Fluorocarbon Liquid Research Articles

Analysis of Plasma and Gas Characteristics According to the Recovery Process Using a New Alternative Gas

Perfluorocarbon (PFC) gas, which is predominantly used in the etching and chamber cleaning processes of semiconductor manufacturing, is very stable and remains on Earth for long periods. Moreover, it has a high global warming potential because it blocks the emission of radiant heat from the Earth and contributes to global warming. To mitigate these effects, the waste PFC gas can be recovered and reused, which also limits the unnecessary waste of resources. In this study, the liquid fluorocarbon C6F6, which has a high C/F ratio and exists as a liquid at room temperature, was selected as an alternative to PFC gas, and adsorption and recovery were performed through an adsorption module during the plasma process. To characterize the recovered gas, residual gas analysis was performed on the gases recovered during etching. In addition, optical emission spectroscopy and printed circuit board probes were used to characterize the plasma. Finally, the feasi-bility of the gas recovery process was evaluated by comparing the thicknesses of the CF polymers produced in Si and SiO2 using an ellipsometer. The results revealed that the C6F6 had similar characteristics before and after recovery, confirming that this gas can be reused and is suitable for use in semiconductor manufacturing as a green alternative.

Preliminary Study on Pharmacokinetics and Antitumor Pharmacodynamics of Folic Acid Modified Crebanine Polyethyleneglycol-Polylactic Acid Hydroxyacetic Acid Copolymer Nanoparticles.

Liver cancer is associated significantly with morbidity and mortality. The combination of low-intensity ultrasound with nanomedicine delivery systems holds promise as an alternative for the treatment for liver cancer. This study focuses on the utilization of folic acid (FA) modified nanoparticles, which are loaded with fluorescent dye DiR and liquid fluorocarbon (PFP). These nanoparticles have the potential to enhance liver cancer targeting under ultrasound stimulation and future applications in vivo. The pharmacokinetics and tissue distribution of folic acid-modified Crebanine polyethylene glycol-polylactic acid copolymer nanoparticles (FA-Cre@PEG-PLGA NPs) were investigated. The pharmacokinetic parameters, liver targeting, and in vivo distribution were assessed. Additionally, the inhibitory impacts of FA-Cre@PEG-PLGA NPs in combination with ultrasonic irradiation on the proliferation and acute toxicity of H22 cells of mouse hepatoma were investigated in vitro. The tumor targeting and anti-tumor efficacy of FA-Cre@PEG-PLGA NPs were assessed utilizing a small animal in vivo imaging system and an in situ hepatocellular carcinoma transplantation model, respectively. The pharmacokinetic studies and tissue distribution tests demonstrated that FA-Cre@PEG-PLGA NPs conspicuously prolonged the half-life and retention time of the drug in rats, and the liver targeting effect was pronounced. Additionally, the in vivo acute toxicity test indicated that FA-Cre@PEG-PLGA NPs had minimal adverse reactions and could fulfill the aim of attenuating the drug. The outcomes of the animal experiments further substantiated that FA-Cre@PEG-PLGA NPs had a longer retention time at the tumor site, a superior anti-tumor effect, and less damage to liver and kidney tissue. The integration of FA-Cre@PEG-PLGA NPs with ultrasound irradiation demonstrated exceptional safety and potent anti-tumor efficacy in vivo, presenting a promising therapeutic strategy for the treatment of liver cancer through the combination of ultrasound technology with a nanomedicine delivery system.

On Excess CO2 within a Hermetically Sealed 14-Pin Butterfly Package: Solubility of CO2 within Fluorocarbon Liquids

In this paper, we examine the presence of excess CO2 found within a hermetically sealed 14-pin butterfly package. Excess CO2 within a hermetically sealed package can suggest that the internal structures of the package have degraded significantly over the lifetime of the package. The level of CO2 discovered within the butterfly package was inconsistent with the controlled sealing gas environmental composition, and the gas composition of concurrently sealed packages. A literature review of industry technical papers and academic studies show that fluorocarbon liquids preferentially absorb CO2 at levels 4-5 times greater than other gasses such as oxygen and nitrogen. Previous experimental and computational methods found that fluorocarbon liquids can absorb CO2 at levels of 1.5-1.6 mol%, which is greater than the calculated maximum amount of absorbed CO2 (0.91 mol%) found within the butterfly package. The Internal Gas Analysis (IGA) of the butterfly package confirmed that it is highly likely that when butterfly package ingested the fluorocarbon liquid, the CO2 was absorbed in solution and thus ingested into the device. Given that the butterfly package was initially filled with 12% ppmv of helium and it retained the helium at a significant level, the phenomenon of a one-way leaker preserved the evidence of CO2 absorbed in the fluorocarbon liquid.

