Lifetime Cancer Risk Research Articles

Terrestrial gamma radiation dose (TGRD) rates and radiological risk assessments in Tiru region of the Naga Schuppen Belt, India

The aim of the present study is to assess the levels of dose rates and the potential risks of exposure to terrestrial gamma radiations in indoors and outdoors in houses in Tiru coal mining area. A highly sensitive portable micro-R gamma survey metre incorporated with a NaI (Tl) scintillator has been used for this study. Indoor and outdoor gamma dose rates (GDRs) have been estimated to be 58.5-178.3 nGy h-1 and 55.5-81.9 nGy h-1, respectively, with averages of 89.7 7.4 nGy h-1 and 65.7 5.8 nGy h-1, considerably higher than the reported global population-weighted averages. The annual effective doses (AEDs) for indoors and outdoors have been estimated to be in the ranges of 0.29-0.87 mSv y-1 and 0.07-0.1 mSv y-1, with averages of 0.44 0.04 mSv y-1 and 0.08 0.01 mSv y-1, which are marginally higher than the reported global averages. The excess lifetime cancer risk (ELCR) has been calculated and found to be in the range of 1.2 10-3-3.4 10-3 with an average of 1.8 10-3. This study contributes significantly to the scientific understanding of radiation exposure in an open-cast coal mining area as well as its potential impact on human health.

Sex differences in cancer incidence amongst people with cardiovascular disease: a large British population study

Abstract Background Studies have shown that patients with cardiovascular disease (CVD) have an incremental risk of death due to noncardiac causes. This is especially attributable to cancer developments during long term follow up. The two diseases share pathophysiological mechanisms that extend beyond traditional risk factors. With well-established sex disparities in CVD, it becomes imperative to investigate whether similar sex-based differences exist in both the incidence of cancer and cancer-related mortality, in participants with CVD vs those without CVD. Purpose We aim to analyse the sex differences in incident cancer and cancer-related mortality between people with and without CVD. Methods Participants were drawn from a large British population based prospective cohort study and followed up for a median of 26.2 years. Participants were stratified by sex and whether they developed CVD over the study follow-up. The cumulative incidence of cancer, excluding non-melanoma skin cancers were calculated. Sex-specific lifetime risks were determined accounting for competing risks of death. Cause-specific hazard ratios were determined using Royston-Parmar models. Models were adjusted for ethnicity and time-updated covaries, including material deprivation, CV risk factors, lifestyle factors, comorbidities, and medication. Participants’ CVD status was time-updated over the study follow-up as this was diagnosed. Results Out of a total of 22, 534 participants, free of cancer at baseline, 53.7% were women. Mean (standard deviation) age was 58.6 (9.3) for women and 59.5 (9.3) for men, at baseline. Men were older and had more comorbidities. Hypertension and obesity were risk factors more prevalent amongst men, while women were more likely to be smokers at baseline. Participants with CVD had more comorbidities, were more likely to smoke, have higher HbA1cs and be obese than those without CVD. The adjusted lifetime risks of incident cancer in participants with CVD at age 75 were higher in men (13.9%) compared to women (10.1%). This translates into a cause-specific hazard ratio (cHR) (99% confidence interval) for incident cancer (men vs. women) of 1.41 (1.27 - 1.55). Similar findings were demonstrated in participants with no CVD (10.2% for men and 8.2% for women), corresponding to a cHR of 1.27 (1.15 - 1.40). Furthermore, men had a higher risk of cancer-related mortality compared to women in participants with CVD 1.54 (1.33 - 1.78), as well as among participants without CVD 1.34 (1.17 - 1.53). Conclusion Our study showed an association between CVD and the lifetime cancer risk in both sexes after extensive adjustment. Furthermore, we show that men have a higher risk of cancer incidence and cancer-related mortality than women, regardless of comorbid CVD. However, these associations, were stronger in participants with CVD. It is vital to identify driving forces of such disparities to achieve health equity.

