Squared value of 0.643 anxiety followed by 0.579 depression and 0.263 blood pressure. Conclusion: A combination of Spiritual Mindfulness and Breathing Exercises effectively reduce the level of anxiety, depression and blood pressure of ischemic stroke patients.

Explaining the Propositions of the Sound Heart Model as Spiritual Health Theory: Research Methodology

Background: Holistic, community-oriented health services require attention to spiritual health at all levels of prevention, in the spectrum of health and disease, throughout life. Spiritual health services are professional theory-based practice. The purpose of the study is to report the research methods of explaining the propositions of the Sound Heart Model as a Spiritual Health Theory. Methods: The theory was designed by using qualitatively derived theory based on the Concept-Integration method in six stages. An in-depth philosophical review of two decades of research indicated the need for spiritual empowerment. Concept analysis clarifies the concepts of therapeutic relationships and therapeutic content as spiritual communication, knowledge enhancement, skill training, and spiritual motivation. To validate the findings, in addition to Morse et al. suggestions, the findings were reviewed in four specialized national sessions "Chair of Behavioral Sciences", "Narrative Sciences Chair", "Pre-Summit Sessions" and "Summit Session" of "Chairs of Theorizing, Criticism and Scientific Debate" in the “Supreme Council of the Cultural Revolution”. Conclusion: Spiritual self-care of parents, teachers and clergy is a priority. Secure attachment to the prophets and following their lifestyle is the basis of spiritual self-care. Spiritual self-care of parents, teachers and clergy creates spiritual mentoring competence. The correct religious behavior of spiritual mentors provides the possibility of model-oriented education. Spiritual communication based on compassion and empathy can create secure attachment, trust and security. Spiritual mentors should provide spiritual training without coercion and violence with "scaffolding". Mentors can facilitate the stages of faith growth and correct cognitive errors by increasing spiritual knowledge. Explaining the spiritual reason for life's sufferings increases resilience against suffering. By teaching "relationship development skills" with nature, self, people and God along with thinking about "the truth of religion", they can create a positive image of God and secure attachment to God. So that people can take refuge in God as a safe haven and feel safe.

Mirabegron in the Management of Overactive Bladder Syndrome.

Overactive bladder (OAB) negatively affects work productivity and quality of life in sufferers. Its overall impact is likely to increase as a result of increasing prevalence in an ageing population. The pathophysiology of OAB is not completely understood but the β3-adrenoceptor, which is highly expressed in the urinary bladder, is thought to be important for mediating human detrusor relaxation during the storage phase. Clinical trial results have demonstrated that mirabegron, a selective β3-adrenoceptor agonist offers substantial clinical efficacy and good adherence rates over 12 months. Furthermore, due to its different mechanism of action, it is likely to offer a favourable tolerability profile when compared with antimuscarinic agents, resulting in improved persistence over long-term treatment. Finally, from a health economic perspective, despite its higher drug acquisition cost, mirabegron has been found to be cost-effective, owing to the greater increase in quality-adjusted-life-years gained, when compared to antimuscarinic medications. The PubMed database was searched for English language articles published between 1 January 2005 to 31 January 2022, on the subject of mirabegron. Search terms included “mirabegron”, “overactive bladder”, “β3-adrenoceptor agonist”, “urinary incontinence”. This review summarises the evidence for mirabegron as a treatment option for the management of OAB.

