Human Linkage Research Articles

Context Effects on Human Milk Oligosaccharide Linkage Conformation and Dynamics Revealed by MA'AT Analysis.

An emerging NMR method, MA'AT analysis, has been applied to investigate context effects on the conformational properties of several human milk oligosaccharides (HMOs). The MA'AT model of the β-(1→4) linkage in the disaccharide, methyl β-lactoside (MeL), was compared to those obtained for the same linkage in the HMO trisaccharides, methyl 2'-fucosyllactoside (Me2'FL) and methyl 3-fucosyllactoside (Me3FL), and in the tetrasaccharide, methyl 2',3-difucosyllactoside (Me2',3DFL). MA'AT analysis revealed significant context effects on the mean values and circular standard deviations (CSDs) of the psi (ψ) torsion angles in these linkages. α-Fucosylation at both O2'Gal and O3Glc of MeL to give Me2',3DFL significantly constrained librational motion about ψ (70% reduction in the CSD) and shifted its mean value by ∼18°. α-Fucosylation at the O3Glc of MeL to give Me3FL constrained ψ more than α-fucosylation at the O2Gal to give Me2'FL. These effects can be explained by the expected solution conformation of Me3FL, which closely resembles the Lewisx trisaccharide. Comparisons of MA'AT models of ψ to those obtained by 1 μs aqueous molecular dynamics simulation (GLYCAM06) revealed identical trends, that is, MA'AT analysis was able to recapitulate molecular behavior in solution that was heretofore only available from MD simulation. The results highlight the capabilities of MA'AT analysis to determine probability distributions of molecular torsion angles in solution as well as degrees of librational averaging of these angles.

Green infrastructure and well-being nexus within slums: a Lagos case

ABSTRACT Green infrastructure includes network of natural systems and environmental features that deliver ecosystem services which improves human well-being. This article reports a study dealing with health-related impacts of green infrastructure within a low-income informal urban setting. The study utilized a quantitative approach through survey data collection from residents in Ajegunle-Ikorodu community in Lagos, Nigeria. The residents’ survey (sample size = 455) was conducted to understand socio-economic and housing characteristics of the residents; green features available; pattern of Park Use. It elicited self-reported health information on physiological well-being and mental health. The Warwick-Edinburgh Mental Well-being Scale was used for mental health assessment. Inferential and descriptive statistical analysis was conducted on the data collected. This study shows a generally low presence of Green Infrastructure. Regression analysis (p = 0.033) affirms the positive link between green spaces and mental health. Contrary to popular opinion, the study revealed no correlation between some aspects of self-reported health and green features. The findings highlight the need to develop and maintain green spaces to optimize health benefits. By exploring the connections between greening and well-being in slums, the study contributes to knowledge on human health-nature linkages among low-income urban residents in context of developing countries.

Climate change and health: The case of mapping droughts and migration pattern in Iran (2011-2016).

Migration and mobility of population have been reported as a common reaction to drought. There is historical evidence to suggest the health effects of droughts and human migration linkage in Iran. This study aimed to map the drought and migration patterns in Iran in 2011 and 2016 and explore their possible health impacts. This sequential explanatory mixed-method study was done in two stages of spatial analysis and qualitative study. Data mapping was conducted through the equal interval classification and using drought, migration, and agriculture occupation data based on provincial divisions in Iran in 2011 and 2016. This qualitative study was conducted using the content analysis approach. The in-migration rate was higher in 2011 rather than 2016. Migration to cities was much higher than migration to villages in both years. The frequency of male migrants was higher than females in all provinces in 2011 and 2016. Physical and mental diseases as well as economic, sociocultural, education, and environment effects on health were extracted from the qualitative data. A holistic picture of droughts and migration issues in Iran and their health consequences were achieved by the present research. Further research is needed to explore the determinants of health impacts of climate change in vulnerable groups. Public health problems can be prevented by adaptive and preventive policy-making and planning. This can improve the coping capacity of the population facing droughts and enforced migration.

