Short Life Research Articles

Glioblastoma and its interaction with neurogenesis

Glioblastoma (GBM) is the most frequent and aggressive malignant primary tumor of the central nervous system in adults, with an incidence of 3.23 per 100,000 people. Despite the existence of various therapeutic approaches, the absence of a cure and the unfavorable prognosis persist for this neoplasm, with a median survival of approximately 8-15 months and a 5-year survival rate of 6.9%. In this review, we address the epidemiology, histopathology, molecular characteristics, and treatment of GBM. We highlight the relationship of GBM with the microenvironment in the lateral ventricle wall and the cerebrospinal fluid. The location of GBM in this region results in more aggressive tumors and shorter life expectancy for patients. Understanding the malignancy mechanisms that hinder remission, treatment, and positive prognosis opens the possibility of improving diagnostic and therapeutic interventions against GBM.

(Cost-)effectiveness and implementation of a combined lifestyle intervention for outpatients with severe mental illness (GOAL!): a hybrid quasi-experimental study protocol.

People with severe mental illness (SMI) face not only impaired mental health, but also a greater risk of physical comorbidities and a shorter life expectancy compared to the general population. A poor lifestyle plays a substantial role in this disparity. Combined Lifestyle Interventions targeting multiple lifestyle behaviors can improve mental and physical health, and quality of life. However, there is currently no appropriate structural support for people with SMI in outpatient care in the Netherlands. The Combined Lifestyle Intervention for Outpatients with SMI (GOAL!) is developed to address this gap. This study examines the (cost-)effectiveness and implementation of GOAL!. In a type 1 hybrid quasi-experimental study with a mixed-method matched design, GOAL! participants (N = 50) are compared to people receiving care as usual (N = 50). The GOAL! program includes group and individual sessions, given by allied health professionals, over a period of two years. The first year starts with a 3-month intensive course on physical activity and nutrition, followed by 9 months of aftercare covering various lifestyle topics tailored to the group's needs. There is close collaboration with local stakeholders to facilitate transfer to the community setting. The second year focuses on maintaining established activities in one's daily living environment. Our primary outcome will be the change in physical activity, comparing GOAL! participants to those receiving care as usual. Secondary outcomes are changes in other lifestyle behaviors, physical health, mental well-being, and healthcare and societal costs. Additionally, achieving lifestyle-related goals, adverse effects, and barriers and facilitators to implementation are examined. Measurements are obtained at start (T0), and after 3 (T1), 12 (T2) and 24 months (T3). This study investigates the effects of GOAL! on lifestyle behaviors, health outcomes, implementation factors and cost-effectiveness after two years, aiming to offer valuable insights into the effectiveness and implementation outcomes of lifestyle interventions for outpatients with SMI. ClinicalTrials.gov (Identifier: NCT05600205). Prospectively registered on October 26, 2022.

The Application of 1-MCP in Combination with GABA Reduces Chilling Injury and Extends the Shelf Life in Tomato (Cv. Conquista)

Tomatoes have a short shelf life, and refrigeration is commonly used to extend tomato quality. However, suboptimal temperatures can lead to chilling injury (CI), reducing their marketability. In this study, the combined application of 10 mM γ-aminobutyric acid (GABA) and 0.5 µL L−1 of 1-methylcyclopropene (1-MCP) were used as strategies to reduce postharvest CI and prolong storability during tomato commercialization. Both treatments have individually demonstrated their effectiveness in lowering physiological disorders in tomatoes. When applied, the combined treatment resulted in the lowest CI and rot incidence levels compared with the control and individual treatments. Additionally, the combined application effectively delayed weight loss, fruit softening, respiration rate, ethylene production, and increased chlorophyll and flavonoid content. The synergistic application of these substances improved the postharvest quality during storage, reducing quality losses. For this reason, the combination of GABA and 1-MCP could be an effective tool to minimize tomato waste during commercialization by increasing resilience to cold storage and extending the overall fruit shelf life during refrigerated storage.

Sharing of data archive of radiation exposure animal experiments in QST/NIRS and IES.

