Levels Of Executive Control Research Articles

A systematic review and meta-analysis of predictors of response to trauma-focused psychotherapy for posttraumatic stress disorder.

Although trauma-focused psychotherapy (T-F psychotherapy) is the treatment of choice for posttraumatic stress disorder (PTSD), up to one half of patients do not respond to this treatment. Attempts to improve response to T-F psychotherapy have focused on augmenting fear extinction-based factors. Here, a systematic and meta-analytic review of predictors of T-F psychotherapy outcome was conducted with the goal of using an aggregate data-driven approach to elucidate baseline factors associated with treatment outcome. There were 114 studies that met inclusion criteria (N = 61, 970; Mage = 40.1 years; 40.1% female). There were 237 effect sizes across 24 meta-analytic categories. Poorer treatment response is associated with lower pretreatment levels of activation of fear-related brain regions, psychophysiological reactivity to fear provocation, trauma-related cognitions, anger, depression, high-risk alleles of genes linked to fear, lower levels of executive control, and social support. A range of other factors also predicted poorer responses including being male, non-Caucasian, older in age, early trauma occurrence, more trauma experience, history of combat trauma, as well as comorbid sleep, pain, poor quality life, and alcohol abuse difficulties. This review provides one potential explanation for the limited success of T-F psychotherapy augmentation strategies that have focused only on fear circuity mechanisms at the exclusion of other factors. Here, poor response relating to predictors of early trauma onset and comorbidity are consistent with clinical presentations of complex PTSD, which may suggest T-F psychotherapy is less effective for this condition. This collective evidence suggests that clinicians should consider a tailored approach that targets potential barriers to successful treatment response. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Complex cognition and individual variability: a mixed methods study of the relationship between creativity and executive control.

One of the methodological challenges of educational neuroscience is understanding real world cognition in the multifaceted environment of the classroom. Complex cognition does not simplify to processes (which might be satisfactorily measured in the lab) but to sets of activities, likely to vary between individuals, which involve the iterative use of multiple processes, as well as the environment, over an extended period of time. As such, studying complex cognition requires methodological flexibility; any single method is unlikely to provide complete answers. We illustrate this idea with our research exploring the relationship between executive control (EC) and creativity in primary school age children; in it, we used both qualitative and quantitative tools and a novel approach to bringing both sets of findings together. Quantitative findings helped inform 'how much' a participant could deploy EC or creative thinking, while qualitative findings told us more about 'how' they deployed EC in their creativity. Through triangulating findings, we gained insights which would have remained obscure using either approach alone; namely, first, that wide variation in how children deploy EC in creativity means that the same creative results can be achieved with very different levels of EC involvement, and second, that high levels of EC can limit creativity. We argue that, beyond the specific findings of this study, there might be useful broader methodological lessons for educational neuroscience. We also attempt to demystify mixed methods by showing that a multi-pronged approach is more feasible than many assume; for example, by using existing, familiar tools in novel ways. In our work, we redeployed well-established quantitative tests used in creativity research as stimuli for qualitative investigation. For educational neuroscience to evolve its understanding of complex cognition, we suggest it might benefit from being innovative, open-minded and ambitious in how it exploits the diversity of methodological tools available.

Differential effects of parental control on preschool‐age adjustment depending on child effortful control

AbstractThis study examined whether parental control differentially predicted children's effortful control and adjustment depending on children's levels of executive control and delay ability. Using longitudinal data, the study included 241 preschool‐age children and their mothers. Fifty‐seven percent of the sample was lower income and included 64% White, 10% Latino/Hispanic, 9% Black, 3% Asian‐American, 2% Native or American Indian, and 12% multiple racial/ethnic backgrounds. Interactions between aspects of parental and child control at 3‐years‐old were tested as predictors of mother‐reported child effortful control at 4.5 years and teacher‐reported adjustment at 5.5 years. Children's early levels of executive control and delay ability moderated the relations of some forms of parental control with child outcomes, although several hypothesized interactions were nonsignificant. Low parental autonomy respect predicted higher externalizing for children initially high in executive control but predicted lower externalizing for children initially low in executive control. Conversely, high autonomy respect predicted higher impulsivity for children low in delay ability but higher social competence for children high in delay ability. Finally, low maternal negative control predicted higher internalizing for children low in delay ability, whereas it predicted higher internalizing for children high in delay ability. These findings suggest that in some cases the type and degree of parental control should match a child's level of effortful control to support their social, emotional, and behavioral adjustment optimally.

