Life Patterns Research Articles

Association of patient-reported disease burden and treatment switching among patients with plaque psoriasis on nonbiologic systemic therapy

Introduction: Better understanding of the relationship between quality of life and treatment patterns in psoriasis may help guide therapeutic algorithms. This study evaluated the association between patient-reported disease burden and treatment switching from nonbiologic to biologic therapy in patients with plaque psoriasis enrolled in the CorEvitas Psoriasis Registry.
 Methods: This cross-sectional study included biologic-naive patients aged ≥18 years who had used nonbiologic systemic therapy 28–365 days prior to their registry enrollment between April 2015 and August 2022. A switch to biologic therapy was defined as the introduction of biologic treatment up to 45 days post-enrollment, in addition to or in place of the initial nonbiologic systemic therapy. Measures of patient-reported disease burden collected at enrollment were: the Dermatology Life Quality Index (DLQI); Work Productivity and Activity Impairment Index (WPAI); itch, skin pain, fatigue, and Patient Global Assessment (PGA), measured on visual analog scales (VAS); and the EuroQoL 5-Dimension, 3-Level (EQ-5D-3L) questionnaire. The association between each patient-reported disease burden measure and switching to biologic therapy was evaluated using multivariable logistic regression models, adjusting for age, sex, race, ethnicity, work status, body mass index, psoriasis duration, psoriatic arthritis status, disease severity, number of prior nonbiologic therapies used, and history of difficult-to-treat areas. A secondary analysis stratified each model by patients with PASI scores ≤2 or >2.
 Results: Of 848 patients included in the analysis, 323 (38.1%) switched to biologic treatment at enrollment. Significantly higher odds of switching were observed for patients reporting greater vs lesser burden on the DLQI (adjusted odds ratio [aOR] = 1.55; 95% CI, 1.08–2.23); VAS measures of itch (aOR = 2.14; 95% CI, 1.49–3.08), skin pain (aOR = 2.18; 95% CI, 1.45–3.29), fatigue (aOR = 1.66; 95% CI, 1.15–2.40), or PGA (aOR = 3.09; 95% CI, 1.94–4.91); or WPAI activities impairment (aOR = 2.51; 95% CI, 1.72–3.65). Numerically higher odds of switching were observed for greater vs lesser burden measured by EQ-5D-3L. In the secondary analysis, 52 of 330 patients with PASI scores ≤2 (15.8%) switched to biologic treatment. Among patients with PASI scores ≤2, those with greater vs lesser burden for VAS itch, skin pain, or PGA, or with impairment of their usual activities as measured by EQ-5D-3L had significantly higher odds of switching to biologic treatments.
 Conclusion: Data collected from real-world patients with plaque psoriasis suggest that, in addition to disease severity, patient-reported disease burden, such as itch and skin pain, may be an important driver of switching from a nonbiologic to biologic therapy, even among patients with a low degree of skin involvement.
 Sponsored by: CorEvitas.

Menopause Status and Risk Factors for COVID-19 in the Elderly

The cessation of the menstrual cycle in women (menopause), which usually occurs in women aged over 40 years, is often accompanied by significant impacts on both physical and psychological health. During menopause, women experience a decrease in estrogen levels which is a protective factor in the woman’s body by decreasing chemokine ligand 2 expression during inflammation. Postmenopausal women who have experienced a decrease in their protective agents are more susceptible to being exposed to viruses. This study identified the correlation between menopause status and risk factors for COVID-19 by using Spearman rho. The participants in this retrospective cross-sectional study were 30 elderly women, 33 to 64 years old, at Posyandu lansia (Integrated Health Care System for Elderly) who expressed their willingness to participate in this study from April 1st until June 19th, 2022, by online survey or by filling out the menopause health and risk factor of COVID-19 questionnaires manually. Risk factors of COVID-19, such as comorbid disease, lack of exercise, low healthy life patterns, and obesity, have a significant correlation with the menopausal status of elder women. Half of them had graduated from senior high school and got menarche at 9 years old. Twenty per cent of them had a risk factor of COVID-19, and more than half of them used contraception. The number of elder people who were already in menopause was 27 per cent. Elderly people should improve their immune systems and prepare for menopause to lower the incidence of COVID-19 infection.
 Keywords: COVID-19, elderly, menopause, risk factors