Angular bandwidth for the non-focusing stimulated Brillouin scattering pulse compression

Laser pulse duration compression by stimulated Brillouin scattering (SBS) with a non-focusing scheme is a suitable candidate for high energy sub-nanosecond pulse generation owing to its high load capability and simple structure. The angular deviation of the feedback seed from the pump light path has a serious impact on the non-focusing SBS pulse compression. In this paper, we study the influence of this effect both numerically and experimentally. Firstly the pulse compression characteristics of 20th-order super-Gaussian-shaped pulses with 5 ns duration are analyzed theoretically. Then an experiment was carried out with a single-frequency high power Nd:glass laser system at the frequency-doubled wavelength of 527 nm which delivers 5 ns super-Gaussian-shaped pulses with single pulse energy over 10 J. Heavy fluorocarbon liquid FC-40 was used as the active SBS medium. The compressed pulse duration of sub-400 ps with an energy efficiency of ∼ 50 % is obtained when the laser is normally incident on the rear cell window. ± 4° deviation between the feedback Stokes light and pump laser halves the energy efficiency and doubles the compressed pulse duration. The experimental results agree well with the numerical calculations. The results of this paper will provide a basis for the design of self-pumped SBS pulse compressor and pave a way for higher energy sub-nanosecond pulse generation in the future.

Photoacoustic Vaporization of Endoskeletal Droplets Loaded with Zinc Naphthalocyanine.

Vaporizable endoskeletal droplets are solid hydrocarbons in liquid fluorocarbon droplets in which melting of the hydrocarbon phase leads to the vaporization of the fluorocarbon phase. In prior work, vaporization of the endoskeletal droplets was achieved thermally by heating the surrounding aqueous medium. In this work, we introduce a near-infrared (NIR) optically absorbing naphthalocyanine dye (zinc 2,11,20,29-tetra-tert-butyl-2,3-naphthalocynanine) into the solid hydrocarbon (eicosane, n-C20H42) core of liquid fluorocarbon (C5F12) drops suspended in an aqueous medium. Droplets with a uniform diameter of 11.7 ± 0.7 μm were formed using a flow-focusing microfluidic device. The solid hydrocarbon formed a crumpled spherical structure within the liquid fluorocarbon droplet. The photoactivation behavior of these dye-containing endoskeletal droplets was investigated using NIR laser irradiation. When exposed to a pulsed laser of 720 nm wavelength, the dye-containing droplets vaporized at an average laser fluence of 65 mJ/cm2, whereas blank droplets without the dye did not vaporize at any fluence up to 100 mJ/cm2. Furthermore, dye-loaded droplets with a smaller, polydisperse size distribution were prepared using a simple shaking method and studied in a flow phantom for their photoacoustic signal and ultrasound contrast imaging. These results demonstrate that dye-containing endoskeletal droplets can be made to vaporize by externally applied optical energy. Such droplets may be useful for a variety of photoacoustic applications for sensing, imaging, and therapy.

Centrifugally automated Solid-Phase Extraction of DNA by immiscible liquid valving and chemically powered centripetal pumping of peripherally stored reagents

This paper presents two flow-control technologies for use on centrifugal Lab-on-a-Disc systems. The first, immiscible liquid valving, selectively blocks microfluidic channels using a high-density liquid fluorocarbon (FC-40). Used with a specific channel geometry, the FC-40 can permit liquid to enter a chamber but prevents it flowing back along the same path and so acts as “liquid” check-valve. The same liquid can be combined with a water-dissolvable film to provide an extremely robust liquid routing structure. The second technology uses CO2 gas, created by wetting of commodity baking powder by water, to centripetally pump liquid from the periphery of the disc to the centre of the disc. The technologies are combined with valving schemes based on strategically placed, solvent-selective dissolvable films (DFs) to demonstrate repeated pumping of a liquid sample from the edge of the disc to the centre of the disc. The flow-control technologies are then combined to demonstrate fully automated Solid-Phase Extraction (SPE) of DNA with reagent storage on the periphery of the disc. We report an extraction efficiency of 47% measured relative to commercial spin-columns.

