Medicine Library Research Articles

Cognitive behavioral therapy combined with selective serotonin reuptake inhibitors for premature ejaculation: A systematic review and meta-analysis.

Premature ejaculation (PE) remains one of the most common male disorders. Many clinical trials have shown that cognitive behavioral therapy (CBT) has significant efficacy in the treatment of PE. The purpose of this article is to review the current evidence regarding the efficacy and safety of CBT combined with selective serotonin reuptake inhibitors (SSRIs) for treating PE. We selected eligible randomized controlled trials (RCTs) from databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biology Medicine (CBM), Pubmed, Embase, and Cochrane Library. All data in this paper were analyzed using STATA 17.1 software. Cochrane Evaluator's Manual 5.3 was used to assess the quality of the included literature. Data collection was conducted up until May 2024. Finally, 15 high-quality randomized controlled trials were included, with 1243 patients, 653 experimental groups and 590 control groups. The meta-analysis showed that, compared with SSRIs alone, behavioral therapy combined with SSRIs can significantly prolong the IELT of PE patients, and improve perceived control over ejaculation, Chinese Index of Premature ejaculation-5 (CIPE-5), sexual life satisfaction, and spouses' sexual life satisfaction. Furthermore, there were no significant differences in side effects between the two groups. In addition, the published bias test results showed no significant bias. CBT combined with SSRIs could be a viable alternative for the treatment of PE. Both cognitive and behavioral training or behavioral training alone as a supplement to SSRIs are effective, with no significant increase in adverse reactions.

Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial

BackgroundDeveloping interventions for older adults with subjective cognitive decline (SCD) has the potential to prevent dementia in this at-risk group. Preclinical models indicate that Citrus-derived phytochemicals could benefit cognition and inflammatory processes, but results from clinical trials are still preliminary. The aim of this study is to determine the effects of long-term supplementation with Citrus peel extract on cognitive performance and inflammation in individuals with SCD.MethodsEighty participants were randomly assigned to active treatment (400 mg of Citrus peel extract containing 3.0 mg of naringenin and 0.1 mg of auraptene) or placebo at 1:1 ratio for 36 weeks. The primary endpoint was the change in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total score across the 36-week trial period. Other cognitive outcomes included tests and scales evaluating verbal memory, attention, executive and visuospatial functions, and memory concerns. The secondary endpoint was the change of interleukin-8 (IL-8) levels over the 36-week trial period in a subsample of 60 consecutive participants. An Intention-to-treat approach with generalized linear mixed models was used for data analysis.ResultsThe RBANS total score showed significant improvement in both Citrus peel extract and placebo groups at 36 weeks (p for time < .001, d = 0.36, p time x treatment = .910). Significant time effects were also found in cognitive domains of short- and long-term verbal memory (p < .001) and scales of subjective memory (p < .01), with no significant time x treatment interaction. The largest effect sizes were observed in verbal memory in the placebo group (d = 0.69 in short-term, and d = 0.78 in long-term verbal memory). Increased IL-8 levels were found at 36-week follow-up in both Citrus peel extract and placebo groups (p for time = .010, d = 0.21, p time x treatment = .772). Adverse events were balanced between groups.ConclusionsIn this randomized clinical trial, long-term Citrus peel extract supplementation did not show cognitive benefits over placebo in participants with SCD, possibly due to high placebo response. These findings might have specific implications for designing future nutraceutical trials in individuals experiencing SCD.Trial registrationThe trial has been registered at the United States National Library of Medicine at the National Institutes of Health Registry of Clinical Trials under the code NCT04744922 on February 9th, 2021 (https://www.clinicaltrials.gov/ct2/show/NCT04744922).

Adoption of the voluntary conflict of interest statement on PubMed.

