Cord Blood Lipid Profile Research Articles

Studies of Lipid Profiles Among Infants with Respiratory Distress Syndrome

Background: Respiratory distress syndrome (RDS) is known as hyaline membrane disease (HMD). It is the major cause of neonatal respiratory distress, especially in preterm infants Infants with RDS present with tachapnea, cyanosis, grunting, subcostal and intercostal retractions and nasal flaring. Oliguria with mild generalized edema may be present. Oxygen requirement may increase rapidly and is typically higher than that seen in infant with transient tachapnea of the newborn (TTN). Objective: to evaluate the relationship between the maternal and cord blood lipid profiles in preterm babies with respiratory distress syndrome. Methods: This is a case control study which was conducted on 50 preterm neonates admitted to the neonatal intensive care unit of Shebin El-Kom teaching hospital between January 2020 and October 2021. Results: the mean of total cholesterol was significantly higher in infants whose mothers had received antenatal steroid for lung maturity than those whose mothers had not (P<0.05). But there was no significant difference in the mean of levels of TG, HDL-cholesterol, LDL-cholesterol and VLDL cholesterol between both groups. Also, There is a positive correlation between weight gain during pregnancy and neonatal cord blood levels of (Total cholesterol, TG, HDL-C, LDL-C and VLDL-C), There is a positive correlation between maternal blood levels of (total cholesterol, TG, LDL-C and VLDL-C) and their neonatal cord blood levels of (total cholesterol, TG, HDL-C, LDL-C and VLDL-C), There is a positive correlation between the maternal blood level of HDL-C and their neonatal cord blood levels of (total cholesterol and HDL-C).also, the cutoff values of cord blood (total Cholesterol, HDL-C, and LDL-C) below which RDS can be predicted are 80, 45.5 and 23.2 mg/dl respectively with a sensitivity of 83.3%, 86.7% and86.7% and with specificity of 95%, 80% and 70% respectively. Conclusion: RDS is accompanied with lipid alteration in the infants and their mothers. The results of this study point to the importance of measuring maternal serum and cord blood lipid profile as a predictor for the occurrence of RDS.

Using Lipid Parameters in Predicting Preterm Infants with Respiratory Distress Syndrome

Background: Respiratory distress syndrome is a clinical diagnosis which is warranted in a preterm newborn with respiratory difficulty, including tachypnea (>60 breaths/min), chest retractions, and cyanosis in room air that persist or progress over the first 48-96 hr of life, and a characteristic chest radiographic appearance. Objective: to assess the cord blood lipid profile for predicting of preterm infants with respiratory distress syndrome. Methods: This is a case control study which was conducted on 50 preterm neonates admitted to the neonatal intensive care unit of Shebin El-Kom teaching hospital between January 2011 and October 2011. Results: the mean of weight gain during pregnancy in mothers of preterm with RDS was lower than the control group and the difference was statistically highly significant (P<0.01). Also, there was significant difference (P<0.05) regarding mode of delivery and antenatal steroid, however; no statistical significant difference was detected regarding maternal age, maternal weight, maternal BMI, pre-gravid height, the ruptured membrane > 24 hr and parity between both groups. the mean of total cholesterol, HDL-cholesterol and LDL-cholesterol in the cord blood was lower in group A than in group B and the difference was statistically highly significant (P <0.01), but there was no significant difference regarding the mean of both triglycerides and VLDL-cholesterol in both groups (P>0.05).the mean of total cholesterol, HDL-cholesterol and LDL-cholesterol was lower in mothers of preterm infants with RDS than in control group and the difference was statistically highly significant (P <0.01), but there was no significant difference was detected regarding the mean of levels triglycerides and VLDL-cholesterol in both groups (P >0.05).the cutoff values of cord blood (total Cholesterol, HDL-C, and LDL-C) below which RDS can be predicted are 80, 45.5 and 23.2 mg/dl respectively with a sensitivity of 83.3%, 86.7% and 86.7% and with specificity of 95%, 80% and 70% respectively. Conclusion: We conclude that RDS is accompanied with lipid alteration in the infants and their mothers. The results of this study point to the importance of measuring of maternal serum and cord blood lipid profile as a predictor for the occurrence of RDS.

