Anatomical variations (AV) are modifications in morphological features that do not imply functional impairment. Among the structures most affected by them are the blood vessels, of which the superior (SMA) and inferior (IMA) mesenteric arteries (IMA) stand out. This study aimed to carry out a systematic review with meta-analysis in order to identify the prevalence of different SMA and IMA VAs. The steps taken followed the PRISMA guidelines and the study protocol was registered and published on the PROSPERO platform (CRD42022336763). For the meta-analysis, the R-studio was used, adopting the random distribution model, the chi-square test, and the I-square test to investigate heterogeneity and its amplitude, respectively. After all the steps described in the protocol, 124 articles were obtained for systematic review and 23 for meta-analysis. The most prevalent vertebral level of origin of the SMA was at L1, (95% CI; 0.58: 0.41–0.73; X12= 14.90, p < 0.001; I2= 93%), and that of the IMA was at L3 (IC 95%; 0,40: 0,22–0,62; X12= 10,32, p = 0,001; I2= 90%). Normal prevalence of SMA was observed in 77% of subjects (95% CI; 0.66–0.85; X152= 322.02, p < 0.001; I2= 95%).It also calculated the different prevalence regarding the vessels of origin of the SMA and its branches, which was not always possible to be carried out with the IMA, due to the scarcity of this information in the primary studies included in this review.
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