In 2017, the National Library of Medicine (NLM) added a voluntary field for conflict of interest (COI) statements ("posted COI") on the abstract page of PubMed, but the extent to which it is used is unknown. This repeated cross-sectional study examined journals and articles indexed on PubMed from 2016 through 2021. We described the proportion of all journals with at least one article that included a posted COI and the percentage of all articles that included a posted COI over time. We also examined 100 randomly selected articles published between June 2021 and May 2022 from each of the 40 highest impact journals. For these, we established whether the articles had published COIs, and, of these, the proportion that included a posted COI. Among approximately 7,000 journals publishing articles each year, the proportion of journals with at least one article with a posted COI statement increased from 25.9% in 2016 to 33.2% in 2021. Among nearly 400,000 articles published each year, the proportion of articles that included a posted COI also increased from 9.0% in 2016 to 43.0% in 2021. Among 3,888 articles published in the 40 highest impact journals in 2021-2022, 30.2% (95% CI: 28.7%-31.6%) had published COIs; of these, 63.3% (95% CI: 60.4%-66.0%) included a posted COI. Use of the PubMed COI statement has increased since it became available in 2017, but adoption is still limited, even among high impact journals. NLM should carry out additional outreach to journals that are not using the statement to promote greater transparency of COIs.

Implementing a prenatal health screening intervention for future fathers in Montreuil, France: most users are immigrants facing hardship

BackgroundPrenatal care provides pregnant women with repeated opportunities for prevention, screening and diagnosis that have no current extension to future fathers. It also contributes to women’s general better access to health. The goal of PARTAGE study was to evaluate the level and determinants of adherence to a prenatal prevention consultation dedicated to men.MethodsBetween January 2021 and April 2022, we conducted a monocentric interventional study in Montreuil hospital. We assessed the acceptance of a prenatal prevention consultation newly offered to every future father, through their pregnant partner’s prior consent to provide their contact details.ResultsThree thousand thirty-eight women provided contact information used to reach the fathers; effective contact was established with 2,516 men, of whom 1,333 (53%) came for prenatal prevention consultation. Immigrant men were more likely to come than French-born men (56% versus 49%, p < 0·001), and the more they faced social hardship, the more likely they were to accept the offer. In multivariate analysis, men born in Subsaharan Africa and Asia were twice as likely to attend the consultation as those born in Europe or North America.ConclusionAcceptance of this new offer was high. Moreover, this consultation was perceived by vulnerable immigrant men as an opportunity to integrate a healthcare system they would have otherwise remained deprived of.Trial registrationRegistry: ClinicalTrials.gov, US National Library of Medicine https://classic.clinicaltrials.gov/ct2/show/NCT05085717Clinical Trial number: NCT05085717.Date of registration: 20/10/2021.

RESTAURAÇÃO BIOMIMÉTICA EM DENTE TRATADO ENDODONTICAMENTE: RELATO DE CASO CLÍNICO

Biomimetic dentistry is constantly evolving evolution, seeking inspiration from nature to develop technologies and biocompatible materials that mimic the structure and function of natural dental tissues. tissues. This innovative approach aims to improve the effectiveness of dental treatments by preserving tooth structure, improving the adhesion of restorative restorative materials, restoring structural integrity and replicating natural biomechanics. With a focus on regenerating and replacing lost dental tissues, biomimetic dentistry promises to revolutionise clinical practice, offering practice, offering more effective and safer solutions to patients through biomimetic products with improved properties. This study aims to aim of this study is to report a clinical case of restoration of a tooth treated tooth, using the principles of biomimetic dentistry to preserve tooth structure the tooth structure. Research was carried out in the following electronic databases databases: National Library of Medicine (PUBMED), Virtual Health Library (BVS), Brazil (BVS), Brazil Scientific Electronic Library Online (SciELO) from 2019 to 2024. Following the Biomimetic Dentistry approach, the use of intracanal pins was avoided in the restoration was avoided, prioritising methods that improve adhesion and reduce resin shrinkage and reduce the shrinkage of the composite resin. These techniques were considered sufficient to carry out the restoration, even in cases of extensive tooth loss after root canal treatment after root canal treatment.

