Lifespan Research Articles

Sustainable Combination of Waste with Waste: Utilization of Biomass to Recover Critical Metals from Spent Lithium ion Batteries

The generation of e‐waste from lithium ion batteries (LIBs) is rapidly increasing due to the rising utilization of LIBs in portable electronics, and electric vehicles, with an average life span of 3‐5 years. The disposal of spent LIBs is a major environmental concern due to the presence of high percentages of toxic heavy metals and corrosive electrolytes. Efficient and sustainable recycling of spent LIBs has become immensely important, both environmentally and from a circular economy perspective, as LIBs serve as secondary sources of critical metals needed for renewable energy conversion and storage systems. We provide a concise review of metal recovery from spent LIBs using waste biomass in a green and sustainable approach for resource generation, in addition to the valorization of waste biomass. Biomass is used to recover metals from spent LIBs, acting as lixivient, reductant, and as absorbent. We have also discussed a reverse strategy utilizing ‘black mass’ from spent LIBs as catalyst for biomass conversion to value‐added products. The concept of “circular economy” is highlighted in a “killing two birds with one stone” approach through the utilization of biomass for the recovery of metals from spent LIBs and vice versa.

Gibbs states and Brownian models for coexisting haze and cloud droplets.

Cloud microphysics studies include how tiny cloud droplets grow and become rain. This is crucial for understanding cloud properties like size, life span, and impact on climate through radiative effects. Small weak-updraft clouds near the haze-to-cloud transition are especially difficult to measure and understand. They are abundant but hard to capture by satellites. Köhler's theory explains initial droplet growth but struggles with large particle groups. Here, we present a stochastic, analytical framework building on Köhler's theory to account for (monodisperse) aerosols and cloud droplet interaction through competitive growth in a limited water vapor field. These interactions are modeled by sink terms, while fluctuations in supersaturation affecting droplet growth are modeled by nonlinear white noise terms. Our results identify hysteresis mechanisms in the droplet activation and deactivation processes. Our approach allows for multimodal cloud's droplet size distributions supported by laboratory experiments, offering a different perspective on haze-to-cloud transition and small cloud formation.

Immortalized mammosphere-derived epithelial cells retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties.

The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and immunomodulatory properties in vitro, which warrants its study as a potential biologic treatment with the potential to be translated to human medicine. Currently, the use of the MDEC secretome as a therapy is constrained by the limited life span of primary cell cultures and the decrease of secretome potency over cell passages. To address these limitations, early-passage bovine MDECs were immortalized using hTERT, a human telomerase reverse transcriptase. The primary and immortal MDECs were compared morphologically, transcriptomically, and phenotypically. The functional properties and proteomic profiles of the secretome of both cell lines were evaluated and compared. All experiments were performed with both low and high passage cell cultures. We confirmed through in vitro experiments that the secretome of immortalized MDECs, unlike that of primary cells, maintained antimicrobial and pro-migratory properties over passages, while pro-angiogenic effects of the secretome from both primary and immortalized MDECs were lost when the cells reached high passage. The secretome from primary and immortalized MDECs, at low and high passages exerted immunomodulatory effects on neutrophils in vitro. High passage immortalized MDECs retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties, suggesting they may serve as a consistent cell source for therapeutic use.

Introduction of the Digital Gaming Relationship

In recent decades, there has been a growing interest in studying the appeal of digital games. However, there is still a call for further research, especially on the theoretical and methodological advancements. Hence, a novel approach and a concept of the Digital Gaming Relationship (DGR) is presented. The DGR model is adapted from earlier work on physical activity and with the central concept as “meaning,” it provides an alternative perspective to motivation-oriented literature for the field of game studies. With this approach, the fundamental view is that each person has a varying relationship with digital games and gaming over their life span. The relationship builds on the individual’s encounters with the social world of digital gaming and its cultural meanings. In the long term, accruing digital gaming-related knowledge, experiences, and emotional connections contributes to a rich tapestry of meaning, thus creating a deep and meaningful relationship capable of shaping one’s actions, behaviors, and even identity. The framework theorizes the mechanisms of an individual’s socialization process to the digital gaming world and illustrates that the relationship with digital games includes much more than just playing them. In this article, the theoretical roots and key concepts of the DGR are introduced, and the practical applicability of the approach is discussed.

