Lithium Injection Research Articles

I-mode plasma confinement improvement by real-time lithium injection and its classification on EAST tokamak

Abstract I-mode is a promising regime for future fusion reactors due to the high energy confinement and the moderate particle confinement. However, the effect of lithium, which has been widely applied for particle recycling and impurity control, on I-mode plasma is still unclear. Recently, experiments of real-time lithium powder injection on I-mode plasma have been carried out in EAST Tokamak. It was found that the confinement performance of the I-mode can be improved by the lithium powder injection, which can strongly reduce electron turbulence (ET) and then trigger ion turbulence (IT). And it was observed that the ET intensity is inversely proportional to the velocity shear, which suggests that the injection of lithium powder leads to a gradual enhancement of the shear flow, whereby the turbulence is reduced and consequently the confinement is improved. Four different regimes of I-mode have been identified in EAST. The Type I I-mode plasma is characterized by the weakly coherent mode (WCM) and the geodesic-acoustic mode (GAM). The Type II I-mode is featured as the WCM and the edge temperature ring oscillation (ETRO). The Type III I-mode corresponds to the plasma with the co-existence of ETRO, GAM, and WCM. The Type IV I-mode denotes the plasma with only WCM but without ETRO and GAM. It was observed that the WCM intensity is increased with lithium powder injection by the confinement improvement/pedestal temperature increase. EAST experiments demonstrate that lithium powder injection is an effective tool for real-time control and confinement improvement of I-mode plasma.

Lithium ameliorates spinal cord injury through endoplasmic reticulum stress-regulated autophagy and alleviated apoptosis through IRE1 and PERK/eIF2α signaling pathways

ObjectiveThis study aims to investigate the role of apoptosis and autophagy under endoplasmic reticulum (ER) stress in a lithium-treated SCI model. MethodsWe established a rat thoracic 10 (T10) spinal cord contusion model and observed its therapeutic effect by intraperitoneal (IP) injection of lithium. Histological and behavioral recovery with or without lithium injection were evaluated after rat spinal cord injury. In addition, we employed an oxygen-glucose deprivation (OGD)-PC12 cell model to study the effects of lithium on OGD-PC12 cell apoptosis, autophagy and ER stress. ResultsWe found that lithium administration to SCI rats reduced neuronal apoptosis and autophagy, restored rat locomotor function by reducing ER stress via IRE1 and PERK/eIF2α pathways. In vitro experiments confirmed that upon lithium treatment, OGD-PC12 cells resisted ER stress caused by thapsigargin (TG) via the IRE1 and PERK/eIF2α signaling pathways. ConclusionLithium attenuated neuronal apoptosis and autophagy, and facilitates the recovery after spinal cord injury through ameliorating ER stress, providing a new therapeutic mechanism for lithium to treat SCI.

Active Lithium Injection for a Real Time Control of the Divertor Heat Flux for Fusion Devices

Active Lithium Injection for a Real Time Control of the Divertor Heat Flux for Fusion Devices

Impacts of Lithium Injection Positions on Lithium Transport and Heat Flux on EAST with EMC3-EIRENE Modelling

Impacts of Lithium Injection Positions on Lithium Transport and Heat Flux on EAST with EMC3-EIRENE Modelling

Hierarchical porous and lithiophilic CuMn current collector for advanced lithium metal batteries

Lithium metal faces serious problems such as dendrite growth and volume expansion, which make lithium metal batteries lose the opportunity in commercialization. Herein, we report a simple route to prepare a hierarchical porous CuMn (hp-CuMn) current collector (CC) with an epitaxially grown lithiophilic layer to solve these problems. The hp-CuMn with industrialization potential can achieve uniform current distribution and geometric constraints. Meanwhile, the epitaxially grown MnO by annealing the hp-CuMn with surface absorbed oxygen in reductive atmosphere effectively improves the interfacial bonding force and lithiophilicity. Consequently, the hp-CuMn@MnO with thickness about 85 μm (can store Li of 14.45 mAh cm−2 by molten lithium injection, 5 times of the graphite anode) have a small hysteresis voltage and can be stable for up to 1500 h. Full cells with LiFePO4 display ultrahigh capacity retention ratio (96.8 %) after 600 cycles at 2 C, and has good compatibility with the current industry, which verifies the application value.

Treatment pattern and response for cluster headache in Korea: A prospective multicenter observation study.

