Inhalable Dust Levels Research Articles

Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers.

We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of inflammatory markers (CRP, SAA, CC16, IL1B, IL2, IL4, IL5, IL6, IL8, IL10, IL13, and TNF) after the shift. Associations were explored by linear mixed-effects models. We included 170 measurements from 88 production workers exposed to inhalable dust, endotoxin, bacteria, and fungi (25 °C and 37 °C) at geometric mean levels of 0.6 mg/m3, 10.7 EU/m3, 1.6×104 CFU/m3, 4.4×104 CFU/m3, and 103 CFU/m3, respectively, and 14 administrative workers exposed at 7-fold lower levels. No associations were observed between bioaerosol exposures and work-shift change in lung function. IL2, IL6, IL10, and TNF concentrations were positively associated with inhalable dust levels, SAA and IL6 with bacteria, CRP, SAA, IL8, and TNF with fungi (25 °C or 37 °C), with the latter being the only statistically significant finding (exp(β) 1.40, 95% confidence interval 1.01-1.96). This study of recycling workers exposed to bioaerosol levels generally below those of farmers and compost workers and above background levels did not indicate any acute effect on lung function. Several inflammatory markers tended to increase with exposure, suggesting a systemic effect. Future research should combine data from bioaerosol-exposed workers to uncover health risks that may form the basis for health-based occupational exposure limits.

Personal inhalable paper dust exposure and potential determinants among paper industry workers in Ethiopia

PurposeExcessive paper dust during paper production may harm the workers’ respiratory health. We wanted to assess the inhalable paper dust levels and its determinants among paper industry workers.MethodsA study was conducted in Ethiopia to assess the level of personal inhalable paper dust exposure among four paper mills. A total of 150 samples were collected using the IOM sampler attached to Side Kick Casella pumps at a flow rate of 2 L/min. The samples were analyzed in Nemko Norlab, Norway. Linear mixed-effect models were applied to identify determinants of inhalable paper dust.ResultsThe geometric mean of personal inhalable paper dust was 3.3 mg/m3 with 80% of the measurements exceeding the Swedish occupational exposure limit (OEL) of 2 mg/m3. The linear mixed-effects model showed that the level of dust was 28% higher when using high-speed than when using low-speed rewinding machines, while paper mills with an average of more than four machines per job group had 22% higher exposure than paper mills with a lower number of machines. Furthermore, working in packing and preparation was associated with higher dust exposure than in other areas.ConclusionsThe dust exposure levels were above the Swedish OEL for 80% of the samples. This indicates that preventive measures should be established in the industry. The exposure model identified high-speed rewinding machines, a high number of machines, and work in preparation and packing as associated with high levels of paper dust exposure.

Bacterial contamination of coffee and personal exposure to inhalable dust and endotoxin in primary coffee processing factories in Ethiopia.

Endotoxins from gram-negative bacteria might be released when the coffee cherries are processed and may cause respiratory health problems among workers in the coffee industry. The relationship between bacterial contamination and occupational exposure to endotoxin levels has not been thoroughly explored previously in primary coffee processing factories in Ethiopia, or elsewhere. The aim of this study was to characterize the level of personal endotoxin exposure and its relations with bacterial contamination of coffee cherries in such factories in Ethiopia. A cross-sectional study was conducted from March 2020 - February 2021 in 9 primary coffee processing factories in 3 regions in Ethiopia. A total of 180 personal air samples were collected to analyze workers' exposure to inhalable dust and endotoxin. Correlation tests were performed to assess the relationship between total bacteria and endotoxin levels and between inhalable dust and endotoxin levels. The geometric mean (GM) of personal inhalable dust exposure among machine room workers and hand pickers were 9.58mg/m3 and 2.56mg/m3, respectively. The overall GM of endotoxin exposure among machine room workers and hand pickers were 10,198 EU/m3 and 780 EU/m3, respectively. Gram-negative bacteria were found in all 54 coffee samples. The correlation between inhalable dust and endotoxin exposure was significant (r=0.80; P <0.01). About 92% of the samples from hand pickers and all samples from machine room workers exceeded the occupational exposure limit of 90 EU/m3 recommended by the Dutch Expert Committee on Occupational Standards. Prevention and control of bacterial contamination of the coffee in primary coffee processing are suggested to reduce endotoxin exposure that might cause respiratory health problems among coffee workers.

