Linear Accelerator Research Articles

Radioprotective activity of the liposomal composition of quercetin in acute radiation syndrome (experimental study)

Background. The targeted search for new effective radioprotective agents, especially among compounds with antioxidant properties, remains relevant. Among them, quercetin which has a high specific activity against oxidative stress (cited as a «universal antioxidant») deserves attention. The transport liposomal composition of quercetin, which significantly improves its bioavailability and is the basis of the licensed drug «Lipoflavon®» (LF), is known, but the radioprotective properties of this drug have not been studied. The purpose of the work is to position Lipoflavon as a radioprotector for the first time based on the study of radioprotective activity in an acute experiment with total irradiation of rats. Materials and methods. The rat model of acute radiation syndrome (ARS) was carried out by short-term bilateral total body irradiation (TBI) on a CLINAC (6 MeV) linear accelerator at doses of 5.5 and 7.0 Gy. The control rats were sham-irradiated. The test sample of LF was used for the studies. LF (1.5 mg/mL) was administered to rats 30 min before TBI through the tail vein. The control TBI rats were injected with physiological saline. Experimental rats were randomly assigned into groups as follows: group 1 – non-irradiated control (intact animals); group 2 – irradiated control at a dose of 5.5 Gy (TBI5.5); group 3 – irradiation at a dose of 5.5 Gy with administration of LF (LF + TBI5.5); group 4 – irradiated control at a dose of 7.0 Gy (TBI7.0); group 5 – irradiation at a dose of 7.0 Gy with administration of LF (LF + TBI7.0). Clinical characteristics of ARS, overall survival, and the mean survival time of the dead animals were determined. The profiles of lethality («peaks of death») were calculated as total rat lethality (%) in certain time periods of the ARS. In hematological studies, LF was administered 24 h prior to TBI and twice a week the next 4 weeks after TBI. The hematological parameters were monitored on days 3, 7, 14 and 21 after TBI. Results. It was established that prophylactic LF administered 30 min before TBI at doses of 5.5 and 7.0 Gy, which were LD20/30 and DL73.3/30, increased the 30-day survival rate of the irradiated rats to 90 and 40% respectively, compared to 80 and 26.7% in irradiated control, and changed the radiation lethality profile of the rats in the model of ARS. The radioprotective activity of LF manifested in the form of the absence of early and late peaks of death of the irradiated rats and the survival time of more than 30 days after the treatment in 40% of rats with LD73,3/30. Prophylactic and therapeutic administration of LF prevented development of severe leukopenia and thrombocytopenia and contributed to a more rapid and sustained recovery of erythrocytes during the period of ARS. The most efficient radioprotective therapeutic effect of LF was observed in rats with a dose of LD73.3/30. Conclusions. The results of the study substantiate the radioprotective activity of Lipoflavon in ARS and help develop the new approaches to using the licensed drug «Lipoflavon®» as an effective pharmacological therapeutic agent for radiation protection in acute radiation.

Physical start-up of the Nuclear Subcritical Facility “Neutron Source” of NSC KIPT

National Science Center “Kharkov Institute of Physics and Technology” jointly with the Argonne National Laboratory developed, designed and constructed the Subcritical Nuclear Facility “Neutron source based on the subcritical assembly driven by electron linear accelerator”. The article presents the main results obtained during the physical start-up of the plant, the program of which involved the staged loading of fuel assemblies into the core with subsequent measurements of its neutron-physical characteristics. In total, 37 fuel assemblies of WWR-M2 type were loaded into the facility core. The values o f the effective neutron multiplication factor keff and reactivity ρ of the subcritical assembly were measured after each loading step using the multiplication and area ratio methods. In addition, the neutron flux to electron current ratio method was tested for on-line reactivity monitoring. The investigations were performed when the accelerator was operated with 100 MeV electron beam energy, 2.7 μs electron pulse duration, 20 Hz pulse repetition rate and ≤ 40 mA beam pulse current. The obtained results were analyzed in terms of ensuring the facility nuclear safety at the next stage of its commissioning which is the pilot operation.

Assessing focal spot alignment in clinical linear accelerators: a comprehensive evaluation with triplet phantoms.

