Level Of Statistical Significance Research Articles

3D reconstruction of foot metatarsal bones of women using CT images

Bone morphology is a fundamental factor in human anatomy. However, foot and ankle bones have yet to be adequately evaluated in 3-dimensional. It is essential to present the biometric data of anatomical structures. This study formed 3D models of the metatarsal bones of the feet of young women using image processing techniques to examine biometric measurements and determine morphology on these 3D models. This study investigated bone lengths in the metatarsal bones of women feet in Türkiye. A total of ten young female subjects were included as the test group to measure the lengths of their foot metatarsal bones using CT (Computed Tomography) scans, and 20 feet (left/right) were examined. The parameters that were used for the analyses were detector collimation of 64x0.5 mm, section thickness of 0.5 mm, current of 100 mA, tube voltage of 120 kVp, and pixel spacing of 512x512 pixels with a monochrome resolution providing 16-bit gray levels. CT images were processed, and a 3D metatarsal reconstruction was gathered. Then, the biometric measurements were calculated on this 3D model. For the lengths of the volunteers' right/left foot metatarsal bones, statistically significant differences were calculated using a one-sample t-test. For the female metatarsal bones of the left and right feet, statistically significant differences in length were calculated on 3D models. The mean results of the metatarsal length measurements were MT1(metatarsal): 59.52±1.42 mm, MT2: 70.45±1.82 mm, MT3: 66.25±1.82 mm, MT4: 65.12±1.81 mm and MT5: 63.63±1.81 mm. The level of statistical significance was accepted as p <0.05 for the one-sample t-test conducted for each metatarsal bone. The lengths of the right foot metatarsal bones were different from those of the left foot metatarsal bones in the sample. However, this difference was approximately one-tenth of a millimeter. The shortest bone was MT1, and the longest bone was MT2. These measurements are consistent with the anatomical information in the literature. The 3D models from the CT images and the biometric measurements of the metatarsal bones were found to be reliable and accurate.

Ocular effects of eye cosmetic formulations

ABSTRACT Objective To study the ocular effects seen among eye cosmetic wearers in the Indian Population. Methods This cross sectional study was conducted on female participants who had fulfilled the inclusion and exclusion criteria. A detailed history was obtained and thorough ophthalmic evaluation was done. Mann Whitney U test was used. Statistical analysis was done using IBM SPSS. p < 0.05 was taken as the level of statistical significance. Results Among a total of 225 participants in our study, the mean age was 24.23 ± 1.8 which comprised of young student females. Majority of the females used one eye cosmetics with Kajal (n = 156) being the most predominant. Most frequently encountered symptom upon using eye cosmetics was watering from eyes and ocular pain was the least encountered symptom. Anterior segment examination showed- allergic conjunctivitis and meibomian gland dysfunction being the most and least predominant respectively. Our study highlights that Kajal predisposes the eyes to significant ocular morbidity with p = 0.039 for Dry Eye Disease, p = 0.041 for Allergic Conjunctivitis, p = 0.036 for conjunctival pigmentation. Prolonged use of such formulations for more than 4 times a week (p = 0.046) or even daily(p = 0.031)for a duration of either 1-5 years (p = 0.033) or greater than 5 years (p = 0.027) was found to be statistically significant in causing ocular signs. Non removal of eye cosmetics at the end of the day was significant in causing allergic conjunctivitis (p = 0.035) and conjunctival pigmentation (p = 0.021). Plain tap water has been found to be the least effective technique in the removal of such ocular cosmetics with a statistical significance of p = 0.031 in causing ocular signs. Conclusions Eye cosmetics are a significant contributor to the development of ocular surface diseases. Removal of products along with decreased usage seems to be a significant contributor in dampening unwanted adverse effects.