The Role of Primary Care in Achieving Life's Essential 8: A Scientific Statement From the American Heart Association.

To reduce morbidity and mortality rates of cardiovascular disease, an urgent need exists to improve cardiovascular health among US adults. In 2022, the American Heart Association issued Life's Essential 8, which identifies and defines 8 health behaviors and factors that, when optimized through a combination of primary prevention, risk factor management, and effective treatments, can promote ideal cardiovascular health. Because of its central role in patient care across the life span, primary care is in a strategic position to promote Life's Essential 8 and improve cardiovascular health in the United States. High-quality primary care is person-centered, team-based, community-aligned, and designed to provide affordable optimized health care. The purpose of this scientific statement from the American Heart Association is to provide evidence-based guidance on how primary care, as a field and practice, can support patients in implementing Life's Essential 8. The scientific statement aims to describe the role and functions of primary care, provide evidence for how primary care can be leveraged to promote Life's Essential 8, examine the role of primary care in providing access to care and mitigating disparities in cardiovascular health, review challenges in primary care, and propose solutions to address challenges in achieving Life's Essential 8.

Long-term effects of continuous low dose-rate gamma-ray irradiation on mouse hematopoietic cells.

The present work investigates the long-term effects of continuous low dose-rate (20mGy/day to total doses of 1-8Gy) gamma-ray exposure on the hematopoietic cells of specific pathogen-free C3H/HeN mice. Peripheral white blood cell (WBC) counts decreased on days 206, 471, and 486, with no significant changes in red blood cell (RBC) and platelet (PLT) counts. The number of colony forming units (CFU-S and CFU-GM) in the bone marrow and spleen from irradiated mice decreased with increasing total dose on day-12 and day-7. The decrease in bone marrow CFU-S persisted throughout the 400-day irradiation period and did not show any recovery up to 210days postirradiation. These findings suggest that the effects of low-dose-rate (LDR) radiation on the hematopoietic system remain long after the 400-day irradiation was completed. Further investigation showed no significant difference in life spans of non-irradiated W/Wv (c-kit-deficient) mice inoculated with hematopoietic stem cells from irradiated (20mGy/day for 400days) or nonirradiated wild-type mice. These results suggest that the effects of continuous low-dose-rate irradiation are more pronounced in hematopoietic stromal cells than in HSCs themselves.

4-Phenylbutyric acid mitigates ER stress-induced neurodegeneration in the spinal cords of a GM2 gangliosidosis mouse model.

Sandhoff disease (SD), a fatal and rare lysosomal storage disorder (LSD), is caused by a deficiency of the enzyme β-hexosaminidase B and leads to severe accumulation of GM2 gangliosides in lysosomes, primarily within the central nervous system (CNS). This accumulation results in severe neurological impairment, lower motor neuron disease, and death. Currently, there are no effective therapies available for SD. Here, we explored the role of endoplasmic reticulum (ER) stress in the spinal cord during disease progression in an established mouse model of SD and revealed the beneficial outcome of off-label treatment with the FDA-approved drug, 4-phenylbutyric acid (4-PBA). We analyzed the expression and localization of ER stress and cellular apoptosis markers, which revealed significant upregulation of these factors within motor neurons. Additionally, we observed a > 50% reduction in neuronal numbers throughout all spinal cord regions. Our studies also tested the impact of the chemical chaperone 4-PBA on ER stress in mice, and following administration, we observed significant improvements in motor neuromuscular function and life span throughout disease progression. 4-PBA treatment significantly reduced apoptosis in spinal cord neurons and increased the number of choline acetyltransferase (ChAT)-positive neurons, with little effect on astrogliosis or sensory interneurons. Overall, this study provides strong evidence for the role of chronic ER stress in the pathophysiology of SD and highlights 4-PBA as a promising therapeutic treatment for SD and potentially other related LSDs.

Sexual experiences, attitudes, enjoyment and regret in the parent and offspring generations of the Avon Longitudinal Study of Parents and Childhood (ALSPAC): 2022 data sweep.