Early executive control buffers risk for adolescent psychopathology during the COVID-19 pandemic.

The coronavirus disease 2019 (COVID-19) pandemic has had a global impact on youth mental health, and there is a critical need for research examining individual factors that contribute to increased psychopathology during the pandemic. The current study explored whether executive control (EC) abilities in early childhood interact with COVID-related stress to attenuate risk for adolescent psychopathology during the first 6 months of the pandemic. Participants were 337 youth (49% female) living in a small midwestern city in the United States. Participants completed EC tasks when they were approximately 4.5 years old as part of a longitudinal study investigating cognitive development. At annual laboratory visits during adolescence and before the pandemic, participants (Mage = 14.57) reported on mental health symptoms. In July and August of 2020, participants (Mage = 16.57) reported on COVID-related stress and depression, anxiety, and trauma symptoms. COVID-related stress was associated with increased internalizing problems after controlling for prepandemic symptom levels. Further, the impact of COVID-related stress on adolescent internalizing problems was moderated by preschool EC, with higher levels of EC buffering the effects of COVID-related stress on adolescent internalizing problems. Findings highlight the importance of promoting EC early in development, as well as screening for EC deficits and implementing targeted intervention strategies across the lifespan to help reduce the impact of stress on adolescent internalizing problems.

The MEF2A transcription factor interactome in cardiomyocytes

Transcriptional regulators encoded by the Myocyte Enhancer Factor 2 (MEF2) gene family play a fundamental role in cardiac development, homeostasis and pathology. Previous studies indicate that MEF2A protein-protein interactions serve as a network hub in several cardiomyocyte cellular processes. Based on the idea that interactions with regulatory protein partners underly the diverse roles of MEF2A in cardiomyocyte gene expression, we undertook a systematic unbiased screen of the MEF2A protein interactome in primary cardiomyocytes using an affinity purification-based quantitative mass spectrometry approach. Bioinformatic processing of the MEF2A interactome revealed protein networks involved in the regulation of programmed cell death, inflammatory responses, actin dynamics and stress signaling in primary cardiomyocytes. Further biochemical and functional confirmation of specific protein-protein interactions documented a dynamic interaction between MEF2A and STAT3 proteins. Integration of transcriptome level data from MEF2A and STAT3-depleted cardiomyocytes reveals that the balance between MEF2A and STAT3 activity exerts a level of executive control over the inflammatory response and cardiomyocyte cell survival and experimentally ameliorates Phenylephrine induced cardiomyocyte hypertrophy. Lastly, we identified several MEF2A/STAT3 co-regulated genes, including the MMP9 gene. Herein, we document the cardiomyocyte MEF2A interactome, which furthers our understanding of protein networks involved in the hierarchical control of normal and pathophysiological cardiomyocyte gene expression in the mammalian heart.

The Evolution of Parliamentarism in Africa in the Context of Social Transformation and the Formation of a Multipolar World

The Evolution of Parliamentarism in Africa in the Context of Social Transformation and the Formation of a Multipolar World

Neural mechanisms underlying rule selection based on response evaluation: a near-infrared spectroscopy study

The ability of humans to use rules for organizing action demands a high level of executive control. Situational complexity mediates rule selection, from the adoption of a given rule to the selection of complex rules to achieve an appropriate response. Several rules have been proposed to be superordinate to human behavior in a cognitive hierarchy and mediated by different brain regions. In the present study, using a novel rule-selection task based on pre-response evaluations that require several cognitive operations, we examined whether the task is mediated by a specific region of the prefrontal cortex using near-infrared spectroscopy. We showed that the selection of rules, including prior evaluation of a stimulus, activates broader areas of the prefrontal and premotor regions than response selection based on a given rule. The results are discussed in terms of hierarchical cognitive models, the functional specialization of multiple-cognitive operations in the prefrontal cortex, and their contribution to a novel cognitive task.