Immediate implant placement influenced by musical flow: a prospective randomized controlled clinical trial

BackgroundThe purpose of this study was to test how musical flow using baroque (BM) and classical era music (CM) as a non-pharmacological therapy can control anxiety and pain levels among patients undergoing IPI (Immediate post-extraction implants).Methods78 patients who required an IPI were enrolled in this randomized clinical trial. Each patient was assigned to one of the three experimental groups with a simple randomization: Group I (n = 26) listened to BM; Group II (n = 27) listened to CM; and Group III (n = 25) did not listen to music and was the control group (C). The physiological dependent variables analyzed were systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen saturation (SpO2). The psychological dependent variable analyzed was modified dental anxiety scale (MDAS) and visual analogue scale (VAS), measured before and after surgery. In all cases, the level of statistical significance was set at p < 0.01.ResultsStatistically significant differences were found in the SBP decrease in the CM group (p = 0.001, CI = 1.9716–6.5840) and the BM group (p = 0.003, CI = 1.4450–6.4396). Anxiety levels during the intervention decreased in both groups that listened to music: BM group (p = 0.002, CI = 0.645–2.662) and CM group (p = 0.000, CI = 1.523–3.884).ConclusionsPatients undergoing IPI placement surgery can register lower levels of SBP when listening to BM and CM than patients who were not exposed to the musical flow, improving their anxiety levels.

Spatial clustering of domestic violence attitudes toward women in Ghana.

Violence against women is a global public health issue associated with increased morbidity and mortality. The United Nations defines violence against women as "any act of gender-based violence that results in, or is likely to result in, physical, sexual, or mental harm or suffering to women, including threats of such acts, coercion or arbitrary deprivation of liberty, whether occurring in public or in private life". There is paucity of data on the spatial distribution and predictors of violence against women in sub-Saharan Africa. The objective of this study was to investigate the geographical distribution of attitudes toward wife beating in Ghana, a sub-Saharan African country, utilizing data from the 2014 Ghana Demographic and Health Survey (DHS). Participants from over eleven thousand households were surveyed on topics of demographics and justification of wife beating in at least one of five different scenarios. The identification of geographic clusters of men and women who endorsed wife beating was performed using Ripley K functions. The comparison of the spatial distributions of women and men justifying wife beating were performed using spatial relative risk surfaces. The spatial analysis indicated the presence of clusters in women and men's approval for wife beating compared to those who do not approve of wife beating, with a statistical significance level set at p < 0.01. Major spatial clusters of approval of wife beating were in the Northern region, for both men and women, and in the Upper West region of Ghana for the men participants. This is the first study to explore the geographical distribution of attitudes toward wife beating in Ghana, and revealed evidence of several regional heterogeneous clusters where wife beating was more commonly justified by both men and women. Targeted intervention for reducing the justification of wife beating in Ghana should be focused in these regions.

Predictors of under-weight among children younger than 24 months in Nimule Border Town, Eastern Equatoria State, South Sudan: a community-based cross sectional study

BackgroundUnderweight is a public health problem globally, and more severe in South Sudan with wide sub-regional differences. In Nimule border town, which represents other border towns in South Sudan, data on underweight among children below two years is unavailable. Thus, this study set out to assess predictors of underweight among children younger than 24 months in Nimule border town, Magwi County, Eastern Equatoria State, South Sudan.MethodsAn analytical cross-sectional study was conducted in Nimule boarder town targeting 390 children younger than two years. Systematic sampling and simple random sampling methods were used. Data were collected through a researcher-administered questionnaire with both open and closed ended questions. Data was entered in EpiData and then exported into Statistical Package for Social Sciences research (SPSS) version 20 for analysis. Descriptive data analysis was conducted and data were summarized into frequencies and percentages, means with standard deviations, and medians with interquartile ranges. Bivariate analysis was conducted with the Chi-squared and Fisher's exact tests for categorical independent variables, and the student’s t-test for numerical variables. Finally, multivariate analysis was done via logistic regression analysis and results were stated as odds ratios (OR) with corresponding 95% confidence interval (CI). The level of statistical significance was set at 5%.ResultsOut of the total 390 participants, 112 (28.7%) were under weight. The study showed primary (aOR, 0.38; 95% CI, 0.12–1.18; P = 0.095) and secondary (aOR, 0.37; 95% CI, 0.12–1.17; P = 0.091 levels of education were associated with underweight but not tertiary level of education (aOR, 0.76; 95% CI, 0.21–2.74; p = 0.671). Household income of 5000 to 10,000 (aOR, 0.26; 95% CI, 0.10–0.68; P = 0.006) and above 10,000 (aOR, 0.11; 95% CI, 0.04–0.28; P < 0.001) South Sudanese pounds, supplementary feeding before 6 months (aOR; 0.01; 95% CI, 0.02–0.05; P < 0.001) were associated with underweight and irregular hand washing (aOR; 2.17; 95% CI, 1.14–4.11; P = 0.018) was associated with increased odds of underweight.ConclusionsThis study established a high prevalence of underweight. Maternal level of education particularly primary, secondary, higher household incomes in excess of 5,000 South Sudanese pounds reduced the risk of underweight. While irregular hand washing was a risk factor for underweight.