COMMUNICATION SKILLS EXHIBITED BY A CHILD WITH ASPERGER SYNDROME

Autistic children experience verbal and nonverbal communication disorders categorized as primary language disorders and secondary language disorders. The disorder can affect all levels of language and persist into adulthood. In addition, the disorder can have a wide impact on the life of sufferers. On the other hand, the number of people with autism in Indonesia is increasing every year. This study aimed to examine an Asperger Syndrome child’s communication skills using Scovel’s theory which includes four stages, namely conceptualization, formulation, articulation, and self-monitoring. The research design used in this study is qualitative descriptive with the Single Subject Research (SSR) method. Data were gathered from an Asperger Syndrome child registered at SLB 1 in Makassar, through observation, interviews, and documentation. The research instruments were composed of the researcher as the primary instrument, and supporting instruments, which comprised an instrument to assess autism ability, observation guides, interview guides, and recording devices. The autism ability instrument is guided by the Diagnostic and Statistical Manual of Mental Disorders. Data analysis techniques are data transcription, data reduction, data presentation, and conclusion withdrawal. The findings revealed that the child’s level 2-conceptualization ability (requires great support) was influenced by his level of focus, frequency of learning topics, and expression of desire. The child’s formulation ability was at level 2 (needs considerable assistance) and was influenced by his attentiveness and comprehension of a topic. The articulation ability exhibited by the child was at level 1 (needs support) with several articulation disorders, including substitution (sound changes), omission, addition, and distortion (clutter). Due to the child’s inability to recognize speech errors, his self-monitoring ability was classified into level 3 (requires enormous support). Variations in the level of ability shown by the child are a manifestation of deficits in Asperger’s Syndrome.

Siblings’ experiences of having a brother or sister with an eating disorder

IntroductionDespite the huge effect eating disorders (Eds) have on the lives of sufferers and their families there has been little research on the effect an ED has on siblings even though their lives are repeatedly significantly affected by the situation. It is important to gain more insight into the experiences and needs of siblings as the nature and magnitude of the effect of patients EDs on non-affected siblings is mixed in the current research.ObjectivesTo conduct a systematic review allowing an extensive search of the current literature to identify where the current research is lacking. Also, to highlight the need for a greater focus on the effect of EDs on siblings both in research and clinical practice.MethodsA systematic review is being conducted to gain an understanding of the gaps in the literature.ResultsIt is expected that the systematic review will reveal a lack of literature regarding siblings’ experiences of having a brother or sister with an ED. As well as showing the conflicting emotions felt by the siblings, both positive due to the love they feel for their sibling and negative due to the burden they feel.ConclusionsBy raising awareness of the needs of non-affected siblings this research should have a notable impact on their experiences by highlighting the need for specific interventions and support services as well as education about their siblings’ ED.DisclosureNo significant relationships.

Effects of ELF-EMF Treatment on Depression

Introduction: Depression is an extremely widespread disorder that is also highly impactful on the quality of life and general health of individuals, on a global scale. The aim of this study was a preliminary assessment of a potential non-pharmacological treatment, based on extremely low frequency and intensity electromagnetic fields (ELF-EMF), which could potentially reduce the impact of depression on the lives of sufferers. Materials and methods: A preliminary case-control study based in 2centres was conducted during the second half of 2020. The recruited participants were subject either to ELF-EMF treatment (Group α) or to a placebo treatment (Group β) for a total of 5 sessions. Treatment involved non-focused exposure using a radiant mat associated with focused exposure in the cranial area using the same ELF-EMF parameters. Each individual session lasted 36 min and the same ELF-EMF program was used for all 5 therapeutic sessions. The effects of treatment were evaluated by giving the subjects the following self-administration tests: Zung Self-Rating Depression Scale (SDS), Beck Depression Inventory Scale (BDI), and Short-Form 12 (SF12). The tests were administered before starting the treatment cycle (T0), after the 5 sessions (T1), and at a 2 month follow-up (FU). Results: Statistical significance indicating an improvement in the depressed state perceived by the participants was achieved with both the SDS and the BDI, at T1 (T1: SDSα 37.8, SDSβ 46.6, p = 0.012; BDIα 8.7, BDIβ 20.4, p = 0.004) and persisting at FU (T1: SDSα 39.1, SDSβ 49, p = 0.037; BDIα 10, BDIβ 19.9, p = 0.04). As regards SF12, the mental part of the test (MCS12) exhibited a significant improvement at T1in the treated group compared to the placebo (MCS12α 47.40, MCS12β 40.48, p = 0.048), but this was not confirmed at FU. During the treatment period there were no drop-outs from the 2 groups and no adverse events were reported in the treatment group. Conclusions: Treatment with ELF-EMF demonstrated safety and efficacy for reducing the gravity of perceived depressed state.