A fundamental parameter to evaluate the beam delivery precision and stability on a clinical linear accelerator (linac) is the focal spot position (FSP) measured relative to the collimator axis of the radiation head. The aims of this work were to evaluate comprehensive data on FSP acquired on linacs in clinical use and to establish the ability of alternative phantoms to detect effects on patient plan delivery related to FSP. FSP measurements were conducted using a rigid phantom holding two ball-bearings at two different distances from the radiation source. Images of these ball-bearings were acquired using the electronic portal imaging device (EPID) integrated with each linac. Machine QA was assessed using a radiation head-mounted PTW STARCHECK phantom. Patient plan QA was investigated using the SNC ArcCHECK phantom positioned on the treatment couch, irradiated with VMAT plans across a complete 360° gantry rotation and three X-ray energies. This study covered eight Elekta linacs, including those with 6 MV, 18 MV, and 6 MV flattening-filter-free (FFF) beams. The largest range in the FSP was found for 6 MV FFF. The FSP of one linac, retrofitted with 6 MV FFF, displayed substantial differences in FSP compared to 6 MV FFF beams on other linacs, which all had FSP ranges less than 0.50mm and 0.25mm in the lateral and longitudinal directions, respectively. The PTW STARCHECK phantom proved effective in characterising the FSP, while the SNC ArcCHECK measurements could not discern FSP-related features. Minor variations in FSP may be attributed to adjustments in linac parameters, component replacements necessary for beam delivery, and the wear and tear of various linac components, including the magnetron and gun filament. Consideration should be given to the ability of any particular phantom to detect a subsequent impact on the accuracy of patient plan delivery.

Does a peer review group consensus process for MR-Linac patients affect clinical care? Evaluation of impact and feasibility

Background and purposePeer review is an important component of quality assurance in radiotherapy. To our knowledge, there are no studies reporting on the feasibility and outcomes of the peer review process for magnetic resonance (MR) guided radiotherapy (MRgRT) on the MR linear accelerator (MR-Linac) despite the planning complexity involved and its evolving clinical indications. This study aimed to quantify the rate of change in treatment plans post-peer review and the time and resources required. Materials and methodsFifty-five cases presented at weekly MR-Linac peer review meetings across two centres from 8 June to 21September 2023 were prospectively collected. Cases were analysed to determine the rate and extent of plan changes based on the Peer Review Audit Tool for radiation oncology (PRAT) developed by the Royal Australian and New Zealand College of Radiologists (RANZCR). ResultsPeer review resulted in changes to 36.4 % of treatment plans (n = 20), with 3.6 % (n = 2) having major changes requiring deferment of treatment. The most frequent changes were to organs at risk (OAR) volumes involving both delineation and increased OAR sparing (16.4 %, n = 9), total dose and fractionation (10.9 %, n = 6) and target volume dose coverage (5.5 %, n = 3). Patients with SBRT plans (39.1 % cf 22.2 %), oligometastatic/oligoprogressive sites (38.1 % cf 30.7 %) and reirradiation cases (41.2 % cf 34.2 %) had higher rates of change. Cases took a mean of 7 min (range 2–15 min) to discuss. ConclusionThe high rates of plan changes support the value of peer review in MRgRT. We recommend, where possible that all MRgRT cases, particularly those involving SBRT plans, oligometastatic/oligoprogressive sites, and/or reirradiation, be subject to peer review.