Hip Dysplasia in Adults: Surgical Correction vs. Conservative Treatment Options

Introduction: Developmental Dysplasia of the Hip (DDH) is an anatomical deformation resulting from abnormal formation of the structures that make up the hip joint. Due to abnormal biomechanics patients with hip dysplasia usually develop radiographic osteoarthritis. Aim of the study: Despite the introduction of screening tests in children, DDH remains an issue among adults. For this group of patients, it is essential to begin treatment as early as possible to prevent early-onset osteoarthritis of the hip joint. In adults it is often too late to implement non-invasive methods such as braces or orthoses. Therefore, in this study, we aim to describe other treatment options for adults with DDH, considering both surgical and non-surgical methods. In the following work, we present both the advantages and complications associated with these surgical methods. Additionally, we describe the non-surgical alternative method of progressive resistance training (PRT) and consider the possibilities of combining it with surgical techniques. We also discuss the potential for pharmacological treatment. Material and Methods: Review of studies available through open-access sources on PubMed, Google Scholar, and the National Library of Medicine. Conclusions: The decision to quickly implement an appropriate treatment plan is crucial for improving the patient's quality of life. The choice of treatment method should consider the patient's age and the severity of the disease. Adults with DDH are most often qualified for surgical procedures, which include periacetabular osteotomy (PAO) and total hip replacement (THR). However, for some patients, surgical procedures may be contraindicated or impossible, and in such cases, other non-invasive methods, such as resistance training or appropriate pharmacotherapy, should be considered. Keywords: hip joint, osteoarthritis, surgery, conservative therapy, hip, Surgical Correction

Approaches to Treating Knee Osteoarthritis: Surgery vs. Non-Surgery Treatment

Introduction: Knee Osteoarthritis (KO) is a progressive, chronic disease that damage the joint cartilage of a knee and leads to a changes in a anatomy of the joint. Both surgical and non-surgical methods are used to treat the disease. In this study, we will compare the invasive vs non-invasive methods of KO treatment. Objectives: The review and presentation of the current state of knowledge on Treating Knee Osteoarthritis, comparing surgery vs non-surgery methods. Material and Methods: Review of the studies available on open access sources at PubMed, Google Scholar and National Library of Medicine. Conclusions: Surgery approach for the Knee Osteoarthritis treatment are more durable, have better pain relief and treat casually the OA. Similar effects cannot be reached by non-surgery methods yet. However, there is a big promise in future studies about non-surgery methods, which can also raise a Quality of Life significantly and even avoid or postpone an operation in some groups of patients.

Curcuma-Based Nutritional Supplements and Risk of Age-Related Macular Degeneration

Curcuma-based nutritional supplements (CBNS) are natural anti-inflammatory and antioxidant agents that may confer benefits against age-related macular degeneration (AMD). To examine the association between the use of CBNS and the risk of development or progression of AMD. This was a retrospective cohort study with data collection in June of 2024. Data were gathered from the aggregated electronic health records research network, TriNetX (Cambridge, Massachusetts). Patients without AMD were included in the study before propensity score matching (PSM); these included those taking and not taking CBNS. Patients with no history of AMD were stratified by instances of CBNS prescription records. Patients with a history of early nonexudative AMD stratified by instances of CBNS prescription records were also identified. PSM was performed to control for baseline demographics and medical comorbidities. Patients were stratified by whether or not they were taking CBNS using RxNorm (National Library of Medicine) codes. Relative risk (RR) of developing nonexudative AMD, exudative AMD, advanced nonexudative AMD or geographic atrophy (GA), blindness, or requiring intravitreal anti-vascular endothelial growth factor (VEGF) therapy. A total of 66 804 patients (mean [SD] age, 64.9 [10.1] years; 44 124 female [66.1%]) taking CBNS and 1 809 440 patients (mean [SD] age, 67.0 [9.5] years; 999 534 female [55.2%]) not taking CBNS were included in this study. Among patients without a history of AMD aged 50 years or older, CBNS use was associated with lower rates of developing nonexudative AMD (RR, 0.23; 95% CI, 0.21-0.26; P < .001), advanced nonexudative AMD or GA (RR, 0.11; 95% CI, 0.07-0.17; P < .001), exudative AMD (RR, 0.28; 95% CI, 0.24-0.32; P < .001), blindness (RR, 0.46; 95% CI, 0.36-0.59; P < .001), or requiring intravitreal anti-VEGF therapy (RR, 0.15; 95% CI, 0.13-0.17; P < .001) when compared with matched patients not taking CBNS. Results were consistent among subsets of patients 60 and 70 years or older, respectively. Among patients with early nonexudative AMD, subsequent instances of CBNS prescription records were associated with lower rates of developing advanced nonexudative AMD or GA (RR, 0.58; 95% CI, 0.41-0.81; P < .001) when compared with matched patients with early nonexudative AMD without a CBNS prescription record. Results of this cohort study suggest that a reduced risk of developing AMD or progression to later stages of AMD was associated with subsequent use of CBNS. Further investigation to validate these findings, safety, and potential pharmacoprotective mechanisms of CBNS in AMD are suggested.