A retrospective study of the prevalence of calcium deposits around the dens axis via cone beam computed tomography

ABSTRACT Objective This study aimed to evaluate the relationship between the presence of calcium deposits (CDs) around the dens axis and patients’ age, gender, and systemic diseases. Methods This retrospective study was carried out by examining CBCT. Basic descriptive statistical analyses and normality tests were performed on all variables. The assumption of normality was checked using the Shapiro-Wilk method. The statistical significance level was accepted as a p-value less than 0.05. Results CDs were observed in a total of 99 (21.9%) individuals. The incidence of CDs statistically significantly increased with age (p < .01),while it didn’t statistically significantly differ between genders (p = .47). 13% were systemically healthy, while 55% had hypertension. The incidence of CDs was statistically significantly higher in individuals with hypertension. Conclusions In the presence of CDs, the patient should be referred to a medical doctor to confirm the diagnosis of CDS and prevent possible complications.

Conduction system pacing improved cardiac functions and functional capacity in heart failure with reduced ejection fraction and right bundle branch block

Abstract Conduction system pacing (CSP) is increasingly accepted as an alternative to biventricular pacing in heart failure (HF) patients with left bundle branch block (LBBB) and non-LBBB. However, its efficiency in right bundle branch block (RBBB) is ill-defined. Herein, we report on the clinical outcomes of CSP in HFrEF patients with wide QRS complex and RBBB morphology. His-bundle (HBP) or LBB-area pacing (LBBAP) was attempted as a primary strategy in patients with RBBB, QRS duration ≥130 ms and left ventricular ejection fraction (LV EF) &amp;lt;35% and NYHA class II to IV HF despite optimized medical treatment for at least 6 months. Data on functional status, NT-pro-BNP levels and echocardiographic parameters were collected during follow-up and expressed as mean ± SEM, Statistical significance was calculated with Student’s paired t-test and chi square distribution. CSP was performed in 12 RBBB-HF patients (age 64.3±2.9 years) with mean QRS duration of 150±4 msec and baseline LV EF of 25.4±2.3%. The aetiology of HF was ischaemic (6 patients) and non-ischaemic cardiomyopathy (6 patients). During the procedure, HBP was achieved in 7 and LBBAP in 5 patients, resulting in a significant reduction in the QRS-duration (115±2.6 msec, P&amp;lt;0.0001) as compared with baseline value. CSP improved LV function (LV EF= 31.8±2.8%, P=0.009) as well as NYHA functional class (25% of the patients with NYHA II and 75% with NYHA III before vs. 33% with NYHA I, 33% with NYHA II and 33% with NYHA III after CSP, P=0.048) as compared to what was obtained prior to the procedure. A numerical decrease was also found in NT-proBNP levels (4735±2606 ng/ml before CSP vs. 3972±1883 ng/ml after CSP) which did not reach the level of statistical significance (P=0.45). In conclusion, CSP improved both quality of life and LV function in HFrEF patients with RBBB. Our results support the use of CSP in HFrEF patients with QRS width&amp;gt;130msec and RBBB morphology.

Comparative evaluation of the effectiveness and safety of acne treatment with systemic isotretinoin in monotherapy and together with combined oral contraceptives in women