A comparative study of cord blood lipid profile in term, pre term and small for gestational age - appropriate for gestational age neonates

A comparative study of cord blood lipid profile in term, pre term and small for gestational age - appropriate for gestational age neonates

Cord blood lipid correlation network profiles are associated with subsequent attention-deficit/hyperactivity disorder and autism spectrum disorder symptoms at 2 years: a prospective birth cohort study

BackgroundAttention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are neurodevelopmental conditions with early life origins. Alterations in blood lipids have been linked to ADHD and ASD; however, prospective early life data are limited. This study examined (i) associations between the cord blood lipidome and ADHD/ASD symptoms at 2 years of age, (ii) associations between prenatal and perinatal predictors of ADHD/ASD symptoms and cord blood lipidome, and (iii) mediation by the cord blood lipidome. MethodsFrom the Barwon Infant Study cohort (1074 mother-child pairs, 52.3% male children), child circulating lipid levels at birth were analysed using ultra-high-performance liquid chromatography-tandem mass spectrometry. These were clustered into lipid network modules via Weighted Gene Correlation Network Analysis. Associations between lipid modules and ADHD/ASD symptoms at 2 years, assessed with the Child Behavior Checklist, were explored via linear regression analyses. Mediation analysis identified indirect effects of prenatal and perinatal risk factors on ADHD/ASD symptoms through lipid modules. FindingsThe acylcarnitine lipid module is associated with both ADHD and ASD symptoms at 2 years of age. Risk factors of these outcomes such as low income, Apgar score, and maternal inflammation were partly mediated by higher birth acylcarnitine levels. Other cord blood lipid profiles were also associated with ADHD and ASD symptoms. InterpretationThis study highlights that elevated cord blood birth acylcarnitine levels, either directly or as a possible marker of disrupted cell energy metabolism, are on the causal pathway of prenatal and perinatal risk factors for ADHD and ASD symptoms in early life. FundingThe foundational work and infrastructure for the BIS was sponsored by the Murdoch Children's Research Institute, Deakin University, and Barwon Health. Subsequent funding was secured from the Minderoo Foundation, the European Union's Horizon 2020 research and innovation programme (ENDpoiNTs: No 825759), National Health and Medical Research Council of Australia (NHMRC) and Agency for Science, Technology and Research Singapore [APP1149047], The William and Vera Ellen Houston Memorial Trust Fund (via HOMER Hack), The Shepherd Foundation, The Jack Brockhoff Foundation, the Scobie & Claire McKinnon Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women Our Children's Fund Raising Committee Barwon Health, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, Geelong Medical and Hospital Benefits Association, Vanguard Investments Australia Ltd, the Percy Baxter Charitable Trust, and Perpetual Trustees.

The association of exposure to polychlorinated biphenyls with lipid profile and liver enzymes in umbilical cord blood samples

Evidence on prenatal exposure to polychlorinated biphenyls (PCBs) and its effects on newborns and potential biological mechanisms is not well defined yet. Therefore, this study aimed to examine whether PCBs are associated with lipid profile and non-invasive markers of hepatocyte injuries in samples of blood obtained from the umbilical cord. This study included 450 mothers-newborn pairs. Umbilical levels of PCBs were measured using Gas Chromatography/Mass Spectrophotometry (GC/MS). Lipid profile including low-density lipoprotein (LDL-C), total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C), as well as liver enzymes i.e., alanine amino transferase (ALT), aspartate amino transferase (AST), γ-glutamyl-transferase (GGT) and alkaline phosphatase (ALP) were determined from umbilical cord blood samples. Quantile g-computation analysis was applied to evaluate the collective influence of PCBs on both lipid profiles and liver enzymes, along with the impact of lipid profiles on liver enzymes. Exposure to the mixture of PCBs was significantly associated with increases in ALP, AST, ALT, and GGT levels in cord blood samples, with increments of 90.38 U/L (95%CI: 65.08, 115.70, p < 0.01), 11.88 U/L (95%CI: 9.03, 14.74, p < 0.01), 2.19 U/L (95%CI:1.43, 2.94, p < 0.01), and 50.67 U/L (95%CI: 36.32, 65.03, p < 0.01), respectively. Additionally, combined PCBs exposure was correlated with significant increases in umbilical TG, TC, and LDL-C levels, with values of 3.97 mg/dL (95%CI: 0.86, 7.09, p = 0.01), 6.30 mg/dL (95%CI: 2.98, 9.61, p < 0.01), and 4.63 mg/dL (95%CI: 2.04, 7.23, p < 0.01) respectively. Exposure to the mixture of lipids was linked to elevated levels of AST and GGT in umbilical cord blood samples. Furthermore, a noteworthy mediating role of TC and LDL-C was observed in the association between total PCBs exposure and umbilical cord blood liver enzyme levels. Overall our findings suggested that higher levels of umbilical cord blood PCBs and lipid profile could affect liver function in newborns.

