Changes In Light Transmission Research Articles

Study of Electrochromic Properties of PEDOT:PSS for Tunable Filter Optics with Lithium Salt Electrolyte

Nowadays, conductive polymers based on poly(3,4-ethylenedioxythiophene), poly(styrene sulfonic acid), or PEDOT:PSS, have been employed as a flexible and transparent coating in various significant electronic applications. With the demand for electrochromic properties, such as in electronic displays, further research into its electrooptic properties is required, especially the systematic understanding to obtain the optimized switching. Our research investigates the electrooptic properties of the PEDOT:PSS film, particularly the refractive index changing under various applied biases. The electrochromic device is prepared in a simple fashion, and the electroactive layer of PEDOT:PSS thickness is defined via spin-coating between two indium tin oxide (ITO) substrates. To increase the switching properties of PEDOT:PSS, lithium perchlorate (LiClO4) was prepared in acetonitrile, as the electrolyte in varied concentrations of 1.195 M, 1.5 M, and 2.0 M, respectively. A potential voltage of -4.0 V to 0.0 V is utilized to study the device's electrochromic properties with the step 5 mV/s continuously. Finally, the optical properties are characterized using the spectroscopy method based on real-time measurement of the transmission spectrum and transmission matrix calculations. The change in visible light absorption, transmission, and film color is recorded under a switching cycle that shows consistent behavior. This allows the further utilization of such a hybrid structure for possible tunable filter applications. Keywords: Electrochromic, PEDOT:PSS, Optical, Lithium salt, Electrolyte

Results of the gasochromic response on hydrogen of WO3 thin films deposited by electron beam evaporation

Among chromogenic materials, tungsten trioxide (WO3) is of great interest. It is a colourlesssemiconductor characterised by a lack of toxicity and high chemical stability. WO3 exhibits gasochromicproperties, meaning that the material undergoes reversible changes in optical properties when it isexposed to gas. These properties make tungsten oxide a suitable material for sensing applications. Thispaper presents the results of an analysis of the surface, structural and optical properties of tungstenoxide thin films fabricated by electron beam evaporation and annealed at 400C to 800C. Opticalproperties, including gasochromic properties, were determined from light transmission spectra inan atmosphere containing hydrogen at the concentrations ranging from 50 ppm to 500 ppm. Theoptical properties of WO3 films without and with a palladium catalyst layer are applied. Annealing thesamples at temperatures above 400C resulted in crystallisation of the layers, and further post-processmodification at 800C led to sublimation, the formation of islands of crystalline grains of large size anda significant deterioration in optical properties. A change in the light transmission coefficient occurredfor all samples with the catalyst layer applied after the introduction of a hydrogen-argon mixture.Based on the results, it can be concluded that the layers annealed at 400C had the best gasochromic properties due to the greatest changes in light transmission under hydrogen. The study confirmsthat it is possible to improve the gasochromic response of tungsten trioxide thin films produced byelectron beam evaporation using thermal modification, which, to the best of current knowledge, hasnot previously been achieved.Keywords: electronics, WO3, electron beam evaporation, gasochromic properties, optical properties,annealing, optical hydrogen gas sensor

In vitro comparison of platelet aggregation between zalunfiban and selatogrel in healthy donors