Determination of heavy metals and health risk assessment in drinking water in Bukayriyah City, Saudi Arabia

Abstract Heavy metal levels, including arsenic, lead, cadmium, mercury, chromium, and nickel, were analyzed in 124 samples of tap and filtered water obtained from Bukayriyah city, Saudi Arabia, using inductively coupled plasma mass spectrometry. Additionally, measurements of total dissolved solids, conductivity, and pH were also performed. The study also evaluated the potential non-cancer and cancer risks (CRs) associated with the ingestion of these heavy metals for both children and adults. The results indicated that the average concentrations of heavy metals in both tap and filtered water were found to be below the recommended limits set by the World Health Organization and the Gulf Standard Organization. To assess the non-carcinogenic risks, the chronic daily intake (CDI), hazard quotient (HQ), and hazard index were calculated for analyzed metals present in both tap and filtered water. In both the children and adult populations, the CDI indices for heavy metals in tap and filtered water followed the order of Cr > Hg > Ni > Pb > As > Cd. However, it is worth noting that the CDI values for tap water were higher than those for filtered water for both children and adults. The descending order of HQ values is as follows: Hg > Cr > As > Cd > Pb > Ni. This indicates that the HQ values for all metals are below the acceptable limit of 1. These findings confirm that the exposure to the examined metals from both tap and filtered water in Bukayriyah City is within safe limits and poses no non-carcinogenic risks. To assess the carcinogenic risks, the incremental lifetime cancer risk (ILCR) and total carcinogenic risk (TCR) were calculated. The order of ILCR values for both children and adults in tap and filtered water is as follows: Ni > Cr > Cd > As > Pb. All ILCR values were below the acceptable limit of 10−6 to 10−4. However, TCR values exceeded this threshold range only for children exposed to tap water, with a value of 1.43 × 10−4. Thus, children exposed to tap water have a potential risk of developing carcinogenic diseases.

Elemental composition and health risk assessment of PM10, PM2.5, at different microenvironments: Addis Ababa, Ethiopia.

This study was designed to evaluate the health risks faced by inhabitants living in the slum areas of Addis Ababa, Ethiopia. The levels of PM2.5 and PM10 and elemental composition of the PM10 were measured in indoors (in the kitchen and living room) and outdoors (at the roadside). A total of 75 sampling locations (45 indoor and 30 outdoor) were selected for the study. The levels of PM2.5 and PM10 were determined using an AROCET531S instrument, while an universal air pump was used for the sampling of PM10 for the determination of trace elements by inductively coupled plasma-optical emission spectroscopy (ICP‒OES). The health impacts of PMs on the inhabitants of twelve microenvironments (MEs), where they spend much of their daily time, were estimated. The total amounts of PM2.5 and PM10, and trace metals in PM10 found in the nine or twelve MEs ranged from 10.6-119, 128-185, and 0.007-0.197 μg m-3, respectively. According to the United States Environment Protection Agency (USEPA) guidelines, ten of the twelve MEs can cause significant health problems for inhabitants (HI > 1) due to PM2.5 and PM10. Thus, special attention should be given by stakeholders/inhabitants to minimize the health impacts on long-term exposure. This study assessed the risk of levels of trace elements on the inhabitants who spend most of their daily lives. The study revealed that the lifetime cancer risk values for the individual and cumulative trace elements were within the tolerable range set by the USEPA guidelines.

Assessment of natural radioactivity levels in rice samples and their implications for radiological protection

ABSTRACT This study investigates the levels of natural and artificial radioactivity in rice samples collected from various local markets in Islamabad, Pakistan. The 226Ra, 232Th, and 40K activity concentrations were measured through gamma-ray spectrometry with a NaI(Tl) detector. The average activity concentrations were 1.67 ± 1.19 Bq kg−1 for 226Ra, 3.31 ± 1.83 Bq kg−1 for 232Th, and 88.51 ± 11.65 Bq kg−1 for 40K. Calculated radium equivalent (Raeq) values ranged from 7.35 to 18.08 Bq kg−1, with a mean value of 11.11 Bq kg−1, all below the permissible maximum of 370 Bq kg−1. The absorbed dose rates ranged from 6.85 to 16.39 nGy h−1, with an average of 10.64 nGy h−1, falling below the acceptable limit of 51 nGy h−1. The outdoor and indoor radiation hazard indices (Hex and Hin) had mean values of 0.03, both below the threshold value of one. The external and internal hazard indices (Iγ and Iα ) were both 0.088, also below the critical value of one. The excess lifetime cancer risk (ELCR) ranged from 0.28 to 0.11, with a mean value of 0.18, which is less than the critical value of one. Overall, the radioactivity levels in the analyzed rice samples are within the acceptable limits set by the International Commission on Radiological Protection and are below global averages. These results offer important insights into the radiological safety of rice consumption in the study area.