Determining the Correlation between Cord Blood Lipid Profile and Birth Weight among Term Babies

Aims: This study aimed to examine the association between cord blood lipid levels and neonatal birth weight.&#x0D; Study Design: Hospital based prospective cross-sectional study.&#x0D; Place and Duration of Study: Study was conducted in Government medical College Nagpur, a tertiary care hospital that provides maternal and child health services between June 2011 to March 2013&#x0D; Methodology: We enrolled 200 healthy pregnant women who attended antenatal clinics in our hospital. We collected 5 mL of cord blood from the umbilical vein and measured the serum levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol using spectrophotometric methods. We calculated LDL cholesterol using Friedewald’s formula, and we measured anthropometric parameters using standard methods.&#x0D; Results: Neonates with SGA had significantly lower birth weight (2.24 ± 0.3 vs 2.83 ± 0.4; P &lt; 0.01), head circumference (31.5 ± 1.5 vs 33.4 ± 1.8; P &lt; 0.04), recumbent length (51.2 ± 0.3 vs 53.6 ± 0.2; P &lt; 0.04), and Ponderal Index (2.24 ± 0.5 vs 2.35 ± 0.2; P &lt; 0.03) than AGA babies. The cord blood lipid profile levels were also significantly lower (P &lt; 0.001) in AGA than SGA babies. There was a positive correlation between birth weight and total cholesterol (r = 0.31; P &lt; 0.001) and triglycerides (r = 0.46; P &lt; 0.001), and a small positive correlation between birth weight and HDL cholesterol (r = 0.157; P = 0.013).&#x0D; Conclusion: SGA babies had significantly higher cord blood lipid profile levels than AGA babies. The lipid profile of umbilical cord blood is related to the fetal nutritional status and growth and development. This may have implications for the prevention and management of low birth weight and its associated complications

Comparison of umbilical cord blood lipid profiles between appropriate and small for gestational age newborns with their mothers’ lipid profiles: a case-control study from tertiary care centre of Karnataka

Background: Fetal malnutrition and fetal growth restriction results in dysfunctions of neuroendocrine system, pancreas and adipose-tissue; finally increasing the food intake and decreasing energy use. This results in an increase in adipose deposition and insulin-resistance and ultimately increasing chances of adult metabolic-diseases. This study makes an effort to compare and contrast the lipid-profiles of Small for Gestational Age (SGA) and Appropriate for Gestational Age (AGA)newborns correlating and with their mother’s lipid-profiles. Methods: This was a case-control study, conducted in the Departments of Pediatrics and OBG of Karwar Institute of Medical Sciences,Karwar, Karnataka,India over a period of twelve months(January-2021 to January-2022). With 500neonates, 357appropriate for gestational age (AGA) and 143 small for gestational age(SGA) babies were included for the study as controls and cases for their lipid profiles using their cord-blood. Results: here, we found that SGA-babies had lower gestational age (37.40±1.01 weeks) at birth compared to AGA-babies (39.22±1.05 weeks) which was statistically significant. The mean Total Cholesterol (TC) level (84.47±27.39 mg/dl) was higher in SGA-babies compared to AGA-babies (56.87±32.28 mg/dl) and this difference was statistically highly significant (p value&lt;0.0001). The mean very low density lipoprotein (VLDL) level (14.10±10.67 mg/dl) was higher in SGA-babies than AGA-babies (7.17±3.69 mg/dl) with p value&lt;0.0001 (highly significant). The mean low density lipoprotein (LDL) level (38.74±19.85 mg/dl) was higher in SGA-babies compared to AGA-babies (25.63±14.15 mg/dl) and this difference was statistically significant (p value&lt;0.0001). The mean high density lipoprotein (HDL) levels of AGA and SGA-babies were comparable with low statistical significance (26.70±14.90 mg/dl of SGA; 24.45±9.567 mg/dl of AGA, p value 0.095). Conclusions: Levels of all lipids were observed to be higher in SGA babies than in AGA babies. Mothers who gave birth to SGA babies were found to have statistically significant high VLDL levels.