Abstract Background Two subcutaneously injected antiplatelet drugs, zalunfiban and selatogrel, are under development for prehospital administration for STEMI and (N)STEMI, respectively. Zalunfiban is a glycoprotein IIb/IIIa inhibitor that produces high-grade inhibition of platelet aggregation induced by ADP or a thrombin receptor activating peptide (TRAP) within 15 minutes. Selatogrel is a P2Y12 inhibitor that produces high-grade inhibition of platelet aggregation initiated by ADP within 15 minutes. We have studied the relative potencies of the drugs at levels achievable in vivo in inhibiting platelet aggregation. Since trisodium citrate (TSC) has been reported to enhance the antiplatelet effect of zalunfiban and inhibit the antiplatelet effect off selatogrel, aggregation studies were performed with both blood anticoagulated with TSC and the non-chelating anticoagulant PPACK. Whereas both ADP and thrombin are present at the site of vascular injury within seconds, we tested the effects of both ADP and TRAP. Purpose To compare directly the effects of zalunfiban and selatogrel on ADP- and TRAP-induced platelet aggregation. Methods Light transmission platelet aggregometry was performed within 4 hours of blood collection (BioData PAP-8E). Whole blood from healthy donors not taking aspirin (N=10) was anticoagulated with 3.2% TSC and 100 μM PPACK. Platelet-rich plasma (PRP) was prepared and adjusted to a platelet count of 250,000/µl. Three clinically relevant incremental concentrations of zalunfiban and selatogrel were added to PRP and platelet aggregation was initiated with 20 μM ADP or 20 μM TRAP. Tracings were recorded for at least 10 minutes after agonist addition. Platelet aggregation was quantified based on the instrument’s measurement of the primary slope (PrSl) of aggregation, which is a measure of the change in light transmission per unit time sustained over at least a 15 second period. Results In TSC-anticoagulated PRP, zalunfiban was more effective in inhibiting the PrSl of both ADP- and TRAP-induced platelet aggregation at all drug concentrations [Figure 1, panel A and B]. In PPACK-anticoagulated PRP, selatogrel showed greater inhibition of ADP-induced platelet aggregation at the lowest concentration tested, similar inhibition at the intermediate concentration, and slightly less inhibition at the highest doses. In sharp contrast, with TRAP-induced aggregation, zalunfiban demonstrated dose-related inhibition, reaching greater than 80% inhibition at the highest dose, whereas selatogrel produced less than 20% inhibition at all three doses. Conclusion Selatogrel is a potent inhibitor of ADP-induced platelet aggregation, but has low impact on TRAP-induced platelet aggregation, whereas zalunfiban is a potent inhibitor of both ADP and TRAP-induced platelet aggregation. The difference between the drugs needs to be considered in light of the known generation of thrombin at the site of vascular injury within seconds.Comparison of Platelet Inhibition

Polymerisation of cyanoacrylates: The effect of sclero-embolic and contrast agents.

The objective is to investigate the interaction of sclero-embolic and contrast agents with the polymerisation of medical grade n-butyl-cyanoacrylates. An in vitro spectrophotometric absorbance method was developed to detect changes in light transmission to measure n-BCA polymerisation. The initiation and the rate-of-polymerisation of mixtures of n-BCA with sclero-embolic and contrast agents were investigated. Initiation of polymerisation: VENABLOCK™ and HISTOACRYL® were the fastest agents to polymerise, while VENASEAL™ was the slowest. Rate of polymerisation: Hypertonic saline inhibited the polymerisation of all n-BCAs, while hypertonic glucose prolonged the polymerisation rate. ETHANOL and detergent sclerosants had no effect. Contrast agents OMNIPAQUE™ and ULTRAVIST® initiated and prolonged the polymerisation of n-BCA, but in contrast, LIPIODOL® failed to initiate the process. The commercially available medical cyanoacrylates differ in their polymerisation rates. These polymerisation rates are further affected when these products are used in conjunction with other compounds, such as sclero-embolic and contrast agents.

Changes in Light Transmittance of Greenhouse Covering Materials and Cucumber Growth as Affected by Particulate Matter

Changes in Light Transmittance of Greenhouse Covering Materials and Cucumber Growth as Affected by Particulate Matter

High performance polythiophene derivative with good electrochromic and energy storage properties electrochemical synthesized in boron trifluoride diethyl etherate