Characteristics of SiO2 Etching by Capacitively Coupled Plasma with Different Fluorocarbon Liquids (C7F14, C7F8) and Fluorocarbon Gas (C4F8)

Characteristics of SiO₂ Etching by Capacitively Coupled Plasma with Different Fluorocarbon Liquids (C₇F₁₄, C₇F₈) and Fluorocarbon Gas (C₄F₈)

Wireless Electrohydrodynamic Actuators for Propulsion and Positioning of Miniaturized Floating Robots

Autonomous soft robots require compact actuators generating large strokes and high forces. Electro‐fluidic actuators are especially promising, they combine the advantages of electroactive polymers (low‐power consumption, fast response, and electrical powering) with the versatility of fluidic systems (force/stroke amplification). EHD (electrohydrodynamic) actuators are electro‐fluidic actuators whose motion results from charges being induced and accelerated in a liquid. They are extremely compact, silent, and low power (≤10 mW). They have been recently demonstrated in stretchable pumps and for the wireless propulsion of simple floating robots. This study demonstrates simultaneous wireless propulsion (2.5 mm s−1) and control of a 1 cm sized robot using a single DC signal. Voltage is applied between an electrode on the floating robot and a fixed one, both exposed to a dielectric liquid. Results support the underlying physical mechanism as EHD and characterize robot motion with different fluorocarbon liquids and voltages between 400 and 1800 V. Path following is demonstrated with a 3 × 3 array of electrodes. EHD actuators prove to be a simple, compact, low power alternative to magnetic and acoustic actuators for wireless powering and control of miniaturized robots, with applications in precision assembling at the micro/mesoscale, lab‐on‐chip, tactile displays, and active surfaces.

A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging

Conventional atlases of the human brainstem are limited by the inflexible, sparsely-sampled, two-dimensional nature of histology, or the low spatial resolution of conventional magnetic resonance imaging (MRI). Postmortem high-resolution MRI circumvents the challenges associated with both modalities. A single human brainstem specimen extending from the rostral diencephalon through the caudal medulla was prepared for imaging after the brain was removed from a 65-year-old male within 24 h of death. The specimen was formalin-fixed for two weeks, then rehydrated and placed in a custom-made MRI compatible tube and immersed in liquid fluorocarbon. MRI was performed in a 7-Tesla scanner with 120 unique diffusion directions. Acquisition time for anatomic and diffusion images were 14 h and 208 h, respectively. Segmentation was performed manually. Deterministic fiber tractography was done using strategically chosen regions of interest and avoidance, with manual editing using expert knowledge of human neuroanatomy. Anatomic and diffusion images were rendered with isotropic resolutions of 50 μm and 200 μm, respectively. Ninety different structures were segmented and labeled, and 11 different fiber bundles were rendered with tractography. The complete atlas is available online for interactive use at https://www.civmvoxport.vm.duke.edu/voxbase/login.php?return_url=%2Fvoxbase%2F. This atlas presents multiple contrasting datasets and selected tract reconstruction with unprecedented resolution for MR imaging of the human brainstem. There are immediate applications in neuroanatomical education, with the potential to serve future applications for neuroanatomical research and enhanced neurosurgical planning through “safe” zones of entry into the human brainstem.

A High-Resolution Interactive Atlas of the Human Brainstem Using Magnetic Resonance Histology

Abstract INTRODUCTION Traditional atlases of the human brainstem are limited by the inflexible, sparsely-sampled, two-dimensional nature of histology or the low spatial resolution of magnetic resonance imaging (MRI). Magnetic resonance histology (MRH) uses postmortem high-resolution MRI to circumvent the challenges associated with both modalities. METHODS A human brainstem specimen extending from the rostral diencephalon through the caudal medulla was removed from a 65-year-old male within 24 hours of death. The specimen was formalin-fixed for two weeks, then rehydrated and placed in a custom-made MRI compatible tube and immersed in buffered liquid fluorocarbon. MRI was performed in a 7-Tesla machine with 120 unique diffusion directions. Acquisition time for anatomic and diffusion images were 14 hours and 208 hours, respectively. Segmentation was performed manually. Deterministic fiber tractography was done using strategically chosen regions of interest and avoidance, with manual editing using expert knowledge of human neuroanatomy. RESULTS Anatomic and diffusion images were rendered with isotropic resolutions of 50 μm and 200 μm, respectively. Spatial resolution was high enough to visualize individual fasciculi of the descending corticospinal tracts intercalated between the transverse pontocerebellar fibers. Ninety different structures were segmented and 11 different fiber bundles were rendered with tractography. Angular resolution was high enough to visualize crossing fibers, such as those of the superior cerebellar peduncle. Both gray and white matter can be visualized in 3D simultaneously, such as the subthalamic nuclei and corticospinal tracts, as may be used in deep brain stimulation. CONCLUSION We used MRH to enable unprecedented resolution in digital imaging of the human brainstem and adjacent diencephalic structures, and we then performed comprehensive segmentation and tractography to render an interactive, three-dimensional atlas of both gray and white matter. This atlas has immediate applications in neuroanatomical study and education, with the potential for future neurosurgical applications in enhancing neurosurgical planning through “safe” zones of entry into the human brainstem. We are currently building the computer infrastructure to make this atlas publicly-available.