Only limited data are available regarding the treatment status and response to cluster headache in an Asian population. Therefore, this study aimed to provide a real-world treatment pattern of cluster headache and the response rate of each treatment in an Asian population. Patients with cluster headache were recruited between September 2016 and January 2019 from 16 hospitals in Korea. At the baseline visit, we surveyed the patients about their previous experience of cluster headache treatment, and acute and/or preventive treatments were prescribed at the physician's discretion. Treatment response was prospectively evaluated using a structured case-report form at 2 ± 2 weeks after baseline visit and reassessed after three months. Among 295 recruited patients, 262 experiencing active bouts were included. Only one-third of patients reported a previous experience of evidence-based treatment. At the baseline visit, oral triptans (73.4%), verapamil (68.3%), and systemic steroids (55.6%) were the three most common treatments prescribed by the investigators. Most treatments were given as combination. For acute treatment, oral triptans and oxygen were effective in 90.1% and 86.8% of the patients, respectively; for preventive treatment, evidence-based treatments, i.e. monotherapy or different combinations of verapamil, lithium, systemic steroids, and suboccipital steroid injection, helped 75.0% to 91.8% of patients. Our data provide the first prospective analysis of treatment responses in an Asian population with cluster headache. The patients responded well to treatment despite the limited availability of treatment options, and this might be attributed at least in part by combination of medications. Most patients were previously undertreated, suggesting a need to raise awareness of cluster headache among primary physicians.

Analyzing Turning Behavior after Repeated Lithium, Ketamine, or NaCl Injection and Chronic Stress Exposure in Mice

A single chronic stress is often considered a potential reinforcer in psychiatric disorders. Lithium and ketamine both seem to ameliorate the consequences of stress. Here, male mice were either injected with lithium carbonate (LiCl), ketamine hydrochloride (KET), or sodium chloride (NaCl; controls) over nine consecutive days. Treatment was followed by 2 h of restraint stress over the first seven days. On the 9th day, 2 h after injection, all animals were tested in the open field, and novel object tests and behavior were analyzed using the toolbox ‘DeepLabCut’. To exclude an effect of generally altered locomotion activity on turning behavior, further parameters were assessed. Treatment before chronic stress exposure did not influence the total number of turns, nor the direction of turning behavior in the open field and the novel object test. Additionally, general locomotion did not differ. However, mice treated with LiCl showed a stronger turning bias (i.e., larger absolute lateralization quotients) in the novel object test when compared to mice treated with KET. This study underlines the potential of investigating turning behavior as a sensitive and reliable marker of stress reaction. Additionally, analyzing behavioral asymmetries in the context of psychopharmacological treatment can render new insights.

Comparison of active impurity control between lithium and boron powder real-time injection in EAST

The lithium and boron powder have been successfully real-time injected into Experimental Advanced Superconducting Tokamak (EAST) high-confinement (H−) mode discharges, showing good wall conditioning effects, especially on the impurities control. Both of lithium and boron powder particles are gravitationally accelerated into the upper edge of a upper single null discharge. The lithium powder real-time injection effectively reduced the tungsten impurity content both in the plasma edge and core. Contrary to the lithium injection, the boron injection mainly reduced the impurities content in the plasma core, while the impurities increased in the edge. This mainly due to that there was an edge harmonic mode stimulated by boron injection, providing sufficient particles transport. Moreover, the impurities control through boron injection has much wider operation windows than lithium powder injection. Furthermore, there was accumulative wall conditioning effects after sequential boron powder injection discharges.

3D Modelling of the Lithium Injection Experiment in H-Mode Plasma of EAST

Investigations of lithium transport in H-mode plasma of EAST tokamak have been performed by the three-dimensional fluid code EMC3-EIRENE. The simulation results show that the toroidally-localized lithium injection at the low field side (LFS) leads to a toroidally non-axisymmetric distribution of the Li1+ and Li2+ ions. The field line tracing approach is utilized to carry out a detailed study on the distributions of the Li1+ and Li2+ ions. It is found that Li1+ ions mainly reside at the LFS while Li2+ ions can transport from LFS to the high field side. The relationship between mean free path and connection length for Li1+ and Li2+ ions has been discussed. The 3D line-integration images of deuterium and lithium emission spectra modelled by EMC3-EIRENE are in qualitative consistency with the experiment results.