Long-term analysis of BTEX concentrations and health risks in semi-arid urban regions

Rajasthan, experiencing rapid industrialization and urbanization, faces critical air quality challenges, particularly concerning toxic volatile organic compounds (VOCs) such as BTEX (Benzene, Toluene, Ethylbenzene, Xylene). This study presents a long-term analysis of BTEX concentrations across various cities in Rajasthan, India, using data from the Central Pollution Control Board (CPCB) from 2017 to 2022. The findings revealed that the average ∑BTEX concentrations increased from 4.15 µg/m3 in 2017 to 12.29 µg/m3 in 2022, with a temporary decline in 2020. The Hazard Quotient (HQ) values for BTEX exposure ranged from 0.052 to 0.15 for males, 0.056 to 0.17 for females, and 0.09 to 0.29 for children over the study period, indicating higher health risks for children. Similarly, the Lifetime Cancer Risk (LCR) values varied from 6.04 × 10⁻⁶ to 1.92 × 10⁻5 for males, 1.09 × 10⁻⁶ to 2.24 × 10⁻5 for females, and 1.17 × 10⁻5 to 3.73 × 10⁻5 for children. The results demonstrate that children are at a greater cancer risk from BTEX exposure compared to adults. This study emphasizes the urgent need for effective air pollution control measures and continuous monitoring to protect public health, particularly vulnerable populations like children.

Health risk assessment of heavy metals in black tea infusion by Monte Carlo simulation

AbstractTea leaves and their infusion have been interested in the populations because of their therapeutic and relaxing effects. However, tea plant is prone to heavy metals' bioaccumulation. Regarding the high consumption of tea infusion, concentration of arsenic, cadmium, and lead in black tea infusion was determined by inductively coupled plasma mass spectrometry. Tea infusion was prepared by addition of 45 mL deionized water to 1 g tea leaves followed by heating at 90°C for 10 min. After analysis, carcinogenic and noncarcinogenic risks of heavy metals were investigated by Monte Carlo simulation in two age groups of children and adults younger and older than 15 years old, respectively. According to the results, Hazard Quotient (HQ) of three heavy metals in both children and adults was equal and lower than 0.01. Furthermore, incremental lifetime cancer risk (ILCR) of arsenic in Iranian black tea consumers (<1.5 × 10−6) and lead in all consumers (about 2.55 × 10−7) was within the acceptable range introduced by US EPA (≤10−6). ILCR of arsenic in children and adults consuming foreign tea infusion was within the range of 10−6–10−4. Our further investigation revealed that the highest area (75%–85%) of cumulative frequency distribution for arsenic ILCR in foreign tea consumers was related to ILCR ≤10−5 which is the acceptable range determined by the World Health Organization. Therefore, there was no serious concern about the intake of heavy metals by tea infusion in Iranian children and adults.

Low doses of ionising radiation: definitions and contexts

The term 'low dose' is applied to different levels of dose depending on the circumstances of exposure, with the potential for confusion unless the reasoning is clear. The United Nations Scientific Committee on the Effects of Ionising Radiation has defined low absorbed doses of ionising radiation as below about 100 mGy, and low dose rates as below 0.1 mGy min-1 (6 mGy h-1). These values relate to the interpretation of scientific evidence from epidemiological and biological studies. The International Commission on Radiological Protection has used similar values of 100 mSv and 5 mSv h-1 and applied this categorisation directly to the specific situation of patients undergoing diagnostic procedures: doses below 100 mSv were referred to as 'low' and doses below 10 mSv as 'very low'. Consideration of other exposure situations suggest that the same terms can be used for exposures received by emergency workers. However, for workers and members of the public in planned exposure situations, it is suggested that the term 'low dose' applies to doses below 10 mSv and 1 mSv, respectively - that is, below the dose limits. In each case, dose is being used as a surrogate for risk - risks at low doses are uncertain and estimates may change, but order of magnitude considerations are sufficient in most cases. Doses of < 100 mSv, < 10 mSv and < 1 mSv correspond to life-time cancer risk estimates of the order of < 10-2, < 10-3 and < 10-4, respectively.&#xD.

