The present report describes a family of five infected by parasitic mite, Sarcoptes scabiei in the city of Kashan in central Iran. Family members had to see a doctor due to severe itching at night, insomnia, rash, and burning sensation in the hands and legs, waist, chest and genitals. After the examination, the doctor was suspicious to the contamination caused by mite Sarcoptes, so referred all the family members to a medical laboratory. Father and two sons of the family were infected by mite in their hands, shines, waist, chest, and genitals. Morally, just hands and shins of the mother and daughter were examined, and contamination was determined. The sample provided by microscopic investigation and observation of morphological features was recognized. In terms of ethics and family satisfaction, just pictures were taken from the legs and waist of the son. All infected individuals were treated. For treatment of the family, once a week-use of lindane lotion 1%, and Crotamiton of 10% before sleep every night was recommended. After two weeks, patients were treated, and symptoms were reduced ad the third week and vanished at the fourth week.