The Effect of Family Social Support and Self Esteem in Improving the Resilience of Tuberculosis Patients

An individual's ability to survive determines the success of treatment is called resilience. Family social support and self-esteem are factors that affect resilience and play an important role in the lives of sufferers who are determined to recover. This study aims to find out the relationship of family social support and self-esteem with the resilience of TB sufferers in the working area of Bangetayu Health Center. This research used analytical observational methods with a cross-sectional design, the total sample was 30 respondents with a total sampling technique. The instruments used are medical records, demographic data questionnaires, MSPSS questionnaires, RSES questionnaires, and resilience questionnaires and then data processed with spearman rho tests. Statistical test results found a relationship between family social support and resilience showed a value of ρ = 0,000 (ρ ≤ 0,05) and rho (r) = 0,809 which means there is a very strong correlation, as well as a relationship between self-esteem and resilience that shows the value of ρ = 0,000 (ρ ≤ 0,05) and rho value (r) = 0,787, then there is a strong correlation between variables and accompanied by a positive pattern. Thus, there is a significant relationship and a positive direction of the relationship. This study shows that the higher the family social support and self-esteem, the higher the resilience of TB sufferers.

Chronic pelvic pain in women

Chronic pelvic pain (CPP) is a common and complex condition. It affects up to 24% of women worldwide (1:6) and has a prevalence rate similar to asthma or back pain. The International Association for the study of Pain defines it as: ‘chronic or persistent pain perceived in structures related to the pelvis of either men or women. It is often associated with negative cognitive, behavioural, sexual, and emotional consequences as well as with symptoms suggestive of lower urinary tract, sexual, bowel, pelvic floor or gynaecological dysfunction.’ CPP lasts over 6 months and causes functional problems to the lives of sufferers.

Dietary Practices of Women with Endometriosis: A Cross-Sectional Survey.

Background: Endometriosis causes deleterious effects on the lives of sufferers across multiple domains impacting quality of life. Commonly utilized pharmaceutical interventions offer suboptimal efficacy in addition to potentially intolerable side effects for many women. There is some evidence for dietary therapies reducing endometriosis symptoms, but little data on dietary preferences/strategies used, and their impact, in a community setting. Methods: A cross-sectional online survey was conducted between October and December 2017 to investigate the self-management strategies employed by women with endometriosis. Participants were aged 18-45 years, living in Australia, and had a surgically confirmed diagnosis of endometriosis. Results: Four hundred eighty-four responses were included for analysis, with 76% of women reporting the use of general self-management strategies within the last 6 months. Of these, 44% of respondents reported using dietary strategies for symptom management. Reducing or eliminating gluten, reducing or eliminating dairy, and the low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet were the most commonly reported dietary strategies utilized. Respondents reported a 6.4/10 effectiveness score for reduction in pelvic pain with dietary changes, with no difference in pain reduction between the various diets used. Furthermore, women self-reported significant improvements in comorbidities such as gastrointestinal (GI) disturbance (39%), nausea and vomiting (15%), and fatigue (15%). Conclusions: Dietary modifications are a very common self-management strategy employed by people with endometriosis, with the greatest benefit reported on GI symptoms. Reducing or eliminating gluten, dairy, or FODMAPs or a combination of these was the most common strategy. No single diet appeared to provide greater self-reported benefits than others.

Glandula Tiroid Problem: Literature Review

Thyroid cancer is the most common endocrine system neoplasm.Based on the "Pathologycal Based Registration" in Indonesia, thyroidcancer is a cancer with the highest incidence in the ninth rank.According to statistics from the National Cancer Institute (NCI), theincidence of thyroid cancer in men is about 2.5 per 100.000population and women around 6.7 per 100.000 population. Thyroidcancer can affect all age groups and the frequency increases afterthe age of 50 years. Only about 5% can affect the age of 15-20 years.NCI also states that this thyroid cancer can affect 16.000 people peryear. Diagnosis is important to improve the quality of life forsufferers. Clinical diagnosis is the basis for determining furthermanagement, so that knowledge and skills are needed indetermining the diagnosis. The first treatment for a cancer is thebest chance for the patient to achieve optimal cure rates, as is thecase for thyroid cancer.

