Liposarcoma Of Larynx Research Articles

Myxoid liposarcoma of hypopharynx- A diagnostic and management dilemma

Sarcomas are malignant neoplasms arising from connective tissue. They represent roughly 1% of all cancer cases reported. Overall, only 4-9% of all liposarcomas occur in head and neck region. A small uncommon group of soft tissue tumours are distinguished by their unique and consistant ability to produce an overwhelming abundance of myxoid ground substance along with the proliferating cells that constitute the tumour. Grossely all these neoplasms have a variable gelatinous quality. Because of the voluminous stroma most of these tumours have some findings that overlap with one another. Nonetheless each tumour has a composite set of morphologic, immunophenotypic, ultrastructural and genotypic features exclusive to itself.26 (Wakely 1999) Hypopharyngeal localization is rarely described in the literature. Golledge et a111 (1995) reviewed the literature and reported 76 cases of liposarcoma of head and neck including 4 cases of their own. 38% of liposarcomas of head and neck involve larynx and /or pharynx.78% of these laryngeal pharyngeal cases arise in the supra glottic region and were well differentiated. Han et a113 (2014) reported a total of 37 cases of Laryngeal liposarcoma reported in English or French literature. Although more common in other areas, it is rarely found in the aero-digestive tract. Liposarcomas typically occur in middle aged to older adults. These tumors are typically misdiagnosed secondary to their indolent, asymptomatic course and similarities in appearance to other benign lesions. An understanding of these lesions will help clinicians appropriately manage their patients. Keywords: Liposarcoma, Well-differentiated liposarcoma, Hypopharynx.

One case report of pleomorphic liposarcoma of larynx

One case report of pleomorphic liposarcoma of larynx

A Case of Liposarcoma of the Larynx

Liposarcoma is the second most common soft-tissue malignancy following malignant fibrous histocytoma. Only 5.6% of liposarcomas are found in the head and neck, and most arise in soft neck tissue. Liposarcoma of the larynx is extremely rare, with only 34 cases reported in the English literature. We report case number 35. The World Health Organization (WHO) identifies five histological liposarcoma subtypes-well-differentiated, myxoid, round cell, pleomorphic, and dedifferentiated. Our subject was a 38-year-old man with well-differentiated a primary arytenoids liposarcoma. We treated him using wide-excision direct-suspension laryngoscopy, entirely preserving laryngeal structures and function. Laryngeal liposarcoma is easily mistaken for a benign soft tissue tumor. We diagnosed our subject with well-differentiated liposarcoma based on genetic studies confirming murine double minute 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) amplification having the characteristic giant chromosome derived from the 12q(13-15) region. Laryngeal liposarcoma recurrence is high, but with no reported cervical lymph node metastasis. Wide surgical excision is the mainstay of treatment, although the usefulness of radiation therapy remains to be determined. Because well-differentiated liposarcoma has low malignancy, we retain larynx function and recommend removing a tumor surgically with sufficient margins and comprehensive long-term follow-up.

Laryngeal dedifferentiated liposarcoma

Soft tissue liposarcomas are quite common in the adult population, whereas liposarcoma of the larynx is exceedingly rare. We describe an exceptional case of liposarcoma of the posterior aspect of the left arytenoid in a 62-year-old woman who was treated with two endoscopic excisions and adjuvant radiotherapy (RT). This is the 32nd case of laryngeal liposarcoma reported in the English literature. After a 20 months follow-up, no local, regional recurrences or distant metastases were detected, and no functional complications are described for the patient. This case report highlights that endoscopic surgical treatment enables excellent organ and functional preservation. However, recurrence of laryngeal liposarcoma is the principal risk, so extended follow-up is essential. RT has no defined role in treatment but can be discussed, especially considering the surgical margins and recurrence status.

