You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History/Evaluation and Markers1 Apr 20121729 N-ACETYLTRANSFERASE-2 GENE POLYMORPHISMS AND PROSTATE CANCER SUSCEPTIBILITY IN LATIN AMERICAN PATIENTS Mario Lima, Leonardo Reis, Ana Carolina Guilhen, Fabiana Granja, Mariana Oliveira, Ubirajara Ferreira, and Laura Ward Mario LimaMario Lima Campinas, Brazil More articles by this author , Leonardo ReisLeonardo Reis Campinas, Brazil More articles by this author , Ana Carolina GuilhenAna Carolina Guilhen Campinas, Brazil More articles by this author , Fabiana GranjaFabiana Granja Campinas, Brazil More articles by this author , Mariana OliveiraMariana Oliveira Campinas, Brazil More articles by this author , Ubirajara FerreiraUbirajara Ferreira Campinas, Brazil More articles by this author , and Laura WardLaura Ward Campinas, Brazil More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1690AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We investigated the role of N-acetyltransferases (NAT) in prostate cancer (PCa) susceptibility. NAT are polymorphic in the population and metabolize important carcinogenic products directly involved in the tumor initiation process. METHODS This prospective case-control study comprised a cohort of consecutive 227 men – 126 with prostate cancer and 101 with benign prostatic hyperplasia (BPH) –, using the polymerase chain reaction-based restriction fragment length polymorphism method. NAT2 slow or fast acetylators genotypes were determined by the combination of four variant alleles. Lifetime occupational history, dietary patterns, cigarette smoking, and other anamnestic data were obtained by interviews. RESULTS We were not able to find any correlation among smoking, dietary patterns, parameters of tumor aggressiveness or patient outcome and any NAT2 genotypes or phenotypes considered in separate or in different combinations. However, there was an association between NAT2T481C (OR=0.47; 95% C.I=0.26-0.84; p=0.01) and NAT2A803G (OR=0.57; 95% C.I=0.33-0.97; p=0.04) polymorphisms and PCa protection. Conversely, the presence of NAT2G857A genotype increased the risk of PCa more than 3 times (OR=3.57; 95% C.I=1.39-9.15; p=0.005). Slow acetylator NAT2*7A and NAT2*6B genotypes occurred in 10.31% of PCa but in none of BPH patients (p=0.0007). CONCLUSIONS We suggest that the investigation of germline polymorphisms of NAT2 gene may be useful in the assessment of Latin American patients at risk for PCa. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e697 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mario Lima Campinas, Brazil More articles by this author Leonardo Reis Campinas, Brazil More articles by this author Ana Carolina Guilhen Campinas, Brazil More articles by this author Fabiana Granja Campinas, Brazil More articles by this author Mariana Oliveira Campinas, Brazil More articles by this author Ubirajara Ferreira Campinas, Brazil More articles by this author Laura Ward Campinas, Brazil More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...