How much does the carcinogenic risk of inorganic arsenic exposure from rice increase with higher brown rice consumption? An estimation for five regions around the world

Substituting brown rice for white rice can increase the carcinogenic risk of inorganic arsenic (iAs) exposure, given that brown rice has a higher iAs content than white rice. This study estimated changes in the incremental lifetime cancer risk (ILCR) of iAs exposure from rice with increases in the proportion of brown to total rice consumption (PBT) in five regions around the world, including North America, Latin America, Europe, Asia, and Oceania. The results demonstrated that the magnitude of the increase in the ILCR of iAs exposure from rice expressed as an increase in PBT, ranged from 0.02 to 0.43 per 10,000 people for each 10 % increase in PBT. The highest increase was observed in Asia, followed by Latin America, North America, Oceania, and Europe. The daily rice consumption rate rather than the increase in iAs content is the critical factor responsible for regional differences in higher carcinogenic risk with increased PBT. This study also suggests that when considering the carcinogenic risks of iAs exposure from rice, substituting brown rice for white rice is feasible in North America and Europe but not in Asia and Latin America, while in Oceania, a partial substitution of brown rice for white rice (<55 %) is feasible.

Assessment of heavy metal concentration in pelagic fish species and associated health risks along the Kanyakumari coast, India – a baseline study

ABSTRACT This research examines heavy metal concentration in fish from the Kanyakumari coast of India, emphasising its ecological consequences and possible health hazards for consumers. The study investigates the levels of several heavy metals such as zinc, manganese, iron, cadmium, copper, chromium, cobalt, lead, and nickel in different organs of multiple pelagic fish species obtained from the Kanyakumari fish landing site. Concentrations of heavy metals exhibit considerable variation among different fish organs and species, with distinct patterns identified for each metal. Muscle tissue often demonstrates reduced amounts of heavy metals in comparison to other organs. Except Zn and Fe, other heavy metals in fish muscle were above the acceptable limits set by health organisations. Cadmium was found to be 36-fold higher than the permissible limit, followed by nickel (30.4) and lead (7.6). Copper, nickel, and cadmium provide possible health hazards according to the Target Hazard Quotient (THQ). Lead and cadmium exhibit Excessive Lifetime Cancer Risk (ELCR) markedly above tolerable thresholds. Large predatory fish, such as Thunnus thynnus, exhibit elevated levels of contaminants such as cadmium. Environmental conditions, aquatic habitat, and dietary intake affect metal build-up in fish. The research employs multiple analytical methods and statistical methods, such as Atomic Absorption Spectrophotometry, correlation and Principal Component Analysis, to evaluate heavy metal concentrations and their interrelations. The study underscores the critical necessity for monitoring and mitigation techniques to combat heavy metal pollution in coastal waters and its possible effects on human health through fish intake.

Extensive investigation of seasonal and spatial fluctuations of BTEX in an industrial city with a health risk assessment

There are many pollutants in the air that can be harmful to human health. Their impact varies based on factors such as the kind of pollutant, duration of exposure, and concentration levels. Volatile organic compounds are particularly significant carcinogens among the various pollutants present in the air. Consequently, people who are exposed to these harmful airborne pollutants suffer permanent consequences. This study examines the properties of BTEX compounds—benzene, toluene, ethylbenzene, and xylene—as well as their sources and risk assessments throughout a one-year period from March 21, 2019, to March 20, 2020, in Karaj, Iran’s largest industrialized city. First, utilizing a geographical information system that covered the entire city, 17 locations within Karaj were chosen for this purpose. Then, samplings were carried out in the spring, summer, autumn, and winter months with the NIOSH 1501 method. During the research period, 68 samples of BTEX compounds were collected. The adsorption of these contaminants on the activated carbon adsorbents was performed using an environmental sampling pump with a flow rate of 0.2 L/min for 1 h. The samples were subsequently prepared using a carbon disulfide solution and injected into a GC-FID for analysis. In this research, the average annual concentration of BTEX compounds in the air of Karaj city was obtained at 33.01 µg/m3. Autumn and spring had the highest and lowest average concentrations of BTEX compounds, respectively. In addition, sites 5 and 8 had the highest average annual concentrations of these pollutants. The sourcing conducted in this study showed that transportation and fuel consumption, as well as industries, were the primary sources of pollution in the city. In addition, the excess lifetime cancer risk was higher than the guideline value in some sites and lower in others. Furthermore, the Hazard Quotients were lower than 1, but in general, the citizens of Karaj were at serious risk from exposure to this group of pollutants.