Exposure levels of dust, endotoxin, and microorganisms in the Danish recycling industry.

Recycling of domestic waste and a number of employees in the recycling industry is expected to increase. This study aims to quantify current exposure levels of inhalable dust, endotoxin, and microorganisms and to identify determinants of exposure among recycling workers. This cross-sectional study included 170 full-shift measurements from 88 production workers and 14 administrative workers from 12 recycling companies in Denmark. The companies recycle domestic waste (sorting, shredding, and extracting materials from waste). We collected inhalable dust with personal samplers that were analysed for endotoxin (n = 170) and microorganisms (n = 101). Exposure levels of inhalable dust, endotoxin, and microorganisms and potential determinants of exposure were explored by mixed-effects models. The production workers were 7-fold or higher exposed to inhalable dust, endotoxin, bacteria, and fungi than the administrative workers. Among production workers recycling domestic waste, the geometric mean exposure level was 0.6 mg/m3 for inhalable dust, 10.7 endotoxin unit (EU)/m3 for endotoxin, 1.6 × 104 colony forming units (CFU)/m³ of bacteria, 4.4 × 104 CFU/m³ of fungi (25 °C), and 1.0 × 103 CFU/m³ of fungi (37 °C). Workers handling paper or cardboard had higher exposure levels than workers handling other waste fractions. The temperature did not affect exposure levels, although there was a tendency toward increased exposure to bacteria and fungi with higher temperatures. For inhalable dust and endotoxin, exposure levels during outdoor work were low compared to indoor work. For bacteria and fungi, indoor ventilation decreased exposure. The work task, waste fraction, temperature, location, mechanical ventilation, and the company size explained around half of the variance of levels of inhalable dust, endotoxin, bacteria, and fungi. The production workers of the Danish recycling industry participating in this study had higher exposure levels of inhalable dust, endotoxin, bacteria, and fungi than the administrative workers. Exposure levels of inhalable dust and endotoxin among recycling workers in Denmark were generally below established or suggested occupational exposure limits (OEL). However, 43% to 58% of the individual measurements of bacteria and fungi were above the suggested OEL. The waste fraction was the most influential determinant for exposure, and the highest exposure levels were seen during handling paper or cardboard. Future studies should examine the relationship between exposure levels and health effects among workers recycling domestic waste.

Occupational Bioaerosol Exposures Associated with Poultry Farming

ABSTRACT This study aimed to investigate occupational exposure to particulate dust, endotoxin, and (1–3)-β-D-glucan among workers involved in various poultry farming activities. A total of 298 personal samples were collected from randomly selected individuals from exposure groups based on distinct poultry farming activities comprising broiler farms, rearing, laying, hatchery, and catching activities. Aside from the inhalable particulate dust concentration that was determined, filter extracts were also analyzed for (1–3)-β-D-glucan and endotoxin using the endpoint Glucatell® and Limulus amoebocyte lysate (LAL) assays, respectively. Data were analyzed using STATA 12 and linear regression models developed. The mean (GM) dust particulate concentration was 11.04 mg/m3 (GSD = 3.87); 2298 endotoxin units (EU/m3) (GSD = 10.56) and 149 ng/m3 for (1–3)-β-D-glucan (GSD = 4.62). A modest positive correlation was observed between log-transformed endotoxin and (1–3)-β-D-glucan concentrations (Pearson r = 0.44, p < .001), whilst a moderate negative correlation was observed for inhalable dust particulate and (1–3)-β-D-glucan (Pearson r = −0.33, p < .001). However, there was a very poor correlation between inhalable dust and endotoxin (Pearson r = −0.02, p < .001). In the regression models, exposure group based on the nature of farming activity explained 50% of the variability in dust particulate and glucan levels. For dust particulate, rearing activities were significant predictors of higher dust levels compared to hatchery work, while rearing, laying, broiler and catching activities were significant predictors of higher endotoxin or glucan levels. Furthermore, working in a small broiler was a significant determinant of elevated glucan exposures. Farms using automated laying activities had significantly higher particulate levels compared to those using manual laying activities. This study revealed that workers engaged in poultry farming activities were exposed to significantly high levels of inhalable particulate dust, endotoxin, and (1–3)-β-D-glucan concentrations, posing an increased risk for adverse respiratory health effects in these farm workers.