Study of cord blood lipid profile of term (appropriate and small for gestational age) and preterm (appropriate and small for gestational age) newborns with special reference to atherogenic index: a cross-sectional study

Background: Atherosclerotic cardiovascular diseases is a major cause for morbidity and mortality in adult population. Increasing awareness about the origin of the atherosclerosis in early life has renewed interest in determination of various lipid fractions in paediatric age group. Therefore, the present study was planned to estimate the lipid levels in Term (Appropriate and small for Date) and Preterm (Appropriate and Small for Date) newborn as well to plan meticulous follow-up of babies with a deranged profile. Aim was to study cord blood lipid profile of term and preterm (appropriate and small for date) newborns with special reference to atherogenic index. Methods: This cross-sectional study was conducted at neonatal section of department of paediatrics in collaboration with department of obstetrics and gynaecology and Rajiv Gandhi centre for diabetes and endocrinology Jawaharlal Nehru medical college, Aligarh Muslim University. A total of 200 newborns were enrolled in the study. Cord blood samples were collected from placental side at birth and analysed for lipid profile which includes total cholesterol, triglycerides, low density and high-density lipoprotein and atherogenic index. Results: All the lipid parameters were higher among the low-birth weight babies when compared with the normal birth-weight babies, the difference was statistically significant for total cholesterol, triglyceride, HDL and VLDL cholesterol. Conclusions: Prematurity is a factor associated with a more Atherogenic lipid profile is reaffirmed and SGA as an additional risk factor has been proven giving scope for future research and primordial prevention.

ASSESSMENT OF LEVELS OF LIPID PROFILE, APOLIPOPROTEINS, AND ATHEROGENIC INDEX IN CORD BLOOD OF NEONATES ACCORDING TO GESTATIONAL AGE

Background: A considerable amount of cholesterol is needed by human body for the maintenance of tissue and various bodily metabolisms. Cardiac disorders are major cause for morbidity and mortality in recent years. Cord blood lipoprotein is influenced by factors such as placental insufficiency, mode of delivery, and conditions affecting fetal growth. The present study was planned to analyze cord blood lipid profile, apolipoproteins, and atherogenic index in different gestational age and compare them gender wise. Methods: A cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Geetanjali Medical College and Hospital, Udaipur. The study group included 640 neonates, divided into two groups on the basis of gestational age into near-term neonates (34–37 weeks) and term neonates (&gt;37 weeks). The cord blood samples were taken from placental side of umbilical cord at birth. The blood was tested to determine lipid profile, apolipoproteins, and atherogenic index. Results: The results showed total cholesterol, triglyceride, HDL-C, LDL-C, ApoA-1, and Apo B level higher in near-term neonates group than term neonates. TC, TG, HDL-C, VLDL-C, and apolipoprotein A-1 were negatively correlated but LDL-C and apolipoprotein B were positively correlated with gestational age. Conclusion: The study showed that the gestational age is associated with lipid parameters. Prematurity as a factor was associated with atherogenic index.

Mediation effect of cord blood cortisol levels between maternal prepregnancy body mass index and birth weight: a hospital-based cross-sectional study.