In this study, novel poly(3,4-dibromothiophene) (PDBrTh) is firstly prepared through electrochemical polymerization method using boron trifluoride diethyl etherate (BF3·Et2O) as polymeric solvent. In BF3·Et2O, the electrochemical oxidation potential of 3,4-dibromothiophene is significantly reduced compared with in Acetonitrile/Tetrabutylammonium tetrafluoroborate (ACN/TBATFB) system, which provides conditions for high quality polymer preparation. The prepared PDBrTh in BF3·Et2O shows good electrochemical activity and thermal stability. The electrochromic and supercapacitive performance of the prepared PDBrTh are also studied. The color of the prepared PDBrTh can be reversibly changed between red and blue with fast response time and high optical contrast. Galvanostatic charge-discharge test shows that the prepared PDBrTh also has good electrochemical energy storage performance. The specific capacitance value of the PDBrTh can reach to 229.6 F g−1 under the current density of 1 A g−1, showing good energy storage capacity. An all-polythiophenes electrochromic supercapacitor device (ESD) is constructed by prepared PDBrTh and poly(3,4-ethylenedioxythiophene), the color of the device can change between red and dark blue. The ESD also shows good energy storage property and robust charge-discharge stability. Moreover, the ESD shows obvious color changes and corresponding light transmittance changes during the charging and discharging process, realizing intelligent visual monitoring of the energy storage state. This study shows that the prepared PDBrTh has good practical application potential in the field of intelligent wearable energy storage.

Precise patterning of carbon films on polyethylene terephthalate polymer substrates using femtosecond lasers

A carbon film on a polyethylene terephthalate (PET) substrate is a novel type of flexible laminated material with unique mechanical and electrical properties, making it suitable for the fabrication of various flexible electronic components. However, due to its micron-level thickness, conventional mechanical processing methods are incapable of precisely removing the carbon film without damaging the substrate. Femtosecond laser processing is an advanced technique for achieving precise etching of thin-film materials due to its non-contact, high-precision, and minimal thermal effects. Therefore, we use femtosecond lasers to achieve precision etching of carbon resistive films on PET substrates to minimize substrate damage. In this study, a series of orthogonal and single-factor experiments were conducted to optimize the laser processing parameters. Various measurement and characterization methods, including X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, Raman spectroscopy, ultraviolet–visible spectroscopy, and confocal microscopy, were employed to analyze the removal of the carbon layer, changes in light transmittance, surface quality, and chemical composition of the processed substrate. Furthermore, the mechanisms of carbon film removal and PET substrate damage are explained.

Tunnel lighting calculation model based on bidirectional reflectance distribution function: Considering the dynamic changes in light transmittance in road tunnels

The current tunnel lighting calculation method does not completely consider the dynamic change in light transmittance in a tunnel and reflection characteristics of the tunnel sidewall. Thus, the measured and calculated values of road surface illuminance present a considerable difference, which seriously affects the tunnel lighting design and quality evaluation. To overcome this limitation, in this study, in addition to theoretical analysis and measured experiments, the changing trend in light attenuation is analyzed and a light attenuation model is established. Next, a bidirectional reflectance distribution function that can accurately reflect the reflection characteristics of tunnel sidewall is combined with the light attenuation model and calculation steps based on optical theory to construct a tunnel lighting calculation model considering light transmittance (TLCM-LT). Finally, theoretical calculation and actual measurement verification are conducted via an experimental tunnel simulation, and the results obtained using TLCM-LT are compared with the values calculated based on the Commission Internationale de l'éclairage (CIE), Illuminating Engineering Society of North America (IESNA), and Industry Standards of the People’s Republic of China (JTG) specifications. The results show that the average relative error of the TLCM-LT in a smoke-free environment is 1.31 %. In the presence of smoke, the average relative error of the model fluctuates in the range of 2.19–6.8 % with the change in light transmittance in the tunnel, which is significantly lower than the errors obtained based on the CIE, IESNA, and JTG specifications. Compared with a cement sidewall, the average increase rates in road surface illuminance and illuminance uniformity of the highly diffuse reflective sidewall are 23.21 and 3.65 %, respectively.

Characterization of Synthetic Polymer Coated with Biopolymer Layer with Natural Orange Peel Extract Aimed for Food Packaging.