Naloxone Distribution Models in the United States: A Scoping Review.

Increasing naloxone distribution is a high priority means to mitigating opioid overdose rates in the United States. Since a variety of naloxone distribution models exist, with differences in infrastructure and funding between states and health-systems, it is important to review their differences and understand the strengths and barriers to widespread implementation of each model. The following 4 databases were searched for articles reporting on naloxone distribution models: (1) PubMed/Medline (National Library of Medicine), (2) Embase (Elsevier), (3) Scopus (Elsevier), and (4) the Cochrane library. Reports from all years written in English that discussed naloxone distribution models in the United States were included, as were all study designs. Of 5825 articles initially identified, 173 were selected for full text review. Of these, 49 met full criteria and were included for data extraction and analysis. Most distribution models occurred in community-based opioid education and naloxone distribution programs and in community pharmacies via a standing order/statewide protocol. Most programs reported strengths related to feasibility, but frequently reported cost as a limitation. Fewer studies described distribution models in ambulatory care or hospital settings, though these studies also highlighted strengths related to feasibility, particularly with support from working partners, and when utilizing an interprofessional care approach. Few studies reported health/economic outcomes data associated with naloxone distribution, such as changes in the number of patient/layperson access, the number of opioid overdose reversals, or cost-savings. This review outlines the many ways in which naloxone is distributed in the United States and emphasizes a need for improved outcomes data collecting/reporting in the various settings where naloxone is distributed. This would allow for future studies to evaluate which distribution model factors are associated with improvements in health outcomes, such as increased layperson access, and lower opioid overdose/mortality rates.

A ATUAÇÃO DO FISIOTERAPEUTA NA PREVENÇÃO DE QUEDAS EM IDOSOS: Revisão Integrativa

This study aims to identify in the literature the main actions of the physiotherapist in the prevention of falls in the elderly. Falls in the elderly are common, being one of the main causes of mortality, morbidity and disability. It becomes common for falls to occur in old age, meticulous care is required, as this issue may be linked to other events that may arise, such as diseases. In view of the above, physiotherapy plays a crucial role in the prevention of falls. The Pubmed (US National Library of Medicine), SciELO (Scientific Electronic Library Online) and LILACS databases were used, where articles between the years 2018 to 2024 were selected. Based on a detailed search, 213 articles were found after applying the eligibility criteria for full reading, and 7 articles were selected for the present study. The evidence from this review makes it possible to conclude that the physiotherapist's role in preventing falls in the elderly is effective. The studies analyzed demonstrate that the application of exercises related to balance, muscular strength, and assessment using the Berg scale contributes to reducing the risk of falls.

Surgical correction of posttraumatic triphalangeal joint flexion contractures of the fingers (systematic literature review)