ANALYZING ISABEL ALLENDE’S THE HOUSE OF SPIRIT: A DISCIPLINARY POWER

This study discusses Isabel Allende’s The House of Spirit in relation to the notion of disciplinary power. The House of the Spirit explores the amalgamation of diverse social groupings and their collective pursuit of dominance. The novel's actions and motifs are influenced by a class system that is characterized by a division into two distinct groups. One group consists of the white, educated elite of European descent who hold positions of power in politics, business, and administration. This qualitative research employs Foucault’s notion of disciplinary power refers to a specific form of power used by those in positions of authority over their subordinates, with the aim of influencing and regulating their behavior according to their own desires. The study concludes that power moves from different institutions to daily life and affects with routine and pattern of life on large scales. It has also discovered that power is common issue and debate of daily life Latin America. There are number of events and incidents in Latin American society portrayed in the selected novel which are changed, molded and regularized on the basis of power. Keywords: disciplinary power, dominance, elites, authority.

Manajemen Strategik dan Manajemen Operasional serta Implementasinya pada Lembaga Pendidikan

Education is a long-term investment in order to fulfill Indonesia's future pattern of human life. First, education as a project meant to enhance the human body's intellectual potential through a teaching and learning procedure Second, education contributes to the formation of an ethnically diverse society through the transmission of the values it includes. Third, education is one of the guarantees of a better, more honorable existence. Education must develop and evolve in educational institutions in a better path in order to become an investment. The use of operational and strategic management in educational institutions is one of the theoretical ideas put forth. The management of educational institutions is anticipated to be able to direct and impact the quality of educational products/outcomes including curriculum, institutional management administration, and student affairs through these two theoretical notions.

The Impact Of Walkways and Open Spaces on Promoting Sustainable Pattern of Life in the Campus Case Study Of Mahlia Girls' Campus Jazan University , Saudi Arabia

The term "University Campus" defines an institutional place that is usedfor education as the primary activity for a large number of students and staff, thephysical environment of a campus includes buildings, open spaces and all theessential infrastructures needed to function effectively .The concept of‘Walkability’ provides an important principle of sustainability in such places, thequality of campus environment in terms of walkways and open spaces haspositive influence on ‘Walkability’. The quality of which the built environmentenables the mobility of pedestrians define it's walkability .This study examinesthe impact of walkways and open spaces on walkability in Mahlia Girls' Campusof Jazan University. The author investigated the existing conditions of the campusand their impact on creating a sustainable pattern of life .The research methodsapplied a mix of methods: a walkability audit tool to record data of physical builtenvironment elements was developed and tested, a questionnaire and directobservation. The resulting data were statistically analysed. The results obtainedwere supported by graphical illustrations prepared by the author. The researchfound certain physical infrastructure challenges that influence female students andstaff willingness to walk. Results emphasis major factors such as landscape ,width and connectivity of the walkway ,weather protection and shading ,appropriate urban furniture for activities such as seating and places forrefreshment .The conclusions are summarized to provide design guidelines for theimprovement and enhancement of existing conditions.