Background Changes in maternal weight affect the maternal and fetal hypothalamic-pituitary-adrenal axis, influencing birth weight and contributing to the fetal origin of adult diseases (Barker’s hypothesis). This study primarily focused on cord blood cortisol levels and identified the association between maternal prepregnancy body mass index (pre-BMI) and birth weight. It also assessed cord blood lipid profile changes related to maternal pre-BMI, birth weight, and cord blood cortisol levels.Purpose To study the mediation effect of cord blood cortisol level between maternal pre-BMI and birth weight and its correlation with cord blood lipid profile.Methods A total of 169 maternal-neonatal pairs were included at 2 tertiary care centers. Mediation analysis was used to estimate the extent of the association between maternal weight changes and birth weight.Results For each unit increase in maternal pre-BMI, birth weight increased by 90.5 g; for every kilogram increase in gestational weight, birth weight increased by 128.44 g. No considerable mediation effect of cortisol was found between pre-BMI and gestational weight gain or between rate of weight gain and birth weight. Pre-BMI and birth weight had a significant negative correlation with high-density lipoprotein cholesterol (HDL-C) levels, i.e., HDL-C was decreased by 1.1 mg/dL for every unit increase in BMI (P=0.017) and for every 100-g increase in birth weight, HDL-C decreased by 0.6 mg/dL (P=0.046). A significant positive correlation was found between cord blood lipid profile and cortisol levels, especially HDL-C (P=0.041).Conclusion Cord blood cortisol levels did not mediate the association between maternal weight change and birth weight. A positive correlation was noted between cord blood cortisol levels and HDL-C level. Cord blood HDL-C level was negatively correlated with maternal pre-BMI and birth weight.

Umbilical cord serum lipid profile of healthy neonates- A single center study from rural Tamil Nadu, India

Introduction and Aim: Umbilical cord lipid profile of neonates might help facilitate the assessment of risk of developing atherosclerotic disorders later in life. This study prospectively measures the cord blood lipid profile of healthy newborn at birth in medical college hospital in rural Tamil Nadu. Material sand Methods: Consecutive full-term newborns (n=105) were enrolled for this study. Umbilical cord blood sample was collected from placental end of the cord immediately after delivery of placenta of each baby and sent to the lab for lipid profile estimation. Results: In the newborns born to non-diabetic mothers, the mean cord blood total serum cholesterol (TC) was 73.31mg %, triglyceride (TGL) was 51.50mg %, high-density lipoproteins (HDL) 24.62 mg % and low-density lipoproteins (LDL) 51.73 mg %. Amongst newborns born to diabetic mothers, the mean TC was 113 mg % (P = 0.001), TGL 98.08mg% (P = 0.045) HDL 28.75 mg% (P = 0.130) LDL 73.48mg% (P = 0.007). Umbilical cord blood lipid profile did not show any significant sex-dependent difference. There was no statistical difference in lipid values between appropriate for gestational age (AGA)and small for gestational age (SGA). Birth weight had a negative correlation to cord blood serum TC and TGL values and showed no correlation to HDL and LDL values. Other parameters including head circumference, length of newborn at birth also showed no correlation to lipid profile. Total cholesterol, TGL and LDL were significantly elevated in newborns born to diabetic mothers. There was no statistical difference in cord blood lipid profile of babies born to mothers who were hypertensive. Conclusion: Infants born to diabetic mothers tend to have significantly elevated lipid values at birth and must be followed regularly later in life to diagnose and treat dyslipidemia and diabetes, to prevent onset of premature atherosclerotic coronary artery disease in this population.

Cord Blood Lipid Profile at Delivery and Association with Birth Weight among Term Babies

Background: Abnormal birth weight is a leading risk factor for neonatal morbidity and mortality, abnormal lipid profile levels may be involved. Aim: The aim of this study was to evaluate the relationship between cord blood lipid profile levels and neonatal birth weight of babies. Materials and Methods: Two hundred apparently healthy pregnant women attending antenatal clinics a Specialist Hospital in Benin City were recruited into the study. Five (5 mL) milliliters of cord blood was collected from the umbilical vein into plain bottle. The serum levels of total cholesterol, triglycerides, and high-density lipoprotein (HDL) were determined using spectrophotometric techniques. The low-density lipoprotein (LDL) was calculated using Friedewald's equation, while anthropometric measurements were done using standard techniques. Data were analyzed using Student's t-test and Pearson correlation coefficient. Results: The birth weight (2.34 ± 0.3 versus 3.47 ± 0.4; P &lt; 0.01), head circumference (32.3 ± 1.3 versus 34.4 ± 2.8; P &lt; 0.04), recumbent length (50.2 ± 0.5 versus 54.6 ± 0.2; P &lt; 0.04), and Ponderal Index (2.14 ± 0.5 versus 24.5 ± 0.2; P &lt; 0.02) were significantly lower in babies with small for gestational age (SGA) than appropriate gestational age. The total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol were significantly lower (P &lt; 0.001) in SGA than appropriate for gestational age (AGA) babies. Total cholesterol (r = 0.21; P &lt; 0.004) and triglycerides (r = 0.31; P &lt; 0.001) correlated positively with the weight of babies. Conclusion: AGA babies had significantly higher lipid profile levels compared to SGA babies.

