Editor, In a randomised clinical study, Jeon et al.1 concluded that in healthy patients with a normal airway, remifentanil 2 or 3 μg kg−1 combined with thiopental 5 mg kg−1 provided acceptable conditions for lightwand intubation without muscle relaxants. However, in our view, there are several issues related to the study design that warrant cautious interpretation of the results. First, after induction of anaesthesia with remifentanil and thiopental, facemask ventilation was maintained for 60 s with 2% sevoflurane in 50% nitrous oxide in oxygen at a total flow rate of 4 l min−1 in all patients. Because sevoflurane has a low blood-gas solubility coefficient (0.67), its onset is very fast.2 Moreover, a synergistic interaction for sedation and analgesia has been shown between remifentanil and sevoflurane.3,4 Thus, we believe that if sevoflurane had not been used during induction of anaesthesia, as in previous studies,5,6 a different result would have been obtained. Second, just like their and other studies have shown,1,7 adequate depth of anaesthesia is critical to successfully perform blind lightwand intubation without muscle relaxants. Inadequate depth of anaesthesia can result not only in delay or failure of lightwand intubation, but also puts the patients at risk of laryngospasm, and even airway damage, due to incomplete relaxation of the larynx. Moreover, in managing difficult airways, smooth intubation without coughing is an important factor to ensure a safe procedure. Thus, we argue that criteria of ‘good’ intubating conditions in this study should not have included a cough response after tracheal intubation, because it is a sign of inadequate inhibition of airway reflexes in anaesthetised patients.8 Also, it is questionable whether the advantage of a faster return to spontaneous ventilation should be achieved at the expense of inferior intubating conditions, especially when managing difficult airways, such as in patients with cervical injury. Third, the sample size calculation in this study was based on a previously similar study,6 and a sample size of 32 patients per group was selected to detect a projected difference of 30% between the groups, with respect to excellent intubating conditions for a type I error of 0.05 and a power of 0.8. Because there was only an absolute difference of 18% (84 versus 66%) in excellent intubating conditions between groups R2 and R3, a statistically significant difference was not achieved. However, the small sample size may have prevented the authors from excluding a type II error when comparing the incidences of excellent intubating conditions between groups R2 and R3. Assuming that the difference of 18% was real, about 85 patients per group would have been required to have an 80% chance of finding a difference. Therefore, this small sample study does not allow the conclusion that remifentanil 2 and 3 μg kg−1, administered concomitantly with thiopental 5 mg kg−1, may provide acceptable conditions for lightwand intubation without muscle relaxants. Fourth, in the methods section, there was no mention of whether intubating conditions and duration of apnoea were assessed by an independent investigator unaware of the doses of remifentanil. If not so, validity of these data remains questionable. Acknowledgements Assistance with the letter: none declared. Financial support and sponsorship: none declared. Conflicts of interest: none declared.