Liposarcoma of the Larynx

The objective was to review the presentation, diagnosis, treatment, and prognosis of patients with laryngeal liposarcoma (LLS). A case is reported, and a retrospective review of the English-language literature is presented. All published cases of LLS with adequate histopathologic documentation and clinical information were included for review. Thirty cases of LLS have been reported. A majority of these patients are men between 40 and 70 years of age. The most common location of the tumor is the supraglottis, and the presenting complaints are similar to those of other laryngeal neoplasms. Although these neoplasms recur often and can cause significant morbidity, they are typically of low grade and rarely metastasize. The outcomes of this disease are generally good when it is treated with wide surgical excision. Cases of LLS are extremely rare. Because the histologic changes are frequently subtle, LLS can be easily mistaken for a benign tumor. As a result, the diagnosis requires a high index of suspicion and diligence in examining biopsy specimens. Computed tomography and magnetic resonance imaging can assist in the diagnosis and surgical approach. Genetic and immunostaining analysis techniques may also prove to have valuable prognostic, diagnostic, and therapeutic implications for this disease. Wide surgical excision is the mainstay of treatment. The use of radiotherapy and chemotherapy in treating this cancer remains experimental, but might be considered on a case-to-case basis for palliation or to treat aggressive variants of the disease.

A 60-Year-Old Woman With History of Hoarseness and Dysphagia

A 60-Year-Old Woman With History of Hoarseness and Dysphagia

P148: Case of Laryngeal Liposarcoma with Extended Course of Recurrences

Otolaryngology–Head and Neck SurgeryVolume 129, Issue 2 p. P260-P260 Scientific Posters P148: Case of Laryngeal Liposarcoma with Extended Course of Recurrences Christopher Donovan Lansford presenter MD, Christopher Donovan Lansford presenter MD Durham, NCSearch for more papers by this authorDavid L Witsell MD MHS, David L Witsell MD MHS Durham, NCSearch for more papers by this author Christopher Donovan Lansford presenter MD, Christopher Donovan Lansford presenter MD Durham, NCSearch for more papers by this authorDavid L Witsell MD MHS, David L Witsell MD MHS Durham, NCSearch for more papers by this author First published: 17 May 2016 https://doi.org/10.1016/S0194-59980301183-5Read the full textAboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume129, Issue2August 2003Pages P260-P260 RelatedInformation

Case of laryngeal liposarcoma with extended course of recurrences

Case of laryngeal liposarcoma with extended course of recurrences

Liposarcome du larynx. Revue de la littérature à propos d'un cas

Liposarcoma of the larynx is an uncommon tumor. Only 27 cases have been described in literature. We report a new case occurring in a 50-year-old patient. The treatment consisted of a total laryngectomy with lymph node dissection followed by adjuvant irradiation. Prognosis for laryngeal liposarcoma is better than that of non laryngeal liposarcoma. This tumor is at high risk of local recurrence and seldom has metastatic potential.

Liposarcoma of the larynx treated with radiotherapy.

Liposarcoma of the larynx is an extremely rare malignancy. Only 18 cases have been reported in the literature. We herein report the first case of primary liposarcoma of supra-glottic larynx in a 53-years old male patient successfully treated with radiotherapy in August-September 1992. He currently remains free of the disease 4.5 years since the initial diagnosis.

Laryngeal Liposarcoma

Laryngeal liposarcomas are rare, with only 13 previously well-documented cases (to our knowledge). We report an additional case, which documents the use of computed tomography for treatment planning. Laryngeal liposarcomas appear to have a better prognosis than nonlaryngeal liposarcomas; therefore, a critical analysis of reported cases enabled us to identify clinical characteristics that contribute to the favorable prognosis. We also propose a rational therapeutic approach.

Primary Liposarcoma of the Larynx

Laryngeal liposarcoma is an unusual tumor. Only 16 cases have been previously reported. We describe a new case of well-differentiated laryngeal liposarcoma and review the literature. The tumor was treated by surgical removal. Immunohistochemical study showed an immunophenotype consistent with liposarcoma. The case described is of the oldest patient (83 years old), the second to be found in a woman, and the second to be localized to one true vocal cord (according to the literature reviewed). The patient is still free of tumor 2 years later. The treatment and prognosis of liposarcoma of the larynx are discussed.