This research was aimed to make biolayer coatings enriched with orange peel essential oil (OPEO) on synthetic laminate, oriented poly(ethylene-terephthalate)/polypropylene (PET-O/PP). Coating materials were taken from biobased and renewable waste sources, and the developed formulation was targeted for food packaging. The developed materials were characterized for their barrier (O2, CO2, and water vapour), optical (colour, opacity), surface (inventory of peaks by FTIR), and antimicrobial activity. Furthermore, the overall migration from a base layer (PET-O/PP) in an acetic acid (3% HAc) and ethanol aqueous solution (20% EtOH) were measured. The antimicrobial activity of chitosan (Chi)-coated films was assessed against Escherichia coli. Permeation of the uncoated samples (base layer, PET-O/PP) increased with the temperature increase (from 20 °C to 40 °C and 60 °C). Films with Chi-coatings were a better barrier to gases than the control (PET-O/PP) measured at 20 °C. The addition of 1% (w/v) OPEO to the Chi-coating layer showed a permeance decrease of 67% for CO2 and 48% for O2. The overall migrations from PET-O/PP in 3% HAc and 20% EtOH were 1.8 and 2.3 mg/dm2, respectively. Analysis of spectral bands did not indicate any surface structural changes after exposure to food simulants. Water vapour transmission rate values were increased for Chi-coated samples compared to the control. The total colour difference showed a slight colour change for all coated samples (ΔE > 2). No significant changes in light transmission at 600 nm for samples containing 1% and 2% OLEO were observed. The addition of 4% (w/v) OPEO was not enough to obtain a bacteriostatic effect, so future research is needed.

Monitoring the freshness of fish fillets by colorimetric gelatin composite film incorporated with curcumin extract

This study aimed to develop a colorimetric intelligent gelatin composite film incorporated with curcumin to monitor fish fillets' freshness. Chicken skin gelatin composite film's sensing ability in NH3 environments in light transmission and color changes was studied and compared to bovine gelatin composite films. A spoilage test was also performed to evaluate the practical application of colorimetric intelligent films in monitoring the real-time freshness of fish fillets within 4 days of storage time. The results showed that both films possessed low ultraviolet (0.41–1.00) and visible light transmission values (0.16–2.69) while exhibiting good response towards NH3 by changing their color from yellow to reddish-orange, with more obvious color changes at higher relative humidity and response time. The films also showed distinct color changes from yellow to reddish-orange, which were correlated with changes in pH levels of fish fillets within 4 days of storage time. Hence, this indicates that chicken skin gelatin-curcumin composite films could be utilized in colorimetric intelligent food packaging as a visual indicator to monitor the freshness of fish fillets.

Enhanced Visible Light Transmittance and Phase Transition in ZnO/VO2 /AL2O3 Bilayer Thin Film for Energy Efficient Smart Windows.

To ameliorate the limitation of low visible light transmittance of smart window, single phase Vanadium dioxide (VO2) and bilayer of Zinc oxide ZnO/VO2 on Al2O3 substrate were fabricated using the Radio frequency (RF) sputtering technique. These films were deposited at different temperature ranges starting from 28 degrees Celsius which goes up to 90 degrees Celsius. Structural Phase transition was witnessed from monoclinic to rutile phase after a critical temperature (Tc) of 68 degrees Celsius. Structural characterisation was done using the X-rays diffraction(XRD) analysis technique at grazing incidence mode by using monochromatic X – rays (λ = 0.06926 nm). Further, the morphology of the surface structures was studied by using field emission scanning electron microscopy (FESEM). The visible light transmittance change was studied using the Ultra Violet (UV) – Vis spectroscopy in transmittance mode at room temperature. This increased transmittance of the bilayer deposited can be a potential way out to have more efficient smart windows.

The Effects of Staining and Cleaning on the Color and Light Transmittance Changes of a Copolyester Retainer Material with Different Surface Textures.