Structure of working memory in children from 3 to 8 years old.

Several models of working memory (WM) have been proposed in the literature. Most of the research on the architecture of WM is based on adults or older children, but less is known about younger children. In this study, we tested various models of WM on a sample of 739 Italian children, ranging in age from 3 to 8 years, primarily of European heritage and from medium to medium-high socioeconomic background. Participants were assessed with 12 WM tasks, systematically varying the modality and level of executive control required (based on the number of activities to be performed at once: retention alone, ignoring distractors, and dealing with dual tasks). We examined younger children (n = 501, Mage = 56.8 months, SD = 6.4, 48% boys) and older children (n = 238, Mage = 80.0 months, SD = 9.0, 58% boys) separately using multigroup confirmatory factor analyses. A Bayesian analytical approach was adopted. Our results suggested that a four-factor model distinguishing between verbal, visual, spatial-simultaneous, and spatial-sequential components of WM achieved the best fit. Overall, the WM structure was very similar in the two groups. We further explored this result with an additional model with a central executive factor loaded on high-control tasks only and found evidence for the presence of an executive control component. The contribution of this factor in terms of explained variance was only modest, however. Our findings demonstrate that it is important to distinguish between WM components in young children. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Возрастные и индивидуальные особенности тренировки зрительной кратковременной пространственной памяти

Cognitive training is known to increase the plasticity of the brain’s neural networks and reduce the expectation of cognitive dysfunction during aging. However, opinions differ regarding the age, individual and time range of the training efficiency. Thus, the aim of the work was to clearing the temporal dynamics of changes in the short-term visual spatial memory of older people in comparison with young people and the dependence on its baseline level. The study involved 65 people of retirement age (M = 65.8; SD = 7.5 years) (GR1) and 92 university students (M = 20.1; SD = 1.4 years) (GR2). To determine the spatial memory, we used a modified “Visual Patterns Test” technique posted on the website psytest.nstu.ru. After a lecture on the methods of formation and implementation of cognitive resources, the study participants were asked to carry out memory training in a free mode at home in order to achieve a consistently maximum result. It is shown that by significantly lower values of short-term visual spatial memory in GR1 than in GR2 in the first testing session, to increase its efficiency, GR1 requires more than 80 sessions of training during some months, while GR2 requires 20 sessions during one-two weeks. The achievement of maximum memory indices occurs faster at its initially high values; however, the effect of training in the first sessions is more pronounced in persons with low memory values, regardless of age. It can be concluded that the effectiveness of spatial memory training at the initial stages is determined by the learning potential, and the realization of the compensatory resources of the brain, whereas the achievement of a result comparable to the young in the elderly is determined by the high level of executive control of behavior, which ensures long-term memory training.

Executive control under stress: Relation to reappraisal ability and depressive symptoms

Depression is characterized by difficulties regulating emotions, which may result from executive control impairment. For some individuals, stress exposure leads to executive control impairment. The current study examined whether executive control measured under conditions of acute stress is associated with reappraisal ability and prospectively predicts symptoms of depression during a stressful time of life. Sixty-six participants completed either a laboratory stress induction or a control task. Executive control was measured before and after the stress induction or control task. Reappraisal ability was measured by self-reported negative emotion while viewing aversive images. Participants reported depressive symptoms at baseline and during a period of life stress. Lower levels of executive control under stress were associated with reduced reappraisal ability. Lower levels of executive control under stress also prospectively predicted higher depressive symptoms. Finally, reduced reappraisal ability prospectively predicted higher depressive symptoms. Findings suggest that level of executive control when under stress may contribute to reappraisal ability and symptoms of depression during a time of life stress.