Metabolic parameters in cord blood of neonate of mothers with obese and non-obese PCOS and controls: retrospective cohort study

BackgroundPolycystic ovary syndrome (PCOS) is characterized by reproductive disorder and increased risk of metabolic syndrome. This study aimed to assess the metabolic parameters in the cord blood of neonate of mothers with obese PCOS and comparison with non-obese PCOS and controls.MethodsThis retrospective cohort study was conducted in Arash and Kamali Hospital in 2017–2018. The biochemical test was conducted on 78 neonates from obese PCOS mothers, 78 neonates from non-obese PCOS mothers, and 78 neonates from healthy mothers. Finally, cord blood lipid profile and insulin and blood sugar were determined by specific kits. Correlations between variables were compared with chi-square, Mann-Whitney’s U, Kruskal-Wallis H tests and regression model by SPSS 23 and P < 0.05 was considered significant.ResultsTriglycerides (TG) and high-density lipoprotein cholesterol (HDL) were higher in cord blood of newborn of obese PCOS women than non-obese PCOS and controls (P = 0.02, P < 0.001, respectively). Also, the mean insulin was higher in cord blood of neonate of non-obese PCOS women than in obese PCOS and controls (12.26 ± 12.79 vs. 11.11 ± 16.51 vs. 6.21 ± 10.66, P = 0.01). But in the study, there was no significant difference between the mean of umbilical cord low-density lipoprotein cholesterol (LDL), total cholesterol and blood sugar in three groups. The logistic regression model showed that metabolic parameters were related to PCOS.ConclusionsIn the present study, there was a significant difference between the mean of umbilical cord HDL, cholesterol, and the insulin level in the three groups. But, there was no significant association between the mean of blood sugar, LDL, and TG in the groups. The metabolic disorder in PCOS might affect cord blood lipid and insulin and adulthood health.

886 Placental hofbauer cell density is associated with increased neonatal birthweight and cord blood lipids

Maternal obesity is associated with adverse offspring cardiometabolic programming. Hofbauer cells (HC) are resident fetal tissue macrophages and are altered in pathological pregnancy conditions associated with fetoplacental immune activation. We sought to determine whether the number and activation state of placental Hofbauer cells (HC) as determined by CD163 and CD68 expression are associated with adverse maternal and/or cord blood lipid profiles. This is a cross-sectional study of 27 women undergoing planned cesarean delivery at term; women with hypertension or diabetes were excluded. Fasting maternal plasma, placental samples, and cord blood were collected at delivery. Maternal body mass index (BMI) at delivery and neonatal birthweight were obtained by chart review. Fasting lipid profiles (Total cholesterol, HDL, LDL, VLDL, triglycerides) were measured in maternal and cord blood at delivery. Immunohistochemistry was performed on serial placental sections for CD163 and CD68, markers of HC activation. Numbers of CD163+ and CD68+ cells per mm2 of villous area were quantified in terminal villi using ImageJ software and compared to maternal and fetal parameters using Spearman correlations. 41% of women were obese (N=11, pre-pregnancy BMI ≥ 30 kg/m2), and mean BMI at delivery was 33.2±7. CD163+ cells/mm2 was positively correlated with BMI at delivery (Spearman ρ=0.54, P=0.005), neonatal birthweight (ρ=0.42, P=0.03), and cord blood triglycerides (ρ=0.43, P=0.02), but not cord VLDL (ρ=0.37, P=0.06); Fig 1. CD68+ cells/mm2 was correlated with BMI at delivery (ρ=0.43, P=0.03), cord blood triglycerides (ρ=0.43, P=0.03) and cord blood VLDL (ρ=0.40, P=0.04) but not birthweight (ρ=0.24, P=0.24); Fig 2. Maternal lipids were not correlated with HC density. Fetoplacental immune activation was associated with neonatal birthweight, and altered cord blood lipid profiles in the setting of maternal obesity. Future studies will focus on HC activation as an indicator versus. mediator of offspring cardiometabolic programming.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