Introduction Triphalangeal joint flexion contracture of the fingers is a common and challeging posttraumatic hand condition. The goal of surgical treatment is to correct finger deformity and increase interphalangeal range of motion.The objective was to systematize data on the causes of post-traumatic triphalangeal joint flexion contracture of the fingers and methods of surgical correction.Material and methods The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru), the National Library of Medicine (www.pubmed.org), ScienceDirect, Google Scholar, Ovid databases according to PRISMA recommendations. Literature searches included both Russian and English studies, with one or more cases of post-traumatic triphalangeal joint flexion contracture of the fingers with the deformity surgically corrected. Cases of non-traumatic flexion contractures were excluded. Etiological factors of flexion contractures, heterogeneity of definitions and methods for recording the range of motion in the joint, anatomical features, surgical correction of flexion contractures and postoperative complications were reviewed.Results Common causes of flexion contractures included burns (32.3 %), dislocations and fracturedislocations of the finger joints (23.5 %). The median postoperative follow-up period was 13.5 months after surgical treatment. Surgical correction was produced with external fixation device (EFD) in 40 % of cases, open procedures performed in 50 % and a combined technique employed in one case (10 %). Based on calculations of the odds ratios of postoperative complications, a weak positive linear relationship was revealed between EFD and pain syndrome, and a weak negative linear relationship was observed between the open procedure and pain.Discussion There is heterogeneity of approaches regarding methods for correcting flexion contractures, surgical approaches, techniques for mobilizing joints and releasing the anatomical structures of the finger with open procedures, the distraction rate with EFD, methods for repair of soft tissue defects following the treatment of flexion contractures of interphalangeal joint of a finger.Conclusion Open procedures are commonly used for precise elimination of all components of flexion contracture of the joint and repair of soft tissue defects of the finger. A weak positive linear relationship was revealed between EF and pain syndrome. There was no significant correlation between open techniques and complications. There were no correlations between the treatment method and the contracture type; there are no treatment regimens for patients with this pathology.

Open Access Publishing Metrics, Cost, and Impact in Health Professions Education Journals

Publishing in health professions education (HPE) journals is an integral component of academic discourse and career progression. Research in this field is shifting to an open access (OA) publishing model. To identify the characteristics and publishing models of HPE journals and explore potential associations between publication costs and journal metrics. This cross-sectional study was conducted between September 20, 2023, and February 14, 2024, using the World Bank purchasing power parity (PPP) index to analyze relative costs of article processing charges (APCs). Data on journal characteristics, impact metrics, APCs, and waiver or discount were extracted from the National Library of Medicine, Scimago, Scopus, journal websites, and email correspondence with editorial staff of journals. All HPE journals indexed in PubMed, written in or translated into English, and with HPE as a core component of their mission were included in the analysis. Two-year impact factor, H-index, cite score, Scientific Journal Ranking, and APC. Among the 51 journals included, 27 (53%) adopted OA-only and 24 (47%) adopted hybrid publishing models. The median (IQR) APC for all journals was $2820.00 ($928.00-$3300.00). Associations were observed between impact factor and APC (β coefficient, $386.84; 95% CI, $226.84-$546.84; P < .001) and between cite score and APC (β coefficient, $282.40; 95% CI, $148.12-$416.61; P < .001). Of 20 journal websites with information regarding fee waivers or discounts, 7 journals (35%) confirmed fee waiver or discount. The PPP index analysis of the top 39 countries publishing HPE research showed that the financial burden of meeting the median APC for publication was 1.94 to 10.26 times higher for authors from lower-income countries than for authors from the US. Results of this cross-sectional study suggest that adoption by HPE journals of an OA publishing model was high but access to APC waivers or discounts was limited. These factors create barriers to equitable OA practices, necessitating concerted efforts, such as increasing transparency of publishing costs, implementing economic impact analysis, expanding waivers to eligible authors, and applying holistic impact factor scoring.

Ethnomedicinal and Phytopharmacological Aspects of Vernonia amygdalina (Bitter Leaf) Utilized as a Traditional Medicinal Herb