Institute for Radiological Science (NIRS), National Institutes for Quantum Science and Technology (QST), and Institute for Environmental Sciences (IES) have conducted large-scale animal experiments for radiation risk analyses in terms of life shortening and cancer prevalence. It is important to store data and biological samples from these large-scale experiments for sharing and future use since the economic and practical limitations, as well as the ethical considerations, make it difficult. QST/NIRS established an archive called the Japan Storehouse of Animal Radiobiology Experiments (J-SHARE) for the purpose of storing and sharing these historic collections. We plan to integrate the data and tissue specimen images obtained at the IES into J-SHARE by standardizing the archive format, with the aim of maximizing the results of radiation biology research. This integration is expected to contribute to the generation of new knowledge for radiation risk assessment and the provision of scientifically based information on radiation protection.

Physio-Metabolic Mechanisms Behind Postharvest Quality Deterioration in Broccoli (Brassica oleracea var. Italica) and Swiss Chard (Beta vulgaris L. var. Cicla): A Review

Leafy vegetables are among the potential foods that can combat food insecurity in developing countries. Their major drawback is a short shelf life, which limits their supply chain and is commonly associated with their high metabolic activities. Leafy vegetables have a high water content, which determines their freshness. Moisture loss through respiration and transpiration at postharvest storage is one quality attribute that leads to rapid quality deterioration. Little has been carried out in studying the mechanisms associated with the quality deterioration of leafy vegetables; however, understanding these mechanisms may aid in developing effective preservation measures. Furthermore, recent literature reviews that focus on discussing the mechanisms that lead to quality loss in leafy vegetables are scarce. The current paper aims to review the physiological and biochemical processes associated with quality deterioration in leafy vegetables. The respiration, ethylene production, moisture loss, colour, and texture are highly associated with the quality deterioration of fresh produce and, thus will be discussed critically in selected leafy vegetables, namely: broccoli and Swiss chard. The findings from this review indicate that the quality deterioration in leafy vegetables is primarily enzymatic. Understanding the mechanisms of quality deterioration involves identifying the specific enzymes responsible for each metabolic process and examining the internal and external factors that influence enzyme activities.

Abstract 4137939: Mosaic loss of Y chromosome is associated with increased all-cause mortality in patients with ST-segment elevation myocardial infarction

Introduction: Mosaic loss of Y chromosome (LOY), a common subtype of somatic mosaicism, is characterized as loss of the entire Y chromosome in a mosaic manner and increases with age. Accumulating evidence has manifested the positive link between LOY and shorter life expectations in elderly men as well as common age-associated diseases, such as cancer and cardiovascular diseases. Experimental studies also demonstrated that hematopoietic LOY in mice induced cardiac fibrosis and led to increased mortality. However, little is known about LOY and prognosis of ST-segment elevation myocardial infarction (STEMI). Hypothesis: We hypothesized that LOY may be associated with lower survival rate of patients with STEMI. Aims: Investigating the impact of LOY in peripheral blood cells on prognosis of patients with STEMI. Methods: This study prospectively enrolled 928 males and 272 females undergoing primary percutaneous coronary intervention for STEMI. LOY was measured in 928 males using droplet digital polymerase chain reaction technique. Results: During a median follow-up of 3.99 years, 93 males (10.0%) and 45 females (16.5%) died. After adjusting for traditional cardiovascular risk factors, the risk of all-cause mortality in males with LOY ≥ 18% (the 90th percentile of LOY) increased to 2.45 (95% confidence intervals [CI]: 1.16–5.15, P = 0.018), 2.11 (95% CI: 1.11–4.01, P = 0.024), and 1.88 (95% CI: 1.02–3.45, P = 0.043) times during 1-, 2-, and 3-year follow-up, respectively, compared to males with LOY < 18%. Among males without prior MI, those with LOY ≥ 18% had an increased risk of all-cause mortality compared to those with LOY < 18% (adjusted hazard ratio 1.93, 95% CI: 1.01–3.67; P = 0.045); this was not observed for males with prior MI. Female patients had a 1.71-fold (95%CI: 1.04–2.81; P = 0.035) increased risk of all-cause mortality than males with LOY < 18%, whereas the risk was similar to males with LOY ≥ 18%. Conclusion: LOY was associated with an increased risk of all-cause mortality in male STEMI patients, particularly in those without prior MI. Detecting LOY in STEMI patients could help further refine sex differences in prognosis and assist in identifying male patients with better prognoses.