Objective. To give a comparative evaluation of the effectiveness and safety of acne treatment with systemic isotretinoin in monotherapy and together with combined oral contraceptives in women. Materials and methods. 65 women with severe papulo-pustular acne took part in the study. They were divided into two groups: group I consisted of 35 women who used systemic isotretinoin for acne in monotherapy; group II included 30 women who took systemic isotretinoin together with combined oral contraceptives. A comprehensive clinical and laboratory study was conducted. The study included a biochemical blood test to determine the lipid profile, liver transaminases, and hormonal homeostasis. The obtained results were analyzed using the methods of parametric and nonparametric statistics, the standard error (m) was used in the calculations, the level of statistical significance was noted at p 0.05. Results. In women treated for acne with systemic isotretinoin in monotherapy relief occurs in 4 weeks, and complete clinical recovery in 24 weeks after the beginning of therapy; when using systemic isotretinoin together with combined oral contraceptives, relief is determined in 2 weeks, and complete clinical recovery in 16 weeks of treatment. The main side effects of systemic isotretinoin were cheilitis, skin xerosis, retinoic dermatitis and telogen alopecia. Cheilitis was revealed in the majority of patients in both groups equally. Xerosis of the skin, retinoic dermatitis and telogen alopecia were more often observed in the 1st group. In women of the 1st group, the level of progesterone was significantly higher and the level of estradiol was lower than in women of the 2nd group. Conclusions. Systemic isotretinoin has shown high efficacy and safety in treatment for acne in women. Combined oral contraceptives normalize hormonal homeostasis, which helps to eliminate acne. When using systemic isotretinoin in combination with combined oral contraceptives, the main clinical effect occurs earlier, and adverse reactions are less frequent and less severe than in monotherapy. The combined use of systemic isotretinoin and combined oral contraceptives is the optimal method of acne treatment in women.

Development of an alginate–chitosan biopolymer composite with dECM bioink additive for organ-on-a-chip articular cartilage

In vitro use of articular cartilage on an organ-on-a-chip (OOAC) via microfluidics is challenging owing to the dense extracellular matrix (ECM) composed of numerous protein moieties and few chondrocytes, which has limited proliferation potential and microscale translation. Hence, this study proposes a novel approach for using a combination of biopolymers and decellularised ECM (dECM) as a bioink additive in the development of scalable OOAC using a microfluidic platform. The bioink was tested with native chondrocytes and mesenchymal stem cell-induced chondrocytes using biopolymers of alginate and chitosan composite hydrogels. Two-dimensional (2D) and three-dimensional (3D) biomimetic tissue construction approaches have been used to characterise the morphology and cellular marker expression (by histology and confocal laser scanning microscopy), viability (cell viability dye using flow cytometry), and genotypic expression of ECM-specific markers (by quantitative PCR). The results demonstrated that the bioink had a significant impact on the increase in phenotypic and genotypic expression, with a statistical significance level of p < 0.05 according to Student’s t-test. The use of a cell-laden biopolymer as a bioink optimised the niche conditions for obtaining hyaline-type cartilage under culture conditions, paving the way for testing mechano-responsive properties and translating these findings to a cartilage-on-a-chip microfluidics system.

Navigating nephrology: unveiling pharmacist perspectives on renal dose adjustment in Saudi Arabia - a comprehensive cross-sectional analysis.

Chronic kidney disease (CKD) is a major public health concern in Saudi Arabia. it is pertinent to mention that in the Southwestern region of Saudi Arabia. Hypertension and diabetes mellites are considered the major drivers of CKD. Research has documented worldwide the inappropriate dose adjustments in patients, ranging from 25% to 77%, of drugs requiring dose modifications. Pharmacists are pivotal members of the healthcare team, tasked with addressing issues pertaining to medications. This study aims to unveil pharmacist perspectives on renal dose adjustment in Saudi Arabia an important step in gauging their involvement in promoting healthy behaviours. A cross-sectional study design was conducted from December 2023 to January 2024 among pharmacists working in diverse healthcare settings, including clinical and hospital pharmacies, retail, and community pharmacies who had direct encounters with patients diagnosed with CKD. A validated questionnaire, the Renal Dose Adjustment-13 (RDQ-13) was used for this study. For comparing the knowledge, attitude, and perception scores of pharmacists statistical tests like One-Way ANOVA, and independent t-test; while for factors influencing the knowledge, attitude, and perception scores a multivariate linear regression was performed. The statistical significance level was set at 0.05. A total of 379 pharmacists completed the questionnaire, the knowledge score of pharmacists was 22.06 ± 2.81, while the attitude score was 8.56 ± 2.62 and the practice score was 5.75 ± 2.25. The findings of multivariate linear regression analysis indicated a statistically significant positive association between knowledge score and pharmacist's age while for practice score the findings revealed a statistically negative association between working setting and designation of pharmacists. The pharmacist in Saudi Arabia exhibited a proficient knowledge score of drug dosage adjustment pertinent to renal function while the attitude and practice score was less as compared to the knowledge score.

