Light-responsive Nanoparticles Research Articles

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment.

Cancer is a complex and multifaceted disease that continues to be a global health challenge. It exerts a tremendous burden on individuals, families, healthcare systems, and society as a whole. To mitigate the impact of cancer, concerted efforts and collaboration on a global scale are essential. This includes strengthening preventive measures, promoting early detection, and advancing effective treatment strategies. In the field of cancer treatment, researchers and clinicians are constantly seeking new approaches and technologies to improve therapeutic outcomes and minimize adverse effects. One promising avenue of investigation is the utilization of the Fenton reaction, a chemical process that involves the generation of highly reactive hydroxyl radicals (·OH) through the interaction of hydrogen peroxide (H2O2) with ferrous ions (Fe2+). The generated ·OH radicals possess strong oxidative properties, which can lead to the selective destruction of cancer cells. In recent years, researchers have successfully introduced the Fenton reaction into the cancer microenvironment through the application of nanotechnology, such as polymer nanoparticles and light-responsive nanoparticles. This article reviews the progress of the application of the Fenton reaction, catalyzed by polymer nanoparticles and light-responsive nanoparticles, in the cancer microenvironment, as well as the potential applications and future development directions of the Fenton reaction in the field of tumor treatment.

Degradation of cefadroxil drug by newly designed solar light responsive alcoholic template-based lanthanum ferrite nanoparticles

In this work, lanthanum ferrite nanoparticles were synthesized via a simple co-precipitation method. Two different templates, namely sorbitol and mannitol, were used in this synthesis to tune the optical, structural, morphological, and photocatalytic properties of lanthanum ferrite. The synthesized lanthanum ferrite-sorbitol (LFOCo-So) and lanthanum ferrite-mannitol (LFOCo-Mo) were investigated through Ultraviolet–Visible (UV–Vis), X-ray diffraction (XRD), Fourier Transform Infra-Red (FTIR), Raman, Scanning Electron Microscopy-Energy Dispersive X-ray (SEM-EDX), and photoluminescence (PL) techniques to study the effects of the templates on the tunable properties of lanthanum ferrite nanoparticles. The UV–Vis study revealed a remarkably small bandgap (2.09 eV) of LFOCo-So compared to the LFOCo-Mo having a band gap of 2.46 eV. XRD analysis revealed a single-phased structure of LFOCo-So, whereas LFOCo-Mo showed different phases. The calculated crystallite sizes of LFOCo-So and LFOCo-Mo were 22 nm and 39 nm, respectively. FTIR spectroscopy indicated the characteristics of metal-oxygen vibrations of perovskites in both lanthanum ferrite (LFO) nanoparticles, whereas a slight shifting of Raman scattering modes in LFOCo-Mo in contrast to LFOCo-So showed the octahedral distortion of the perovskite by changing the template. SEM micrographs indicated porous particles of lanthanum ferrite with LFOCo-So being more uniformly distributed, and EDX confirmed the stoichiometric ratios of the lanthanum, iron, and oxygen in the fabricated lanthanum ferrite. The high-intensity green emission in the photoluminescence spectrum of LFOCo-So indicated more prominent oxygen vacancies than LFOCo-Mo. The photocatalytic efficiency of synthesized LFOCo-So and LFOCo-Mo was investigated against cefadroxil drug under solar light irradiation. At optimized photocatalytic conditions, LFOCo-So showed higher degradation efficiency of 87% in only 20 min than LFOCo-Mo having photocatalytic activity of 81%. The excellent recyclability of the LFOCo-So reflected that it could be reused without affecting photocatalytic efficiency. These findings showed that sorbitol is a useful template for the lanthanum ferrite particles imparting outstanding features, enabling it to be used as an efficient photocatalyst for environmental remediation.

Remediation of recalcitrant pollutants in water solution using visible light responsive cerium-doped tungsten trioxide nanoparticles.