Effect of Moringa oleifera L. Leaf Solution Concentration and Length of Storage on the Internal Quality of Duck Eggs (Anas platyrhyncos domesticus)

Duck eggs have a delicious taste, are easily digested by the body, and contain quite good nutrition.However, duck eggs have a short self life. This study aims to determine the effect of the length of storage and concentration of Moringa leaf solution on the internal quality of duck eggs. This study was conducted in September-October 2023 at the Livestock Production Laboratory of Animal Husbandry Study Program, Faculty of Agriculture, Universitas Sumatera Utara. The design used in this study is a complete random design, factorial pattern, namely 4 concentration solution treatment (R0 = without soaking, R1 = 10%, R2 = 20%, R3 = 30%), 5 Treatment of Length of Storage (L0 = 0 days, L1 = 7 days, L2 = 14 days, L3 = 21 days, L4 = 28 days) with 2 replications. The parameters used in this study include the egg white index (albumen), the egg yolk index (yolk), the percentage of decreased egg weight and the degree of acidity (pH) of eggs. The results showed that the number of concentrations of 30% solution had a significant effect (p <0.05) on the albumen index, yolk index and pH, but did not affect the percentage of decreased egg weight. The length of storage has a significant effect on the internal quality of duck eggs. The treatment interaction is a significant effect (p <0.05) against the egg white index (albumen) and egg pH. Treatment with a 30% moringa leaf solution had better results for 28 days compared to treatment without soaking.

Piwi mutant germ cells transmit a form of heritable stress that promotes longevity.

The C. elegans Argonaute protein PRG-1/Piwi and associated piRNAs protect metazoan genomes by silencing transposons and other types of foreign DNA. As prg-1 mutants are propagated, their fertility deteriorates prior to the onset of a reproductive arrest phenotype that resembles a starvation-induced stress response. We found that late-generation prg-1 mutants with substantially reduced fertility were long-lived, whereas early- or mid-generation prg-1 mutants had normal lifespans. Loss of the stress response transcription factor DAF-16 caused mid- or late-generation prg-1 mutants to live very short lives, whereas overexpression of DAF-16 enabled both mid- and late-generation prg-1 mutants to live long. Cytoplasmic P-bodies that respond to stress increased in long-lived late-generation prg-1 mutants and were transmitted to F1 but not F2 cross-progeny. Moreover, moderate levels of heritable stress shorten late-generation prg-1 mutant longevity when DAF-16 or P bodies are deficient. Together, these results suggest that the longevity of late-generation prg-1 mutants is a hormetic stress response. However, dauer larvae that occur in response to stress were not observed in late-generation prg-1 mutants. Small germ cell nucleoli that depended on germline DAF-16 were present in late-generation prg-1 mutants but were not necessary for their longevity. We propose that prg-1 mutant germ cells transmit a form of heritable stress, high levels of which promote longevity and strongly reduce fertility. The heritable stress transmitted by prg-1/Piwi mutant germ cells may be generally relevant to epigenetic inheritance of longevity.

A brief report: Lessons learned using wearable technology to collect data from adults receiving medications for opioid use disorder