Taekwondo win-loss determining factors using data mining-based decision tree analysis: focusing on game analysis for evidence-based coaching

BackgroundPurpose In this study, the purpose of this study is to identify the determinants of winning and losing in taekwondo by applying decision tree analysis, one of the data mining techniques, based on the 2022 World taekwondo championships women’s competition.Methods272 women’s games in the taekwondo championships in Guadalajara held by the WT in 2022 were used. For data processing, an independent sample t-test was performed for differences in game content variables according to the win/lose group, and a decision tree analysis was performed to confirm game content variables affecting the win/lose group. To check the predictive power of the model, classification accuracy, standard error, and misclassification estimates were calculated. All statistical significance levels were set at 0.05.ResultsFirst, it was found that there was no statistically significant difference only in body attack (attempt) and number of kicking variables according to the winning and losing groups(p > .05), and there were differences in all other game content variables(p < .05). Second, as a result of conducting a decision tree analysis to confirm the determinants of winning and losing in taekwondo sparring, winning situation, tie situation, and number of kicks were identified as important variables.ConclusionThe World taekwondo championships are analyzed in the currently changed taekwondo competition rules to identify important factors, and at the same time, based on this, data-based coaching is expected to improve performance.

The Effects of Eccentric Training on Undulatory Underwater Swimming Performance and Kinematics in Competitive Swimmers

This study aimed to evaluate the effects of a five-week training program on undulatory underwater swimming (UUS) in swimmers and to compare the specific effects prompted by two different training protocols on UUS performance and kinematics. Swimmers (n = 14) were divided into in-water only (WO) (18.61 ± 2.62 years, FINA points: 507 ± 60) and water + dry-land training groups (with conical pulleys) (WD) (18.38 ± 2.67 years, FINA points: 508 ± 83). Three countermovement jumps (CMJ) and three maximal UUS trials were performed before and after a five-week training period. The training program comprised 14 × 30-min sessions. The WO group repeated the same 15-min block twice, while the WD group performed one block of 15 min in the water and the other block on land performing lower limb exercises with conical pulleys. Seven body landmarks were auto-digitalized during UUS by a pre-trained neural network and 21 kinematic variables were calculated. The level of statistical significance was set at p &lt; 0.05. Significant time × group interaction in favour of the WD group was observed for mean vertical toe velocity (p = 0.035, = 0.32). The WD group experienced enhancements in mean and maximum underwater velocity, kick frequency, maximum shoulder angular velocity, as well as mean and maximum vertical toe velocity (p &lt; 0.05). The WO group exhibited an enhancement in CMJ height (p &lt; 0.05). In conclusion, UUS performance was improved in adolescent swimmers after five weeks of specific training, only when combining water and conical pulley exercises. Coaches should include dry-land specific lower limb exercises in addition to in-water training to improve UUS performance.

Pilot study for three-dimensional cephalometric Enlow's counterpart analysis: Vertical track. Two-dimensional and three-dimensional comparison.

The introduction of cone beam computed tomography (CBCT) in dentistry has given orthodontists the possibility of studying craniofacial structures in three dimensions. Despite the possibility to obtain lateral cephalograms synthesized from CBCT, this approach still does not provide a fully three-dimensional evaluation of the patient's anatomy. While there has been some success in adapting traditional two-dimensional cephalometric analyses to three dimensions, the specific application of Enlow's cephalometric analysis using CBCT remains unexplored. This pilot study aims to introduce a novel approach for performing Enlow's vertical track analysis using CBCT images. Eighteen CBCT images of skeletal Class I (ANB = 2 ± 2) subjects (12 males and 6 females, aged from 9 to 19 years) with no history of previous orthodontic treatment were selected. For each subject, 2D Enlow's vertical track analysis was performed on lateral cephalograms extracted from the CBCT images, and separately, 3D vertical track analysis was directly performed on the CBCT images. To validate the proposed method, we compared the differences between the posterior vertical counterpart (PVC) and the middle vertical counterpart (MVC), as well as between the middle vertical counterpart (MVC) and the anterior vertical counterpart (AVC), as obtained from both the two-dimensional and three-dimensional analyses. The Kolmogorov-Smirnov normality test was applied for each variable to check whether data were normally distributed and a paired Student's t-test was performed. The level of statistical significance was .05. The comparison between three-dimensional PVC-MVC (-0.43 ± 0.37 cm) and two-dimensional PVC-MVC (-0.53 ± 0.36 cm) revealed no statistical difference (P = .27). Similarly, no significant difference (P = .28) was observed between two-dimensional MVC-AVC (-0.56 ± 0.34 cm) and three-dimensional MVC-AVC (-0.47 ± 0.37 cm). The method proposed by this study to realize the vertical track analysis on 3D images is valid and superimposable on that described by Enlow on lateral cephalograms.