Human health risk assessment of potentially toxic and essential elements in medicinal plants consumed in Zabol, Iran, using the Monte Carlo simulation method

Medicinal plants (MPs) have long been used for their therapeutic properties in traditional forms of medicine. However, the presence of potentially toxic elements (PTEs) in MPs raises concerns about their safety, efficacy, and potential adverse effects on human health. The current study aimed to determine the level of potentially toxic and essential elements (PTEEs) in commonly consumed MPs in Zabol, Iran, along with their health risk assessments. To conduct the present study, 10 types of MPs widely used in Zabol, Iran, were selected, and 15 samples of each type (150 samples in total) were taken. Each sample was analyzed for the presence of various PTEEs using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) for Lead (Pb), cadmium (Cd), chrome (Cr), nickel (Ni), copper (Cu), zinc (Zn), iron (Fe), aluminum (Al) and manganese (Mn); and Atomic Absorption Spectrometry (AAS) for arsenic (As) and mercury (Hg). Finally, to better comprehend the scope of exposure and its possible effects, the Monte Carlo simulation method is successfully applied to assess human health risks related to PTEs in MPs. Statistical analysis revealed statistically significant (P < 0.001) variations in PTE averages among MP types. Furthermore, all samples’ overall PTE mean concentration (range: 0.18 to 215.5 µg/kg) was below the World Health Organization’s (WHO) regulatory standards. Probabilistic health risks, including non-carcinogenic-target hazard quotient (THQ) for each element, total target hazard quotient (TTHQ) for all elements, and carcinogenic-incremental lifetime cancer risk (ILCR) for each element, and total carcinogenic risk (TCR) for all elements, were significantly lower than the acceptable limit for children and adults. Accordingly, it can be said that consuming MPs sold in Zabol is safe for children and adults regarding carcinogenic (ILCR/TCR = 10− 4) and non-carcinogenic (THQ/TTHQ = 1) effects. In light of the findings presented here, and to our understanding, the primary factor contributing to lower levels of PTEs in MPs in Zabol City markets is the cultivation of plants in nonindustrialized areas, separate from urban and industrial zones. This practice keeps them from environmental contaminations, including soil quality and water sources. It is recommended that it is essential to regulate the sources that enhance the transfer of PTEs and other harmful pollutants from surroundings to the soil and, consequently, MPs. It is also suggested that, like chemical drugs, MPs should undergo rigorous testing by quality control agencies before being made available to the market.

Assessment of the activity concentration of radon and its health hazard in surface water around the Rooppur Nuclear Power Plant (RNPP) site, Bangladesh

ABSTRACT Radon is a colourless, unscented, radioactive inert gas. As a gaseous element, Rn-222 can be effectively breathed in, leading to a health hazard. The main objective of this study is to measure the amount of Rn-222 concentration in surface water and its associated health hazards around the Rooppur Nuclear Power Plant (RNPP) construction site area in Bangladesh. Twenty water samples were collected each year (2022 and 2023) from different specific locations of the Padma River and investigated for radon concentration through a Durridge RAD7 detector with RAD H2O accessories. The range of radon activity in surface water measured from 0.070 ± 0.035 to 0.385 ± 0.211 BqL−1 with a mean activity of 0.194 ± 0.114 BqL−1 in the year 2022 and in the year 2023, the range of radon activity in surface water measured from 0.035 ± 0.070 to 0.455 ± 0.239 BqL−1 with an average activity of 0.228 ± 0.140 BqL−1. All the radon concentration results were below the recommended limits of WHO (100 BqL−1) and USEPA (11.1 BqL−1). The ranges of annual effective dose (AED) were from 0.1911 to 1.051 µSvy−1 and from 0.095 to 1.242 µSvy−1 in the years 2022 and 2023, respectively, which were lower than the AED recommended by WHO (0.1 mSvy−1). The mean values of excess lifetime cancer risk are 0.0021 × 10−3 and 0.0025 × 10−3 in the years 2022 and 2023, respectively, which were lower than the average standard value recommended by UNSCEAR (0.29 × 10−3). The result of this investigation can be applied as baseline data for radon concentration measurement in the under-construction nuclear power plant site area vicinity of Bangladesh.