Study of cord blood lipid profile at birth and its relation to gestational maturity and birth weight

Background: Dyslipidemia is attributed for coronary artery diseases. Early detection of dyslipidemia in neonatal cord blood could help to identify possible future risk factors of coronary artery diseases in new born.&#x0D; Aims and Objectives: This study was undertaken to compare lipid profile of small for gestational age (SGA) or preterm and appropriate for gestational age (AGA) or near-term neonates.&#x0D; Material and Methods: A total of 60 neonates were included; of which 33 were AGA and 27 SGA neonates. 2 ml of blood was obtained from the umbilical vein immediately after cord clamping at delivery from each subject and kept in a plain vial, after the serum separation analyzed for biochemical parameters.&#x0D; Results: In SGA neonates, mean TC (total cholesterol), TG (triglycerides) LDL (low density lipoprotein cholesterol), HDL (high density lipoprotein cholesterol) and triglycerides were 66.60±17.76 mg/dl,57.32±23.7 mg/dl, 54.06±20.11 mg/dl, 19.06±17.03mg/dl respectively. SGA neonates had more TC, TG and LDL than AGA neonates (P&lt;0.05). There was significant difference in mean lipid profile between preterm andnear-term neonates. Thus, lipid profiles in SGA neonates in thisstudy are higher than that of AGAneonates.&#x0D; Conclusion: It can be concluded that preterm babies are exposed to more hypercholesterolemia and potentially more atherogenic environment than their term counterparts.

Comparison of Lipid Profile in the Cord Blood in the Hypertensive and Non hypertensive Mothers: A Case-control Study

Introduction: Cord blood would be a feasible and simple method for detecting cholesterol level at birth. Neonatal lipids level could serve as a guide to know the physiological levels of lipids required for maintaining the normal bodily mechanisms. Aim: To compare the cord blood lipid profile of 300 newborn babies born to hypertensive and normotensive mothers. Materials and Methods: The case-control study was done in the Department of Paediatrics, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, India, for the period of one year from Jan 2019 to Jan 2020. A total of 300 pregnant ladies were included in the study. They were divided in two groups: group A consisted of 150 newborns who were born to 150 hypertensive mothers and group B consisted of 150 newborns who were born to 150 non hypertensive mothers. Five millilitres of cord blood were collected from the placental end of the umbilical vein, and then the serum was separated by centrifugation. Data was collected and mean±SD were calculated. Chi-square test and Mann Whitney test were done for statistical analysis. Results: When the cord blood was evaluated for the cholesterol, Triglyceride (TG) (p-value 0.001), High Density Lipoprotein (HDL) (p-value 0.001) and Low Density Lipoprotein (LDL) (p-value 0.001) level; it was found that in group A the levels were more in mean value as compared to the non hypertensive group, where the level was found to be lower than the mean value. The difference was found to be statistically significant. Conclusion: Hypertensive status of mother could impact neonatal lipid profile; however, larger prospective studies are required to validate these results.

A comparative study to assess the umbilical cord blood lipid profile between normal and low birth weight babies in a tertiary care hospital

A comparative study to assess the umbilical cord blood lipid profile between normal and low birth weight babies in a tertiary care hospital

Metabolic Profiling of 713 Newborns and Parents in the Norwegian Mother, Father and Child Cohort Study