This study evaluated the efficacy of different cleaning methods with respect to changes in the color and light transmittance of both rough and smooth thermoformed, copolyester retainer specimens, after staining in different solutions. Four hundred copolyester sheets (Essix ACE) specimens were fabricated over molds with different surface textures, smooth and rough. The specimens were stained in four different solutions (n = 100 per solution) over 28 days; then, each of the four groups of 100 stained specimens was sub-divided into five groups of 20 specimens and subjected to a different destaining solution. The specimens were sub-divided with half subjected to an additional ultrasonic cleaning procedure. Light transmittance and color changes were analyzed using a spectrometer/integrating sphere assembly and a spectrophotometer. Mean difference comparisons were performed using appropriate statistical tests at p = 0.05. All five destaining solutions proved to be effective at removing coffee and tea stains. The surface roughness of the retainer material plays a significant role in the ability of cleaning solutions to remove stains, demonstrating a greater effect on cleaning rough specimens with respect to improvements in light transmittance and greater changes in color. Additionally, an ultrasonic cleaning unit generally enhanced the ability of all five solutions to clean the tea-stained specimens. However, the enhancements were only significant for light transmittance.

Clot Waveform Analysis for Monitoring Hemostasis.

Clot waveform analysis (CWA) is a recently developed global coagulation assessment, based on the continuous observation of changes in light transmittance, absorbance, or light scattering that occurs as fibrin formed in a plasma sample during routine clotting tests such as activated partial thromboplastin time (aPTT) and prothrombin time (PT). CWA can utilize qualitative waveform patterns as well as sensitive quantitative parameters and can be used as a simple method to assess global hemostasis, and can be applied to various challenging clinical situations. Although not all coagulation analyzers currently in use are able to provide CWA, the number of analyzers available to do so is increasing, as the usefulness of this process has become more widely recognized. CWA can be based on the coagulation mechanism of aPTT, an intrinsic trigger, and this has been reported in many studies, including diagnosis and treatment of patients with hemophilia, disseminated intravascular coagulation, and monitoring of anticoagulants and thrombosis. CWA using trace amounts of tissue factors also has the potential to expand the applications of this technology. Recently, there have been reports of the combined evaluation of fibrinolytic dynamics. Among the existing global coagulation assays, CWA may prove to be the easiest to standardize in clinical practice. However, more extensive testing using standardized methods in various clinical settings is needed to determine the true role of CWA in the evaluation of hemostasis and thrombosis in the future.

Smoke deposition to water surfaces drives hydrochemical changes

AbstractThis study presents a unique data set from a laboratory experiment where we explored changes in the chemical composition of deionized water samples exposed to smoke. Inside a laboratory hood, water samples placed into a chamber were exposed to smoke for up to 60 min. The pattern of variations in hydrochemistry observed over time with increasing smoke exposure was similar in response to two different smoke treatments generated from burning tree litter. To estimate the smoke dosage and assess the consistency of replicate smoke treatments, we conducted additional experiments to evaluate changes in light transmission. Smoke inputs to the deionized water samples drove changes in hydrochemistry, with increases in acidity (with decreasing pH values), the content of organic matter (with increasing concentrations of dissolved organic carbon and dissolved organic nitrogen), and the content of inorganic N species (with increasing concentrations of ammonium, nitrate, and nitrite). The study was conducted on deionized water samples, and the results may not be directly transferrable to natural waters. Stream or lake waters that are low in ionic strength, poorly buffered, or low in acid‐neutralizing capacity might respond the most similar to the results of this study. In contrast, well‐buffered surface waters having higher acid‐neutralizing capacity would be more likely to neutralize acidic inputs from the smoke without significant effects on water quality. The publicly available dataset associated with this study will contribute to further consideration of the relative importance of short‐term changes in hydrochemistry driven by in‐stream inputs (e.g., changes in water chemistry from direct smoke deposition to the water surface) in contrast to terrestrial inputs (e.g., changes in water chemistry stemming from altered flow paths and source areas of the burned watershed landscape).