An Analysis of the Development Strategy and Organizational Structure of Taiwan's Design Industry

Taiwan's design industry has established design characteristics and styles during the short period of more than 30 years of development, making Taiwan's designed products rank on the world stage. Based on the current design development direction, the analysis of the existing design organization, and the input and implementation of design by Taiwan enterprises, this research discusses the factors for the successful development of Taiwan's design industry by means of historical analysis and case comparison. The study found that in the timeline of Taiwan's design development, the focus is on industrial management innovation, design diagnosis, product development, etc., and it is supplemented by trying to increase the competitiveness of products and promoting international design. At the same time, it is actively constructing the design of each enterprise Environment, including the implementation of multiple counselling measures, the establishment of various design technical support systems, the design of intellectual property rights protection systems, and the provision of corporate subsidies, training channels, etc., plus government agencies have proper control over design policies, future design directions, and national budget resources. Development strategies such as design division and cooperation carried out by non-governmental and semi-official organizations have promoted Taiwan's design to shine in the world. The changes brought about by computer technology and the Internet to human life patterns have changed the functional positioning of the design industry. Today, after experiencing the new crown pneumonia epidemic, the business behavior models that people are familiar with are changing. In the changing situation, the traditional commercial space business model is rapidly shrinking, but human existence must be in the physical environment, and the new real-virtual experience model will definitely change the way of life. This is the creativity and challenge of this generation of design industry practitioners.

STRATEGI INOVASI E-COMMERCE DALAM MENGHADAPI GLOBALISASI ( STUDI KASUS JD.ID)

Advances in information technology are one of the fundamental things in technological development that cannot be stopped, this will continue to grow to be large and can provide a large level of change in the pattern of people's lives. E-commerce can be said as the development of information technology. And one company that does this is JD.ID. JD. ID is an e-commerce company that has the positioning of "original goods" offered to consumers. This is JD.ID's biggest strength and has an e-commerce strategy that really attracts consumers' attention. The data collection method used in this study is a survey, where the problem discussed is how the phase of change and innovation can be implemented at JD.ID. The method used to analyze is McKinsey 7S. The results that will be obtained from this journal are phases of change that may and/or can be recommended to JD.ID, as a recommendation and/or input so that JD.ID can develop into an even bigger e-commerce company and JD.ID can become the broader e-commerce market leader. Changes must always be made to be able to adapt to the needs required by society and on the one hand is flexibility in dealing with this.

Russian Overcoming of Global Value-Based Segregation

The article provides a modern answer to Adam Smith’s classic question on how exactly the vital assets of peoples are created in the states. It is shown that vital assets in the states are originally created through extraction (for a human), production (for a human) and imputation (into a human), which are three qualitatively different main types of vital creativity. This results in identification of three main patterns of life: extractive, productive and imputative. It is argued that with any basic form of life creativity, creation of a changing variety of life assets in the states is carried out mainly due to inclusion of a larger mental component in all creative chains. However, creation of a larger mental capacity can occur only through the concomitant and inevitable expenditure of both the same energy and the same information. Inevitable need for this mentioned expenditure (consumption) is the creative "damnation" of mankind. Strategies for Russia's exit from modern interstate exploitation are described. It is а proved that strategically and epochally the best way for Russia to get out of this system of exploitation is to recreate a sovereign, full-fledged three-pattern vitality, where combination of the main life patterns satisfies the life code that is historically inherent in Russia. It is shown that due to the presence of the mentioned “damnation”, modern Russia has got an energy “lever” that is sufficient (if used correctly) to create its own anti-segregation macro-regional cooperants without pattern-based segregation.

Identifying Space Grammar in the Unit Plans of High-rise Apartments in Indonesia

Rapid population growth and severe traffic congestion in Jakarta have encouraged the government to introduce the concept of transit oriented development (TOD), which has led to the active constructions of high-rise apartments. To understand the distinctive features of Indonesian high-rise apartments, total 86 unit plans from 20 high-rise apartment projects were analyzed and a field survey was conducted in August 2017. This study employed Seo’s (2007a; 2007b) graph-theoretic methodology to analyze the spatial configurations of the unit plans. The major results are as follows. First, the most prominent order of primary spaces found in these cases was Entrance-Kitchen-Dining-Living-balcony. In this arrangement, the kitchen is located near the entrance, unlike the layout of traditional houses where the kitchen is placed away from the entrance. Second, the public and private spaces are clearly separated, which is a reflection of Western layouts, and of the traditional layout of Indonesian houses where there was a clear separation of public and private spaces. Third, the guest area (GA), the most unique space in Indonesian houses, was not found in all cases as a consequence of space limitations. It is expected to develop unit plans that carefully reflect Indonesian life patterns and housing needs.