On the replacement of water as coupling medium in scanning acoustic microscopy analysis of sensitive electronics components

The present paper studies the use of isopropyl alcohol and fluorocarbon liquids as coupling fluids for acoustic microscopy non-destructive testing of electronic flight components. For these components the standard coupling liquid water sometimes should be avoided in order to minimize sample contamination. The sound velocities of three different fluorocarbon liquids are measured, their ultrasound attenuation coefficients are estimated, and comparative failure analysis images on various electronics components are obtained by using water and these four alternative coupling liquids.

Jet-Printing Microfluidic Devices on Demand.

There is an unmet demand for microfluidics in biomedicine. This paper describes contactless fabrication of microfluidic circuits on standard Petri dishes using just a dispensing needle, syringe pump, three‐way traverse, cell‐culture media, and an immiscible fluorocarbon (FC40). A submerged microjet of FC40 is projected through FC40 and media onto the bottom of a dish, where it washes media away to leave liquid fluorocarbon walls pinned to the substrate by interfacial forces. Such fluid walls can be built into almost any imaginable 2D circuit in minutes, which is exploited to clone cells in a way that beats the Poisson limit, subculture adherent cells, and feed arrays of cells continuously for a week. This general method should have wide application in biomedicine.

Iron(II) phthalocyanine Loaded and AS1411 Aptamer Targeting Nanoparticles: A Nanocomplex for Dual Modal Imaging and Photothermal Therapy of Breast Cancer.

PurposeA multi-functional nanoplatform with diagnostic imaging and targeted treatment functions has aroused much interest in the nanomedical research field and has been paid more attention in the field of tumor diagnosis and treatment. However, some existing nano-contrast agents have encountered difficulties in different aspects during clinical promotion, such as complicated preparation process and low specificity. Therefore, it is urgent to find a nanocomplex with good targeting effect, high biocompatibility and significant therapeutic effect for the integration of diagnosis and treatment and clinical transformation.Materials and MethodsNanoparticles (NPs) targeting breast cancer were synthesized by phacoemulsification which had liquid fluorocarbon perfluoropentane(PFP) in the core and were loaded with Iron(II) phthalocyanine (FePc) on the shell. The aptamer (APT) AS1411 was outside the shell used as a molecular probe. Basic characterization and targeting abilities of the NPs were tested, and their cytotoxicity and biological safety in vivo were evaluated through CCK-8 assay and blood bio-chemical analysis. The photoacoustic (PA) and ultrasound (US) imaging system were used to assess the effects of AS1411-PLGA@FePc@PFP (A-FP NPs) as dual modal contrast agent in vitro and in vivo. The effects of photothermal therapy (PTT) in vitro and in vivo were evaluated through MCF-7 cells and tumor-bearing nude mouse models.ResultsA-FP NPs, with good stability, great biocompatibility and low toxicity, were of 201.87 ± 1.60 nm in diameter, and have an active targeting effect on breast cancer cells and tissues. With the help of PA/US imaging, it was proved to be an excellent dual modal contrast agent for diagnosis and guidance of targeted therapy. Meanwhile, it can heat up under near-infrared (NIR) laser irradiation and has achieved obvious antitumor effect both in vitro and in vivo experiments.ConclusionAs a kind of nanomedicine, A-FP NPs can be used in the integration of diagnosis and treatment. The treatment effects and biocompatibility in vivo may provide new thoughts in the clinical transformation of nanomedicine and early diagnosis and treatment of breast cancer.