ABSTRACT Background Incorporating wearable technology into substance use disorder research enables continuous, objective, and remote data collection, facilitating symptom monitoring to prevent relapse. However, implementation challenges may hinder data collection. This paper aims to assess adherence patterns to a wrist-worn wearable device, and to share lessons learned from incorporating wearable technology to collect physiological data from adults with opioid use disorder. Methods Employing a prospective observational design, we used convenience sampling to recruit adults receiving medications for opioid use disorder in outpatient settings. Wearable adherence was measured by days and nights worn over eight weeks, acceptability by a visual analog scale, and anecdotal notes tracked study activities and challenges. Results Twenty-three participants completed baseline, and 16 (70.0%) completed the study. Daytime and nighttime wearable adherence averaged 60.1% and 47.7%, respectively. Wearable adherence was highest at the earlier phase of the study (67.7%) and plateaued after overtime. User-related and technical challenges included digital illiteracy, protocol nonadherence, low motivation, measurement errors, and short battery life. Unique challenges included wearable design concerns and sleep problems. Conclusions This study demonstrates the feasibility of wearable use and highlights the potential to overcome challenges. Proactively sharing insights can facilitate wearable technology adoption for both participants and researchers.

Effect of Sucrose, Salicylic Acid (SA), Sulfosalicylic Acid (SSA), Silver Nano and Ajwain E.O on Vase Life of Single Tuberose (Polianthes tuberosa L.)

Tuberose is a highly valued flower known for its vibrant colors, elegance, and captivating fragrance. It is prominent in floral arrangements, both as a cut flower and in the perfume industry. Despite its visual appeal, tuberose flowers have a relatively short shelf life. To address this, researchers have explored various chemical treatments to enhance the longevity and quality of cut tuberose. An experiment was conducted at the Department of Floriculture and Landscaping, College of Horticulture & Forestry, Kumarganj, Ayodhya, during the 2023-24 period. The study, which followed a completely randomized design with sixteen treatments and three replications, aimed to determine the effects of different chemical solutions on the vase life of tuberose (Polianthes tuberosa L.). The results demonstrated significant differences among the treatments in various parameters, including changes in fresh weight, percentage change in spike length, longevity of the five basal florets (in days), vase solution uptake (in ml), vase life (in days), time taken for the first five florets to open, individual floret longevity, period of prime beauty, time taken for full spike opening, time for the first floret to fade, and time for the entire spike to fade. Among the treatments, the solution containing salicylic acid and sucrose proved to be the most effective in extending vase life. The combination of 2.5% sucrose, 50 ppm salicylic acid, and 150 ppm silver nanoparticles (T12) achieved the highest longevity for the five basal florets, lasting 4.75 days. Additionally, the treatment with 2.5% sucrose and 150 ppm silver nanoparticles (T8) resulted in 100% of florets opening. The longest vase life of 9.83 days was observed with the combination of 2.5% sucrose, 50 ppm salicylic acid, and 150 ppm silver nanoparticles (T12). This study underscores the effectiveness of specific chemical treatments in significantly improving the vase life and overall quality of cut tuberose flowers.

Evaluation of Performance Improvement Rate of Plastic Production System Using ARENA: A Case Study of Phoenix Plastic Services

Production improvement has become essential to all industrial activity because of the fierce competition among today's production systems and organizations and the unquenchable customer demand. The shorter product life cycle has significantly increased the demand for prompt reactions to increase the productivity and efficiency of these industrial systems. This study examined the evaluation of performance improvement rate of plastic production system using ARENA. The report provided by the plastics industry was used in the study to analyze and assess the rate of performance improvement of the plastic manufacturing system. The location of the bottleneck was determined by the research following a thorough analysis of the plastic company's data, which included information on all manufacturing lines and procedures. The research employed Arena to assess and compute the rate of improvement in system performance while accounting for the material transporting process throughout the production line. The conveyor velocity maintains a lock at 75m/min, despite the company's report stating that the transports run at 30m/min. The optimized and unoptimized processes when obtained from a finished recycling process running for 1000 working hours, indicate that the conveyor process had 1045 and 1027 entity input and output, respectively, and the transporter process had 953 and 929 entities input and output respectively. The remaining number left when considering the number that enters the system with the number that leaves the system went to waste, resulting from the sorting and demagnetization process. The introduction of the conveyor brings 10.549% in the production rate and 50% decrease on expenses spent in labor. Through the conveyor system's speed control factor, which is an automated procedure, the system's percentage increment may be further raised. By raising the conveyor system's speed, more items will be produced. Conveyor system installation free up more space for additional production-related equipment, increasing products formed and the company's profit. The cost of purchasing and installing the conveyor will be covered by the excess profit.