Vernonia amygdalina Delile, commonly known as “bitter leaf,” is a shrub in the Asteraceae family, widely seen in tropical regions of Africa. Vernonia amygdalina is found to be traditionally used in African medicine. Various parts of this plant, especially the leaves, are utilized to treat ailments such as fever, diabetes, and gastrointestinal issues. Research from multiple researchers has shown a wide range of phytochemical and bioactive compounds present in Vernonia amygdalina; examples are terpenoids, tannins, alkaloids, saponins, flavonoids, steroids, glycosides, etc., which have contributed to the medicinal properties of Vernonia amygdalina. Vernonia amygdalina has shown its therapeutic and remedial potentials due to the presence of phytochemicals which exhibit effects such as anti-microbial, anti-inflammatory, anti-cancer, anti-oxidant, anti-diabetic, anti-hyperglycemic, anti-diarrheal, anti-helminthic, anti-pyretic, and anti-nociceptive effects. In this article, the authors highlight recent progress in using Vernonia amygdalina and its therapeutic effects. Research, review, and case study articles were used to write this review. The articles were obtained from academic websites such as Research Gate, Google Scholar, the National Library of Medicine, African journals online, and Semantic journals, and some articles were obtained through a simple Google search. Articles that discussed the medicinal, ethanopharmacological, and therapeutic properties of Vernonia amygdalina were selected for the review. Search terms such as “Vernonia amygdalina,” “bitter leaf,” “phytochemical properties,” and “therapeutic effects” were used to search for relevant articles on the academic databases. Boolean operators such as “AND” and “OR” were used to refine the search further and ensure a comprehensive selection of articles.

Successful strategies for preventing and controlling violence against people with intellectual disabilities: a scoping review

BackgroundViolence against people with intellectual disabilities is unfortunately a reality all over the world, as they are one of the populations most vulnerable to various forms of aggression. Assertive prevention and control measures are crucial to tackle and reduce this problem. The aim of this study was to map and summarize the main measures for preventing and controlling domestic violence against people with intellectual disabilities. MethodsThis was a scoping review conducted in accordance with the JBI guidelines. The databases consulted were: National Library of Medicine (PubMed); Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science; Excerpta Medica DataBASE (EMBASE); Latin American and Caribbean Health Sciences Literature (LILACS) and SCOPUS. Studies included in this review reported on strategies to address domestic violence against people with intellectual disabilities, published in the last ten years, in Portuguese, Spanish or English.ResultsA total of 11 studies were included in this review. Six studies had high methodological quality and five had moderate. Cognitive-behavioral intervention programs, educational technologies and/or auxiliary tools, along with the full participation of people with intellectual disabilities in domestic violence prevention measures are appropriate strategies for dealing with this issue.ConclusionDomestic violence against people with intellectual disabilities is relatively unexplored in the health-field scientific literature. Prevention and control measures should be developed with the active involvement of people with intellectual disabilities, generating engagement and knowledge. Preventive measures should be adapted to the personal context and conditions of individuals with special needs, such as those with persistent or chronic mental disorders.

A INSTABILIDADE POSTURAL NO ENVELHECIMENTO COMO FATOR DE RISCO DE QUEDA EM IDOSOS

Aging is defined as a natural, progressive and irreversible development, something common to all human beings and which can bear the influence of social, economic, psychological and political factors. Postural instability is reported worldwide as a geriatric syndrome but it is also defined as the individual's inability to adjust to an upright posture to preserve and maintain balance, thus the body's sensory information is not understood. Aging causes physical changes and impairs balance control due to motor and sensory deficits. The objective of this work is to point out postural instability in aging as a risk factor for falls in the elderly. The present study is an integrative review of the literature, with data collected from the following databases: U.S. National Library of Medicine (PUBMED) and Scientific Electronic Library Online (SCIELO). The inclusion criteria were: Studies published from 2018 to 2023 in Portuguese and English, randomized clinical trials, meta-analysis and compatible themes. In the search, 23,781 studies were identified. Of these, after initial exclusion by titles and abstracts, a total of 26 articles were selected according to the eligibility criteria for full reading, and 10 articles were finally included. Considering the results of the analysis of this integrative review, it can be concluded that postural instability is considered a risk factor for falls in elderly people.