Appraisal of contamination, hydrogeochemistry, and Monte Carlo simulation of health risks of groundwater in a lithium-rich ore area.

This study incorporated hydrogeochemical facies, the entropy-weighted water quality index (EWQI), multivariate statistics, and probabilistic human exposure assessment to investigate hydrogeochemistry, analyze groundwater quality, and estimate potential risks to human health in a lithium-rich ore area (Jadar River basin, Serbia). The findings designated the Ca·Mg-HCO3 hydrogeochemical type as the predominant type of groundwater, in which rock weathering and evaporation control the major ion chemistry. Due to the weathering of a lithium-rich mineral (Jadarite), the lithium content in the groundwater was very high, up to 567mg/L, with a median value of 4.3mg/L. According to the calculated EWQI, 86.4% of the samples belong to poor and extremely poor quality water for drinking. Geospatial mapping of the studied area uncovered several hotspots of severely contaminated groundwater. The risk assessment results show that groundwater contaminants pose significant non-carcinogenic and carcinogenic human health risks to residents, with most samples exceeding the allowable limits for the hazard index (HI) and the incremental lifetime cancer risk (ILCR). The ingestion exposure pathway has been identified as a critical contaminant route. Monte Carlo risk simulation made apparent that the likelihood of developing cancerous diseases is very high for both age groups. Sensitivity analysis highlighted ingestion rate and human body weight as the two most influential exposure factors on the variability of health risk assessment outcomes.

Health risk assessment of lead and cadmium exposure from food and snuff in Pakistani population

BackgroundSmokeless tobacco (SLT) is a tobacco-based product consumed without burning or smoking. Snuff, commonly known as naswar, is a widely used SLT product in Pakistan. This study is designed to investigate the concentrations of lead (Pb) and cadmium (Cd) in snuff and their associated health risks to consumers. MethodsBlood samples from snuff consumers and non-consumers were analyzed for Pb and Cd concentrations. Additionally, samples of drinking water and wheat flour were also analyzed for Pb and Cd. Health risk assessments were calculated using hazard quotient (HQ) and incremental lifetime cancer risk (ILCR) for Pb and Cd. ResultsSnuff consumers had significantly higher blood-Pb and blood-Cd levels compared to non-consumers. Approximately 38.5 % of snuff consumers were found to exceed blood-Pb levels from the safe limits (10 µg dL⁻¹) of the World Health Organization (WHO), while 48.9 % of snuff consumers were found to exceed blood-Cd levels from the WHO safe range of 0.03–0.12 µg dL⁻¹. Snuff samples contained Pb and Cd concentrations ranging from 5.3 to 22.4 µg g⁻¹ and 0.5–2.2 µg g⁻¹, respectively. Drinking water and wheat flour samples were found within the safe limits for Pb and Cd concentration, suggesting snuff as the primary source of exposure. Health risk assessments indicated elevated HQ values, for Pb (38.9 %) and Cd (14.3 %) detected in snuff, surpassing the safe HQ threshold of 1. Concerning ILCR from snuff, values for Pb were within the acceptable range, but alarmingly 100 % of samples for Cd exceeded the safe limits of USEPA (1.0×10⁻⁴), indicating a significant cancer risk in snuff users. ConclusionThis study highlights the exceeded Pb and Cd concentrations in snuff as well as also reporting significant carcinogenic and non-carcinogenic health risks to consumers. These findings emphasized the urgent need for regulatory bodies to ensure the safety of snuff before selling in the market. Public Health Professionals should also initiate educational campaigns to raise awareness among consumers and manufacturers about various health risks associated with the snuff.

