Lining Of Stratified Squamous Epithelium Research Articles

Congenital Epulis in a Neonate: A Rare Cause of Oral Cavity Mass

Background: Congenital epulis is a benign tumor of the oral cavity, rarely seen in newborns. Clinical Description: A term, female neonate presented soon after birth with a 5 cm × 3 cm × 2.5 cm, firm, lobulated, noncompressible, nonfluctuant oral cavity mass, arising from the right maxillary alveolar ridge with a pedunculated base. Management and Outcome: The lesion posed an obstacle to the establishment of breastfeeds or paladai feeds along with the potential to compromise the airway for which the mass was excised in toto under general anesthesia. Histopathology revealed a lining of stratified squamous epithelium, large polygonal cells with abundant granular, eosinophilic cytoplasm, and a prominent vascular stroma with no evidence of malignancy suggesting the diagnosis of congenital epulis and immunohistochemistry confirming the same. Conclusion: Congenital epulis are rare tumors of the oral cavity which have excellent results if resected early.

EXTENSIVE INFLAMED ORTHOKERATINIZED ODONTOGENIC CYST IN THE MANDIBLE: A CASE REPORT

The orthokeratinized odontogenic cyst is a relatively uncommon developmental cyst of an unknown etiology not constituting a distinct clinical entity. A 23-year-old man reported episodes of pain and swelling in the posterior right mandible. On clinical examination, erythematous mucosa of the region and an expansion of the vestibular cortical plate was seen. Radiographic examination showed and extensive well-circumscribed unilocular radiolucency in the body region extending to angle of the mandible. A fine needle aspiration was performed revealing purulent content. Histopathologic analysis of surgical specimens from an incisional biopsy revealed fragments of tissue exhibiting cystic lesion, with epithelial lining of stratified squamous epithelium with prominent orthokeratinization on the surface; the cyst wall showed areas of inflammation with lymphocyte predominance. A marsupialization was carried out, and the patient is on 1 year of clinical-radiographic follow-up with no recurrences. The orthokeratinized odontogenic cyst is a relatively uncommon developmental cyst of an unknown etiology not constituting a distinct clinical entity. A 23-year-old man reported episodes of pain and swelling in the posterior right mandible. On clinical examination, erythematous mucosa of the region and an expansion of the vestibular cortical plate was seen. Radiographic examination showed and extensive well-circumscribed unilocular radiolucency in the body region extending to angle of the mandible. A fine needle aspiration was performed revealing purulent content. Histopathologic analysis of surgical specimens from an incisional biopsy revealed fragments of tissue exhibiting cystic lesion, with epithelial lining of stratified squamous epithelium with prominent orthokeratinization on the surface; the cyst wall showed areas of inflammation with lymphocyte predominance. A marsupialization was carried out, and the patient is on 1 year of clinical-radiographic follow-up with no recurrences.

Odontogenic keratocyst mimicking paradental cyst.

Objective. The aim of this paper is to present an uncommon clinical and radiographic aspect of odontogenic keratocyst (OKC) mimicking paradental cyst. Methods. A 32-year-old female patient showed a well-delimited radiolucent lesion connected with the root of the left third molar with close anatomical relationship with the mandibular canal. The clinical, radiographic, and anamnestic features lead us to diagnose a paradental cyst that was treated by enucleation after extraction of the partially impacted tooth. Results. Histological analysis showed typical histological features of PKC such as the presence of a lining of stratified squamous epithelium with a well-defined basal layer of palisading columnar of cuboidal cells. Conclusion. Initial X-ray analysis and the position of the lesion related to the third mandibular tooth caused us to mistakenly diagnose a paradental cyst. We were only able to identify the cyst as an PKC rather than a paradental cyst after histological analysis.

Multiple myeloma presenting as gingival hyperplasia

Multiple myeloma is a malignant neoplasm that is characterized by a monoclonal proliferation of plasma cells. Oral and maxillofacial manifestations as an initial sign or symptom of multiple myeloma are rare. A 58-year-old male patient presented with generalized gingival enlargement for last 6 months. Based on clinical presentation, a diagnosis of gingival hyperplasia was made. After Phase I therapy, excisional biopsy was taken in anterior mandibular region and excised tissue was sent for histopathological examination. The histopathology report revealed a lining of stratified squamous epithelium with foci of ulceration. The subepithelial zone showed infiltration by sheets of mainly binucleate and multinucleate plasma cells, few cells being less differentiated. Rounded cytoplasmic inclusion bodies were identified in many of these cells. After a series of clinical investigations, a case of “multiple myeloma” was diagnosed. Patient presenting with generalized gingival hyperplasia should be worked up for systemic disease like multiple myeloma.

The buccal bifurcation cyst: A prospective study of treatment outcomes in 44 sites

Objective. The clinical, radiographic, and histologic features of the mandibular buccal bifurcation cyst were studied to further define this lesion. The treatment and outcomes were also analyzed. Study design. This prospective study, which spanned 3 years, included 32 patients. Their ages ranged from 5.5 to 11 years (mean of 7.5). A total of 44 buccal bifurcation cysts were treated solely with enucleation, and patients were followed up for 2.5 to 3 years. Results. All lesions were located at the buccal bifurcation of the mandibular first molar. Tilting of the buccal cusps, causing prominence of the lingual cusps, occurred in 75% of the cases. The lesion extended from the buccal bifurcation to the tooth apex in 81.2%, and a periosteal reaction on the lateral surface of the mandible adjacent to the cyst was noted in 68.8% of the cases. All of the 44 histologic reports were nonspecific, but showed a cyst lining of stratified squamous epithelium with chronic inflammation. Microbiology consisted of mixed oral flora. Complete radiographic healing in all sites without recurrence was noted in 2.5-year follow-up. The periodontal pocket depth around all the involved teeth was normalized. No loss of the mandibular first molars occurred. Conclusions. The mandibular buccal bifurcation cyst is a distinct site-specific and age-specific clinical entity treatable by enucleation without tooth extraction.

A new technique using cultured epithelial sheets for the management of epistaxis associated with hereditary haemorrhagic telangiectasia

A new technique for the treatment of severe epistaxis associated with hereditary haemorrhagic telangiectasia is described. The nasal septum and inferior turbinates, surgically denuded of respiratory epithelium, were grafted using autografts of cultured epithelial sheets derived from buccal epithelium. All patients upon whom this technique has been used have shown considerable lessening in the frequency and severity of their epistaxes although two patients received grafts on two occasions, in each case approximately three months apart. It is postulated that a nasal lining of stratified squamous epithelium is likely to be more resistant to trauma than the normal respiratory type, and this is supported by the observation that bleeds very seldom occur from the oral cavity in this syndrome.

Pemphigus Vulgaris of the Esophagus

Excerpt Because skin and esophagus have in common a lining of stratified squamous epithelium, it is not surprising that certain diseases affecting this epithelium can involve both organs. Thus vesi...