Determination of indicators allowing to evaluating the hemostatic activity of chitosan without a biological experiment

The biopolymer chitosan is widely used for the development of local hemostatic agents. However, the physicochemical parameters of chitosan that determine its hemostatic properties have not yet been determined. Standard quality control of chitosan-containing raw materials and medical products on its basis do not allow us to make a conclusion about the effectiveness of their use for stopping bleeding. The most reliable method for assessing hemostatic activity remains in vivo experiment on large animals. The aim of this study was to determine additional physicochemical parameters of chitosan, which would make it possible to predict its hemostatic activity without conducting a biological experiment. In this work, using the methods of nuclear magnetic resonance spectroscopy, spectrophotometry and viscometry, it has been shown that the ability to initiate hemostasis is depending of the molecular weight and degree of deacetylation of chitosan, but not enough linearly. The hemostatic properties in vitro increases in a series of samples with a relatively constant molecular weight with an increase in the degree of deacetylation. As well as in a series with the same degree of deacetylation with an increase in molecular weight. However, at molecular weight values more than 300 kDa, the viscosity of the polymer causes the opposite effect: with an increase in the degree of deacetylation, the hemostatic activity decreases. The best ability to initiate hemostasis have chitosan samples with a degree of deacetylation of 90.0%–97.4% and molecular weight 145.7–284.7 kDa, in which at pH of solution close to physiological, a significant part of the molecules transitioned from conformation state rigid rod to state globule. It was accompanied by an abrupt change in light transmission of the solution. It was concluded, that it is possible to study conformational states by spectrophotometry to assess the hemostatic activity of chitosan samples without performing biological experiment.

Implications of Wound Healing on Subcutaneous Photovoltaic Energy Harvesting.

Cardiac pacemakers must be regularly replaced due to depleted batteries. A possible alternative is proposed by subcutaneous photovoltaic energy harvesting. The body's reaction to an implant can cause device encapsulation. Potential changes in spectral light transmission of skin can influence the performance of subcutaneous photovoltaic cells and has not yet been studied in large animal studies. Subcutaneous implants measuring changes in the light reaching the implant were developed. Three pigs received those implants and were analyzed for seven weeks. Spectral measurements with known irradiation were performed to identify possible changes in the transparency of the tissues above the implant during the wound healing process. A histological analysis at the end of the trial investigated the skin tissue above the subcutaneous photovoltaic implants. The implants measured decreasing light intensity and shifts in the light's spectrum during the initial wound healing phase. In a later stage of tissue recovery, the implants measured a generally reduced light intensity compared to the healthy tissue after implantation. The spectral distribution of the measured light at the end of the trial was similar to the first measurements. The histological analysis showed subcutaneous granulation tissue formation for all devices. The varying reduction of light intensity reaching the implants means that safety margins must be sufficiently high to ensure the power. At the end of the wound healing process, the spectral distribution of the light reaching the implant is similar to healthy tissue. Optimizations of spectral sensitivity of photovoltaic cells are possible.

Chemical, thermal, and mechanical properties and ultraviolet transmittance of novel nano‐hydroxyapatite/polyethylene terephthalate milk bottles

AbstractPolyethylene terephthalate (PET)/nano‐hydroxyapatite (nHAp) composite granules were obtained using twin‐screw extruder. Preforms were prepared by injection molding and then PET/nHAp bottles were produced by blow molding. For PET bottles with nHAp, the migration amounts of carboxylic acid (COOH), acetaldehyde (AA), diethylene glycol (DEG), and isophthalic acid (IPA); glass transition temperature (Tg); melting temperature (Tm); and the maximum crystallization temperature (Tcry) were measured. The load‐carrying capacity, burst strength, stress cracking, and regional material distribution tests were carried out on the bottles. X‐ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and ultraviolet transmittance analyses were conducted to explain the changes in mechanical, chemical, physical properties, and light transmission of bottles. It was found out that the COOH amount increased and the AA content decreased with increasing nHAp amount. On the other hand, no change was observed in the amounts of DEG and IPA. Although the mechanical properties such as load‐carrying capacity and burst strength of the bottles have improved, it has been determined that the standard environmental stress crack resistance test procedure cannot be applied to such a composite. Experimental findings indicate that nHAp disrupts the chemical structure of PET and it isolates harmful chemicals such as AA by forming intermolecular bonds. Moreover, with the addition of up to 0.8% nHAp, PET bottles block the light transmission approximately 80% within 400–700 nm wave length zone. The study demonstrates that the PET/nHAp composite bottles can be used in the food industry, particularly in the packaging of milk and milk products which are vulnerable to light exposure.