HUBUNGAN GAYA HIDUP DENGAN KUALITAS HIDUP PADA PENDERITA MASALAH KAKI DIABETIK

An increasing number of people with diabetes globally results in an increasing number of complications from diabetes, such as diabetic foot problems. Diabetic foot problem is one of the complications that most causes a decrease in the quality of life in sufferers. The aim of this study was to determine the relationship between lifestyle with quality of life in people with type 2 diabetes with diabetic foot problems. This research uses quantitative research with a case-control design with a retrospective approach. The number of respondents in this study was 50 people using the purposive sampling technique. The measuring instrument used to assess lifestyle is the Fantastic Lifestyle Score, while to assess the quality of life (WHOQOL) BREF. The statistical test used is the chi-square test. In this study, the p-value was 0.044 (α= 0.05) so that statistically there was a relationship between lifestyle with quality of life. Based on the odds ratio, the value was 3.886 (95% CI, 1.191-12.681), meaning that respondents who had a bad lifestyle were 3.8 times more likely to have a bad quality of life. The results showed that lifestyle was significantly related to the quality of life, where the better the lifestyle, the better the quality of life. This research can also be an input for health workers to make health services an effort to increase knowledge about the lifestyle and quality of life of people with diabetes.

Predictors of Psychological Outcomes and the Effectiveness and Experience of Psychological Interventions for Adult Women with Chronic Pelvic Pain: A Scoping Review.

ObjectiveCPP affects approximately 15% of women worldwide and has significant psychological, physical and financial impact on the lives of sufferers. Psychological interventions are often recommended as adjuncts to medical treatment for women with chronic pelvic pain (CPP). This is as women with CPP experience higher rates of mental health concerns and difficulties coping with their pain.. However, recent systematic reviews have highlighted that the efficacy of psychological interventions is not conclusive in this population. This review aimed to identify predictors of mental health outcomes and effective psychological techniques and interventions in women with CPP to inform the development of future psychological therapies.MethodsScoping review using the method outlined by Arskey & O’Malley (2005). Relevant databases, reference lists and grey literature were searched to identify effective mental health interventions and predictors of psychological outcomes for women with CPP.ResultsMethodological concerns made identifying predictors of mental health outcomes and effective psychological interventions difficult. However, cognitive behavioural therapy and Mensendieck therapy emerged as therapeutic interventions with the best evidence for women with CPP. A number of useful predictors of mental health outcomes and techniques included in effective interventions were identified.ConclusionThe evidence provided in this review has the potential to inform future research directions and the development of targeted psychological interventions for women with CPP.

Myricitrin regulates proliferation, apoptosis and inflammation of chondrocytes treated with IL-1β

Osteoarthritis (OA) is a clinical disease which seriously affects the quality of life of sufferers. Although the pathogenesis of OA has not been fully unraveled, it is may be due to increased levels of pro-inflammatory cytokines, activation of inflammation-related signaling pathways, and degradation of extracellular matrix. Osteoarthritis is characterized by chronic joint pain, swelling, stiffness, limited movement or joint deformity, all of which seriously affect the quality of life and health of the affected individuals. Myroside (Myr) is a polyphenolic hydroxyflavone glycoside extracted from the fruits, bark and leaves of myroside and other natural plants. It has many pharmacological properties, especially anti-inflammatory effects. In the present study, primary chondrocytes of IL-1β rats were used to simulate pathological environment of chondrocytes in OA, and to explore the effect of Myr on chondrocytes. It was found that Myr improved the viability and proliferation of chondrocytes, and also inhibited apoptosis in these cells. Moreover, Myr reduced the expressions of inflammatory factors, and inhibited inflammatory reactions in chondrocytes. These findings provide good experimental basis for the clinical application of Myr in the prevention and treatment of progressive degeneration of cartilage in OA.