Radiochromic film EBT3 calibration for linear accelerator in 10 MV

Radiochromic film is used to applications in dosimetry have become increasingly significant for studies on radiotherapy. Due to sensitivity to exposure to ionizing radiation, radiochromic films are commonly used to obtain dose distribution maps and for calibration curves. The calibration curves in the radiochromic films can be use radiochromic films as a dosimetry method and then seek the generation of images with lower dose deposition and higher diagnostic quality. When ionizing radiation interacts with matter it generates energy deposition. Radiation dosimetry is important for medical applications of ionizing radiation due to the increasing demand for diagnostic radiology and radiotherapy. The film is a dose measurement method that records the energy deposition by the darkening of its emulsion. Radiochromic films have a little visible light sensitivity and respond better to ionizing radiation exposure. The aim of this study is to obtain the resulting calibration curve by the irradiation of radiochromic film strips, making it possible to relate the darkening of the film with the absorbed dose, to measure doses in experiments with X-ray beam of 10 MeV in Linear Accelerator. The objective of this study is to obtain the calibration curves of the radiographic film for exposure with X-ray beam in Linear Accelerator scanner for realize measures of typical doses found in radiotherapy. It was used Gafchromic EBT Radiochromic Film, which shows little sensitivity to visible light and a response in the range of 0.1 to 10 Gy for X-ray beam. In the experiments, a Solid Water Phantom, with a 30x30x2.0 cm³. The strips were scanned and processed using the ImageJ software to obtain the intensity values resulting from the absorbed radiation by grayscale. The darkening responses on film strips according to the doses were observed and they allowed obtaining the corresponding numeric values to the darkening for each specific dose value. From the numerical values of darkening, a calibration curve was obtained.

Hyperloop New Mode of Transportation

Today conventional mode of transportation is rail, road, water, and air. These modes of transport are relatively slow and expensive or a combination of relatively slow and expensive. Hyper loop is latest mode of transportation which is fast and inexpensive to change the pattern of transportation. Similar to Linux, hyper loop is also open and unique design concept. By bringing this concept to reality, it will help people to travel from one city to another city in a very small time and also at a low cost. The hyper loop capsule would accelerate with the help of linear electric motor and traverse through the tube at a high speed. By using passive magnetic levitation or air bearing, capsule will run above their track. Hyper loop consists of a low-pressure tube with capsules that are travelled at low and high speed throughout the length of the tube. The capsules are supported with the help of cushion of air. To accelerate the capsules the magnetic linear accelerator is fitted at various stations on the hyperloop tube. To enter and exit the passengers the passage may be left either at the end of the tube or branches along the tube length. Let's see how the hyperloop change mode of transportation.

Implementation of an ionization chamber array for linear accelerator monthly dosimetry QA.

The IC Profiler (ICP) manufactured by Sun Nuclear Corporation (SNC) is an ionization chamber (IC) array used for linear accelerator dosimetry measurements. Previous work characterized response of the ICP under various conditions, but there is limited work of its implementation into monthly QA measurement procedures. This work quantifies ICP accuracy and variables that affect accuracy for beam output measurements, and demonstrates feasibility of using the ICP for all recommended monthly dosimetry measurements. A total of 1985 output measurements on six Varian TrueBeam and Edge linear accelerators were performed using three ICP with quad wedges (QWs) and were compared with conventional IC measurements. The accuracy of the ICP for beam output was characterized as the difference between the ICP and IC. Variables that affect ICP accuracy, including gain settings, calibrations, and template baselining as well as machine or energy-specific bias were investigated. Measurements of profile constancy, energy, dose rate constancy, wedge factors, and gating were performed. The initially observed mean output difference between the ICP and IC was 0.16% (0.61%). When gain settings were optimized, the output difference accuracy improved to -0.02% (0.38%). The output accuracy of the ICP was not dependent on array, dose, temperature and pressure calibrations, or template baselining. Statistically, ICP output accuracy was dependent on machine and beam energy, but clinically, all measurements fell within 0.5% of unity. ICP measurements of energy, dose rate constancy, and wedge factors matched passing results with conventional IC in water measurements. Gating and beam profile constancy measurements demonstrated good stability using the ICP. Finally, monthly dosimetry QA using ICP was completed in an average of 33 min compared to 66 min using the IC. This work demonstrated the feasibility and efficiency of using the ICP, with specific considerations, as a measurement device for dosimetric linear accelerator monthly QA.