Neuroprotective Effect of Intravitreal Single-Dose Lithium Chloride after Optic Nerve Injury in Rats

ABSTRACT Objective Lithium is an old drug to control bipolar disorder. Moreover, it presents neuroprotective effects and supports neuronal plasticity. The aim of this study was to evaluate neuroprotective effect of intravitreal lithium after optic nerve injury. Methods Three dosages of lithium chloride, including 2 pmol, 200 pmol, and 2 nmol, were injected intravitreally after rat optic nerve injury. Proteins expression were assessed by western blot. Nitric oxide (NO) metabolites were measured by Griess test. Visual evoked potential (VEP) and optical coherence tomography (OCT) measurement were performed after trauma induction, in addition to H & E and TUJ1 staining of ganglion cells. Results Western blot depicted lithium can significantly increase antiapoptotic Bcl-2 protein level and reduce p-ERK, Toll-like receptor 4 (TLR4) and proapoptotic proteins such as Bax level in retinal tissue and Griess test reflected that NO metabolites level decreased in lithium treated eyes (P < .05). While, OCT showed no significant changes (P = .36 and P = .43 comparing treated group with trauma) in retinal ganglion cell layer thickness after lithium injection, VEP P2 wave amplitude increased significantly (P < .01) in lithium-treated eyes and its latency reduced (P < .05 for N1 wave and P < .01 for P2 wave). Tuj1 antibody-labeled retinal ganglion cells analyzing showed that the number of retinal ganglion cells were significantly higher in lithium treated eyes compared to untreated eyes with optic nerve injury. Conclusion It seems intravitreally lithium has optic nerve neuroprotective effects by various mechanisms like overexpression of antiapoptotic proteins, suppressing proinflammatory molecules and proapoptotic factors, and decreasing nitric oxide.

Penetration of pressure-injected lithium nitrite in concrete and ASR mitigating effect

The objective of this study is to clarify optimal conditions for suppressing the expansion of ASR-deteriorated concrete by pressure-injecting a lithium nitrite solution. To investigate the ASR-mitigating effect of lithium nitrite, concrete mixtures with two types of reactive aggregates were impregnated with lithium nitrite by pressurized injection at three steps of ASR. The effects of different timings on the penetration of lithium nitrite driven by the pressure gradient and on the suppression of expansion were examined through tests.The expansion rate started to decrease immediately after injecting a lithium nitrite solution into the concrete in the propagation period (PP) with severe ASR cracking and an expansion strain of 2000 micro. With a lithium-sodium molar ratio of 0.6 or more, further expansion was significantly reduced. On the other hand, expansion continued even after application of lithium nitrite when the solution was injected into the concrete in the early propagation period (EPP) with slight ASR cracking and an expansion strain of 400 micro, and the final strain eventually exceeded that of the concrete that had been subjected to the lithium injection in the PP.It is assumed that the lithium nitrite solution migrates through ASR cracks first because of the pressure gradient and then diffuses into the bulk mortar. The degree of expansion could also be affected by at which stage of ASR the lithium ions reach the reactive aggregates and the ASR gel.

Overview of lithium injection and flowing liquid lithium results from the US–China collaboration on EAST

A multi-institutional team consisting of national labs and universities has been conducting research to understand and control the plasma-material interface (PMI) to improve long pulse discharge control and performance in the EAST device in Hefei, China. One particular focus of the group has been to evaluate the performance of different plasma-facing component (PFC) technologies and materials, particularly lithium. Flowing liquid lithium PFC technologies are currently into their third generation of development and deployment in EAST, demonstrating recycling control and mitigation of edge-localized modes (ELMs). A lithium powder dropper has also been used to control ELMs while a lithium granule injector has demonstrated ELM triggering and pacing. To support this work, the facilities at the Center for Plasma Material Interactions such as HIDRA are being commissioned and utilized to develop/test the technologies before deployment on EAST. This paper will present a summary of the collaborative lithium PMI program on EAST.

Investigation of edge impurity transport and divertor fluxes by toroidally localized lithium injection on EAST with EMC3-EIRENE

Three-dimensional (3D) edge fluid transport code EMC3-EIRENE has been employed to study lithium transport in the scrape-off layer (SOL) of EAST with the toroidally localized lithium injection experiment. The simulated profiles of the density of the Li ions show that the Li1+ ions mainly populate at the upper private region, while the Li2+ and Li3+ ions distribute at the upper X-point and upstream SOL regions. The synthetic 3D line-integrated LiII emission image obtained by EMC3-EIRENE is in reasonable agreement with the experimental profile measured by the CCD camera system on EAST. The impacts of the poloidal locations of Li injection (LI) have been studied to evaluate the variation of the Li impurity transport and emission behaviors, which shows a strong dependence on the poloidal position of LI. It is found that the LI at the outer midplane is the most effective location to radiate the power and reduce the heat flux deposition on the divertor targets, in comparison with the other poloidal injection locations.