In order to attain a solar energy-driven photocatalyst for wastewater remediation, cerium-doped WO3 (W1-xCexO3 with x = 0, 0.02, 0.04, 0.06, and 0.08) nanoparticles have been synthesized via a chemical co-precipitation technique. X-ray diffraction (XRD) analysis confirmed that W1-xCexO3 nanoparticles retained their monoclinic structure even after doping. The presence of the vast number of defects produced in the WO3 lattice was corroborated by Raman spectroscopy. Scanning electron microscopy confirmed the spherical shape of the nanoparticles with particle size range 50-76 nm. The optical band gap of W1-xCexO3 nanoparticles decreases from 3.07 to 2.36 eV with an increase in x, as confirmed by UV-Vis spectroscopy. Photoluminescence (PL) spectroscopy confirmed that the minimum rate of recombination was observed for W1-xCexO3 with x = 0.04. Degradation efficiency was explored for methyl violet (MV) and rhodamine-B (Rh-B) with 0.01 g of photocatalyst in a photoreactor chamber having a 200-W xenon lamp as a visible source of light. The results showed that the maximum photo-decolorization towards MV (94%) and rhodamine-B (79.4%) was observed in x = 0.04 sample in just 90 min because of its least recombination rate, highest adsorption capacity, and optimum band edge positions. Intriguingly, it has been observed that the modification with cerium in WO3 nanoparticles enhances the photocatalytic activity by narrowing the band gap and by efficaciously lowering the recombination rate due to electron entrapment by defects produced in the lattice.

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

A novel light responsive nanosphere was constructed, and it was used as a drug carrier to investigate the loading and release properties of the Quercetin (QU). In this paper, mesoporous silica nanoparticles (MSN) were used as a substrate, and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce —NH2, and the azobenzene-4,4′-dicarboxylic acid (AZO) was used as light responsive agent to introduce the group of —N = N—, and then β-cyclodextrin (β-CD) was combined with AZO through host–guest interaction to construct light responsive nanoparticles (MSN@β-CD). The structure and properties of the carrier were analyzed by FTIR, BET, XPS, TGA, XRD, SEM and TEM. In vitro drug release studies showed the release rate of QU@MSN@β-CD (dark) was 12.19% within 72 h, but the release rate of QU@MSN@β-CD (light 10 min) was 26.09%, exhibiting a light-responsive property. The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU. Therefore, the controllable light-responsive drug delivery system has great application prospects.

Preparation of near-infrared light responsive upconversion nanoparticles TiO2/(Ca,Y)F2:Tm,Yb for photodynamic antitumor therapy

Preparation of near-infrared light responsive upconversion nanoparticles TiO2/(Ca,Y)F2:Tm,Yb for photodynamic antitumor therapy

The dynamic therapeutic effect of a targeted photothermal nanovaccine incorporating toll-like receptor 7 agonist enhanced cancer immunotherapy.

Photothermal therapy (PTT) is a noninvasive and effective thermal therapeutic approach. Near-infrared (NIR) light responsive organic nanoparticles (NPs) have been shown to enhance the efficacy of cancer PTT. However, photothermal ablation induced NPs are currently more effective in treating primary and metastatic cancer. Herein, we designed a NIR light responsive theranostic nanosystem that combines PTT with immunotherapy. The caffeic acid doped polyaniline NPs (CA-PANi) were explored for their potential as PTT agents and their ability to mediate immunogenic cell death (ICD). The nano-theranostic agent of CA-PANi functionalized with the RGD (Arg-Gly-Asp) peptide plays a functional role in targeting integrin receptor overexpressed cancer cells. Furthermore, to enhance the immune response in the immune suppressive tumor microenvironment (iTME), imiquimod (R837) a Toll-like receptor 7 agonist that can promote dendritic cell (DC) maturation greatly inhibits tumor growth and tumor recurrence by initiating a strong antitumor immune response. Therefore, combination of PTT and immunotherapy involving CA-PANi-R837-RGD (denoted as CPRR) to improve the therapeutic effect will provide a nanovaccine strategy for targeted antitumor therapy.

NIR-II Responsive Upconversion Nanoprobe with Simultaneously Enhanced Single-Band Red Luminescence and Phase/Size Control for Bioimaging and Photodynamic Therapy.