Evaluating the difference in perception of the Akinosi technique among dentistry students: A comparison between theoretical and practical learning.

Effective pain control is crucial in dental practice; thus, local anesthetic techniques have been extensively taught. The Halstead technique is the most commonly used inferior alveolar nerve block despite its relatively high failure rate. On the other hand, the Vazirani‒Akinosi technique (VAT) is less commonly taught. This study evaluated changes in final-year students' perceptions of VAT after a period of active learning. This prospective randomized study was performed in 2022 and included fifth-year dental students (n=91). The study group (n=49) received practical VAT training during oral surgery internships, whereas the control group (n=42) did not. A Likert-scale questionnaire assessed students' perceptions, theoretical knowledge, and difficulty levels. An independent sample t-test was used for comparison and the statistical significance level was set at p<0.05. The survey response rate was 100%. Statistical analysis revealed significant differences between the groups for seven of the 12 questionnaire statements (p<0.05). Overall, perception scores favored the study group, indicating a more positive response. The statements related to theoretical knowledge, except for one statement, showed no significant differences (p>0.05). Practical training significantly improved students' perceptions of VAT, demonstrating the importance of active learning in dental education. Faculties should integrate active learning methods to enhance students' clinical skills and prepare them for professional practice.

Comparative effect of physical health training and psychological training of the theory of reasoned action (TRA) model on the life quality of patients with diabetes in Tehran, Iran: utilization of message texting

Background and purposeProviding physical health and mental health training promotion is necessary for a sustainable change in attitude and lifestyle of diabetic patients. The present study was conducted with the aim of comparing the effect of physical health training and psychological training of the theory of reasoned action (TRA) model on the life quality of patients with type 2 diabetes.MethodsThis experimental study was conducted in 2022 with two intervention groups and one control group consisting of 129 patients with type 2 diabetes who were referred to Imam Khomeini Hospital in Tehran. Over the course of one month, each individual in intervention group 1 received 15 text messages focusing on physical health, while intervention group 2 received 15 psychological text messages related to the TRA. The control group did not receive any text messages during this period. The data collection tool used was the “Audit of Diabetes-Dependent Quality of Life (ADDQoL)” questionnaire, which was completed by the participants before and after the intervention. The data were analyzed using SPSS version 16 software at a statistical significance level of 0.05.ResultsIn the intervention-1 group, the average life quality score was 8.51 units (P < 0.001), while in the intervention-2 group, it was 19.25 units (P < 0.001) higher than the control group. The psychological training group had a 17.62 units (P < 0.05) lower average fasting blood sugar (FBS) and a 10.74 units (P < 0.001) higher average quality of life compared to the physical training group.ConclusionThe results of this study showed that the effectiveness of psychological training of the TRA model in improving life quality and reducing FBS in patients with diabetes is greater than physical health training. It is suggested that policy makers and health managers base future plans on physical health promotion training along with TRA model mental health training for the development of education in patients with diabetes. Specialists and healthcare workers can also act to improve personal health characteristics, especially those related to reducing FBS and increasing the quality of life of patients with diabetes, by using training through mobile phone text messages, particularly with psychological content TRA based.

Diagnostic Value of Clear Cell Likelihood Score v1.0 and v2.0 for Common Subtypes of Small Renal Masses: A Multicenter Comparative Study.