Exposure assessment to inhalable and respirable dust in the post - earthquake construction sites in the city of l'Aquila.

ObjectivesFollowing an earthquake that occurred in middle Italy in 2009, the involved territory hosted in 10 years thousands of construction sites. The aim of this study is to assess inhalable, respirable, and respirable crystalline silica exposure of the construction workers involved in the rebuilding activities.MethodsSix construction companies joined the study and hosted the air sampling activities. We identified four work tasks: bricklayer and similar; scaffolder and carpenter; manual demolition; other tasks. We reported 8‐h time‐weighted concentrations.ResultsThe “All tasks” geometric mean concentration of inhalable dust was 4.73 mg/m3 and the higher, TLV exceeding exposure was observed for “Manual demolition workers” (13.92 mg/m3, GM). The “All tasks” geometric mean concentration of respirable dust was 0.25 mg/m3 and no TLV‐exceeding exposure (geometric mean values) was observed among the work‐related groups. About the respirable crystalline silica dust exposure, the “All tasks” average concentration was 0.004 mg/m3. No TLV‐exceeding exposure was observed among the whole data sample.ConclusionsThe comparison of the results shows that manual demolition workers are exposed to high levels of inhalable dust, exceeding the TLV‐TWA (Threshold Limit Values‐Time Weighted Average) limit of 10 mg/m3. About the respirable dust concentration, none of the analyzed work task dust concentrations exceeded the TLV‐TWA limit of 3 mg/m3 (geometric mean values). Measurements of respirable crystalline silica dust have shown levels below the threshold limit value of 0.025 mg/m3. Our findings overall match with the available scientific data.

Personal inhalable dust and endotoxin exposure among workers in an integrated textile factory

The aim of this study was to determine personal exposure to inhalable dust and endotoxin levels among workers in an integrated cotton-processing textile factory and exposure variability across the different work sections. Full shift measurements were carried out using inhalable conical samplers with 37 mm glass-fiber filters. Personal inhalable dust was determined gravimetrically, and endotoxin levels were analyzed by kinetic chromogenic Limulus Amebocytes Lysate assay. The geometric means of personal dust and endotoxin concentrations were 0.75 mg·m−3 and 831 EU·m−3, respectively. The highest dust and endotoxin concentrations were observed in carding section (1.34 mg·m−3 and 6,381 EU·m−3, respectively). Altogether, 11% of dust and 89% of endotoxin samples exceeded workplace exposure limits. This study showed a moderate correlation between inhalable dust and endotoxin (r = 0.450, p < 0.001). Our findings indicate that low dust exposure does not guarantee a low exposure to endotoxin.

Biomonitoring of Metal Exposure During Additive Manufacturing (3DPrinting).