Evaluation of Radioactivity Concentration and Hazard Indices in ash Some Hospitals Incinerators in Baghdad / Al Resafa

Due to their harmful effects on human health and their tendency to cause cancer, radionuclide concentrations and risk indicators have been measured in hospital incinerator ash. This was done by collecting samples ash of Hospitals Incinerators, examining them, and identifying the risks that emerged from the examination. Three samples Only taken for the study from certain hospitals affiliated with the Baghdad Al-Rusafa Health Department. High purity germanium gamma spectrometer (HPGe) were used to analyze the samples. The concentrations of potassium isotopes (K-40) range from (147.1±16.5 to 214.4±21.1 Bq/kg), While the range of concentrations for Ra-226 isotopes is (7.52±1 to 19±1.8 Bq/kg), and lead (Pb-212) isotope concentrations ranged from (10.1±1.1 to 11.1±1.5 Bq/kg). In addition, the isotope concentration of actinium (Ac-228) is 8.05±1. Radium equivalent (), risk index , annual effective dose equivalent radioactivity level index ), absorbed dose rate D, and lifetime cancer risk were calculated. The results showed that no radiation risk Only indicated by any of the risk indicators. This indicates that the ash from the hospital incinerator does not pose any radioactive danger.

Risk assessment and quantification of elemental concentrations in river and stream in Nigeria

The rising prevalence of elements in surface water is becoming a major global environmental problem due to their resistance to change and capacity to accumulate in organisms. Humans are causing significant heavy metal contamination in the aquatic environment, which is killing aquatic creatures. The purpose of this study is to determine the elemental composition of surface water in Ogun State. Water samples were collected from a river that flows alongside Liberty Estate in Ewupe, Ado-Odo Ota Local Government Area, and a stream that runs alongside Pacific Estate in Iganmode. The element composition of water samples was determined using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Several components were found to exceed the limitations imposed by the World Health Organisation (WHO) and the Environmental Protection Agency (EPA). In River I, sodium (Na) had the highest apparent concentration, whereas titanium (Ti) had the lowest average concentration. In River II, silicon (Si) had the highest apparent concentration, whereas chromium (Cr) had the lowest average concentration. Titanium (Ti) had the lowest mean concentration value, whereas sodium (Na) appeared to have the highest concentration in stream I. Stream II has the highest concentration of sodium (Na), while Uranium (U) has the lowest average concentration value. Nonetheless, the incremental lifetime cancer risk (ILCR) values for adults and children who drink river and stream water are similar, ranging from 10–9 to 10–8. This implies a high carcinogenic risk (CR) linked with drinking water from both sources. Children who had access to both stream and river water demonstrated higher risk levels than adults. Routine studies of the state's streams and rivers should be conducted to avoid the subtle impact that may emanate from the water bodies.

8042 A Rare Case of Papillary Thyroid Carcinoma in a Patient with Li-Fraumeni Syndrome

Abstract Disclosure: K.M. Bakhtawar: None. G. Jaiswal: None. Li-Fraumeni syndrome (LFS) is an autosomal dominant syndrome with a high lifetime probability of cancer at an early age. The spectrum of cancers primarily includes osteosarcoma, soft tissue sarcoma, breast cancer, brain tumors, leukemia, and Adenoid cystic carcinoma. Prior studies have estimated the cumulative cancer risk to be about 50% by age 40 and as high as 90% by age 60. As screening for TP53 mutations has improved and more patients are identified, the LFS cancer spectrum has expanded to include thyroid cancer. However, the occurrence of thyroid cancer in LFS has not been extensively assessed in the literature. A recent study examined cancer patients carrying the Brazilian p.R337H TP53 mutation which demonstrated that out of 101 patients, 11 had thyroid cancer (10.9%). In our case, a 45-year-old female with a past medical history of Li-Fraumeni syndrome, Von Willebrand disease, Pulmonary embolism, HER-2 positive invasive ductal carcinoma of the left breast status post chemotherapy, and bilateral mastectomy presented for evaluation of papillary thyroid carcinoma (PTC). An enlarged thyroid was initially identified on physical exam by the PCP with a follow-up thyroid ultrasound showing bilateral nodules. The right upper pole 1.9 x 1.3 x 1.6 cm nodule was biopsied revealing PCT. Following neck ultrasound demonstrated mildly enlarged lymph nodes on the right side, level 2A 1.5 cm and level 3 1.6 cm. The patient subsequently underwent total thyroidectomy and lymph node dissection. The pathology report revealed a 1.4 cm PTC in the upper right pole, a 0.9 cm PCT in the isthmus, and a 0.8 cm PTC in the left midpole. 4/62 lymph nodes were positive with the largest deposit of 1 cm. All margins were negative for carcinoma with no angioinvasion or lymphatic invasion. She was staged as T1bN1bM0. We are awaiting post-operative Thyroglobulin level to assess the need for Radioactive iodine. BRAFV600E and P53 mutation was identified. The patient carries known heterozygous mutation p.R1755H in the TP53 gene with an estimated lifetime cancer risk of 93%. This particular mutation has not been associated with thyroid cancer in prior studies. Although thyroid cancer is an uncommon manifestation of LFS, this case begs the importance of further studies to explore this association which may then lead to early screening and treatment of thyroid cancer in individuals with founder TP53 mutations. Presentation: 6/1/2024