Clear cell likelihood score (ccLS) is reliable for diagnosing small renal masses (SRMs). However, the diagnostic value of Clear cell likelihood score version 1.0 (ccLS v1.0) and v2.0 for common subtypes of SRMs might be a potential score extension. To compare the diagnostic performance and interobserver agreement of ccLS v1.0 and v2.0 for characterizing five common subtypes of SRMs. Retrospective. 797 patients (563 males, 234 females; mean age, 53 ± 12 years) with 867 histologically proven renal masses. 3.0 and 1.5 T/T2 weighted imaging, T1 weighted imaging, diffusion-weighted imaging, a dual-echo chemical shift (in- and opposed-phase) T1 weighted imaging, multiphase dynamic contrast-enhanced imaging. Six abdominal radiologists were trained in the ccLS algorithm and independently scored each SRM using ccLS v1.0 and v2.0, respectively. All SRMs had definite pathological results. The pooled area under curve (AUC), accuracy, sensitivity, and specificity were calculated to evaluate the diagnostic performance of ccLS v1.0 and v2.0 for characterizing common subtypes of SRMs. The average κ values were calculated to evaluate the interobserver agreement of the two scoring versions. Random-effects logistic regression; Receiver operating characteristic analysis; DeLong test; Weighted Kappa test; Z test. The statistical significance level was P < 0.05. The pooled AUCs of clear cell likelihood score version 2.0 (ccLS v2.0) were statistically superior to those of ccLS v1.0 for diagnosing clear cell renal cell carcinoma (ccRCC) (0.907 vs. 0.851), papillary renal cell carcinoma (pRCC) (0.926 vs. 0.888), renal oncocytoma (RO) (0.745 vs. 0.679), and angiomyolipoma without visible fat (AMLwvf) (0.826 vs. 0.766). Interobserver agreement for SRMs between ccLS v1.0 and v2.0 is comparable and was not statistically significant (P = 0.993). The diagnostic performance of ccLS v2.0 surpasses that of ccLS v1.0 for characterizing ccRCC, pRCC, RO, and AMLwvf. Especially, the standardized algorithm has optimal performance for ccRCC and pRCC. ccLS has potential as a supportive clinical tool. 4. Stage 2.

An Analysis of Surgical Factors Associated with Clinically Significant Eyelid Edema (CSEE) in Patients Undergoing Blepharoplasty: Lid Crease Techniques Associated with CSEE

Purpose: Severe postoperative edema after eyelid surgery can have negative clinical and psychological effects. In this study, we investigated whether surgical factors, including surgical techniques and suture type, were associated with clinically significant eyelid edema (CSEE). Methods: A chart review was performed on 269 patients who underwent upper eyelid blepharoplasty with or without external levator advancement by 2 surgeons at a single institution between January 2021 and December 2022. Postoperative photos were graded by 2 physicians for eyelid edema using a standardized grading scale ranging from 0 (no edema) to 3 (severe edema). CSEE was defined either as having a grade of 3 at any point postoperatively or any grade that was 1 or greater after 90 days postoperatively. Logistic regression controlling for race was used for analysis; the statistical significance level was defined as p &lt; 0.05. Results: Of 269 patients, 56 developed CSEE. Of those who underwent blepharoplasty with mini crease enhancement (closure with every other bite incorporating levator aponeurosis), 40.5% developed CSEE versus 12.5% of those without (p &lt; 0.001). Patients with lid crease formation using buried interrupted sutures had greater CSEE than those with externalized interrupted sutures removed at 1 week (43.8% versus 11.5%, p &lt; 0.01). There was no increased risk of CSEE with additional procedures performed versus blepharoplasty alone. Conclusions: Patients who underwent blepharoplasty with mini crease enhancement, where more than 4 sutures are placed from skin to levator, and/or had buried suture lid crease formation had greater rates of CSEE.

Vertical jump neuromuscular performance of professional female handball players-starters vs. non-starters comparison.

Given the complex nature of the handball as a game, players are required to possess a distinct set of physical and physiological attributes to attain peak performance. With the countermovement vertical jump (CVJ) being widely implemented as a non-invasive and time-efficient testing modality in sports settings, the purpose of the present study was twofold: (a) to establish a CVJ profile of professional female handball players and (b) to examine differences in force-time metrics between starters and non-starters. Forty-two professional female handball players (e.g., SuperLeague) volunteered to participate in this study. Each athlete performed three maximum-effort CVJs with no arm swing while standing on a uni-axial force plate system sampling at 1,000 Hz. Independent t-tests were used to examine differences in each variable between starters and non-starters. The results revealed that starters attained superior performance within the eccentric phase of the CVJ when compared to non-starters, particularly in terms of eccentric peak velocity (-0.957 ± 0.242 vs. -0.794 ± 0.177 m·s-1), eccentric mean power (320.0 ± 77.7 vs. 267.1 ± 75.2 W), and eccentric peak power (929.0 ± 388.1 vs. 684.4 ± 214.2 W). While not reaching the level of statistical significance, moderate-to-large effect sizes were observed for concentric impulse, peak velocity, and mean and peak force and power, all in favor of players included in the starting lineup (g = 0.439-0.655). Overall, these findings suggest that at the top-tier level of handball competition, the ability to secure a spot in a starting lineup may be possibly influenced by the athlete's eccentric performance capabilities. Thus, the development of lower-body eccentric strength and power may positively impact on-court athlete performance and ultimately help the team secure the desired game outcome.