Communicating international politics narratives of security, democracy and human rights in contemporary society: indexing and analysis using online monitoring data.

The role of the current research is to set up a conceptual and analytical framework of the security, democracy and human rights linkage in contemporary society mainly based on the indexing, monitoring and research of online content for the period 1945-2019. Due to the focused timeline outlining the scientific research for the period 1945-2019, the paper favors both quantitative and qualitative approaches that follow a systemic framework of several thematic clusters which act as supporting pillars of analytical research by using Google Ngrams: (a) norms and constitutional values and principles; (b) civil and legal liberties; (c) human and individual approaches; (d) institutional governance and organizational establishment; (e) freedoms, civil and political rights. The research results explore the variations in the frequency of appearances of the selected concepts in the specialized literature indexed by the Google platform indicating essential aspects of the conceptual and theoretical evolutions in strict dependence to the significant resolutions of the Security Council of the United Nations adopted in the same period and focusing on three central concepts: security, democracy and human rights. The spectrum of research singles out fifteen figures and an integrated analysis of contextual, historical, political, institutional, legal and social factors. The research aims to expand the field of reference and analysis of the three notions of security, democracy and human rights by integrating the multifactorial and multi-conditional analysis for the interpretation of the results of the fifteen figures. In the broader framework of online monitoring and complementarily with the spectrum of UNSC resolutions, the research will use contemporary topics, intensely debated, used and monitored, focusing on the conceptual and linguistic study and on the relationship between the analytical inventory of scientific research and the international decision-making spectrum. This relationship is mediated by the lexicon of politics and the sociology of international relations, which reflected a growing evolutionary linguistic semantics since 1945, the year of the establishment of the United Nations.

Autonomous Vehicles and the Linkages to Smart Mobility: Impact and Implications on Digital Globalisation

Abstract Human civilisation is undergoing a transformation, perceived as the institutionalisation of digital globalisation. The 20th century witnessed greater strides in the form of the internet revolution, automobile technologies and smart mobility, related transformation, dissemination and integration of related technologies as well, leading to the emergence of digital globalisation. The integration of cyber-physical systems has accelerated the rate of urbanisation, and the currently prevailing enhanced standards of living have increased the number of automobiles in cities that have been integrated into the digitally globalised ecosystems, leading to the emergence of autonomous vehicles (AVs). The present study analyses the emerging threats and vulnerabilities of AVs and smart mobility, which have created more security concerns for AVs across nation-states, leading as well to the emergence of digital globalisation. The article theorises the aspects of human security linkages and utilises a capacity matrix (qualitative approach) to examine the development, institutionalisation and integration of AVs into digital globalisation and the related challenges emerging along with it.

Why losing Australia's biodiversity matters for human health: insights from the latest State of the Environment assessment.

Why losing Australia's biodiversity matters for human health: insights from the latest State of the Environment assessment.

International Humanitarian Law and the US-China Rivalry: National Interests and Human Rights Linkage

International Humanitarian Law and the US-China Rivalry: National Interests and Human Rights Linkage

A blueprint for enduring human services cross-jurisdictional data linkage, adapted to achieving outcomes for people with disability.