BackgroundAdditive manufacturing (AM) is a rapidly expanding new technology involving challenges to occupational health. Here, metal exposure in an AM facility with large-scale metallic component production was investigated during two consecutive years with preventive actions in between.MethodsGravimetric analyzes measured airborne particle concentrations, and filters were analyzed for metal content. In addition, concentrations of airborne particles <300 nm were investigated. Particles from recycled powder were characterized. Biomonitoring of urine and dermal contamination among AM operators, office personnel, and welders was performed.ResultsTotal and inhalable dust levels were almost all below occupational exposure limits, but inductively coupled plasma mass spectrometry showed that AM operators had a significant increase in cobalt exposure compared with welders. Airborne particle concentrations (<300 nm) showed transient peaks in the AM facility but were lower than those of the welding facility. Particle characterization of recycled powder showed fragmentation and condensates enriched in volatile metals. Biomonitoring showed a nonsignificant increase in the level of metals in urine in AM operators. Dermal cobalt and a trend for increasing urine metals during Workweek Year 1, but not in Year 2, indicated reduced exposure after preventive actions.ConclusionGravimetric analyses showed low total and inhalable dust exposure in AM operators. However, transient emission of smaller particles constitutes exposure risks. Preventive actions implemented by the company reduced the workers' metal exposure despite unchanged emissions of particles, indicating a need for careful design and regulation of the AM environments. It also emphasizes the need for relevant exposure markers and biomonitoring of health risks.

Major environmental characteristics of swine husbandry that affect exposure to dust and airborne endotoxins

ABSTRACTInhalation of organic dust or endotoxin in the dust is considered a major risk factor for occupational respiratory illnesses. Eighteen environmental characteristics associated with animal husbandry were surveyed at 36 swine farms in seven provinces throughout South Korea. Association of these factors with levels of indoor inhalable or respirable dust or endotoxin in each type of dust was analyzed using backward stepwise multiple linear regression models. Mean levels of inhalable and respirable dust were 0.5 ± 0.35 and 0.13 ± 0.12 mg/m3 air, respectively, and mean endotoxin levels were 676 ± 463 and 48.4 ± 68.2 EU/m3, respectively, in each dust. Factors negatively associated with inhalable dust levels included pig age, indoor farm temperature, number of pigs in the building, hr/week of indoor farm work, and partly slatted floor. Factors positively associated with inhalable dust levels included floor cleaning by manual scraping and slurry deposit duration. Factors negatively associated with the level of endotoxin in inhalable dust included pig age, temperature, number of pigs, hr/week of indoor farm work, and partly slatted floor. Factors negatively associated with respirable dust level included area of the confinement building, whereas factors positively associated with respirable dust level included the number of pigs and stocking density. Endotoxin levels in respirable dust were negatively associated with h/week of indoor farm work and partly slatted floor. Overall, data suggest that husbandry variables may be adjusted to control dust and airborne endotoxin levels in swine farms.

Biomonitoring of workers using nuclear magnetic resonance-based metabolomics of exhaled breath condensate: A pilot study

Exhaled breath condensate (EBC) is a non-invasive biological matrix that allows easy access to the lung epithelial lining fluid. It can provide, for instance, useful biochemical information in workers following inhalatory exposure. Recently, nuclear magnetic resonance (NMR)-based metabolomics has been applied to EBC profiling to identify metabolic phenotypes (“metabotypes”) of relevance in respiratory medicine.We aimed at verifying if NMR-based metabolomics of EBC, combined with statistical analysis, could find differences in metabolomic profiles between groups of subjects occupationally exposed to levels of airborne inhalable dust, phenol, formaldehyde and volatile organic compounds (VOCs) below regulatory limits.Samples were collected from 20 blue-collar workers without wearing a mask (therefore “exposed” to ambient air) and after wearing a mask (“not exposed”). This procedure was only allowed after the standard air quality tests had shown levels of airborne xenobiotics below the occupational exposure limit or even below the LOD. Ten white-collar controls were also included.After partial least squares discriminant analysis, the exposed to the controlled plant environment and the not exposed groups were clearly separated, and discrimination was due to alteration of fatty acids and alcohols, whose statistical significance was also evaluated.Our results show that NMR-based metabolomics of EBC is a useful tool that has the potential to be successfully used in occupational health to distinguish between subjects exposed and non-exposed to very low airborne levels of chemicals.