Background: Lipids are important for fetal development, but the determinants of cord blood lipids have scarcely been studied. We therefore aimed to describe the associations between newborn cord blood lipid and metabolic profile, and maternal and paternal lipid and metabolic profile. Methods: This study is based on 713 mother-father-newborn trios from the Norwegian Mother, Father and Child Cohort Study (MoBa) and uses data from the Medical Birth Registry of Norway. Sixty-four cord blood metabolites detected by nuclear magnetic resonance spectroscopy were analyzed. The false discovery rate (FDR) procedure was used to correct for multiple testing. Findings: We found positive associations between maternal and newborn high-density lipoprotein (HDL) cholesterol, omega 3 and 6 fatty acids, glutamine, isoleucine, leucine, valine, phenylalanine, tyrosine, glucose, citrate, creatinine, and particle concentration of medium and small HDL (0·001 ≤ qFDR ≤ 0·049). Paternal and newborn total-, low-density lipoprotein (LDL)-, HDL3-, remnant-, esterified- and free cholesterol, phosphoglycerides, cholines, phosphatidylcholines, sphingomyelins, apolipoprotein B and A1, total fatty acids, and particle concentration of intermediate-density lipoprotein, large- and medium LDL were positively associated (0·004 ≤ qFDR ≤ 0·047). Sex differences were found for many cord blood lipids. Interpretation: Several cord blood metabolites were associated with maternal and paternal metabolites and newborn sex. This may potentially affect pregnancy- and long-term outcomes. Funding: The University of Oslo; the National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital; the Throne Holst Foundation for Nutrition Research; the Norwegian Health Association; Eckbos Legate; the Freia Corporation Medical Fund; and the Blix Foundation for the Promotion of Medical Research, Norway. Declaration of Interests: During the past five years, MPB reports grants and personal fees from Amgen, grants and personal fees from Sanofi, personal fees from MSD, personal fees from Boehringer Ingelheim, grants and personal fees from Mills AS, and grants from Kaneka, none of which are related to the content of this manuscript. JJC reports grants or personal fees from Mills DA and Amgen, none of which are related to the content of this manuscript. SMU has received research grants and/or personal fees from Mills AS, Tine DA, and Olympic Seafood, none of which are related to the content of this manuscript. KR reports personal fees from Amgen, personal fees from Mills AS, personal fees from The Norwegian Medical Association, personal fees from The Norwegian Directorate of Health, personal fees from Sanofi, personal fees from Takeda, personal fees from Chiesi, personal fees from Bayer, and personal fees from MSD, none of which are related to the content of this manuscript. JRVL has received research grants from Amryt, which are not related to the content of this manuscript. KBH has received research grants or honoraria from Mills AS, Tine SA, Olympic Seafood, Amgen, Sanofi, and Pronova, none of which are related to the content of this manuscript. LKLO, ALB, HKB, TMM, TH, PMM, and MBV declare no conflicts of interest. Ethics Approval Statement: The current study was approved by the Regional Committees for Medical and Health Research Ethics (no. 2017/1285). The study was conducted according to the principles of the Declaration of Helsinki, and all MoBa participants gave written informed consent at the time of inclusion.

Umbilical Cord Blood Lipid Profile in Healthy Neonates in Iran

Background: Coronary heart diseases (CAD) and their risk factors are among the major causes of death in Iran. Since these risk factors begin to develop early in life, it is vital to diagnose those newborns at high risk of CAD. Objectives: The present study investigated the umbilical cord blood lipid profile of term and preterm neonates. Methods: In this cross-sectional study, the lipid profiles of 292 neonates, of which 276 were term and 16 preterm, were examined at a teaching hospital. Results: The lipid profile results of total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein were 69.8, 34.9, 23.6, and 31.5 in term neonates and 80.5, 25.5, 25.1, and 38 in preterm neonates, respectively. Conclusions: According to the current paper, the lipid profiles of eastern Iranian neonates were similar to those reported in global studies. Moreover, except for triglycerides in the female neonates, lipid profiles were significantly higher among the male neonates.

Umbilical Cord Blood Lipid Profile in Healthy Neonates in Iran

Background: Coronary heart diseases (CAD) and their risk factors are among the major causes of death in Iran. Since these risk factors begin to develop early in life, it is vital to diagnose those newborns at high risk of CAD. Objectives: The present study investigated the umbilical cord blood lipid profile of term and preterm neonates. Methods: In this cross-sectional study, the lipid profiles of 292 neonates, of which 276 were term and 16 preterm, were examined at a teaching hospital. Results: The lipid profile results of total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein were 69.8, 34.9, 23.6, and 31.5 in term neonates and 80.5, 25.5, 25.1, and 38 in preterm neonates, respectively. Conclusions: According to the current paper, the lipid profiles of eastern Iranian neonates were similar to those reported in global studies. Moreover, except for triglycerides in the female neonates, lipid profiles were significantly higher among the male neonates.