Cross Adaptation Quality of Life Questionnaire for Periodontitis Patients (Modified Indonesian Version) in Menopausal Women

Background: Changes in steroidal sex hormones in peri- and post-menopausal women affect their bodies, including their periodontal tissues. Disorders of periodontal tissues can impact the patient’s quality of life, so a valid instrument in measuring quality of life is needed in order to know how much periodontitis affects the quality of life of sufferers in peri and postmenopausal women. Objective: This study aimed to examine the validity and reliability of the quality of life questionnaire for patients with periodontitis (modified Indonesian version). Methods: Cross-cultural adaptation was tested in peri- and post-menopausal women aged 45–59 years. The reliability and validity of the questionnaire was examined among 268 women, who lived in Jakarta and were undergoing a periodontal examination to determine periodontitis severity. Results: Cronbach’s α coefficients for internal consistency were: 0.929 (questions related to gums) and 0.942 (questions related to teeth); The test-retest reliability was good as determined based on a test–repeat test involving 27 women; the interclass coefficient was 0.880 (questions related to gums) and 0.878 (questions related to teeth). The construct validity of the questionnaire (questions related to gums and teeth) showed that the questionnaire was significantly associated with oral health and food taste (P<0.001). The discriminant validity of the questionnaire, the influence of the gums on speaking difficulties (P=0.011) and family life (P=0.025) and the influence of the teeth on family life (P=0.020) and mood (P=0.019) could enable differentiation of periodontal severity in peri- and post-menopausal women. Conclusion: This study confirmed the reliability and validity of the quality of life questionnaire for patients with periodontitis (modified Indonesian version) in peri- and post-menopausal women, therefore this questionnaire can be used to measure the quality of life of periodontitis patients in peri and postmenopause in Indonesia.

A Review of Scientific Evidence for THC:CBD Oromucosal Spray (Nabiximols) in the Management of Chronic Pain.

The 20% prevalence of chronic pain in the general population is a major health concern given the often profound associated impairment of daily activities, employment status, and health-related quality of life in sufferers. Resource utilization associated with chronic pain represents an enormous burden for healthcare systems. Although analgesia based on the World Health Organization’s pain ladder continues to be the mainstay of chronic pain management, aside from chronic cancer pain or end-of-life care, prolonged use of non-steroidal anti-inflammatory drugs or opioids to manage chronic pain is rarely sustainable. As the endocannabinoid system is known to control pain at peripheral, spinal, and supraspinal levels, interest in medical use of cannabis is growing. A proprietary blend of cannabis plant extracts containing delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) as the principal cannabinoids is formulated as an oromucosal spray (USAN name: nabiximols) and standardized to ensure quality, consistency and stability. This review examines evidence for THC:CBD oromucosal spray (nabiximols) in the management of chronic pain conditions. Cumulative evidence from clinical trials and an exploratory analysis of the German Pain e-Registry suggests that add-on THC:CBD oromucosal spray (nabiximols) may have a role in managing chronic neuropathic pain, although further precise clinical trials are required to draw definitive conclusions.

An unmet need: Patients with smell and taste disorders.

There are large numbers of patients with olfactory disturbance in the UK and shortfalls in assessment and support amongst mainstream practice in both primary and secondary care leading to significant quality-of-life impairment and potential missed diagnoses. The aim of this study was to determine the key themes which can be identified from the accounts of anosmia sufferers and to identify important areas to target for future research or service development. Qualitative analysis of written patient accounts from patients corresponding with a tertiary smell and taste clinic in the UK. This qualitative study utilised unstructured written patient accounts from consenting patients experiencing olfactory disturbances received by the smell and taste clinic. Framework analysis was performed using Nvivo 10 software. Tertiary smell and taste clinic. Consenting patients who contacted the smell and taste clinic with accounts of their experiences. Themes generated by qualitative analysis with Nvivo software. Accounts submitted by 71 participants were included in the analysis; age range 31-80years, 45 females, 26 males. Themes identified include negative emotional impact, feelings of isolation, impaired relationships and daily functioning, impact on physical health and the difficulty and financial burden of seeking help. Olfactory disturbances have a wide-ranging impact on the lives of sufferers, compounded by a lack of knowledge of the disorder amongst clinicians. There is a role for further support and education both for sufferers and for clinicians, as well as a need to improve our understanding of olfactory disturbance.