Design and characterisation of a minibeam collimator utilising Monte Carlo simulation and a clinical linear accelerator

Objective. Spatially fractionated radiotherapy is showing promise as a treatment modality. Initial focus was on beams of photons at low energy produced from a synchrotron but more recently research has expanded to include applications in proton therapy. Interest in photon beams remains and this is the focus of this paper Approach. This study presents a 3D printed tungsten minibeam collimator intended to produce peak-to-valley dose ratios (PVDR) of between seven and ten with a 1 MV, bremsstrahlung generated, photon beam. The design of the collimator is motivated by a Monte Carlo study estimating the PVDR for different collimator designs at different energies. This collimator was characterised on a clinical linear accelerator (Elekta VersaHD) as well as an orthovoltage unit. Main results. The performance of the fabricated collimator was measured on Elekta VersaHD running in unflattened mode with a 6 MV beam. On the Elekta VersaHD units the PVDR was measured to be between approximately 1.5 and 2.0 at 3 cm deep. For measurements with the orthovoltage unit PVDRs of greater than 10 were observed at a depth of 4 cm. Significance. The results confirmed that the predictions from simulation could be reproduced on linear accelerators currently in clinical usage, producing PVDRs between 2–2.5. Using the model to predict PVDRs using 1 MV photon beams, the threshold considered to produce enhanced normal tissue dose tolerance ( > 7) was surpassed. This suggests the possibility of using such techniques with versions of existing Linac technology which have been modified to operate at low energy and high beam currents.

An automation of Monte Carlo workflow for dosimetry study of an Elekta LINAC delivery system in radiotherapy

PurposeThis study aims to automate the Monte Carlo (MC) workflow utilized for radiotherapy dosimetry, focusing on an Elekta LINAC delivery system. It addresses the challenge of integrating MC simulations into routine clinical practice, making this accurate yet complex method more accessible and efficient for radiotherapy dosimetry. Methods and MaterialsWe developed a user-friendly software featuring a graphical user interface (GUI) that integrates EGSnrc for MC simulations. The software streamlines the process from retrieving Digital Imaging and Communications in Medicine (DICOM) data to executing dose calculations and comparing dose distributions. To validate our proposed tool, we compared its computed doses for IMRT and VMAT plans from the Pinnacle TPS for an Elekta Versa HD linear accelerator against MC simulation results. This comparison utilized our in-house software and GUI as the tool, covering various treatment sites and prescriptions. ResultsThe automated MC workflow demonstrated high accuracy in dose calculations and streamlined integration with clinical workflows. The comparison between the MC-simulated and TPS-calculated doses revealed excellent agreement, highlighting the reliability of MC for independent dose verification in complex treatment scenarios. ConclusionsThe automated MC workflow developed represents a substantial improvement in the practicality and efficiency of MC simulations in radiotherapy. This advancement not only simplifies the dosimetry process but also ensures high accuracy, establishing it as a valuable tool for routine patient-specific quality assurance and the development of specialized treatment procedures.

Analysis on the delivery quality assurance using SunCHECK for the VMAT in halcyon linear accelerator

Analysis on the delivery quality assurance using SunCHECK for the VMAT in halcyon linear accelerator

A Deep Learning Approach for the Fast Generation of Synthetic Computed Tomography from Low-Dose Cone Beam Computed Tomography Images on a Linear Accelerator Equipped with Artificial Intelligence

Artificial Intelligence (AI) is revolutionising many aspects of radiotherapy (RT), opening scenarios that were unimaginable just a few years ago. The aim of this study is to propose a Deep Leaning (DL) approach able to quickly generate synthetic Computed Tomography (CT) images from low-dose Cone Beam CT (CBCT) acquired on a modern linear accelerator integrating AI. Methods: A total of 53 patients treated in the pelvic region were enrolled and split into training (30), validation (9), and testing (14). A Generative Adversarial Network (GAN) was trained for 200 epochs. The image accuracy was evaluated by calculating the mean and mean absolute error (ME and ME) between sCT and CT. RT treatment plans were calculated on CT and sCT images, and dose accuracy was evaluated considering Dose Volume Histogram (DVH) and gamma analysis. Results: A total of 4507 images were selected for training. The MAE and ME values in the test set were 36 ± 6 HU and 7 ± 6 HU, respectively. Mean gamma passing rates for 1%/1 mm, 2%/2 mm, and 3%/3 mm tolerance criteria were respectively 93.5 ± 3.4%, 98.0 ± 1.3%, and 99.2 ± 0.7%, with no difference between curative and palliative cases. All the DVH parameters analysed were within 1 Gy of the difference between sCT and CT. Conclusion: This study demonstrated that sCT generation using the DL approach is feasible on low-dose CBCT images. The proposed approach can represent a valid tool to speed up the online adaptive procedure and remove CT simulation from the RT workflow.