Analisis Pengawasan Dewan Perwakilan Rakyat Daerah (DPRD) Medan terhadap Kinerja Pemerintah Kota Medan

Education is a long-term investment in order to fulfill Indonesia's future pattern of human life. First, education as a project meant to enhance the human body's intellectual potential through a teaching and learning procedure Second, education contributes to the formation of an ethnically diverse society through the transmission of the values it includes. Third, education is one of the guarantees of a better, more honorable existence. Education must develop and evolve in educational institutions in a better path in order to become an investment. The use of operational and strategic management in educational institutions is one of the theoretical ideas put forth. The management of educational institutions is anticipated to be able to direct and impact the quality of educational products/outcomes including curriculum, institutional management administration, and student affairs through these two theoretical notions.

Experiences of transitions in daily life for parents of children with type 1 diabetes: An interpretive description.

In this study, we aimed to explore and describe the experiences of parents whose children have been diagnosed with type 1 diabetes (T1D) and the transitions of daily life. T1D is a long-term illness, and parents of children with T1D often become informal caregivers and face many challenges in their daily lives. A qualitative study design, in line with interpretive description, was used, and a sample of 10 parents of children with T1D participated in individual interviews. The COnsolidated criteria for REporting Qualitative Research (COREQ) checklist was used. The interviews were analyzed using interpretive descriptions. The analysis resulted in one main theme: "The realization of having taken 'daily life' for granted and having to accept a new reality," with six themes showing different transitions in the parents' daily lives, including transitions in daily life patterns, parenthood, in relationships with family and friends, relationships with school personnel, relationships with healthcare personnel, and in knowledge and learning about the illness. Parents experienced multifaceted changes that affected their lives, as shown by the six identified transitions. Being the parent of a child with T1D implies a new reality with complex, irreversible life changes that may be unknown and unspoken to healthcare professionals and society. Healthcare systems, school personnel, and society at large need to improve their knowledge regarding parents' situations to better support them in embracing a new reality for themselves and their children long after the onset of T1D.

AMOBA: Innovation barriers of the millennial generation

The millennial generation is closely related to the Industrial Revolution 4.0, which focuses on digitalization and automation patterns in human life. There are six main barriers: usage perception barriers, perceived value barriers, risk barriers, tradition barriers, image barriers, and perceived cost barriers. Therefore, the role of universities is needed in encouraging the millennial generation to create more contemporary innovations. This study aims to analyze the negative impact of internal and external barriers that affect the low innovation of the millennial generation. The research method is quantitative exploratory, with a total sample of 274 respondents from various private universities in Semarang City. The sampling method used purposive sampling, and the data collection technique used a survey with a questionnaire designed in certain procedure. Analysis of research results using multiple linear regression, which in principle can address the hypothesis statistically and comprehensively. The results of this study are usage perception barriers, perceived value barriers, risk barriers, tradition barriers, image barriers, and perceived cost barriers have a negative significant effect on the low innovation level of the millennial generation. The importance of this research is to encourage university administrators to facilitate students to develop self-competence and create creative innovations.

Tracking stolen bikes in Amsterdam.

Crime has major influences in urban life, from migration and mobility patterns, to housing prices and neighborhood liveability. However, urban crime studies still largely rely on static data reported by the various institutions and organizations dedicated to urban safety. In this paper, we demonstrate how the use of digital technologies enables the fine-grained analysis of specific crimes over time and space. This paper leverages the rise of ubiquitous sensing to investigate the issue of bike theft in Amsterdam-a city with a dominant cycling culture, where reportedly more than 80,000 bikes are stolen every year. We use active location tracking to unveil where stolen bikes travel to and what their temporal patterns are. This is the first study using tracking technologies to focus on two critical aspects of contemporary cities: active mobility and urban crime.