The aim of this data note is to describe data collected in 2022 on sexual history, attitudes, enjoyment and regret. Data were collected from mothers (age range 47–75 years (mean 60.0), n = 4653) their partners (age range 47-83 years (mean 62.9), n= 1945) and offspring (aged ~30 years, females n= 2702, males n=1366) in the Avon Longitudinal Study of Parents & Children (ALSPAC). Many of the questions asked are identical, or similar, to those collected in the British NATSAL (National Surveys of Sexual Attitudes & Lifestyles) surveys. Repeating the same questions in both ALSPAC generations allows for direct inter-generational comparisons within ALSPAC as well as across studies. Areas covered include age at sexual debut; having drunk alcohol, used drugs or contraception at sexual debut; the circumstances under which participants met their first sexual partner; sexual orientation; the Brief Sexual Attitudes Scale; regret at first sexual experience, lifetime experiences of sexual regret and the degree of regret, as well as the reason(s) for that regret; number of sexual partners both in the last two years and over their lifetime; current frequency and enjoyment of sex. ALSPAC provides a rich resource of data collected on a wide variety of topics including details of the participants’ environment, lifestyle, physical and mental health over the life span, including sexual experiences collected retrospectively from the parents, and from the age of 11 in the offspring. There are thus many opportunities for research on a wide variety of topics related to risky sexual behaviours, sexual health, functioning and well-being.

Phytochemical composition and insecticidal activity of Acokanthera oblongifolia (Hochst.) Benth & Hook.f. ex B.D.Jacks. extract on life span and biological aspects of Spodoptera littoralis (Biosd.)

Abstract Plant extracts with insecticidal properties are promising alternatives to conventional insecticides, which may pose risks to human health and the environment in pest management. In the current study, the methanolic extract of Acokanthera oblongifolia (Hochst.) Benth & Hook.f. ex B.D.Jacks. was characterized using high-performance liquid and gas-mass spectrometry chromatography. High-performance liquid chromatography analysis identified 14 polyphenols, the highest of which is chlorogenic acid (65637.79 µg/g), followed by naringenin and pyrocatechol at 2022.98 and 1509.11 µg/g, respectively. However, quercetin, gallic acid, ferulic acid, rutin, and kaempferol showed moderate quantities. The gas chromatography–mass spectrometry analysis identified the major polysaccharide, inositol (15.52%), followed by squalene and triterpene (11.02%) out of 35 polysaccharides. The major fatty acids, 11-octadecenoic acid, methyl ester, and methyl 9-cis, 11-trans-octadecadienoate, were 9.06 and 6.30%, respectively. The crude extract and chlorfluazuron 5% EC at LC15 were evaluated for the life table and biological aspects of S. littoralis (Boisd.) neonates after 48 h under laboratory conditions compared to the control. The toxicity of the LC15 at 48 h of chlorfluazuron 5% EC (0.31 mg/L) excelled the extract (178.95 mg/L) on the neonates. Life span tests showed that the larval longevity of the extract and chlorfluazuron colonies were 27.34 and 30 days, respectively. The control colony completed its life span at 38.66 days, whereas the extract colony ended at the pupae stage at 33.67 days. Biological aspects showed that the tested compounds decreased pupation percentages and weight. Pupae malformations caused by the extract (80.56%) outperformed chlorfluazuron (33.33%). The adult emergency decreased by the extract (0.33%), and no emergency was observed in chlorfluazuron colony. Ultimately, A. oblongifolia extract demonstrated significant life table elongations and developmental impairment, which may suggest potential and eco-friendly use for its prospective commercial preparations in controlling S. littoralis alternatively to chlorfluazuron 5% EC.

Pathophysiology of Congenital Anomalies of the Kidney and Urinary Tract: A Comprehensive Review

Congenital anomalies of the kidney and urinary tract (CAKUT) represent a broad range of diseases with differing mechanisms, clinical presentations, and prognoses. With an estimated prevalence of between 4 and 60 per 10,000 births, CAKUT represents a sizable number of patients for pediatric and adult nephrologists as therapies have progressed, allowing longer life spans. Many CAKUT disorders are associated with genetic mutations, and with advances in genomic sequencing, these genes are being identified at an increasing rate. Understanding these mutations provides insight into these conditions’ molecular mechanisms and pathophysiology. In this article, we discuss the epidemiology, presentation, and outcomes of CAKUT in addition to our current understanding of genetic and molecular mechanisms in these diseases.