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring.

Photoplethysmography (PPG) is a low-cost, noninvasive optical technique that uses change in light transmission with changes in blood volume within tissue to provide information for cardiovascular health and fitness. As remote health and wearable medical devices become more prevalent, PPG devices are being developed as part of wearable systems to monitor parameters such as heart rate (HR) that do not require complex analysis of the PPG waveform. However, complex analyses of the PPG waveform yield valuable clinical information, such as: blood pressure, respiratory information, sympathetic nervous system activity, and heart rate variability. Systems aiming to derive such complex parameters do not always account for realistic sources of noise, as testing is performed within controlled parameter spaces. A wearable monitoring tool to be used beyond fitness and heart rate must account for noise sources originating from individual patient variations (e.g., skin tone, obesity, age, and gender), physiology (e.g., respiration, venous pulsation, body site of measurement, and body temperature), and external perturbations of the device itself (e.g., motion artifact, ambient light, and applied pressure to the skin). Here, we present a comprehensive review of the literature that aims to summarize these noise sources for future PPG device development for use in health monitoring.

Prevalence and Clinical Predictors of Aspirin Resistance in Heart Transplant Recipients

<h3>Purpose</h3> Enhanced platelet activation is strongly associated with the development and progression of transplant vasculopathy. Aspirin is thought to be associated with improved graft survival and reduced cardiac allograft vasculopathy in heart transplant (HT) recipients. The assessment of aspirin resistance by laboratory methods is potentially of great therapeutic importance, as it would enable identification of patients at risk for clinical events and allow intervention to prevent subsequent morbidity or mortality. We aimed to determine the prevalence and clinical predictors of aspirin resistance following HT. <h3>Methods</h3> We evaluated 67 stable HT recipients receiving antiplatelet monotherapy with aspirin (100 mg/day≥1 month). Platelets were stimulated with adenosine diphosphate (ADP) and arachidonic acid (AA), and aggregation was assessed using light-transmitted aggregometry. Aggregation was expressed as the maximal percent change in light transmittance from baseline. Aspirin resistance was defined as AA-induced platelet aggregation of ≥20%. <h3>Results</h3> Mean AA-induced aggregation was 29.6 ±24.8%. Of the total cohort, 40 patients (60%) were aspirin resistant and 27 (40%) were not. Aspirin-resistant patients had higher HbA1c values (7.7%±1.5 vs 5.3%±0.9, p<0.001) and higher prevalence of de-novo donor specific antibodies (DSA) (43 vs 11%, p=0.013). There were no differences in aspirin resistance by baseline donor and recipient characteristics (i.e., age, gender, etiology, BMI, hypertension, hemodynamics, immunosuppression). In a multivariable analysis (Figure) HbA1c and DSA were independently associated with a significantly higher risk of aspirin resistance. <h3>Conclusion</h3> Our study suggests a high rate of aspirin resistance in HT patients, which was associated with higher DSA and HbA1c levels, both known risk factors for transplant vasculopathy and survival. Further studies are needed to correlate aspirin resistance with clinical outcomes and hence to tailor therapeutic interventions.

Experimental study on acoustic condensation fog elimination in traveling wave tube

Acoustic condensation artificial fog elimination has the advantages of wide application range, good economy, flexible and controllable operation area, and does not affect traffic operation. The characteristics of the fog, the frequency and intensity of the acting sound waves have an important influence on the effect of condensation and fog elimination. This paper studies the influence of the frequency of fog on the microscopic particle size distribution and the change of light transmission in the process of fog elimination from both theoretical and experimental aspects. The research results show that for natural fog conditions with low concentration, the time of pure sound wave action takes several minutes to tens of minutes. Under the condition of high-concentration artificial fog, the anti-fog time can be shortened to tens of seconds. Simulations and experiments have both confirmed that sound waves can significantly promote fog elimination, and there is an optimal frequency between 200Hz-700Hz.