Political Culture Patterns of the Mandar Community in Palu

Migrant communities in an area have distinctive patterns both in social life, electoral politics, and non-electoral. Typical patterns will be repeated and become political culture. In this study, the author looks at the political culture of the Mandar people in Palu City, considering that the Mandar people have lived in the town of Palu for a long time. This research is a descriptive qualitative research conducted to find out the political culture patterns of immigrant communities. Data collection techniques used are interviews, observation, and documentation. The results of this study indicate that the type of political culture of the Mandar people in Palu is the type of political culture of the participants. This is shown by the cognitive, affective, and evaluative aspects of the Mandar community which are suitable for all political aspects such as the general system, input objects, and political output objects. Participant political culture in the Mandar community in Palu City results from the level of education and open access to information in the urban environment.

Influence of Gestational Age Correction and Shape-Based Trajectories in the Identification of Children’s Growth Patterns From Birth to 11 Years

ObjectivesChildhood growth reflects nutritional status such as under- or overnutrition and is a determinant of life health. Thus, early detection of sub-optimal growth patterns can help identify modifiable risk factors. Current approaches rely on the trajectory intercept and struggle to capture differences in trajectory shape, which better reflects change over time. This study implemented a novel approach to identify shape-based growth patterns in children from birth to 11 years of age. MethodsWe used anthropometric measures from 3,945 children at postnatal age 3 months, 1, 2, 4, 6 and 11 years from the 2004 Pelotas Birth Cohort (Brazil). Weight-, height- and BMI-for-age Z-scores were calculated using INTERGROWTH21st and WHO growth standards. The impact of gestational age-correction (CA) in preterm-born children (n = 461) was tested, and trajectories were either baseline anchored at zero or not. This produced 4 analytical pipelines for pattern detection (k-means, Frechet’s distance): 1) no CA–no baseline anchoring; 2) no CA–with baseline anchoring; 3) with CA–no baseline anchoring; 4) with CA–with baseline anchoring. ResultsWe found 3 patterns for each Z-score, with “High” (increasing), “Middle” (stable) and “Low” (declining) trajectories. The use of both CA and baseline anchoring highlighted sub-groups of children with specific patterns related to early growth (first 3 months of life). In the non-anchored approach, CA influenced the mean trajectories detected by increasing the intercept and reducing the slope between birth and 3 months. Baseline anchoring identified mean trajectories with steeper slopes during this period, thus, capturing differential growth patterns in early life. ConclusionsDepending on the question, incorporating CA with or without baseline anchoring when analyzing growth patterns can better highlight aspects of early growth versus overall patterns across childhood and can improve growth analyses standardization in population-based studies. Funding SourcesJoannah and Brian Lawson Centre for Child Nutrition, Lawson Family Chair in Microbiome Nutrition Research, CONACyT scholarship, Wellcome Trust, World Health Organization, National Support Program for Centers of Excellence, Brazilian National Research Council, Brazilian Ministry of Health, and Children’s Pastorate.

Robust correlation estimation and UMAP assisted topological analysis of omics data for disease subtyping