Agency and Communion in Brief Entire Life Narratives Across the Life Span.

The evolving life story is integral to personality, and motivational themes are central features of the life story. Personality implies individual differences that are relatively stable over time, but still allow for developmental processes. This study explored both long-term stability and developmental change in thematic content of the life story. Fulfilled and unfulfilled agency and communion were studied in brief entire life narratives across 4 measurements in 12 years in a cohort-sequential design including six cohorts (n = 172; age 8-77). Fulfilled agency and communion, as well as unfulfilled agency exhibited moderate rank order stability over 4 and 8 years, fulfilled communion showed even a modest 12-year stability, whereas unfulfilled communion displayed an unsystematic pattern. Developmentally, multilevel analyses revealed an inverted U-shaped association between age and both fulfilled and unfulfilled agency, peaking in mid-life. Fulfilled communion declined after emerging adulthood, but unexpectedly did not increase again in old age. Unfulfilled communion showed no systematic age trends. Girls and women told life narratives with more fulfilled and unfulfilled communion, whereas genders did not differ in either kind of agency. The content of the life story exhibits rank-order stability over time and systematic mean-level development across the life span.

Smart Sensor Placement For Thermal Monitoring Of Concrete

Structural health monitoring (SHM) has become an inevitable part in a life span of a structure due to its potential to ensure the public safety and to increase the life span of the structure. Monitoring any kind of structures for various parameters, using wireless smart sensors has gained popularity in recent past. This paper discusses the development of low cost real time wireless smart sensor monitoring system to monitor early age concrete temperature in real time. Temperature of two early age concrete mixes (Mix1, Mix2) were measured in real time for 24 hours by using DS18B20 sensors connected with the Node Mc u, which is an open source IOT platform. Temperature measurements were saved and visualized in real time using Thing Speak TM which is an open IoT online platform with MATLAB analytics. The temperature sensor DS18B20 was selected such that it is suitable to measure temperature readings of the concrete without any interference of the chemical reactions in concrete. Calibration methods and temperature variation with different concrete mixes are also discussed. It could be seen that the wireless temperature monitoring system performed adequately and it can be considered as a better low cost alternative for traditional wired temperature monitoring system.

Numerical Prediction of Cavitation Erosion Risk Based on a New Erosion Indicator

ABSTRACTCavitation erosion would degrade the performance of the fluid machinery. To improve the reliability and prolong the life span of fluid machinery, it is necessary to study the mechanism of cavitation erosion and predict the possibility of erosion. Since the erosion power to be measured and calculated is closer to the actual state of cavitation, a new cavitation erosion indicator epp model based on erosion power is proposed, which can reflect the size and region of the erosion generated by cavitation more precisely. Concerning the cases of the axisymmetric nozzle and venturi tube, the prediction of cavitation erosion based on the newly proposed indicator is illustrated. It is found that cavitation erosion mainly occurs near the maximum margin of the cavitation region. This research indicates the possible erosion state of fluid machinery in a cavitation environment and provides a new approach to estimate the state of cavitation erosion.

Ultrafast Tailoring Amorphous Zn0.25V2O5 with Precision‐Engineered Artificial Atomic‐Layer 1T′‐MoS2 Cathode Electrolyte Interphase for Advanced Aqueous Zinc‐Ion Batteries

AbstractVanadium (V)‐based oxides as cathode materials for aqueous zinc‐ion batteries (AZIBs) still encounter challenges such as sluggish Zn2+ diffusion kinetics and V‐dissolution, thus leading to severe capacity fading and limited life span. Here, we designed an ultrafast and facile colloidal chemical synthesis strategy based on crystalline Zn0.25V2O5 (c‐ZVO) to successfully prepare a‐ZVO@MoS2 core@shell heterostructures, where atomic‐layer MoS2 uniformly coats on the surface of amorphous a‐ZVO. The tailored amorphous structure of a‐ZVO provides more isotropic pathways and active sites for Zn2+, thus significantly enhancing the Zn2+ diffusion kinetics during charge–discharge processes. Meanwhile, as an efficient artificial cathode electrolyte interphase, the precision‐engineered atomic‐layer MoS2 with semi‐metallic 1T′ phase not only contributes to improved electron transport but also effectively inhibits the V‐dissolution of a‐ZVO. Therefore, the prepared a‐ZVO@MoS2 and conceptually validated a‐V2O5@MoS2 derived from commercial c‐V2O5 exhibit excellent cycling stability at an ultralow current density (0.05 A g−1) while maintaining good rate capability and capacity retention. This research achievement provides a new effective strategy for various amorphous cathode designs for AZIBs with superior performance.