Occupational exposures of flour dust and airborne chemicals at bakeries in Taiwan

Walk-through surveys were carried out for bakeries in this study to determine the environmental characteristics of bakeries in Taiwan. Questionnaires were administrated to discover whether job-related asthma-like symptoms occurred among workers. Air sampling and analysis were also performed. The results show that the levels of inhalable flour dust ranged from 0.01–0.83 mg m−3 with an average of 0.27 mg m−3. Among the samples collected, 23% of them had concentrations higher than the ACGIH TLV-TWA (0.5 mg m−3), which indicated that inhalable flour dust was an important air pollutant for bakery workers in Taiwan. Airborne chemicals such as diacetyl, acetoin, 2,3-pentanedione, 2,3-hexanedione, 2,3-heptanedione, furfural, and acetaldehyde were also found in various levels in this study. The concentrations of acetaldehyde measured in these bakeries were 37–83 times higher than what have been reported from other studies for residential areas and Chinese restaurants. In addition, the concentrations of total VOCs in the working areas of the bakeries were over 21 times higher than the levels determined in the non-working areas. Based on our results, there appears to be a need to improve the air quality of the working environments of bakeries in Taiwan.

Prevalence of lung function impairment among Greek cement production workers: a cross-sectional study.

Greece is a significant cement producing country. The aim of this study was to investigate the prevalence and risk factors of lung function impairment among Greek cement workers. One hundred thirty- seven cement production workers participated in this study. In addition, 110 employees not exposed to cement dust comprised the control group. The concentration of cement total dust at workplace varied from 1.1 to 11.6 mg/m3. In only one of the measurements, the Threshold Limit Level of 10 mg/m3 has been exceeded. Cement production workers presented a higher prevalence of FEV1<80% in comparison to controls (13.9% vs. 2.7%; Chi-Square Test; p=0.002). Multivariate analysis has shown that cement production workers have recorded an almost 5 fold risk of low lung function, as expressed by FEV1<80%, in comparison to the reference population OR=4.92; 95% C.I.=1.22–12.62). Current smoking was associated with an almost 4- fold increased risk of FEV1<80% (OR=3.91;95% C.I.=1.32–11.56). In conclusion, we found a high prevalence of impaired lung function among Greek cement production workers, despite the fact that total and inhalable dust levels were below the occupational exposure limits.

Inhalable dust, endotoxins and (1\u20133)-\u03b2-d-glucans as indicators of exposure in waste sorting plant environment

The aim of the study was to assess the levels of inhalable dust, endotoxins and (1–3)-β-d-glucans as agents harmful to the respiratory tract of workers of municipal waste sorting plants and interaction between these agents based on the measurements taken in two plants with different processing capacities. The study was conducted in summer season in two waste sorting plants (WSPs) differing in processing capacity. Samples of bioaerosol for inhalable dust (gravimetric method), endotoxins (LAL test in kinetic, chromogenic version) and (1–3)-β-d-glucans (Glucatell test in kinetic version) were collected from 42 sorting workers using individual aspirators with glass fiber filters during the work shift. Average geometric concentrations (geometric standard deviation; min–max) of inhalable dust, endotoxins and (1–3)-β-d-glucans were: WSP1: 1.7 mg m−3 (2.2; 0.6–6.9 mg m−3); 15.9 ng m−3 (2.1; 5.4–78.9 ng m−3), 55.1 ng m−3 (1.8; 20.7–188.6 ng m−3) and WSP2: 0.8 mg m−3 (2.2; 0.2–3.8 mg m−3), 9.8 ng m−3 (2.4; 1.6–29.7 ng m−3), 45.0 ng m−3 (3.2, 5.7–212.9 ng m−3), respectively. A significantly higher concentration of inhalable dust was recorded in WSP1 with bigger processing capacity compared to WSP2 (less processing capacity). Significant (p < 0.05) and very high correlations (Spearman rank R > 0.7) were found between the concentrations of all analyzed harmful agents. Processing capacity of waste sorting plants differentially affects the concentrations of inhalable dust, whereas concentrations of endotoxins and glucans are less clearly affected. This suggests that relative concentrations of endotoxin and glucan are depending on the waste sorting capacity.