A combined analysis of transcriptome and proteome reveals the regulation mechanism of alginate oligosaccharides on alleviating energy deficit in postharvest strawberry

Strawberry exhibits a very short shelf life due to its rapid softening and decay, resulting in postharvest loss. Our previous study showed that AOS, an eco-friendly nontoxic natural product, plays a role in preserving the freshness of strawberries by regulating ABA content and its signaling pathway. Considering the critical role that energy deficit plays in the senescence process of fruits, coupled with the potential influence of plant hormones on energy metabolism. In this study, the molecular mechanism of strawberry postharvest senescence in response to AOS treatment was further explored from the perspective of energy metabolism regulation. This was achieved through a two-layered approach, integrating the direct determination of energy-related substances with a comprehensive joint analysis of transcriptome and proteome data. AOS treatment significantly delayed the loss of ATP, ADP, and AMP contents compared to control fruit, implying that maintaining cell energy is a crucial factor in AOS postponing senescence in strawberry. Subsequently, the mechanisms were further revealed by transcriptome and proteome analysis. Overall, 255 DEGs were screened from the AOS group, mainly related to carbohydrate and energy metabolism, defense, plant hormone, and secondary metabolism. Additionally, A total of 227 proteins were identified that were differentially expressed in the AOS group, and the majority were related to carbohydrate and energy metabolism (85 proteins). Two omics data implied that AOS could effectively regulate the energy metabolism system to maintain the cellular energy level of harvested strawberry during storage, ultimately leading to longer shelf life. Therefore, our findings provide comprehensive information regarding the molecular mechanism underlying the postharvest storage of strawberry treated with AOS. From our results, it can be concluded that AOS postharvest treatment is very useful for keeping fruit quality and extending shelf life by maintaining a higher energy level.

Progress of silicon and graphene composites in lithium-ion battery anodes

As society progresses, the need for high-power, long-life energy supply devices gradually increases. Lithium-ion batteries (LIBs) with large energy reserves and high power have recently become the preferred choice. The anode of LIBs plays a crucial role in battery performance, safety, and cycle life. Typically, graphite materials are used for LIBs anodes. Still, they have drawbacks such as low first-time Coulombic efficiency, capacity degradation, safety issues, short cycle life, insufficient gram capacity, and purity and side reactions, which limit the application of LIBs. Therefore, new harmful electrode materials are in demand. Graphene and silicon are both environmentally friendly and sustainable materials. They both have the advantages of high theoretical capacity and high energy density, which are critical materials for developing LIBs. Combining the two can exert a synergistic effect and jointly improve the cycle stability of the battery. In this paper, we review the preparation methods of graphene and silicon composites in recent years, including mechanical ball milling and hydrothermal and thermal reduction methods. In addition, graphene and silicon composites have been explored for LIBs applications.

Durability of non-woven geotextiles produced from recycled polyethylene terephthalate (PET)

Achieving the goals of sustainable development and circular economy requires recycling and reusing plastic materials. In this research, the durability of five needle-punched non-woven geotextiles were experimentally studied. The geotextiles were made of recycled PET (rPET), virgin PET (vPET), and combinations of rPET and vPET fibers. The samples were hydrolyzed for a period of 14, 28, and 56 days and the retained tensile strength and puncture resistance of the samples were determined at the end of each interval. Moreover, this study took the benefits from the capability of differential scanning calorimetry (DSC), Fourier transforms in infrared spectroscopy (FTIR) analysis, and scanning electron microscopy (SEM) images to interpret the results acquired. Testing on as-received products, it was understood that recycling process could increase crystallinity of the fibers, increasing the fibers fragility, reducing the tensile strength and elongation capacity of rPET fibers. Moreover, considering the borderline value of 50% retained strength, a shorter service life (up to 30%) of rPET products in comparison with vPET products, due to higher degradation rates, was observed.