Lanthanide based upconversion (UC) nanoprobes have emerged as promising agents for biological applications. Extending the excitation light to the second near-infrared (NIR-II), instead of the traditional 980/808 nm light, and realizing NIR-II responsive single-band red UC emission is highly demanded for bioimaging application, which has not yet been explored. Here, a new type of NIR-II (1532nm) light responsive UC nanoparticles (UCNPs) with enhanced single-band red UC emission and controllable phase and size is designed by introducing Er3+ as sensitizer and utilizing Mn2+ as energy manipulator. Through tuning the content of Mn2+ in NaLnF4 :Er/Mn, the crystal phase, size, and emitting color are readily controlled, and the red-to-green (R/G) ratio is significantly increased from ≈20 to ≈300, leading to NIR-II responsive single band red emission via efficient energy transfer between Er3+ and Mn2+ . In addition, the single band red emitting intensity can be further improved by coating shell to avoid the surface quenching effect. More importantly, NIR-II light activated red UC bioimaging and photodynamic therapy through loading photosensitizer of zinc phthalocyanine are successfully achieved for the first time. These findings provide a new strategy of designing NIR-II light responsive single-band red emissive UCNPs for biomedical applications.

Interstitial Photothermal Therapy Generates Durable Treatment Responses in Neuroblastoma.

Photothermal therapy (PTT) represents a promising modality for tumor control typically using infrared light-responsive nanoparticles illuminated by a wavelength-matched external laser. However, due to the constraints of light penetration, PTT is generally restricted to superficially accessible tumors. With the goal of extending the benefits of PTT to all tumor settings, interstitial PTT (I-PTT) is evaluated by the photothermal activation of intratumorally administered Prussian blue nanoparticles witha laser fiber positioned interstitially within the tumor. This interstitial fiber, which is fitted with a terminal diffuser, distributes light within the tumor microenvironment from the "inside-out" as compared to from the "outside-in" traditionally observed during superficially administered PTT (S-PTT). I-PTT improves the heating efficiency and heat distribution within a target treatment area compared to S-PTT. Additionally, I-PTT generates increased cytotoxicity and thermal damage at equivalent thermal doses, and elicits immunogenic cell death at lower thermal doses in targeted neuroblastoma tumor cells compared to S-PTT. In vivo, I-PTT induces significantly higher long-term tumor regression, lower rates of tumor recurrence, and improved long-term survival in multiple syngeneic murine models of neuroblastoma. This study highlights the significantly enhanced therapeutic benefit of I-PTT compared to traditional S-PTT as a promising treatment modality for solid tumors.

Enhanced heterogenous photo-Fenton degradation of tetracycline in aqueous medium by visible light responsive sulphur dopped zinc ferrite nanoparticles

Tetracycline (TC) is a common antibiotic that is eco-toxic and readily develops bacterial resistance, so it must be removed from the water system. Herein, first-time non-metal (Sulphur) dopped Zinc Ferrite (S-ZnFe2O4) was prepared through a single-step calcining process to study the tetracycline removal performance from water. The effects of catalyst dose, initial pH, co-existing anions, and H2O2 concentration on tetracycline removal were explored. The related degradation kinetics were studied using various models with experimental data, and it turned out that S-ZnFe2O4 exhibited an optimum tetracycline removal efficiency of 95.41% after 70 min, which is much better than the majority of Photo-Fenton catalysts. Furthermore, the electron paramagnetic resonance (EPR) analysis and quenching studies revealed that hydroxyl radicals (•OH) and hole (h+) production led to fast tetracycline degradation in the Vis/S-ZnFe2O4/H2O2 system. In particular, the S-ZnFe2O4 demonstrated superparamagnetic properties and high stability, enabling effective catalysis recovery and utilization via an external magnetic field. Based on the degradation products identified by liquid chromatography-mass spectrometry (LC-MS), three possible degradation pathways of TC were proposed in the Vis/S-ZnFe2O4/H2O2 system. In addition, a significant amount of mineralization was found as total organic carbon (TOC) removal efficiencies were 84.4% within 70 min. The toxicity evaluation with activated sludge showed that the TC solution toxicity increased during the first 30 min, but later on significantly decreased as the oxidation proceeded. This work indicates the S-ZnFe2O4 nanoparticles and gives a new outlook for photo Fenton degradation to reduce the amount and toxicity of antibiotics (TC) effectively in water supplies.