Investigation of volatile compounds of Liberica coffee beans fermented at varying degrees of roasting

Liberica coffee (Coffea liberica Bull ex Hiern) has gained worldwide popularity, because it has a unique taste and aroma, and it is able to adapt to peatlands and is more tolerant of disease. Previous studies suggested that fermentation with hydrolytic bacteria could improve flavors, mostly determined by volatile compounds by the roasting process. However, studies about the volatile compounds and their roles in the taste and aroma of this coffee are still limited. This study aimed to investigate volatile compounds from fermented Liberica coffee beans roasted at light roast (150-160°C, 2.2 Mbar, 12 mins); medium roast (175-185°C, 2.2 Mbar, 7.30 mins); and dark roast (200-220°C, 2.2 Mbar, 10 mins). Samples were collected from various fermentation times 0, 4, 8, and 12 hrs and dried. Green beans with a moisture content of 12% were roasted in 3 roast stages. In this work, the extraction of volatile coffee compounds was performed using solid phase microextraction (SPME) and subsequently analyzed by gas chromatography-mass spectrometry (GC-MS). To determine the significance of fermentation time and degree of coffee roasting in the area, a two-way univariate analysis of variance (ANOVA) test was used, followed by a Tukey's honest significant difference (HSD) test with a statistical significance level of p&lt;0.05. The results showed that a total of 59 of the 130 volatile compounds had a significant difference at different roasting degrees to the area of compounds with a statistical significance level of p&lt;0.05. Those compounds consisted of 5 aldehydes, 18 furans, 4 ketones, 9 phenols, 13 pyrazines, 5 pyridines and 5 pyrroles.

Perceptibility and acceptability of lightness difference of a single maxillary central incisor.

The aim of this study was to assess the lightness difference perceptibility and acceptability thresholds, for a single maxillary central incisor, and to investigate possible differences in these thresholds regarding the direction (+ΔL* vs. -ΔL*), the observer group (dentists vs. laypersons), and the gender and age of the observers. A series of images with varying lightness (L*), were created by altering the right maxillary central incisor of a male Caucasian, on a frontal view full-portrait image. Digital modification of one central incisor by 1 ΔL* unit resulted in 15 different images: one control, seven with increased and seven with decreased lightness. The images were presented in random order, on a digitally calibrated monitor, to 158 observers, grouped into 79 dentists, and 79 laypersons, who were asked to evaluate every image and answer whether they perceive a difference and if yes, whether they accept this difference. A multifactorial analysis of covariance was performed to analyze the perception and acceptance of any difference in the central incisors and to estimate the thresholds. The statistical significance level was α = 0.05. Overall, the magnitude of ΔL*, direction of ΔL*, observer group and age were each significant (p < 0.001), as was gender (p = 0.03). The effect of the magnitude of ΔL* interacted with its direction and the observer group (p = 0.045), and the effect of age interacted with the direction of ΔL*, and the gender and the group of the observers. Estimated 50%:50% perceptibility thresholds ranged from 0.1 to 2.7, and 50%:50% acceptability thresholds ranged from 2.3 to 4.5. Overall, dentists perceived lightness differences at lower magnitudes than laypersons; difference in lightness was perceived and accepted at lower magnitudes when the tooth become lighter instead of darker; and female observers perceived and accepted lightness differences at lower magnitudes compared to males. As age increased overall, differences of lightness were perceived and accepted at higher magnitudes. Perceptibility and acceptability of lightness differences of a single maxillary central incisor are affected by the magnitude and the direction of lightness change, as well as the gender, the age, and the type of the observers. Even small changes in lightness are perceivable; however, thresholds of perception and acceptance are dependent on the magnitude and the direction of change and are also dependent on the observer, with women, dentists and younger people perceiving and accepting changes at lower magnitudes of ΔL*.