Effect of war on radiotherapy in Ukraine and how to help.

1513 Background: The full-scale Russian invasion of Ukraine on February 24th, 2022 brought the largest humanitarian disaster to the heart of Europe since the World War II. In this work, we describe the impact of the full-scale Russian invasion on the radiation therapy (RT) services in Ukraine and suggest how to help. Methods: We collected the information on operation of RT centers in Ukraine during the war. In addition, in 2023 an annual survey was conducted by Grigoriev Institute for Medical Radiology in Kharkiv for the IAEA DIRAC database. The survey was sent to 41 RT centers in Ukraine requesting information on equipment, staffing, and patient volume. Due to the war conditions the data provided in the survey is limited to the un-occupied territories. Results: After the initial Russian invasion of Ukraine in 2014 and occupation of Crimea and parts of Donbas, Ukraine lost access to 7 RT centers with 18 external beam radiotherapy (EBRT) machines (17% of total). Just before the full-scale invasion in 2022, there were a total of 44 Co-60 machines (57%) and 33 linear accelerators (43%) in the unoccupied territories. As a result of the full-scale invasion of Ukraine in 2022, almost all RT centers suspended operation in the first weeks of war. The most challenging period for RT in Ukraine was in March when Kyiv (where 20 EBRT machines are located) was partially surrounded by the occupiers. Based on the DIRAC survey, compared to 2021 data, in 2022 the number of radiation oncologists decreased on average by 2.9%, medical physicists by 6.7%, and therapists by 6.5% but there was a large variation in staffing levels depending on the region and its proximity to war. The workload in the RT centers close to the combat zone almost halved, while increasing by 10 - 60% in the western and central Ukraine. The total number of patients treated with EBRT decreased by 11% and brachytherapy by 21%. Brachytherapy services sustained the most interruption (47% decrease in LDR and 18% decrease in HDR patient volume) due to inability to perform source exchanges. Overall, approximately 5,500 less patients were treated in 2022 compared to 2021. Despite the ongoing war, Ukrainian cancer centers installed 8 new linear accelerators, with 5 linear accelerators pending installation. In addition, the Ministry of Heath of Ukraine has recently purchased 15 linear accelerators to replace the aging Co-60 machine fleet as the future source exchanges might not be possible. There is an acute need in helping Ukraine transition from Co-60 to modern IMRT/VMAT linear accelerators. Conclusions: Radiotherapy in Ukraine sustained significant damages since the 2014 Russian invasion, which was exacerbated further by the full-scale invasion in 2022. To support the vitality and absorptive capacity of RT services in Ukraine, the democratic world can help by donating equipment, hardware, software, and participating in training of Ukrainian RT professionals as they transition to modern and high-quality RT care for Ukrainian cancer patients.

6 MV X-band linear accelerator for stereotactic body radiation therapy

This paper presents the development process of a high-dose X-band linear accelerator (LINAC) for radiotherapy machines, specifically focusing on stereotactic body radiation therapy (SBRT). The development process includes a multi-physics design, approach for the radio frequency cavity in the LINAC, with an emphasis on minimizing beam size and maximizing shunt impedance of the LINAC. Commissioning tests were conducted to evaluate the performance of the LINAC, which involved measurements of beam energy, beam size, beam current, and X-ray dose rate.