Visible light responsive S-Doped TiO2 nanoparticles: synthesis, characterization and photocatalytic degradation of pollutants

Visible light responsive S-Doped TiO2 nanoparticles: synthesis, characterization and photocatalytic degradation of pollutants

Stimuli-responsive nanoplatforms for antibacterial applications.

The continuously increasing bacterial resistance has become a big threat to public health worldwide, which makes it urgent to develop innovative antibacterial strategies. Nanotechnology-based drug delivery systems are considered as promising strategies in combating bacterial infections which are expected to improve the therapeutic efficacy and minimize the side effects. Unfortunately, the conventional nanodrug delivery systems always suffer from practical dilemmas, including incomplete and slow drug release, insufficient accumulation in infected sites, and weak biofilm penetration ability. Stimuli-responsive nanoplatforms are hence developed to overcome the disadvantages of conventional nanoparticles. In this review, we provide an extensive review of the recent progress of endogenous and exogenous stimuli-responsive nanoplatforms in the antibacterial area, including planktonic bacteria, intracellular bacteria, and bacterial biofilms. Taking advantage of the specific infected microenvironment (pH, enzyme, redox, and toxin), the mechanisms and strategies of the design of endogenous stimuli-responsive nanoplatforms are discussed, with an emphasis on how to improve the therapeutic efficacy and minimize side effects. How to realize controlled drug delivery using exogenous stimuli-responsive nanoplatforms especially light-responsive nanoparticles for improved antibacterial effects is another topic of this review. We especially highlight photothermal-triggered drug delivery systems by the combination of photothermal agents and thermo-responsive materials. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.

Tumor acidity and near-infrared light responsive drug delivery MoS2-based nanoparticles for chemo-photothermal therapy

The rational design of tumor microenvironment (TME)- multifunctional stimuli-responsive nanocomposites is appealing for effective cancer treatment. However, multidrug resistance remains an obstacle to construct responsive oncotherapy. Herein, a novel MoS2/PDA-TPP nanocomposite loaded with chemotherapy drug of doxorubicin (DOX) is designed for TME dual-response and synergistically enhanced anti-tumor therapy based on the tumor-specific mitochondria accumulation ability and photothermal (PTT) therapy. In detail, the designed MoS2/PDA-TPP nanoplatform can act as a pH-responsive dissociation to endow fast release of DOX under an acidic TME and simultaneously improve the efficiency of PTT. Moreover, the mechanism shows that MoS2/PDA-TPP trigger mitochondrial-dependent apoptosis by producing reactive oxygen species (ROS) and reducing mitochondrial membrane potential (MMP). Most importantly, during PTT procedure, hyperthermia up to 50 °C can effectively induce tumor cell death without causing severe inflammation to adjacent tissues. Tumor targeting double stimulation response of nanocomposites is a novel idea to overcome drug resistance, which will provide a more effective strategy for solving practical problems.

Doxorubicin loaded polyvinylpyrrolidone-copper sulfide nanoparticles enabling mucoadhesiveness and chemo-photothermal synergism for effective killing of breast cancer cells

The synergistic effect of chemo-photothermal therapy by near-infrared light-responsive nanoparticles is being widely researched. The combination of chemo-photothermal effects reduces the regrowth of tumor residuals by enhancing therapeutic coverage when compared with a single treatment modality. In the current study, doxorubicin hydrochloride-loaded polyvinylpyrrolidone-copper sulfide nanoparticles (DP-CuS NPs) were synthesized by a facile one-pot method. DP-CuS NPs showed good muco-adherence and also acted as an efficient chemo-photothermal agent. The polyvinylpyrrolidone (PVP) coating prevented the aggregation of CuS NPs and helped in stabilizing the size (hydrodynamic diameter ̴35nm) of the synthesized nanoparticle. PVP also served as a cargo, enabling the loading of a chemotherapeutic drug (doxorubicin) with an efficiency of ̴75 %. The localized release of doxorubicin was achieved by photothermal/pH trigger upon DP-CuS NPs, enhancing therapeutic efficiency. DP-CuS NPs, when treated with breast cancer cell line (MCF 7), exhibited efficient cancer cell cytotoxicity (cell viability: ̴11 %) and photothermal triggered mucolytic properties. These nanoparticles were also effective in preventing the growth of residual cancer cells through their mucolytic property and chemo-photothermal dual therapeutic effect.

Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT

Although nanoparticles (NPs) bear a great potential in tumour therapy, just a few nanosized drug delivery systems are commercially available. Besides their advantages like passive drug targeting and stable embedment of lipophilic active pharmaceutical ingredients, targeted drug release is a major challenge for a safe therapy. While drug release of commonly used materials depends on physiological factors, nanoparticles prepared by using stimuli responsive polymers offer a promising approach. External irradiation of light-sensitive nanoparticles enables local drug release, resulting in selective accumulation and consequently more effective treatment with less side effects. In this study light-responsive nanoparticles based on a new innovative light-responsive polyester (Nip-SLrPE) combined with poly(DL-lactide-co-glycolide) (PLGA) were prepared and examined for their physicochemical characteristics and light-triggered properties. As model drug the photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorine (mTHPC) was incorporated and light-depending drug release was investigated. Furthermore, cytotoxic potential of selected formulations for PDT and intracellular accumulation of mTHPC were evaluated. In conclusion, nanoparticles based on the new light-sensitive Nip-SLrPE showed auspicious light-responsive properties, resulting in promising results for a smart drug delivery system.

Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses.

Vision is the most dominant of our senses, and it is crucial in every stage of our lives. Ocular diseases, regardless of whether they cause vision impairment or not, lead to personal and financial hardships. The anatomy and physiology of the eye strongly limit the efficacy of current ocular drug delivery strategies. Nanotechnology has been the ground for the development of powerful strategies in several fields, namely in medicine. This review highlights emerging nanotechnology-based solutions for improving ocular drug delivery and thus the bioavailability and efficacy of drugs. We focus our review on ambitious but promising approaches currently emerging to leverage the efficacy of nanoparticle-based systems in ocular therapy: (i) light-responsive nanoparticles, which enable spatiotemporal control of drug release; (ii) mesoporous silica nanoparticles, which offer high surface area-to-volume ratio, simple surface modification, good biocompatibility, and improved bioavailability; and (iii) contact lenses, which serve as a compliant method of nanoparticles use and as drug delivery systems for the treatment of ocular diseases.

Construction of ferrocene modified and indocyanine green loaded multifunctional mesoporous silica nanoparticle for simultaneous chemodynamic/photothermal/photodynamic therapy

Near-infrared (NIR) light responsive multifunctional nanoparticles were constructed by ferrocene modified, indocyanine green (ICG) loaded and β-cyclodextrin (β-CD) capped mesoporous silica (MSN) for collaborative chemodynamic/ photothermal/photodynamic (CDT/PTT/PDT) therapy in vitro. In the multifunctional nanoparticles, the covalently conjugated ferrocene was acted as a catalyst for converting the high level of intracellular hydrogen peroxide (H2O2) into high-toxic hydroxyl radical (OH), the encapsulated ICG was served as both photothermal agent and photosensitizer to generate hyperpyrexia and singlet oxygen (1O2) respectively by absorbing NIR light, and the outmost β-CD was worked as a shielding layer to prevent ICG from leakage and improve the dispersity of as-prepared nanoparticles. After the nanoparticles were endocytosed by cancer cells, the hyperpyrexia generated by ICG upon NIR light irradiation not only is able to directly kill cancer cells for photothermal therapy (PTT), but also enables to dissociate the capped β-CD and thus expose the inner ferrocene. On this basis, the exposed ferrocene could convert the intracellular H2O2 into toxic OH via ferrocene-mediated Fenton reaction for efficiently killing cancer cells (chemodynamic therapy, CDT). Moreover, the generated 1O2 by ICG could further kill the cancer cells for photodynamic therapy (PDT) in a collaborative way. The results of in vitro experiments suggest that the collaborative CDT/PTT/PDT shows significantly amplified inhibition rate of HeLa cells compared to single CDT or dual PTT/PDT, endowing the multifunctional nanoparticles with great potential in cancer synergistic treatments.

Ultrastable Near-Infrared Nonlinear Organic Chromophore Nanoparticles with Intramolecular Charge Transfer for Dually Photoinduced Tumor Ablation.