Exposure to Inhalable Dust, Endotoxin, and Total Volatile Organic Carbons on Dairy Farms Using Manual and Automated Feeding Systems.

Agricultural workers tend to have high exposures to organic dusts which may induce or exacerbate respiratory disorders. Studies investigating the effect of work tasks and farm characteristics on organic dust exposures among farm workers suggest that handling of animal feed is an important exposure determinant; however, the effect of the animal feeding system has not been explored in any detail. To measure the exposure of Irish dairy farmers to inhalable dust, endotoxin, and total volatile organic compounds (TVOCs) during parlour work and to explore whether levels of exposure to these agents depend on the applied feeding system in the farms. Thirty-eight personal exposure measurements were collected from farmers across seven dairy farms. The farms used manual, loft, or semi-automated feeding systems. Information on worker tasks and farm characteristics was collected during the surveys. Associations between exposure concentrations and feeding systems, worker tasks, and other farm characteristics were explored in linear mixed-effect regression models with farmer identity treated as a random effect. Exposure concentrations were variable and had a geometric mean (GM; geometric standard deviation) of 1.5 mg m-3 (1.8) for inhalable dust and 128 EU m-3 (2.5) for endotoxin. More than 50% of the exposure measurements for endotoxin, and organic dust exceeded recommended health-based occupational exposure limits. Endotoxin levels were somewhat lower in farms using semi-automatic feeding systems when compared to those using manual feeding systems but in multivariate regression analysis associations were not statistically significant (β = -0.54, P = 0.4). Performance of activities related to handling and spreading of hay or straw was the strongest determinant for both inhalable dust and endotoxin exposure (β = 0.78, P ≤ 0.001; β = 0.72, P = 0.02, respectively). The level of dust exposure increased also as a consequence of a lower outdoor temperature, and higher ratio of distributed feed per cow (P = 0.01). Stationary measurements of TVOC and CO2 concentrations inside the dairy parlours had a GM of 180 ppb (1.9) and 589 ppb (1.3), respectively. The use of cow teat disinfectants and building ventilation were both strong predictors of TVOC concentrations within parlours. Dairy farm workers can be exposed to high and variable levels of inhalable dust and endotoxin and may be at risk of respiratory disease. Results from this study suggest that exposure control strategies for organic dusts and TVOCs exposures should consider building ventilation and work tasks such as spreading of bedding material, using spray disinfectants and animal feeding. Until effective permanent engineering controls are established farm workers should be encouraged to wear respiratory protective equipment during these tasks.

Occupational Exposure to Cobalt and Tungsten in the Swedish Hard Metal Industry: Air Concentrations of Particle Mass, Number, and Surface Area.

Exposure to cobalt in the hard metal industry entails severe adverse health effects, including lung cancer and hard metal fibrosis. The main aim of this study was to determine exposure air concentration levels of cobalt and tungsten for risk assessment and dose–response analysis in our medical investigations in a Swedish hard metal plant. We also present mass-based, particle surface area, and particle number air concentrations from stationary sampling and investigate the possibility of using these data as proxies for exposure measures in our study. Personal exposure full-shift measurements were performed for inhalable and total dust, cobalt, and tungsten, including personal real-time continuous monitoring of dust. Stationary measurements of inhalable and total dust, PM2.5, and PM10 was also performed and cobalt and tungsten levels were determined, as were air concentration of particle number and particle surface area of fine particles. The personal exposure levels of inhalable dust were consistently low (AM 0.15mg m−3, range <0.023–3.0mg m−3) and below the present Swedish occupational exposure limit (OEL) of 10mg m−3. The cobalt levels were low as well (AM 0.0030mg m−3, range 0.000028–0.056mg m−3) and only 6% of the samples exceeded the Swedish OEL of 0.02mg m−3. For continuous personal monitoring of dust exposure, the peaks ranged from 0.001 to 83mg m−3 by work task. Stationary measurements showed lower average levels both for inhalable and total dust and cobalt. The particle number concentration of fine particles (AM 3000 p·cm−3) showed the highest levels at the departments of powder production, pressing and storage, and for the particle surface area concentrations (AM 7.6 µm2·cm−3) similar results were found. Correlating cobalt mass-based exposure measurements to cobalt stationary mass-based, particle area, and particle number concentrations by rank and department showed significant correlations for all measures except for particle number. Linear regression analysis of the same data showed statistically significant regression coefficients only for the mass-based aerosol measures. Similar results were seen for rank correlation in the stationary rig, and linear regression analysis implied significant correlation for mass-based and particle surface area measures. The mass-based air concentration levels of cobalt and tungsten in the hard metal plant in our study were low compared to Swedish OELs. Particle number and particle surface area concentrations were in the same order of magnitude as for other industrial settings. Regression analysis implied the use of stationary determined mass-based and particle surface area aerosol concentration as proxies for various exposure measures in our study.