Design and thermal-hydraulic analysis of multi-target system with 100 MeV proton linear accelerator for the production of 67Cu and 68Ge radioisotopes

Radioisotopes are widely used in the fields of medicine, science, and industry. The growing demand for medical radioisotopes has driven research on alternative production methods. In particular, both isotopes of 67Cu and 68Ge play vital roles in the medical environment in many countries to be used in the radio-immunotherapy and the positron emission tomography imaging, respectively. This study designed a multi-target system consisting of two Zn and one Ga2O3 plates to enable simultaneous production of the medical radioisotopes 67Cu and 68Ge using 100 MeV proton beams. To understand the thermal effect on the multi-targets, we examined the distribution of energy absorbed in each solid plate target when exposed to an accelerated proton beam through the thermal-fluid analysis based on ANSYS simulation. For confirming thermal stability for two Zn targets and one Ga2O3 target, the modified water flow path inside the multi-target system was designed effectively with the controlled distribution of multiple sub-holes between main inlet and the following four channels. It was confirmed that the newly designed multi-target system of Zn and Ga2O3 solid plates shows higher thermal stability than the case of uniform distribution of water inlet, which means it could be exposed to a higher current beam of 7.57% to decrease the processing time.

Small field dosimetry employing the thermoluminescence technique using a 3D printed phantom

With the advent of new radiotherapy modalities, it has become necessary to apply relatively small fields that are dynamic or static. The use of these field sizes can cause uncertainty in dosimetry, requiring special attention in small field dosimetry. With these mentioned challenges, it is difficult to select a detector with good performance for dosimetry in small fields. TLDs have advantages because they have characteristics such as high spatial resolution and dose response, they offer a promising opportunity to measure the absorbed dose in a small field. The objective of this study is to evaluate the performance of CaSO4:Dy, LiF:Mg,Ti and μLiF:Mg,Ti thermoluminescent dosimeters for clinical photon beams in small field dosimetry using a 3D printed phantom. For clinical application the 6EX linear accelerator from Varian Medical System and the Multillif collimator from BrainLab were used. The 3D printed phantom was subjected to real treatment conditions. The dynamic arc 3D radiosurgery technique was adopted, with a dose of 7 Gy. To decrease statistical variation, the treatment simulation was repeated three times for each dosimeter. The results obtained demonstrated the viability of TLDs for clinical applications from photon beams to small fields. The values showed agreement in percentage terms below ±5% as recommended by the ICRU. The greatest percentage difference found was 1.2% (LiF:Mg;Ti) in relation to the planning system. All thermoluminescent dosimeters presented an uncertainty relatively low, with good stability and reproducibility in all measurements. The 3D printed phantom showed the possibility of achieving real treatment conditions.

Operational Status and Future Plan of Proton Linear Accelerator at KOMAC

Since the second half of 2013, Korea Multi-purpose Accelerator Complex (KOMAC) has been supporting user beam service by using a 100-MeV proton linac and several beam line facilities. Proton beam service fields include various applications and research programs, such as material science, bio-medical science, semiconductor applications as well as nuclear physics and basic science. The 100-MeV linac is composed of an injector based on a 50-keV microwave ion source and two-solenoid LEBT (low energy beam transport), a 3-MeV RFQ with four-vane structure and conventional drift tube linac (DTL), where proton beam is accelerated from 3 MeV to 100 MeV. As the operation period of the proton accelerator exceeds 10 years and the cumulative operating time surpasses 30,000 hours, we judge that it is an opportune time to establish a long-term plan to prepare for the aging of the accelerator. To replace the currently operating RFQ, which shows degradation in performance (especially the beam transmission), we design a new RFQ with some modifications. For DTL, we are supposed to change the quadrupole magnet inside each drift tube from electromagnet type to permanent magnet type because the electromagnet has shown some trouble in view of long term stability. To leap forward in device and utilization technologies, we complete the construction of new facility of a Beam Test Stand (BTS) with a structure similar to the beam injection system (ion source, LEBT, RFQ) of the 100 MeV linear accelerator. We plan to actively conduct beam physics and accelerator research using this facility. Moreover, we are supposed to upgrade the proton linac to 1 GeV for spallation neutron source applications, which will be a long-term plan. In short term, we take phased approach with focusing the first phase at 200 MeV energy upgrade.

Current Applications of PET/MR: Part I: Technical Basics and Preclinical/Clinical Applications.