Versatile surface for solid–solid/liquid–solid triboelectric nanogenerator based on fluorocarbon liquid infused surfaces

ABSTRACT The triboelectric nanogenerator (TENG) is a recent mechanical energy harvesting technology that has been attracting significant attention. Its working principle involves the combination of triboelectrification and electrostatic induction. The TENG can harvest electrical energy from both solid–solid and liquid–solid contact TENGs. Due to their physical difference, triboelectric materials in the solid–solid TENG need to have high mechanical properties and the surface of the liquid–solid contact TENG should repel water. Therefore, the surface of the TENG must be versatile for applications in both solid–solid and liquid–solid contact environments. In this work, we develop a solid–solid/liquid–solid convertible TENG that has a slippery liquid-infused porous surface (SLIPS) at the top of the electrode. The SLIPS consists of a HDFS coated hierarchical Al(OH)3 structure and fluorocarbon liquid. The convertible TENG developed in this study is capable of harvesting electricity from both solid–solid and liquid–solid contacts due to the high mechanical property of Al(OH)3 and the water-based liquid repelling nature of the SLIPS. When the contact occurs in freestanding mode, electrical output was generated through solid–solid/liquid–solid sliding motions. The convertible TENG can harvest electricity from both solid–solid and liquid–solid contacts; thus, it can be a unified solution for TENG surface fabrication.

Dynamically Reconfigurable, Multifunctional Emulsions with Controllable Structure and Movement.

Dynamically reconfigurable oil-in-water (o/w) Pickering emulsions are developed, wherein the assembly of particles (i.e., platinum-on-carbon and iron-on-carbon particles) can be actively controlled by adjusting interfacial tensions. A balanced adsorption of particles and surfactants at the o/w interface allows for the creation of inhomogeneity of the particle distribution on the emulsion surface. Complex Pickering emulsions with highly controllable and reconfigurable morphologies are produced in a single step by exploiting the temperature-sensitive miscibility of hydrocarbon and fluorocarbon liquids. Dynamic adsorption/desorption of (polymer) surfactants afford both shape and configuration transitions of multiple Pickering emulsions and encapsulated core/shell structured can be transformed into a Janus configuration. Finally, to demonstrate the intrinsic catalytic or magnetic properties of the particles provided by carbon bound Pt and Fe nanoparticles, two different systems are investigated. Specifically, the creation of a bimetallic microcapsule with controlled payload release and precise modulation of translational and rotational motions of magnetic emulsions are demonstrated, suggesting potential applications for sensing and smart payload delivery.

Time-of-Sight Liquid Flow Measurements in the Low Nanoliters per Minute Scale.

We describe an affordable and robust measurement technique applicable to nanoscale liquid flow. The approach can provide good precision (<1% RSD) in the 1.5-15 nL/min flow range. The motion of a conductive/nonconductive immiscible segmental interface in a capillary is followed by an admittance detector. The conductive marker segment, e.g., a salt solution, is protected on both sides from the principal flow stream by immiscible guard segments, typically a fluorocarbon (FC) liquid, of significantly greater impedance. Fluorosilylation of the capillary ensures no other liquid film between the FC segments and the wall (perfect piston). A given interface/marker can typically be used only once in interface/front tracking systems. We overcome this by putting the sensor capillary in a valved configuration where the flow direction in the sensor is reversed before the guard/marker segments escape. Several strategies are possible to interpret flow rate from the sensor output, including the rate of the interface movement. During the measurement process, a change in this rate of movement can be detected in <1 s. Small temperature variations in the 25-35 °C range did not affect sensor behavior.

Mobile-surface bubbles and droplets coalesce faster but bounce stronger.

Enhancing the hydrodynamic interfacial mobility of bubbles and droplets in multiphase systems is expected to reduce the characteristic coalescence times and thereby affect the stability of gas or liquid emulsions that are of wide industrial and biological importance. However, by comparing the controlled collision of bubbles or water droplets with mobile or immobile liquid interfaces, in a pure fluorocarbon liquid, we demonstrate that collisions involving mobile surfaces result in a significantly stronger series of rebounds before the rapid coalescence event. The stronger rebound is explained by the lower viscous dissipation during collisions involving mobile surfaces. We present direct numerical simulations to confirm that the observed rebound is enhanced with increased surface mobility. These observations require a reassessment of the role of surface mobility for controlling the dynamic stability of gas or liquid emulsion systems relevant to a wide range of processes, from microfluidics and pharmaceuticals to food and crude oil processing.

Multifunctional fluorocarbon photobioreactor system: a novel integrated device for CO2 segregation, O2 collection, and enhancement of microalgae growth and bioproductions.