Inflammatory markers and exposure to airborne particles among workers in a Swedish pulp and paper mill.

PurposeTo study the relationship between exposure to airborne particles in a pulp and paper mill and markers of inflammation and coagulation in blood. MethodsPersonal sampling of inhalable dust was performed for 72 subjects working in a Swedish pulp and paper mill. Stationary measurements were used to study concentrations of total dust, respirable dust, PM10 and PM2.5, the particle surface area and the particle number concentrations. Markers of inflammation, interleukins (IL-1b, IL-6, IL-8, and IL-10), C-reactive protein (CRP), serum amyloid A (SAA), and fibrinogen and markers of coagulation factor VIII, von Willebrand, plasminogen activator inhibitor, and D-dimer were measured in plasma or serum. Sampling was performed on the last day of the work free period of 5 days, before and after the shift the first day of work and after the shifts the second and third day. In a mixed model analysis, the relationship between particulate exposures and inflammatory markers was determined. Sex, age, smoking, and BMI were included as covariates.ResultsThe average 8-h time-weighted average (TWA) air concentration levels of inhalable dust were 0.30 mg/m3, range 0.005–3.3 mg/m3. The proxies for average 8-h TWAs of respirable dust were 0.045 mg/m3. Significant and consistent positive relations were found between several exposure metrics (PM 10, total and inhalable dust) and CRP, SAA and fibrinogen taken post-shift, suggesting a dose–effect relationship.ConclusionThis study supports a relationship between occupational particle exposure and established inflammatory markers, which may indicate an increased risk of cardiovascular disease.

Industrial hygiene, occupational safety and respiratory symptoms in the Pakistani cotton industry

ObjectivesIn the cotton industry of Pakistan, 15 million people are employed and exposed to cotton dust, toxic chemicals, noise and physical hazards. The aim of this study was to determine...

Personal Exposure to Inhalable Dust and the Specific Latex Aero-Allergen, Hev b6.02, in Latex Glove Manufacturing in Thailand

Latex product manufacturing is an important industry in south-east Asia but has the potential for considerable occupational exposure of workers to latex allergens. Although exposure to latex allergens can result in adverse health reactions, few studies to characterize this exposure have been conducted to date. This study therefore aimed to characterize current airborne inhalable dust and the specific allergen, Hev b 6.02, exposures in this industry in Thailand. Workers were recruited from three factories in the southern part of Thailand. Full-shift inhalable dust personal air sampling was conducted using IOM sampling heads equipped with polytetrafluoroethylene filters at a 2.0 l min(-1) flowrate. After weighing to determine inhalable dust levels, filters were extracted and analysed for Hev b 6.02 using an enzyme immunometric assay. Two hundred and seventy-five workers agreed to participate, resulting in a total of 292 measurements. Geometric mean (GM) personal exposure to inhalable dust was 0.88 mg m(-3), but individual exposures up to 12.34 mg m(-3) were measured. The pattern of exposure was similar across factories, with highest exposures in the stripping (GM 2.08-4.05 mg m(-3) for the 3 factories) and tumbling departments (1.11-2.17 mg m(-3)). Within-worker (day-to-day) variability contributed 92% to total variability. The Hev b 6.02 exposure pattern was similar with time-weighted average GM exposure levels in the oldest factory ranging from 8.7 mg m(-3) in the laboratory to 30.2mg m(-3) in the stripping department. In contrast to inhalable dust exposure, total exposure variability was primary driven by variability between workers (67%). Workers in these latex product factories get routinely exposed to measurable Hev b 6.02 levels, which may give rise to increased incidence of allergic symptoms and occupational asthma. Also, in this measurement campaign a 10mg m(-3), but not 15 mg m(-3), occupational exposure limit for inhalable dust was occasionally exceeded. Highest Hev b 6.02 exposures were found in the stripping and tumbling departments, which would be natural targets for interventions aimed at reducing exposure.