Positron emission tomography/magnetic resonance (PET/MR) imaging has gone through major hardware improvements in recent years, making it a reliable state-of-the-art hybrid modality in clinical practice. At the same time, image reconstruction, attenuation correction, and motion correction algorithms have significantly evolved to provide high-quality images. Part I of the current review discusses technical basics, pre-clinical applications, and clinical applications of PET/MR in radiation oncology and head and neck imaging. PET/MR offers a broad range of advantages in preclinical and clinical imaging. In the preclinic, small and large animal-dedicated devices were developed, making PET/MR capable of delivering new insight into animal models in diseases and facilitating the development of methods that inform clinical PET/MR. Regarding PET/MR's clinical applications in radiation medicine, PET and MR already play crucial roles in the radiotherapy process. Their combination is particularly significant as it can provide molecular and morphological characteristics that are not achievable with other modalities. In addition, the integration of PET/MR information for therapy planning with linear accelerators is expected to provide potentially unique biomarkers for treatment guidance. Furthermore, in clinical applications in the head and neck region, it has been shown that PET/MR can be an accurate modality in head and neck malignancies for staging and resectability assessment. Also, it can play a crucial role in diagnosing residual or recurrent diseases, reliably distinguishing from oedema and fibrosis. PET/MR can furthermore help with tumour characterization and patient prognostication. Lastly, in head and neck carcinoma of unknown origin, PET/MR, with its diagnostic potential, may obviate multiple imaging sessions in the near future.

Beam loss detection based on generation of Cherenkov light in optical fibers in the CERN Linear Electron Accelerator for Research

Cherenkov optical beam loss monitors (oBLMs) based on optical fibers are a revolutionary achievement among the monitoring systems in particle accelerators. Due to the nature of the Cherenkov phenomenon and the intrinsic characteristics of optical fibers, the photon production and fiber light transmission need to be studied to deduce the total amount of Cherenkov photons detected by the photosensors attached at the end of the system. Simulations of the Cherenkov oBLM detector system have been implemented using the software with postprocessing considering the light attenuation and capture factors in the optical fiber. In addition, the study includes the longitudinal beam loss localization of the controlled beam losses produced along the CERN Linear Electron Accelerator for Research (CLEAR) test facility line. In this paper, the Cherenkov photon detection by an oBLM installed in the CLEAR facility is simulated, analyzed, and compared with experimental data. Published by the American Physical Society 2024

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

FLASH-radiotherapy (RT) presents great potential as an alternative to conventional radiotherapy methods in cancer treatment. In this paper, we focus on simulation studies for a linear particle accelerator injector design using the ASTRA code, which permits beam generation and particle tracking through electromagnetic fields. Space charge-dominated beams were selected with the aim of providing an optimized generated beam profile and accelerator lattice with minimized emittance. The main results of the electron beam and ultra-high dose rate (UHDR) simulation dosimetry studies are reported for the FLASH mode radiobiological treatment. Results for the percentage depth dose (PDD) at electron beam energies of 5, 7, 15, 25, 50, 100 MeV and 1.2 GeV for Poly-methyl-methacrylate (PMMA) and water phantom vs. the penetration depth are presented. Additionally, the PDD transverse profile was simulated for the above energies, delivering the beam to the phantom. The simulation dosimetry results provide an UHDR electron beam under the conditions of the FLASH-RT. The performance of the beam inside the phantom and the dose depth depends on the linear accelerator beam’s energy and stability.

An adaptive integral sliding mode control strategy for medical linear accelerator vacuum system

Medical linear accelerators (MLAs) are critical components for radiation therapy, providing a state-of-the-art treatment platform for cancer therapy. The vacuum system is one of the most important MLA subsystems and its stable operation is necessary to generate high-quality beams. For vacuum system pressure control, traditional proportional-integral-derivative (PID) strategies have disadvantages such as inaccurate and imprecise control response due to its simple calculation. This paper presents an innovative adaptive integral sliding mode control (AISMC) strategy aimed at enhancing the response time, precision of control, and capability to reduce disturbances within the MLA vacuum system. In addition, a nonlinear MLA vacuum system mathematical model is established based on mechanism method. Stability of the developed vacuum control system is validated using Lyapunov stability theory. Simulation results illustrate that the proposed AISMC strategy has better response speed and accuracy than traditional PID-based systems, achieving better pressure tracking performance than traditional sliding mode control strategy with PID control. Most important for the proposed controller, system chattering is effectively mitigated.