ObjectivesPeople with disability represent 1 in 6 Australians and use services provided across multiple levels of government. Data is siloed between different governments and service systems, limiting visibility and ability to improve outcomes. Our objective was to progress people-centred data sharing across jurisdictions at scale, focused on people with disability. ApproachMore than 140 engagements with the disability community, governments, researchers, and service providers were conducted to ascertain user and data needs; systematically map enablers and barriers to data use; and outline the requisite technical capabilities and social license for a disability asset. Five demonstration projects tested novel linkage approaches, data flows and access models to inform technical aspects of the design. We adopted an iterative try-test-learn approach and forged consensus through extensive dialogue across all stakeholders to collaboratively design a system for enduring data linkage. The final design was reviewed by external experts to ensure best practice and build trust. ResultsA national disability-focused data asset requires linking data across all human services portfolios, as will be required for most national assets seeking to improve outcomes for particular communities or in particular domains. The proposed approach is three building blocks: national data linkage and integration infrastructure, national data system governance, and streamlined data sharing agreements for multiple uses. Current project-by-project approaches to linkage are proposed to be replaced with new enduring national keys to connect disparate state-based infrastructure and enable streamlined, reusable data curation processes. Collaboration between jurisdictions will be embedded through joint governance of the new infrastructure. Finally, a new approach to data sharing agreements between Australian governments will be developed to create safe parameters for streamlined access within existing legislation and authorisation pathways. ConclusionBy designing to meet information needs across human services, this approach can be leveraged for multiple linked, longitudinal enduring data asset, beyond disability. It multiplies the benefits of upfront efforts to share and improve data, reflects a shared understanding among stakeholders, and moves Australia towards scaled use of people-centred data.

HONEY BUSINESS DEVELOPMENT STRATEGY BASED ON BUSINESS FEASIBILITY AND ROLE OF LAKITAN FOREST MANAGEMENT UNIT IN MUSI RAWAS DISTRICT SOUTH SUMATERA PROVINCE

The objectives of this study were (1) to analyze the role and interests of the KPH Lakitan Musi Rawas Regency in the development of honey business, (2) to analyze the financial feasibility of forest honey management in KPH Lakitan Musi Rawas Regency and to ( 3) to analyze strategies for developing forest honey in KPH Lakitan Musi Rawas District based on financial feasibility and the results of mapping the roles and interests of KPH Lakitan. The sample in this study consisted of 20 of which 3 of them were expert samples from internal KPH Lakitan and 17 of them were forest honey hunters. This paper concludes that based on mapping the roles and interests of KPH Lakitan are dominant in quadrant B, which means that the contribution of facilities and involvement of stakeholders as well as contribution of human resources and linkages between programs from the planning stage to the monitoring stage has been implemented properly. Meanwhile, the result of financial feasibility analysis of the forest honey management business is feasible to continue because, the NPV results were positive > 0, that means the investment will get net benefits. After that, from the result of the SWOT analysis of KPH Lakitan forest honey management, the strategy that can be formed is SO strategy formulation namely by utilizing government support in expanding the marketing network and developing honey bee cultivation technology.
 

Testing the stakeholder pressure, relative advantage, top management commitment and green human resource management linkage

AbstractScholars have acknowledged the importance of green human resource management (HRM). Green HRM has been considered a vital mechanism for companies to move towards a sustainable organisation. However, the factors that drive green HRM have not been thoroughly investigated. This study investigated how green HRM interacts with the linkages among relative advantage, stakeholder pressure, and top management commitment based on the Stakeholder Theory and Resource‐based view theory. Data were collected from 112 large manufacturing firms using a survey. Partial least squares modelling was used to test the hypotheses in the research. All hypotheses were accepted except for relative advantage concerning green analysis and description of job positions, green recruitment and green rewards. Overall, it offers guidelines for decision makers on how to emphasise these factors in organisations and subsequently create a culture of environmentally friendly organisations particularly from the perspective green HRM.