Study of the Impact of Pre- and Real-Time Depositions of Lithium on Plasma Performance on NSTX

The efficiency of two lithium (Li) injection methods used on the National Spherical Torus Experiment (NSTX) are compared in terms of the amount of Li used to produce equivalent plasma performance improvements, namely, Li evaporation over the divertor plates, prior to the initiation of the discharge, and real-time Li injection directly into the plasma scrape-off layer during the discharge. The measurements show that the real-time method can affect the energy confinement and the edge stability of NSTX plasmas in a more efficient way than the Li evaporation method, as it requires only a fraction of the amount of Li used by the evaporation method to produce similar improvements.

Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment.

Lithium has been used for decades to treat Bipolar Disorder. Some of its therapeutic benefits may be through inhibition of Glycogen Synthase Kinase (GSK)-3. Enhanced GSK3 activity associates with development of Alzheimer’s disease (AD), therefore lithium is a currently used therapeutic with potential to be repurposed for prevention of Dementia. An important step toward a clinical trial for AD prevention using lithium is to establish the dose of lithium that blocks GSK3 in Mild Cognitive Impairment (MCI), a high-risk condition for progression to AD. We investigated volunteer recruitment, retention, and tolerance in this population, and assessed biomarkers of GSK3 in MCI compared to control and after lithium treatment. Recruitment was close to target, with higher than anticipated interest. Drop out was not related to lithium blood concentration. Indeed, 33% of the withdrawals were in the first week of very low dose lithium. Most made it through to the highest dose of lithium with no adverse events. We analyzed 18 potential biomarkers of GSK3 biology in rat PBMCs, but only four of these gave a robust reproducible baseline signal. The only biomarker that was modified by acute lithium injection in the rat was the inhibitory phosphorylation of Ser9 of GSK3beta (enhanced in PBMCs) and this associated with reduced activity of GSK3beta. In contrast to the rat PBMC preparations the protein quality of the human PBMC preparations was extremely variable. There was no difference between GSK3 biomarkers in MCI and control PBMC preparations and no significant effect of chronic lithium on the robust GSK3 biomarkers, indicating that the dose reached may not be sufficient to modify these markers. In summary, the high interest from the MCI population, and the lack of any adverse events, suggest that it would be relatively straightforward and safe to recruit to a larger clinical trial within this dosing regimen. However, it is clear that we will need an improved PBMC isolation process along with more robust, sensitive, and validated biomarkers of GSK3 function, in order to use GSK3 pathway regulation in human PBMC preparations as a biomarker of GSK3 inhibitor efficacy, within a clinical trial setting.

Real time wall conditioning with lithium powder injection in long pulse H-mode plasmas in EAST with tungsten divertor

Abstract Real-time lithium powder injection has been applied to long-pulse (>30 s) H-mode plasmas in EAST. This replenishes the active lithium surface that is routinely consumed by plasma-wall interactions. The real-time injection of Li powder into long H-mode discharges effectively suppresses impurity influx and controls recycling on EAST, with an ITER-like tungsten upper divertor. With lithium powder injection, the concentrations W, Mo, and C were reduced by 50% compared to ELMy H-mode discharges. During lithium injection, two effects play a role in the suppression of impurities influx: a reduced divertor temperature and heat flux and hence reduced erosion, and impurity trapping via deposition of a Li film onto plasma-facing surfaces. The ‘fresh’ injected lithium replenishes the film deposited during daily morning evaporation, restoring the wall's pumping capability. Thus, a measurable reduction in the global recycling coefficient was observed.

Real-time reduction of tungsten impurity influx using lithium powder injection in EAST

We report the first successful use of solid material injection, in powder form, to reduce core tungsten impurities in EAST discharges with tungsten divertor plasma-facing components. Tungsten is the leading plasma-facing material for use in ITER as well as future fusion devices. However, tungsten sometimes accumulates in the plasma core of fusion devices, which is an impediment to the achievement of high-power, long-pulse H-modes. In this work, tungsten impurity influx from the tungsten divertor was reduced by real-time injection of lithium powder into EAST discharges. An increase in stored energy and confinement accompanied the sharp reduction of core tungsten with real-time lithium powder injection in L-mode discharges. In H-mode discharges, real-time lithium powder injection reduced the tungsten core impurity emission while also mitigating ELMs. During powder injection, the divertor electron temperature was reduced, which reduced the tungsten source. The tungsten impurity emission remained low in discharges even after active lithium injection was terminated, a signature of improved and lasting wall conditioning in the tungsten divertor.