Deciphering information hidden in the gene expression assays for identifying disease subtypes has significant importance in precision medicine. However, computational limitations thwart this process due to the intricacy of the biological networks and the curse of dimensionality of gene expression data. Therefore, clustering in such scenarios often becomes the first choice of exploratory data analysis to identify natural structures and intrinsic patterns in the data. However, sparse and high dimensional nature of omics data prevents conventional clustering algorithms to discover subtypes that are clinically relevant and statistically significant. Hence, non-linear dimensionality reduction techniques coupled with clustering in such scenarios often becomes imperative to improve the clustering results. In this study, we present a robust pipeline to discover disease subtypes with clinical relevance. Specifically, we focus on discovering patient sub-groups that have a residual life patterns remarkably different from other sub-groups. This is significant because by refining prognosis, subtyping can reduce uncertainty in approximating patients expected outcome. The methodology present is based on robust correlation estimation, UMAP– a non-linear dimensionality reduction method and mapper– a tool from topology. Notably, we suggest a method for improving the robustness of the correlation matrix of gene expression data for improving the clustering results. The performance of the model is evaluated by applying to five cancer datasets obtained through TCGA and comparisons are performed with some state of the art methods of NEMO, RSC-OTRI and SNF with regard to log−rank test and Restricted Life Expectancy Difference. For example in GBM dataset, the minimum separation for any two discovered subtypes is 221 days which is significantly higher than the other methodologies. We also compared the results without using the robust correlation based estimate and observed that robust correlation improves separability between survival curves significantly. From the results we infer that our methodology performs better compared to other methodologies with regard to separating survival curves of patient sub-groups despite using single omics profiles of patients compared to multiple omics profiles of SNF and NEMO. Pathway over-representation analysis is performed on the final clustering results to investigate the biological underpinnings characterizing each subtype.

PROSEDUR AUDIT UNTUK PERUSAHAAN BERBISNIS TANAMAN SAWIT DALAM UPAYA MENCEGAH TERJADINYA SALAH SAJI LAPORAN KEUANGAN

The purpose of this study is to determine audit risks that may arise from audit procedures when carrying out audit procedures, resulting from missing a procedure that must be carried out or a lack of understanding of the client's business, so that misstatements made by the client become uncorrected which causes the presentation of financial statements to not reflect the current state of affairs. which are actually. It is undeniable, the Covid-19 outbreak has had a huge impact on human life patterns, especially interactions between humans both with outsiders of the family and with internal parties in the family, carrying out business activities and living a working life in earning a living. Likewise in the work scope of audit services, the impact of changing patterns of life also affects the planned work pattern at the Public Accounting Firm. As time went by, when the government succeeded in overcoming the development of the covid outbreak, the work pattern at the Public Accountant Firm also changed where currently the audit has even implemented inspections at the client's office. In order to avoid misstatements, the auditor must carry out field checks

How to Realize the Ideal Life of LGBT: Based on Field Observation of Mainland China

In this paper, the ideal life patterns of Chinese lesbian, gay, bisexual, and transgender (LGBT) are investigated. The ideal life includes the views of educational, policy environments, and LGBT-related organizations. The method employed is a semi-structured interview with questions about coming out experience, victimization, support networks, and demands. By the principle of identifying problems and seeking solutions, the inconveniences of LGBT life lead them to find their ideal objective environment by reviewing experience. Key results indicate that plebification outweighs explicit stipulations of anti-discrimination for LGBT people in Mainland China, which addresses the entrenched stigma from a demand perspective. These findings highlight the needs and expectations of living conditions in daily life occasion for LGBT people. Findings also have implications for LGBT-specific laws and regulations regarding suggestions for sex education and plebification in workplaces or schools in Mainland China.

Metagraph-Based Life Pattern Clustering With Big Human Mobility Data

Life pattern clustering is essential for abstracting the groups' characteristics of daily life patterns and activity regularity. Based on millions of GPS records, this research proposes a framework on the life pattern clustering which can efficiently identify the groups that have similar life patterns. The proposed method can retain original features of individual life pattern data without aggregation. Metagraph-based data structure is proposed for presenting the diverse life pattern. Spatial-temporal similarity includes significant places semantics, time-sequential properties and frequency are integrated into this data structure, which captures the uncertainty of an individual and the diversities between individuals. Non-negative-factorization-based method is utilized for reducing the dimension. The results show that our proposed method can effectively identify the groups that have similar life pattern in long term and takes advantage in computation efficiency and representational capacity compared with the traditional methods. We reveal the representative life pattern groups and analyze the group characteristics of human life patterns during different periods and different regions. We believe our work helps in future infrastructure planning, services improvement and policy making related to urban and transportation, thus promoting a humanized and sustainable city.

A Kist o’ Whistles

A Kist o’ Whistles