Make nature's role visible to achieve the SDGs

Non-technical summaryImplicit in the UN's Sustainable Development Goal (SDG) Agenda is the notion that environmental sustainability is intertwined with, and underpins, the 17 Goals. Yet the language of the Goals, and their Targets and indicators is blind to the myriad ways in which nature supports people's health and wealth – which we argue represents a key impediment to progress. Using examples of nature–human wellbeing linkages, we assess the language of all 169 Targets to identify urgent research, policy, and action needed to spotlight and leverage nature's foundational role, to help enable truly sustainable development for all.Technical summaryNature's foundational role in helping achieve the SDGs is implicit rather than explicit in the language of SDGs Goals, Targets, and indicators. Drawing from the scientific literature describing how nature underpins human wellbeing, we carry out a systematic assessment of the language of all 169 Targets, categorizing which Targets aredependentupon nature for their achievement, couldharmnature if attained through business-as-usual actions, or may synergisticallybenefitnature through their attainment. We find that half are dependent upon nature for their achievement – yet for more than two-thirds of those nature's role goes unstated and risks being downplayed or ignored. Moreover, while achieving the overwhelming majority of the 169 Targets could potentially benefit nature, more than 60% are likely to deliver ‘mixed outcomes’ – benefitting or harming nature depending on how they're achieved. Furthermore, of the 241 official indicators <5% track nature's role in achieving the parent Target. Our analysis provides insights important for increasing effectiveness across the SDG agenda regarding where to invest, how to enhance synergies and limit unanticipated impacts, and how to measure success. It also suggests a path for integrating the ‘nature that people need’ to achieve the SDGs into the CBD's post-2020 Global Biodiversity Framework.Social media summaryHarmonizing links between the SDGs and the CBD's post-2020 Global Biodiversity Framework is vital for promoting sustainable development

A profile of the Centre for Health Record Linkage.

The Centre for Health Record Linkage (CHeReL) was established in 2006 as a dedicated health and human services data linkage facility for two Australian jurisdictions, New South Wales and the geographically-nested Australian Capital Territory. The two jurisdictions have their own Governments and separate Health and Human Service systems. The primary purpose of the CHeReL is to make linked administrative and routinely collected health data available to researchers and government within relevant regulatory and governance frameworks. The CHeReL's data governance and technical operations draw on international best practice and have been refined by learnings from other data linkage centres. Over twelve years of operation, more than 2,320 unique investigators from 140 institutions have used the CHeReL, producing 615 publications in peer-reviewed literature. A robust pipeline of new development is expected to further amplify the use of linked data for cutting edge medical research and support a vision of data-informed policy and data-driven government services.

Impact of human resource management practices on TQM: an ISM-DEMATEL approach

PurposeThe theory-building around the quality of human resources has received extensive attention in recent years. Numerous quantitative studies discuss and test theories related to total quality management and human resource linkages. The study aims to understand interlinkages of quality and human resources using Interpretative Structural Modeling (ISM) methodology and DEMATEL.Design/methodology/approachThis paper uses ISM methodology to examine the interrelationship between the identified variables and the DEMATEL approach to find cause–effect relationships. An integrated approach helps managers for better total quality management (TQM) implementation. This study further extended using Total Interpretative Structural Modeling (TISM).FindingsThe integrated approach of ISM and DEMATEL shows that leadership development, hiring process and training development become most important for TQM implementation. The outcome of ISM shows customer satisfaction and corporate image are depending on other practices, where DEMATEL analysis revealed that eight practices cause and remaining are effective practices.Originality/valueThis research's integrated approach helps the firm identify essential practices, and further interdependency can be developed from cause and effect analysis. The study also provided a novel approach to implementing TQM practices.

Education 4.0 in Developing Economies: A Systematic Literature Review of Implementation Barriers and Future Research Agenda

Education 4.0 (EDUC4) was driven by the onset of the Fourth Industrial Revolution (4IR) to meet labor market requirements resulting from learning that is customized, flexible, accessible, and skills-based. As the concept of EDUC4 develops popularity in the education and innovation research domains, various challenges about its implementation have emerged, especially in developing economies. Thus, there is a need to investigate the existing barriers to EDUC4 implementation. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a systematic literature review of journal articles in the Scopus database was conducted. Of the 299 journal articles generated from the initial search on Scopus, 30 met the inclusion criteria and were included in the review. The content analysis yielded 12 barriers which include cybersecurity threat, costly, skills gap of human capital, apprehensive stakeholders, lack of training resources, lack of collaboration, knowledge gap for the customization of curriculum design, insufficient available technologies, health issues, time constraint for material preparation, complexity of learning platforms, and insufficient foundation of basic education. They were then associated with seven themes for better operationalization in Higher Education Institutions (HEIs): (1) human resources, (2) infrastructure, (3) financial, (4) linkages, (5) educational management, (6) learners, and (7) health and environment. Finally, a theoretical predictive model was constructed to present the causal relationships in modeling the problems associated with implementing EDUC4. The insights generated from this work offer both theoretical and practical perspectives for stakeholders of HEIs in the implementation of EDUC4 in developing economies.