TRATAMENTO ESTÉTICO COM RADIOFREQUÊNCIA NO REJUVENESCIMENTO FACIAL: UMA REVISÃO INTEGRATIVA

Introduction: Aging is a natural, continuous, gradual phenomenon or process that manifests itself in a multifactorial and degenerative way in accordance with intrinsic and extrinsic factors, and these affect the entire human body, especially its largest organ, the skin. Aging in the facial region is due to the loss of elastin and collagen proteins, which support the physiological tissue and muscle functions of the skin. There are several aesthetic treatments for facial rejuvenation, among which Radiofrequency can be highlighted to treat sagging skin. Objective: To check the impacts of Radiofrequency as an aesthetic resource for the treatment of facial skin sagging with an emphasis on the rejuvenation process. Methods: it will be used based on the techniques and methods of bibliographic research, which consisted of collecting research sources using scientific platforms: Scientific Electronic Library Online (Scielo), National Library of Medicine (PubMed), Virtual Libraries (BVS). Results: After detecting scientific data using the inclusion and exclusion criteria, reading titles and abstracts, 14 articles were requested, then the pre-selected publications were read in full, paying attention to the proposed theme, 11 were counted. articles for analysis and construction of the review. Conclusion: The studies carried out show that radiofrequency is established as an effective and safe technique for facial rejuvenation, providing significant beneficial results and showed that radiofrequency is a viable and promising alternative for treating signs of facial aging, contributing to the good -being and self-esteem of individuals.

Study on serum vitamin A level in patients with type 1 diabetes: A systematic review and meta-analysis.

There is controversy about the relationship between type 1 diabetes and vitamin A (VA) levels in the body. Through meta-analysis, the results of related studies can be aggregated to more accurately estimate the relationship between type 1 diabetes mellitus (T1DM) patients and the level of VA in the body. Our purpose is to review the study to investigate VA levels in type T1DM patients and to provide recommendations for future studies. Until January 2024, we searched the National Library of Medicine (PubMed), Cochrane Library, Embase Databases, Web of Sciences, Scopus, China National Knowledge Infrastructure (CNKI), VIP databases (VIP) and WAN FANG databases. After a systematic search, 8 case-control studies were included in our meta-analysis. In the process of data inclusion and extraction, the 2 reviewers selected literature independently of each other. In this study, RevMan5.3 software was used for meta-analysis. Eight case-control studies involving 689 participants were screened. The results after meta-analysis showed that there was a significant difference in serum VA between the patients with T1DM and the control group (standardized mean difference [SMD] = -0.82, 95% CI [-1.29, -0.36], P < .001, random effects model) with significant heterogeneity among these studies (P < .001, I2 = 84%). Similarly, the difference in the high-performance liquid chromatography (HPLC) subgroup on serum VA (SMD = -0.99, 95% CI [-1.60, -0.38], P = .002) as well as the difference in the countries of Asia and Europe subgroup on serum VA (SMD = -0.60, 95% CI [-1.15, -0.05], P = .03; SMD = -1.06, 95% CI [-1.88, -0.24], P = .01) were suggested to be statistically significant. A significant result was also observed in the National Diabetes Data Group (NDDG) criteria subgroup (SMD = -0.48, 95% CI [-0.85, -0.12]). Serum VA levels seem to have decreased in T1DM patients. Further research is needed to strengthen this finding and clarify possible impact mechanisms.

Time to Publication in Medical Education Journals: An Analysis of Publication Timelines During COVID-19 (2019-2022).

COVID-19 changed scholarly publishing. Yet, its impact on medical education publishing is unstudied. Because journal articles and their corresponding publication timelines can influence academic success, the field needs updated publication timelines to set evidence-based expectations for academic productivity. This study attempts to answer the following research questions: did publication timelines significantly change around the time of COVID-19 and, if so, how? We conducted a bibliometric study; our sample included articles published between January 2018, and December 2022, that appeared in the Medical Education Journals List-24 (MEJ-24). We clustered articles into three time-based groups (pre-COVID, COVID-overlap, and COVID-endemic), and two subject-based groups (about COVID-19 and not about COVID-19). We downloaded each article's metadata from the National Library of Medicine and analyzed data using descriptive statistics, analysis of variance, and post-hoc tests to compare mean time differences across groups. Overall, time to publish averaged 300.8 days (SD = 200.8). One-way between-groups ANOVA showed significant differences between the three time-based groups F (2, 7473) = 2150.7, p < .001. The post-hoc comparisons indicated that COVID-overlap articles took significantly longer (n = 1470, M= 539; SD = 210.6) as compared to pre-COVID (n = 1281; M = 302; SD = 172.5) and COVID-endemic articles (n = 4725; M = 226; SD = 136.5). Notably, COVID-endemic articles were published in significantly less time than pre-pandemic articles, p < .001. Longer publication time was most pronounced for COVID-overlap articles. Publication timelines for COVID-endemic articles have shortened. Future research should explore how the shift in publication timelines has shaped medical education scholarship.