Analysis the Principle and Applications for Stirling Engines of Household

Abstract. The Stirling engine is a path that was not intensively researched and developed on compared to internal combustion engines. However, with advanced technology one has now compared to the 1800s, Stirling engines can be used for purposes including generating electricity and heat in households. Its potential lays in its high thermal efficiency, long life span, as well as the advantage that it can operate quietly. This study investigates and discusses the applications of Stirling engines in houses. There are a lot of ways that Stirling engines can be implemented in daily life, including micro-CHP, water pump, electricity generator. In the future, with better technologies, Stirling engines may be brought up more due to its high efficiency and other beneficial traits. These results aim to increase the attention to Stirling engines and the possibility of implementing it for residential purposes, possibly leading to further research on the topic to further exploit the potentialities of the Stirling engines.

Robust assembly of electron transfer chain in the brain of Naked Mole-Rat during aging

Naked mole-rats (NMR, Heterocephalus glaber) are the longest-lived rodent species, with a maximum life span of more than 30 years. These long-lived mammals exhibit delayed aging phenotypes and resistance to age-related pathologies including neurodegeneration. Multiple regulatory pathways have been proposed for the anti-aging mechanisms in NMR including enhanced mitochondrial function and suppressed oxidative stress. In this study, we investigated the assembly of the electron transfer chain (ETC) which constitutes the structural base for the regulation of both oxidative phosphorylation and the production of reactive oxygen species (ROS), in brains from young and old NMR and C57BL/6 mice. While ETC assembly declined with aging in C57BL/6 mice, we found that NMR display a robust respiratory chain assembly at older ages in both males and females. Among them, individual complex IV and supercomplexes containing complex I and III or complex III and IV showed the most pronounced differences between two species. Our results indicate that a preserved robust assembly of ETC during aging contributes to enhanced mitochondrial oxidative phosphorylation and suppressed oxidative stress, which may contribute to the longevity and resistance to age-related pathologies in NMR.

Development of Elite Mother Palms from the Best-Performing Slow-Vertical-Growth Oil Palm (Elaeis guineensis Jacq.) Genotypes

Harvesting is a serious issue in oil palm plantations after 15–20 years owing to the increased height of the trees (>9 m). The slow vertical growth of the oil palm dura genotypes is desired for increasing the D × P progenies’ productivity and economic life span upto ten years. A reduced height increment has a long-term impact on harvesting costs. The current study assessed 308 genotypes generated from African germplasm. Over a three year period, the biometric properties of eleven D × D crosses were evaluated in order to quantify genetic parameters and phenotypic correlations, and principal component analysis was performed for genetic attributes of the better-performing dwarf progenies in terms of yield. The evaluated genotypes have a highly significant influence (p < 0.01) on the majority of characteristics. The progenies yielded between 165 and 208 kg of fresh fruit bunches (FFBs) per palm every year. The height increment (HI) varied between 17% and 19%, with an overall average of 18%. Genotypes G8, G300, and G221 had the lowest yearly height increments, measuring 28.98, 29.19, and 30.87 cm, respectively. The outcome of the present study shows that they are slow-height-increment genotypes with a high FFB yield (>25 T/Ha). The creation of dura parents with a slow height increment in combination with a high bunch weight helps for prolonging the productive life of the palm to more than 35 years, adding value to obtain distinct oil palm varieties. Overall, this targeted breeding effort towards developing dwarf oil palm hybrids reflects a strategic approach to addressing specific challenges in oil palm cultivation, ultimately helping to promote the oil palm sector globally.