OMA1 High-Throughput Screen Reveals Protease Activation by Kinase Inhibitors.

Mitochondrial proteases are interesting but challenging drug targets for multifactorial diseases, such as neurodegeneration and cancer. The mitochondrial inner membrane protease OMA1 is a bona fide drug target for heart failure supported by data from human linkage analysis and animal disease models, but presumably relevant for more indications. OMA1 acts at the intersection of energy metabolism and stress signaling. The protease cleaves the structural protein OPA1, which organizes the cristae, as well as the signaling peptide DELE1, which can stimulate the integrated stress response. OMA1 shows little activity under physiological conditions but hydrolyzes OPA1 in mitochondria destined for mitophagy and during apoptosis. Little is known about OMA1, its structure has not been solved, let alone its context-dependent regulation. Autocatalytic processing and the lack of OMA1 inhibitors are thereby creating the biggest roadblocks. This study introduces a scalable, cellular OMA1 protease assay suitable for high-throughput drug screening. The assay utilizes an engineered luciferase targeted to the inner membrane as artificial OMA1 substrate, whereby the reporter signal inversely correlates to OMA1 activity. Testing different screening protocols and sampling different compound collections validated the reporter and demonstrated that both OMA1 activators as well as OMA1 inhibitors can be identified with the assay. Ten kinase-targeted cancer drugs triggered OMA1 in the assays, which suggests─considering cardiotoxicity as a rather common side-effect of this class of drugs─cross-reactivity with the OMA1 pathway.

Pendampingan Kegiatan Posyandu di Desa Bandarkedungmulyo dalam Meningkatkan Persentase Kesehatan Serta Memberikan Sarana Pencegahan Penularan Covid-19

National development in the health sector through posyandu is the development of human resources for the purpose of optimizing the degree of public health as measured by the Maternal Mortality Rate (MMR) per 100,000 live births and the Infant Mortality Rate (IMR) per 1000 live births which are also components of the Human Development Index (HDI). . The goal of posyandu is to reduce the Maternal Mortality Rate (MMR) and the Infant Mortality Rate (IMR) in Indonesia through community empowerment efforts. The targets of the posyandu are all babies, toddlers, pregnant women, breastfeeding mothers, post-partum mothers as well as women at fertile age (WUS) and fertile age couples (PUS). Posyandu activities consist of maternal and child health (KIA), family planning (KB), immunization, improved nutrition, prevention and overcoming diarrhea. Posyandu has a human development linkage, this linkage can be seen from the efforts to reduce MMR and IMR in Indonesia, while in Indonesia MMR and IMR are still very high, this is due to the failure to achieve the 2015 MDG'S target to overcome this problem, it is necessary to revitalize posyandu and implement good management at posyandu so that provide a solution to the AKI and AKB problems. The goal of posyandu to reduce MMR and IMR is to increase life expectancy in Indonesia. If the life expectancy of humans in Indonesia increases it means that the quality of human life will be better so that it can improve the quality of human development from sharing sides nationally in Indonesia.

Fostering technological innovation through management and marketing innovation. The human and non-technological linkage

PurposeThis paper aims to analyse the relationships between management innovation, marketing innovation, technological innovation and the personnel involved in science, technology and innovation activities.Design/methodology/approachThe work used data from the Technological Development and Innovation Survey – Colombian Industry VII 2013–2014. Six logistic regression models are tested for the analysis with 2,045 manufacturing firms.FindingsThe results suggest that the probability to pursue technological innovation diminishes in those firms that introduce management and/or marketing innovations. The same happens in firms seeking non-technological innovations with the introduction of product and process innovations. The human side, administrative and technical staff, working on innovation projects plays a key role in the success of different types of innovations.Originality/valueAt this time, there is a need for research studies with new approaches that look at innovation beyond the technological domain and focus on the human side of innovation and other important aspects such as the managerial contribution to innovation. Theoretically, the work contributes to expanding the scarce literature on the proposed relationship and, as far as is known, it is the only one with empirical data for an emerging economy such as the Colombian one. Empirically, useful information is provided for the design of strategies that seek to improve firms' innovation performance.