EFFECTIVENESS OF ROSELLA AS AN ANTI-INFLAMMATORY

Rosella flower (Hibiscus sabdariffa L.) can be used in the health sector. Rosella petal extract contains flavonoids such as gossypetin, hibiscetin, sabdaretine, alkaloids, and saponins. Rosella has properties such as an antiseptic, diuretic, anti-inflammatory, antibacterial, antioxidant, and can increase endurance. This paper discusses the anti-inflammatory effect of the rosella plant. The purpose of this article is to describe the effectiveness of rosella plant as an anti-inflammatory. This article collects research results from journals, textbooks, and websites accessed through the National Library of Medicine and Google scholar databases as a method. The reference source inclusion criteria are published in 2012-2022 with topics that are in line with the effectiveness of rosella as an anti-inflammatory. The reference source exclusion criteria were literature published before 2012. A total of 25 references were found, 15 references were selected, and 10 references were excluded. The studies have shown that the content of rosella flower extract is able to inhibit the cyclooxygenase enzyme thereby inhibiting the synthesis of inflammatory mediators, namely leukotrienes and prostaglandins and reducing the number of neutrophils so that it can accelerate the wound healing process, however administration of high doses of rosella extract is less effective as an anti-inflammatory because the levels of flavonoids decreased activity at high extract concentrations.

CYRAD: a translational study assessing immune response to radiotherapy by photons or protons in postoperative head and neck cancer patients through circulating leukocyte subpopulations and cytokine levels

BackgroundRadiotherapy has both immunostimulant and immunosuppressive effects, particularly in radiation-induced lymphopenia. Proton therapy has demonstrated potential in mitigating this lymphopenia, yet the mechanisms by which different types of radiation affect the immune system function are not fully characterized. The Circulating Immunes Cells, Cytokines and Brain Radiotherapy (CYRAD) trial aims to compare the effects of postoperative X-ray and proton radiotherapy on circulating leukocyte subpopulations and cytokine levels in patients with head and neck (CNS and ear nose throat) cancer.MethodsCYRAD is a prospective, non-randomized, single-center non interventional study assessing changes in the circulating leukocyte subpopulations and cytokine levels in head and neck cancer patients receiving X-ray or proton radiotherapy following tumor resection. Dosimetry parameters, including dose deposited to organs-at-risk such as the blood and cervical lymph nodes, are computed. Participants undergo 29 to 35 radiotherapy sessions over 40 to 50 days, followed by a 3-month follow-up. Blood samples are collected before starting radiotherapy (baseline), before the 11th (D15) and 30th sessions (D40), and three months after completing radiotherapy. The study will be conducted with 40 patients, in 2 groups of 20 patients per modality of radiotherapy (proton therapy and photon therapy). Statistical analyses will assess the absolute and relative relationship between variations (depletion, recovery) in immune cells, biomarkers, dosimetry parameters and early outcomes.DiscussionPrevious research has primarily focused on radiation-induced lymphopenia, paying less attention to the specific impacts of radiation on different lymphoid and myeloid cell types. Early studies indicate that X-ray and proton irradiation may lead to divergent outcomes in leukocyte subpopulations within the bloodstream. Based on these preliminary findings, this study aims to refine our understanding of how proton therapy can better preserve immune function in postoperative (macroscopic tumor-free) head and neck cancer patients, potentially improving treatment outcomes.Protocol versionVersion 2.1 dated from January 18, 2023.Trial registrationThe CYRAD trial is registered from October 19, 2021, at the US National Library of Medicine, ClinicalTrials.gov ID NCT05082961.