Inhalable Dust Measurements as a First Approach to Assessing Occupational Exposure in the Pharmaceutical Industry

Occupational exposure to active ingredients in the pharmaceutical industry has been the subject of very few published studies. Nevertheless, operations involving active powdered drugs or dusty operations potentially lead to operator exposure. The aim of this study was to collect occupational exposure data in the pharmaceutical industry for production processes involving powdered active ingredients. While the possibility of assessing drug exposure from dust level is examined, this article focuses on inhalable dust exposure, without taking chemical risk into account. A total of 377 atmospheric (ambient and personal) samples were collected in nine drug production sites (pharmaceutical companies and contract manufacturing organizations) and the dust levels were assessed. For each sample, relevant contextual information was collected. A wide range of results was observed, both site- and operation-dependent. Exposure to inhalable dust levels varied from 0.01 mg/m3to 135 mg/m3. Though restricted to dust exposure, the study highlighted some potentially critical situations or operations, in particular manual tasks (loading, unloading, mechanical actions) performed in open systems. Simple preventive measures such as ventilation, containment, and minimization of manual handling should reduce dust emissions and workers’ exposure to inhalable dust.

Exposición ocupacional a agentes químicos en la construcción de edificios

&lt;p&gt;&lt;em&gt;Objetivos: &lt;/em&gt;(i) estimar los niveles de exposición ocupacional a humos y polvos de cromo, hierro y manganeso y polvo inhalable de madera en tareas asociadas a la construcción de edificios; (ii) generar una propuesta de matriz de exposición ocupacional a los agentes estudiados.&lt;/p&gt; &lt;p&gt;&lt;em&gt;Materiales y métodos: &lt;/em&gt;el estudio fue exploratorio e incluyó nueve proyectos de construcción de edificios de cinco empresas. Se utilizaron los métodos de muestreo y análisis descritos en OSHA ID121 y MDHS 14/03. Se determinaron los niveles de exposición ocupacional para el análisis de cumplimiento con el estándar nacional INTE 31- 08-04-01. Se estimó la influencia de los posibles determinantes de exposición mediante pruebas de asociación estadística.&lt;/p&gt; &lt;p&gt;&lt;em&gt;Resultados: &lt;/em&gt;La media de los niveles de exposición ocupacional para polvo inhalable de madera en carpintería fue de 3.55 mg/m&lt;span&gt;3&lt;/span&gt;; se encontró relación entre el tiempo de muestreo y las concentraciones obtenidas. No se detectó la presencia de cromo en las muestras recolectadas. La media de hierro fue de 0.78 mg/m&lt;span&gt;3&lt;/span&gt;; no se encontró relación entre las concentraciones y los posibles determinantes de la exposición. En manganeso, la media fue de 0.04 mg/ m&lt;span&gt;3&lt;/span&gt;; la temperatura fue el factor con mayor influencia.&lt;/p&gt; &lt;p&gt;&lt;em&gt;Conclusiones: &lt;/em&gt;los niveles de exposición ocupacional a hierro, manganeso y polvo inhalable de madera variaron entre constructoras y proyectos. Las concentraciones de polvo se asociaron al tiempo de muestreo y no se encontró evidencia estadística significativa para los determinantes de la exposición a metales.&lt;/p&gt;