Acute human immunodeficiency testing and linkage to Care: An evaluation of community-based 4th generation antigen/antibody testing

As a relatively novel testing algorithm, the experience with 4th generation HIV testing and linkage to care outcomes is limited. The purpose of this study is to report descriptive outcomes regarding patients with acute HIV infection who received antigen/antibody (Ag/Ab) reactive results and linkage to care services. HIV testing and linkage data from four AIDS Healthcare Foundation (AHF) Wellness Centers in Los Angeles County, CA were retrospectively reviewed from January 15, 2016 to May 26, 2018. Patients were screened using the INSTI® HIV-1/HIV-2 Rapid Antibody Test (bioLytical, Richmond, BC). A negative result reflexed to an HIV test on the Abbott Architect Ag/Ab Assay (Abbott Laboratories, Lake Bluff, IL). Out of the total 11,173 patient specimens processed on the Architect platform, 56 received preliminary reactive results and 42 returned for confirmatory viral load testing. Twenty-seven (64%) of the 42 patients were confirmed to be acutely infected with HIV. All 27 patients acutely infected with HIV were linked into care: 22 were linked into AHF’s primary care and the remaining five sought care with a primary care provider external to AHF. Despite low positivity, the 27 acutely HIV-infected patients would have otherwise been missed if the patients had only received the standard-of-care rapid antibody test. Curbing HIV incidence in the United States will require multiple innovative approaches. Detecting acute infections through 4th generation testing is one of the many valuable tools that organizations can utilize in the new decade. Key words: Acute HIV infection, testing algorithms, linkage to care, HIV antigen and antibody combination test, HIV antigen and antibody combination test, Abbott Architect.

Green Infrastructure—Countering Ecosystem Fragmentation: Case Study of a Municipality in the Carpathian Foothills

This paper discusses green infrastructure, which can be considered a useful tool in the process of ensuring the sustainable development of rural structures in the polish Carpathian region. It allows for achieving a better quality of the environment of human life and healthy wildlife linkages. The element that supports defining information about the existing state of green infrastructure and its resources is the green infrastructure fragmentation coefficient based on edge effect calculations, which is the relation between the edge of the patch (circumference) to its surface area. With the use of model analysis of green infrastructure, it is possible to implement the provisions of the Carpathian Convention and coordinate planning documents that facilitate the sustainable development of spatial structures. Our study on the state of green infrastructure in rural areas of the Polish Carpathian Mountains is a source of knowledge about the quality of this area, its natural environment and fragmentation. Determining the territory’s green infrastructure fragmentation coefficient provides an opportunity for higher-precision studies and the detection of threats and integration of GI fragments and addressing proper solutions in conflict areas.

Piracy and the Impaired Cyborg

This paper examines software piracy in the Global South from an accessibility lens, using the bio-technical metaphor of the 'cyborg.' Drawing on qualitative interviews with people with visual impairment (VI) from India and Peru, the paper interrogates the intimate relationships that users have with assistive technologies (ATs). It outlines the effectiveness of ATs in allowing users to actively control and shape their own lives and identities, and describes the various modalities that regulate the human body, technology, and human body-technology linkages. The paper argues that software piracy, when looked through the lens of the 'cyborg,' is an act of self-making that is motivated by a desire to gain autonomy and independence, i.e., it can be understood as a way to overcome the barriers that undermine access to the technological self. Further, software piracy allows a shift in the distribution of power from those who control and regulate the assistive technologies to the cyborgs themselves.