Integration of balanced time perspective and time perception: The role of executive control and neuroticism

Various aspects of psychological time, such as time perspective and time perception, have been studied separately. In the present research, we aimed to integrate these two approaches by examining the link between time perspective and time perception, conceptualized as the subjective passage of time and duration estimation. We also examined the role of executive control in reducing the biases related to psychological time and controlled for neuroticism, a key personality correlate of subjective passage of time. We found that individuals with a less balanced time perspective were less accurate in duration estimation in the range of seconds and that they reported a faster subjective passage of past time intervals. Moreover, a less balanced time perspective was associated with higher levels of neuroticism. Finally, we identified an interaction between a balanced time perspective and executive control in time perception. A less accurate time estimation was more pronounced at lower levels of executive control and of balanced time perspective. The results provide new insight into psychological time.

Delirium is associated with frequency band specific dysconnectivity in intrinsic connectivity networks: preliminary evidence from a large retrospective pilot case-control study

BackgroundPathophysiological concepts in delirium are not sufficient to define objective biomarkers suited to improve clinical approaches. Advances in neuroimaging have revalued electroencephalography (EEG) as a tool to assess oscillatory network activity in neuropsychiatric disease. Yet, research in the field is limited to small populations and largely confined to postoperative delirium, which impedes generalizability of findings and planning of prospective studies in other populations. This study aimed to assess effect sizes of connectivity measures in a large mixed population to demonstrate that there are measurable EEG differences between delirium and control patients.MethodsThis retrospective pilot study investigated EEG measures as biomarkers in delirium using a case-control design including patients diagnosed with delirium (DSM-5 criteria) and age-/gender-matched controls drawn from a database of 9980 patients (n = 129 and 414, respectively). Assessors were not blinded for groups. Power spectra and connectivity estimates, using the weighted phase log index, of continuous EEG data were compared between conditions. Alterations of information flow through nodes of intrinsic connectivity networks (ICN; default mode, salience, and executive control network) were evaluated in source space using betweenness centrality. This was done frequency specific and network nodes were defined by the multimodal human cerebral cortex parcellation based on human connectome project data.ResultsDelirium and control patients exhibited distinct EEG power, connectivity, and network characteristics (F(72,540) = 70.3, p < .001; F(493,1079) = 2.69, p < .001; and F(718,2159) = 1.14, p = .007, respectively). Connectivity analyses revealed global alpha and regional beta band disconnectivity that was accompanied by theta band hyperconnectivity in delirious patients. Source and network analyses yielded that these changes are not specific to single intrinsic connectivity networks but affect multiple nodes of networks engaged in level of consciousness, attention, working memory, executive control, and salience detection. Effect sizes were medium to strong in this mixed population of delirious patients.ConclusionsWe quantified effect sizes for EEG connectivity and network analyses to be expected in delirium. This study implicates that theta band hyperconnectivity and alpha band disconnectivity may be essential mechanisms in the pathophysiology of delirium. Upcoming prospective studies will build upon these results and evaluate the clinical utility of identified EEG measures as therapeutic and prognostic biomarkers.

Mirror Movements are Linked to Executive Control in Healthy and Brain-injured Adults

It has been shown that brain-injured patients (BIP) have exacerbated mirror movements (MM). MM are involuntary contractions occurring in homologous muscles contralateral to voluntary movements, particularly in distal upper limb muscles. Attentional and inhibitory processes have been proposed as key factors to explain the level of MM. However, the link between MM and attentional/inhibitory processes has never been formally tested. The present study aims to test this link in 24 right-handed healthy adults and eight chronic BIP. We investigated the link between the amount/intensity of MM and attentional/inhibitory functions. For each participant, MM produced on each limb were assessed with two tasks, and the attentional and inhibitory functions were assessed with six neuropsychological tests. Our results showed (1) a greater amount and intensity of MM and (2) a selective deficit in sustained attention in BIP compared to healthy adults. Moreover, (3) in all participants – independent of the type of task used to evaluate MM – the amount and intensity of MM was predicted by the level of executive control, assessed by the Trail Making Test. High level of MM was associated with weak executive control abilities. This study is the first to highlight the link between MM and executive functioning, which may have implications for rehabilitation in BIP.