Drosophila as a Model for Human Disease: Insights into Rare and Ultra-Rare Diseases

Rare and ultra-rare diseases constitute a significant medical challenge due to their low prevalence and the limited understanding of their origin and underlying mechanisms. These disorders often exhibit phenotypic diversity and molecular complexity that represent a challenge to biomedical research. There are more than 6000 different rare diseases that affect nearly 300 million people worldwide. However, the prevalence of each rare disease is low, and in consequence, the biomedical resources dedicated to each rare disease are limited and insufficient to effectively achieve progress in the research. The use of animal models to investigate the mechanisms underlying pathogenesis has become an invaluable tool. Among the animal models commonly used in research, Drosophila melanogaster has emerged as an efficient and reliable experimental model for investigating a wide range of genetic disorders, and to develop therapeutic strategies for rare and ultra-rare diseases. It offers several advantages as a research model including short life cycle, ease of laboratory maintenance, rapid life cycle, and fully sequenced genome that make it highly suitable for studying genetic disorders. Additionally, there is a high degree of genetic conservation from Drosophila melanogaster to humans, which allows the extrapolation of findings at the molecular and cellular levels. Here, I examine the role of Drosophila melanogaster as a model for studying rare and ultra-rare diseases and highlight its significant contributions and potential to biomedical research. High-throughput next-generation sequencing (NGS) technologies, such as whole-exome sequencing and whole-genome sequencing (WGS), are providing massive amounts of information on the genomic modifications present in rare diseases and common complex traits. The sequencing of exomes or genomes of individuals affected by rare diseases has enabled human geneticists to identify rare variants and identify potential loci associated with novel gene–disease relationships. Despite these advances, the average rare disease patient still experiences significant delay until receiving a diagnosis. Furthermore, the vast majority (95%) of patients with rare conditions lack effective treatment or a cure. This scenario is enhanced by frequent misdiagnoses leading to inadequate support. In consequence, there is an urgent need to develop model organisms to explore the molecular mechanisms underlying these diseases and to establish the genetic origin of these maladies. The aim of this review is to discuss the advantages and limitations of Drosophila melanogaster, hereafter referred as Drosophila, as an experimental model for biomedical research, and the applications to study human disease. The main question to address is whether Drosophila is a valid research model to study human disease, and in particular, rare and ultra-rare diseases.

Longevity

The value of a person’s life is not reducible to the satisfaction of one’s desires or interests, including the interest in living longer.  A person who takes pleasure in beach vacations each summer may look forward to another stay at the shore next year, but this is not the kind of interest that gives her a reason to continue living.  Assuming she has lived a normal life, one beach vacation more or less will not affect the value of her life, even in the slightest degree. Similarly, we wouldn’t say of a person who has lived a full life that his life would have been more valuable if he hadn’t suffered that wretched toothache several decades ago. The value of a person’s life is not simply a function of the good and bad experiences it contains. More controversially, neither is it simply an aggregate of a person’s accomplishments. Discovering another great self-portrait by Rembrandt (who created nearly 100 of them, so far as we know) would not affect to any degree our assessment of his greatness as an artist.  Rather, the value of a human life is determined by what adds meaning to life, what – and not simply how much – she achieves, or how well she lived up to her ideals.  If this is right, then for most people who live to a reasonable age, living longer will not add value to their lives. The social value of longevity is a question of whether a society in which the median age is higher or human life over time is packaged in fewer individuals is better than a society in which the median age is lower and the same amount of life is packaged in more individuals living shorter lives.  I see no reason for thinking the former society is better and hence no justification for nations like the United States or Great Britain to spend health care resources on promoting longevity of its citizens by adding to the normal lifespan.

Lady Lazarus: An Insight into the Suicidality of Sylvia Plath.

Sylvia Plath (1932-1963) was an American author and poet, perhaps best known for her semi-autobiographical novel The Bell Jar. Her poetical oeuvre was filled with challenging themes of suicidality, mental illness, and a budding feminism, particularly in the poems composed toward the end of her tragically short life. One of these poems, "Lady Lazarus," pushes the bounds of expectation and, some would say, propriety. This short reflective Poet's Pen focuses on Sylvia Plath and the many themes-feminism, suicidality, self-rebirth-for which she would later be known. The poem itself is a melting pot of imagery, drawing themes from the Judeo-Christian perspective, cycles of death and rebirth, and the mythology of the phoenix rising from the ashes.