Near-infrared (NIR) light-responsive nanoparticles (NPs) of organic photosensitizers (PS) hold great promise as phototherapeutic agents for precision photoinduced cancer therapy. However, highly photostable PS nanoparticles with extraordinary photoconversion capacities are urgently desired to fully realize potent phototherapy. Here, NIR nonlinear organic chromophore nanoparticles (NOC-NPs) are shown as single-component PS for dually cooperative phototherapy. Upon 785nm irradiation, excited NOC-NPs pass through intrinsic intramolecular charge transfer (ICT) channel to generate both abundant singlet oxygen and local hyperthermia, affording synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor ablation. Furthermore, NOC-NPs exhibit dramatic photostability, enhanced cellular uptake, effective cytoplasmic translocation, as well as preferable tumor accumulation, further ensuring favorable in vivo singlet oxygen generation and hyperthermia for photoinduced tumor ablation. Thus, NOC-NPs may represent novel high-performance PS for synergistic photoinduced cancer therapy, providing new insights into the development of potent PS for clinical translation.

Visible Light-Responsive Drug Delivery Nanoparticle via Donor-Acceptor Stenhouse Adducts (DASA).

Stimuli-responsive drug release from a nanocarrier triggered by light enables the control of the amount of drug locally. Here, block copolymer micelles based on poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) as the hydrophilic block and a polymer with pendant donor-acceptor Stenhouse adducts (DASA) are used as a means to trigger the release of drugs under green light. The micelles are loaded with ellipticine to yield light-responsive nanoparticles with sizes of around 35nm according to transmission electron microscopy (TEM) analysis. Two micelles with a drug loading content of 4.75 and 7.4wt% are prepared, but the micelle with the higher drug loading content leads to substantial protein adsorption. The release of ellipticine from the micelle, which is monitored using the polarity-sensitive fluorescence of ellipticine, can be switched on by light and off by thermal recovery of DASA in the dark. The micelles are readily taken up by Michigan Cancer Foundation-7 breast cancer cells. Subsequent light irradiation leads to enhanced drug release inside the cell as seen by the enhanced fluorescence.

Recent Advances on Graphene Quantum Dots as Multifunctional Nanoplatforms for Cancer Treatment.

Graphene quantum dots (GQDs), the latest member of the graphene family, have attracted enormous interest in the last few years, due to their exceptional physical, chemical, electrical, optical, and biological properties. Their strong size-dependent photoluminescence and the presence of many reactive groups on the graphene surface allow their multimodal conjugation with therapeutic agents, targeting ligands, polymers, light responsive agents, fluorescent dyes, and functional nanoparticles, making them valuable agents for cancer diagnosis and treatment. In this review, the very recent advances covering the last 3 years on the applications of GQDs as drug delivery systems and theranostic tools for anticancer therapy are discussed, highlighting the relevant factors which regulate their biocompatibility. Among these factors, the size, kind, and degree of surface functionalization have shown to greatly affect their use in biological systems. Toxicity issues, which still represent an open challenge for the clinical development of GQDs based therapeutic agents, are also discussed at cellular and animal levels.

Visible light photocatalytic properties of cubic and orthorhombic SnS nanoparticles

Visible light responsive nanoparticles (NPs) of cubic and orthorhombic phase SnS were prepared via wet chemical route using triethanolamine (TEA) and ethylene glycol (EG) as complexing agents respectively. The average crystallite size of cubic SnS nanoparticles as calculated for (4 0 0) plane increased from 31 nm to 42 nm when pH of the final solution is increased from 10 to 10.6. The HRTEM images indicated highly crystalline nature of the as-grown NPs of SnS with ordered atomic planes. The photocatalytic property of the samples was also explored by the photodegradation of methylene blue (MB) under visible light irradiation. The photodegradation efficiencies of the cubic and orthorhombic SnS nanoparticles over MB dye were found to be 88% and 98% respectively for an irradiation time of 45 min. Electrochemical properties of both the samples were studied by means of cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Orthorhombic SnS NPs with low charge transfer resistance, showed slightly higher photocatalytic activity than the cubic SnS. The results indicate the potential application of SnS NPs in natural sunlight-driven photocatalytic oxidation of industrial dyes and consequent cost-effective treatment of waste water from textile industries.