The modern age of professional competition and the post-COVID-19 situation led to the birth of stressful life. The lifestyle of medical practitioners becomes hectic and disturbing, affecting not only their profession but also their personal lives. This study identifies the factors like Role Overload & Responsibility (ROR), Lifestyle Variations (LV), Family Disruptions (FD), and Stringent Working Conditions (SWC) affecting the occupational performance of doctors. This was exploratory research that identified and validated antecedent work stress factors for the occupational performance of medical professionals in the national capital region. The factors were measured through a self-adapted questionnaire based on the five-point Likert scale. The validation of the factors was verified through the hypothesized model by using structural equation modeling (SEM) on their occupational performance. The study identifies that ROR and SWC affect the National Capital Region (NCR) medical practitioners' occupational performance. Moreover, this study has specific implications for medical professionals and provides the theoretical and practical basis for health issues during the job that severely impacts the employees' personal and professional lives. This study decodes the work stress buster factors that manipulated the effective occupational performance of the employees.