Impact of electronic networks on E‐waste trade: Evidence from ASEAN+6 countries

AbstractThe development of electronic networks promotes economic growth and international trade flows. Because of the short life cycle of electrical and electronic equipment, considerable electronic waste (e‐waste) is generated. We identified the determinants of e‐waste trade, focusing on ASEAN+6 countries and their trading partners for the years 2000 to 2018. The empirical results regarding trade value and trade weight revealed that electronic networks significantly promoted the import of e‐waste into ASEAN+6 countries. The results were robust to using different measures of electronic networks and different estimation methods.

Effect of different packaging methods and storage conditions on postharvest quality and shelf-life of Manila Tamarind (Pithecellobium dulce (Roxb.) Benth.) var. PKM2

Manila tamarind (Pithecellobium dulce (Roxb.) Benth.), is a dry land fruit crop that belongs to the Fabaceae family commonly known Camacchile or Jungle jilebi. Pithecellobium dulce (Roxb.) has the potential to become productive under harsh climatic and edaphic conditions of dry land areas but its pods have a shorter shelf life. The most important objective was to use proper packaging methods to reduce moisture loss, slow down physiological and biochemical changes and prevent spoilage. The study evaluated 8 packaging methods, including different combinations of CFB (Corrugated Fiberboard) lined with 100-gauge polythene film with 0 %, 5 % and 10 % vents, CFB with 0 %, 5 % and 10 % vents, vacuum packing and a control, under cold storage (13-15 °C) and ambient conditions (26 ± 2 °C). On the 15th day of cold storage conditions, vacuum packing showed minimum physiological loss of weight (19.82 %), titratable acidity (0.68 %), ascorbic acid (77.20) and total sugar (8.36 %). Maximum total soluble solids (15.32 ?Brix), Anthocyanin (22.72 mg 100 g-1 m), shelf life (15 days) followed by CFB with 10 % vent. On the 12th day of ambient storage condition, vacuum packing recorded minimum physiological loss of weight (16.42 %), titratable acidity (0.42 %), ascorbic acid (76.13) and total sugar (8.53 %). Maximum total soluble solids (14.93 ?Brix), Anthocyanin (21.83 mg 100 g-1 m) and shelf life (11.5 days) followed by CFB with 10 % vent. In this study, the overall results indicated that both vacuum packaging and CFB with 10 % vent at cold storage had synergistic effect in manila tamarind fruit pods, not only in extending the shelf life but also maintained the physiological and biochemical attributes of manila tamarind.

“Dead Lithium” Formation and Mitigation Strategies in Anode‐Free Li‐Metal Batteries

AbstractThin lithium‐metal foil is a promising anode material for next‐generation batteries due to its high theoretical specific capacity and low negative potential. However, safety issues linked to dendrite growth, low‐capacity retention, and short cycle life pose significant challenges. Also, it has excess energy that must be minimized in order to reduce the battery costs. To limit excess lithium, practical lithium metal batteries need a negative‐to‐positive electrode ratio as close to 1 : 1 as possible, which can be achieved through limiting excess lithium or using an “anode‐free” metal battery design. However, both designs experience fast capacity fade due to the irreversible loss of active lithium in the cell, caused by the formation of the solid electrolyte interphase (SEI), dendrite formation and “dead lithium,” – refers to lithium that has lost its electronic connection to the anode electrode or current collector. The presence of dead lithium in batteries negatively affects their capacity and lifespan, while also raising internal resistance and generating heat. Additionally, dead lithium encourages the growth of lithium dendrites, which poses significant safety hazards. Within this fundamental review, we thoroughly address the phenomenon of dead lithium formation, assessing its origins, implications on battery performance, and possible strategies for mitigation. The transition towards environmentally friendly and high‐performance metal batteries could be accelerated by effectively tackling the challenge posed by dead lithium.