An enhanced greenhouse effect due to high CO2 emissions has become one of the most concerning issues worldwide. Although plant/algae-mediated approaches have been extensively used for CO2 segregation in the last decades, these methods are generally aimed at environment protection. In contrast, less attention has been given to CO2 manipulation that has regrettably caused a decrease in the commercial availability of the associated technologies. To generate a system for practical use, a synthetic fluorocarbon photobioreactor system (FCPBRS) consisting of a CO2 isolation unit, a gas modulation unit, an O2 collection unit, and a microalgal culture chamber was developed in this study. After injecting a 60%-N2/40%-CO2 gas mixture into the CO2 isolation unit for 10days, the results showed that the FCPBRS enabled a > 93% CO2 separation efficiency using a fluorocarbon liquid FC-40 as the CO2 adsorbent. In addition, the growth rate of Nannochloropsis oculata was significantly enhanced when cultured with 20mLmin-1 of the FC-40 flow containing 2% CO2 throughout the time course, resulting in 4.7-, 4.6-, and 4.5-fold (P < 0.05 for each) increases in biomass, total lipid, and eicosapentaenoic acid yields, respectively, compared to the aerated group without FC-40. Moreover, approximately 1600mL of photosynthetic O2 with a ~ 80% collection efficiency was obtained in the O2 collection unit within 10days of FCPBRS operation. These outcomes indicate that the FCPBRS may provide a feasible means to simultaneously achieve CO2 isolation, O2 collection, and enhanced microalgae bioproductions.

Measurement of the threshold of nonfocusing-pumped stimulated Brillouin scattering based on the spatial characteristic of the reflected pulse.

We present a method for measuring the threshold of stimulated Brillouin scattering (SBS) when a large-aperture laser pulse with ultra-Gaussian shape is used as the pump source. By using an optical aperture to filter out part of the backward scattered light, the measured energy efficiency will be conserved below the SBS threshold and nonconserved above the SBS threshold. Based on the differences between the two conditions we can judge whether the pump intensity is above the SBS threshold or not by analysis of the energy efficiency of the system. The experiment is carried out with an Nd:YAG laser, delivering an ultra-Gaussian-shaped pulse with the pulse width of 3ns, beam diameter of about 20mm, and wavelength of 527nm. Heavy fluorocarbon liquid FC-770 is adopted as the nonlinear medium. The measured SBS threshold under this condition is 634 MW/cm2 and it has a good correspondence with the theoretically calculated results.

Enhancement of HIFU ablation by sonosensitizer-loading liquid fluorocarbon nanoparticles with pre-targeting in a mouse model

High intensity focused ultrasound (HIFU) is a noninvasive thermal ablation technique for the treatment of benign and malignant solid masses. To improve the efficacy of HIFU ablation, we developed poly (lactide-co-glycolide) (PLGA) nanoparticles encapsulating perfluoropentane (PFP) and hematoporphyrin monomethyl ether (HMME) as synergistic agents (HMME+PFP/PLGA). Two-step biotin-avidin pre-targeting technique was applied for the HIFU ablation. We further modified the nanoparticles with streptavidin (HMME+PFP/PLGA-SA). HMME+PFP/PLGA-SA were highly dispersed with spherical morphology (477.8 ± 81.8 nm in diameter). The encapsulation efficiency of HMME and PFP were 46.6 ± 3.3% and 40.1 ± 2.6%, respectively. The binding efficiency of nanoparticles to streptavidin was 95.5 ± 2.5%. The targeting ability of the HMME+PFP/PLGA-SA nanoparticles was tested by parallel plate flow chamber in vitro. In the pre-targeting group (HMME+PFP/PLGA-SA), a large number of nanoparticles bound to the peripheral and surface of the cell. In the HIFU ablation experiment in vivo, compared with the other groups, the largest gray-scale changes and coagulation necrosis areas were observed in the pre-targeting (HMME+PFP/PLGA-SA) group, with the lowest energy efficiency factor value. Moreover, the microvessel density and proliferation index declined, while the apoptotic index increased, in the tumor tissue surrounding the coagulation necrosis area in the pre-targeting group. Meanwhile, the survival time of the tumor-bearing nude mice in the pre-targeting group was significantly longer than that in the HIFU treatment group. These results suggest that HMME+PFP/PLGA-SA have high potential to act as synergistic agents in HIFU ablation.