Active Recycling Control Through Lithium Injection in EAST

The coating of tokamak walls with thin layers of lithium has been demonstrated to reduce plasma recycling from the plasma-facing surfaces and to improve overall plasma performance. These effects, including reduced divertor $D_{\alpha }$ emission, the elimination of edge-localized modes, and increased energy confinement have been observed in multiple experiments when lithium coatings are applied before plasma discharges. However, this coating technology does not extrapolate to future long-pulse devices, since the lithium coatings will be passivated by the continual plasma flux onto the surface. In order to provide active conditioning capability, a new technology has been developed that is capable of injecting lithium powder into the scrape-off layer plasma during plasma discharges, where it quickly liquefies and turns into an aerosol. The use of this “lithium dropper” is under study at the Experimental Advanced Superconducting Tokamak (EAST), where the potential benefits of real-time wall conditioning via lithium injection are being tested. Here, we present an analysis of the recycling characteristics during EAST experiments testing active lithium injection in order to assess recycling reduction and control. Lithium aerosol was injected from the top of the machine, with one system dropping lithium near the $X$ -point and another into the low-field side divertor leg. The injection of lithium into the SOL reduced divertor recycling, as evidenced by reduced $D_{\alpha }$ emission with ion flux measured by probes relatively unchanged. This effect is strongest in the active divertor, confirming the lithium is transported to strongly plasma-wetted areas. Quantitative analysis of the recycling changes using the SOLPS edge plasma and neutral transport code indicated a ~20% reduction in recycling coefficient with lithium injection.

Analytic treatment of distributions of lithium neutrals and ions in linear devices

Neutral lithium (Li) has been used for the mitigation of heat flux to the plasma facing components and for the control of hydrogen of fusion plasmas. Radial and axial variations of densities of Li neutrals and ions are obtained analytically for a cylindrical chamber by assuming the classical diffusion with or without the magnetic field (B). Neutrals and ions without B can be expressed as a linear combination of the modified Bessel functions of order zero (I0 and K0), while ions with B are to be expressed as the square root of them. Analytical solutions of Li neutral densities with Dirichlet and Neumann boundary conditions are compared to those using Monte Carlo simulation and experimental values of the LIGHT-1 (Lithium Injection Gettering of Hydrogen and its Transport experiments) device. Proper combinations of the relaxation length and size of the source would produce well fitted profiles similar to those observed experimentally and those using Monte Carlo codes.

Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern

Severity of lithium poisoning depends on the ingested dose, previous treatment duration and renal function. No animal study has investigated neurobehavioral differences in relation to the lithium poisoning pattern observed in humans, while differences in lithium pharmacokinetics have been reported in lithium-pretreated rats mimicking chronic poisonings with enhanced brain accumulation in rats with renal failure. Our objectives were: 1)-to investigate lithium-related effects in overdose on locomotor activity, anxiety-like behavior, spatial recognition memory and anhedonia in the rat; 2)-to model the relationships between lithium-induced effects on locomotion and plasma, erythrocyte, cerebrospinal fluid and brain concentrations previously obtained according to the poisoning pattern. Open-field, elevated plus-maze, Y-maze and sucrose consumption tests were used. In acutely lithium-poisoned rats, we observed horizontal (p<0.001) and vertical hypolocomotion (p<0.0001), increased anxiety-like behavior (p<0.05) and impaired memory (p<0.01) but no altered hedonic status. Horizontal (p<0.01) and vertical (p<0.001) hypolocomotion peaked more markedly 24h after lithium injection and was more prolonged in acute-on-chronically vs. acutely lithium-poisoned rats. Hypolocomotion in chronically lithium-poisoned rats with impaired renal function did not differ from acutely poisoned rats 24h after the last injection. Interestingly, hypolocomotion/concentration relationships best fitted a sigmoidal Emax model in acute poisoning and a linear regression model linked to brain lithium in acute-on-chronic poisoning. In conclusion, lithium overdose alters rat behavior and consistently induces hypolocomotion which is more marked and prolonged in repeatedly lithium-treated rats. Our data suggest that differences between poisoning patterns regarding lithium-induced hypolocomotion are better explained by the duration of lithium exposure than by its brain accumulation.