Estimation of radiological health risks due to 226Ra, 232Th, and 40K in foods consumed in Iraqi Kurdistan Region

ABSTRACT This study investigates the activity concentration of natural radionuclides in a diverse range of food samples in the Koya district markets food baskets, including both domestic and imported products. The samples cover annual crops (e.g. coffee, tea, kidney beans), tree nuts (e.g. almonds, pistachios), and other items (e.g. beef, fish, milk) by using a high-purity germanium (HPGe) detector. This research addresses a notable gap by providing baseline data on radionuclide concentrations and assessing potential health risks. Average activity concentrations for ²²⁶Ra, ²³²Th, and ⁴⁰K were 0.943, 0.367, and 191.8 Bq kg−1, respectively. Radium equivalent activity values ranged from 2.88–58.48 Bq kg−1, all below the safety limit. The average excess lifetime cancer risk (ELCR) was 0.154 mSv a−1, indicating safety for most samples, though coffee and tea showed higher levels. This study provides new data crucial for future research and regulatory monitoring, underscoring the need for further investigation into geological impacts on radionuclide levels.

Traces of the past: assessing the impact of potentially toxic elements from an abandoned mine on groundwater and agricultural soil in San Luis Potosí, México.

The study was conducted in Cerritos, San Luis Potosí, México, near the Guaxcama mine, focused on environmental contamination (groundwater and agricultural soil) from antimony (Sb), arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg). In March 2022, 20 agricultural soil and 16 groundwater samples were collected near the historically cinnabar (HgS)- and arsenopyrite (FeAsS)-rich Guaxcama mine. Hydride generation atomic fluorescence spectrometry (HG-AFS) for As, cold vapor atomic fluorescence spectrometry (CV-AFS) for Hg, and inductively coupled plasma optical emission spectrometry (ICP-OES) for Cd, Pb, and Sb were used for the determinations of potentially toxic elements (PTEs). While concentrations of Cd, Hg, Pb, and Sb in groundwater were below detection limits, As levels exhibited a range from 40.9 ± 1.4 to 576.0 ± 1.0µg/L, exceeding permissible limits for drinking water (10µg/L). In agricultural soil, As was between 7.67 ± 0.16 and 24.1 ± 0.4µg/g, Hg ranged from 0.203 ± 0.018 to 2.33 ± 0.19µg/g, Cd from 2.53 ± 0.90 to 2.78 ± 0.01µg/g, and Pb from 11.7 ± 1.2 to 34.3 ± 4.1µg/g. Only one study area surpassed the Mexican As soil limit of 22µg/g. Sequential extraction (four-step BCR procedure) indicated significant As bioavailability in soil (fractions 1 and 2) ranging from 3.66 to 10.36%, heightening the risk of crop transfer, in contrast to the low bioavailability of Hg, showing that fractions 1, 2, and 3 were below the limit of quantification (LOQ). Crucial physicochemical parameters in soil, including nitrate levels, pH, and organic matter, were pivotal in understanding contamination dynamics. Principal component analysis highlighted the influence of elements like Fe and Ca on phytoavailable As, while Pb and Cd likely originated from a common source. Ecological risk assessments underscored the significant impact of pollution, primarily due to the concentrations of Cd and Hg. Non-cancer and cancer risks to residents through As poisoning via contaminated water ingestion also were found. The hazard index (HI) values varied between 4.0 and 82.2 for adults and children. The total incremental lifetime cancer risk (TILCAR) values for adults ranged from 7.75E - 04 to 1.06E - 02, whereas for children, the values were from 2.47E - 04 to 3.17E - 03.