Spiritual Mental Development Through Hindu Education For HIV AIDS

<p><em>Mental guidance refers to the formation of a complete personality with strong faith and physical strength. If a person's mental state does not get attention it will bring negative impacts. The fragility of one's mental endurance can be overcome by increasing the spiritual deepening of religion. In connection with this optimization of Hindu religious education is very influential in the development of mental and spiritual, especially among people with HIV AIDS. People with HIV AIDS must understand and implement religious teachings so as to avoid negative actions and harm themselves and others. Research on the mental and spiritual development of people with HIV AIDS through the Hindu religious education approach is important to be carried out, in addition to having never been investigated, it can also provide an illustration of tackling the spread of HIV AIDS and increasing the spirit of life for sufferers.</em></p>

The Relationship Between Discharge Planning and The Quality of Life of Patients with Diabetic Ulcer

Introduction: Diabetic ulcer is one of the chronic complications of diabetes mellitus. Several studies in Indonesia reported that the mortality rate of gangrene ulcers in people with diabetes ranged from 17-32%, and diabetic ulcers affected the quality of life of sufferers. All patients hospitalized require discharge planning. From the explanation above, it can be concluded that Diabetes Mellitus is a degenerative disease that indeed requires hospitalization. The purpose of this study is to find out whether the Discharge planning process has a relationship with the quality of life of patients with Diabetic Ulcers. Methods: With the Ex post facto study design, 28 respondentwho were in accordance obtained measurements of discharge planning processes using interview methods and measurements on quality of life using the WHOQOL-BREEF questionnaire with spearman rank non parametric correlation analysis methods. Results: The results of the value are obtained: a = 0.05 with = rs table (0.707), RHO count (0.949)>rs table then categorized in the table Relationship Strengths correlation results obtained in this category is very strong / near perfect with the value 0.76- 1.00. Conclusions:This shows that there is a significant relationship with the strength of a very strong / near-perfect relationship according to the table.

Kualitas Hidup Pasien Tuberkulosis Paru yang Mengalami Stigma Diri (Quality of Life Pulmonary Tuberculosis Patients With Self Stigma))

Pulmonary tuberculosis (TB) is a chronic disease that can bring about the sufferer's self-stigma and also affect his quality of life. A number of studies report that living with TB has a negative influence on the quality of life of sufferers even with or without self-stigma. The purpose of this study was to identify the quality of life of TB patients who experienced self-stigma. This research is a descriptive study, sample were 31 pulmonary TB patients. Data was collected using a questionnaire. Data analyzed by using frequency distribution and percentage. The researcher first screened TB patients who experienced self-stigma. The results showed that 25 people (80.64%) respondents experienced mild self-stigma. A total of 9 respondents (36%) had a quality of life score in the good category and as many as 16 respondents (64%) had enough category with an average quality of life score is 56.57. While respondents who had moderate self-stigma were 6 people (19.36%) with a good quality of life score was 1 person (16.67%) and enough category quality of life score were 5 people (83.33%) with an average quality of life score is 49.92.

The Nutritional and Social Contexts of Celiac Disease in Women: A Qualitative Study.

Previous studies have confirmed that women who are diagnosed with celiac disease report a lower quality of life than men who are diagnosed with the same illness. This article describes the life experiences of women with celiac disease, especially those who adhere to a lifelong gluten-free diet. A phenomenological design based on the Giorgi method was used. Twenty-two women who were diagnosed with celiac disease and were between 16 and 75 years old completed the semistructured interviews. The results showed that celiac disease has differing effects on the lives of women sufferers. The general feeling of being a woman with celiac disease was described as an effort toward achieving a normalized life. Four categories emerged from the results: feelings at diagnosis, limitations in daily life, social perceptions of the illness, and personal meanings of celiac disease. This study shows that celiac disease and its treatment reduce mental and social quality of life in women. Organizations and public institutions should carry out public awareness campaigns targeting celiac disease and promote quality of life in sufferers of celiac disease in general.