SLC2A1 variants cause late-onset epilepsy and the genetic-dependent stage feature

BackgroundThe SLC2A1 gene plays a vital role in brain energy metabolism. SLC2A1 variants have been reported to be associated with early-onset refractory seizures. This study aims to explore the association between the SLC2A1 gene and late-onset epilepsy.MethodsTrios-based whole-exome sequencing was performed on patients with epilepsy without acquired etiologies. The pathogenicity of the variants was assessed according to the American College of Medical Genetics and Genomics (ACMG) guidelines.ResultsA total of 14 heterozygous SLC2A1 variants were identified in 16 unrelated families. The variants were evaluated as “pathogenic” or “likely pathogenic” according to the ACMG guidelines. Ten cases (62.5%) presented with infantile onset seizures and developmental delay/intellectual disability and were diagnosed with developmental and epileptic encephalopathy (DEE). The other six cases (37.5%) exhibited late-onset seizures and normal development. They were diagnosed with idiopathic partial epilepsy (n = 2) or idiopathic generalized epilepsy (n = 4). Further analysis showed that DEE-associated variants tended to cluster in the transmembrane region, whereas the mild epilepsy-associated variants tended to locate in regions outside the transmembrane region, suggesting a potential molecular sub-regional effect. A total of 15 cases had delayed diagnosis, with the longest delay being 22 years. The SLC2A1 expression stage, which is expressed at relatively high level throughout the whole life span, from the embryonic to adult stages with two peaks at approximately four and 14 years, is generally consistent with the seizure onset age. In addition, patients with early-onset age had variants that were potentially associated with severe damage, suggesting a potential correlation between the age of disease onset and the damaging effects of the variants.ConclusionsSLC2A1 variants are associated with late-onset epilepsy, which is consistent with the genetic-dependent stage feature of SLC2A1. Early genetic diagnosis is important for treatment of patients with SLC2A1 variants.

Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project).

Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent. HIGHLIGHTS: Dementia rates are escalating in Africa, largely due to longer life spans and increased prevalence of modifiable risk factors. Yet, few regional interventions have directly targeted lifestyle factors to reduce dementia risk. The multinational Africa-FINGERS study will address this gap by adapting the successful FINGERS lifestyle intervention to African populations. Africa-FINGERS will pioneer a culturally informed, multidomain dementia risk reduction intervention in the African region through feasibility dementia prevention trials in rural and urban sites across Kenya and Nigeria in the first instance, enrolling 600 at-risk adults (≥ 50 years). The program adoptsparticipatory research methods to develop culturally appropriate interventions and build infrastructure to evaluate dementia biomarkers from ante and post mortem samples. A cost-effectiveness analysis will be conducted to guide the strategic implementation of Africa-FINGERS into regional health systems. The Africa-FINGERS strategy aligns with the Worldwide-FINGERS framework and integrates the global Alzheimer's Disease Neuroimaging Initiative approach, emphasizing multimodal analysis.

The association between breast cancer and lung cancer: a bidirectional Mendelian randomization study.

With increasing life spans, breast cancer (BC) survivors may face the possibility of developing second primary cancer (SPC), which can considerably shorten survival. Lung cancer (LC) is a common SPC among BC survivors. This study explored the association between these two cancers through Mendelian randomization (MR) analysis. A bidirectional two-sample MR analysis was conducted with BC genome-wide association study (GWAS) data from the Breast Cancer Association Consortium (BCAC) included 228,951 individuals and the GWAS summary statistics from the Transdisciplinary Research in Cancer of the Lung (TRICL) of LC included 112,781 individuals. The IVW method and MR-RAPS method showed a causal effect of overall BC on lung adenocarcinoma (LUAD) (IVW: OR = 1.060, 95% CI = 1.008-1.116, P = 0.024; MR-RAPS: OR = 1.059, 95% CI = 1.005-1.116, P = 0.033), which indicated that patients with BC had an increased risk of LUAD. However, there is no strong evidence for a causal effect of LUAD on BC. Our study revealed a causal effect of BC on second primary LUAD, suggesting that we should intensify screening for second primary LC in BC survivors. Early intervention and treatment for patients with second primary LC are needed to reduce mortality in BC survivors.