How executive control predicts early reading development

Abstract Attentional and action control are two levels of executive control that are essential to early reading development. Together these levels enable the construction and monitoring of cognitive representations and of efficient task-behavior, which are both necessary to benefit from reading instruction. The longitudinal and unique contributions of this internal and external level of executive control to early reading are still unclear. We therefore examined how these control capacities facilitate reading development from kindergarten to second-grade. Attentional and action control and multiple early reading skills were assessed at all three time points. Structural Equation Modeling showed a mediation effect for attentional control and an indirect effect for action control to subsequent reading skills via the contributions to the precursor of phonological awareness. From these results it can be concluded that both types uniquely allowed for the emergence of kindergarten preliteracy skills, which in turn provided children with a better starting point for reading development in first- and second-grade.

The relationship between working memory and insight depends on moderators: Reply to Chuderski and Jastrzêbski (2017).

Chuderski and Jastrzêbski (2017) found a positive relationship between working memory capacity and insight problem solving, and concluded that "people with less effective cognition" are therefore "less creative" (p. 2003). This interpretation discounts substantial evidence that devoting less executive control facilitates insight. We develop an initial framework for understanding these contradictory findings. We describe (a) how both working memory-demanding processes and less-demanding associative processes impact insight and (b) how individual, situational, and task-specific factors interact to influence whether greater working memory is a help or a hindrance. We propose that insight will be supported if the level of executive control used matches the level of control optimal for different phases of insight problem solving. We use this framework to explain why Chuderski and Jastrzębski's (2017) findings may have differed from DeCaro, Van Stockum, and Wieth (2016), and offer direction for a more unified account of insight problem solving. (PsycINFO Database Record

The personality-related implications of Stroop performance: Stress-contingent self-control in daily life

People with higher levels of executive control, relative to low levels, should be more capable of responding to the problems and stressors of their lives, yet we know very little concerning this lab-to-life interface. Two studies (total N=254) sought to speak to questions of this type using the Stroop task, a classic measure of executive control. Individual differences in Stroop costs were assessed in the laboratory, following which the same people completed daily diary protocols for two weeks. Consistent with neurocognitive theories of executive control, both studies found that people capable of overriding the Stroop effect tended to recruit self-control in response to the stressful circumstances of their lives. By contrast, people with high Stroop costs did not exhibit this problem-focused form of recruitment. The findings extend our knowledge of individual differences in executive control and the manner in which they operate in daily life.

Cognitive advantages of immersion education after 1 year: Effects of amount of exposure

Previous studies with bilingual children have shown that the nature of their second-language instruction has an effect on the development of their cognitive abilities. The aim of this study was to determine whether children who acquire a second language in two different immersion programs for a period of 1year show advantages in executive functions and to examine how the amount of daily exposure affects executive functions. A group of Serbian-speaking second-grade children exposed to the second language for about 5h each day (high exposure group, HEG) and a low-exposure group (LEG) exposed to the second language for about 1.5h each day were compared with an age-matched control group (CG) of monolingual peers on working memory, inhibition, and shifting. Significant group differences were found for working memory, with the HEG performing better than the CG and LEG even after controlling for individual differences in terms of age and intelligence. The three groups did not differ in terms of inhibition and overall shifting abilities, although the control group had a marginally significant advantage on one of the two shifting tasks. Our findings extend previous research by demonstrating that the amount of daily exposure is a significant factor affecting executive functions in early immersion programs for second-language acquisition. In addition, they show that early intensive second-language acquisition can be advantageous for performance on tasks that require a higher level of executive control.

Cognitive Control Therapy as a Depression Treatment: a Review of the Literature

Recent investigations have explored the link between depression and executive function (the ability to process and organise information in order to achieve a goal). The specific aspect of executive function that is linked to depression is executive control, which includes the ability to regulate cognitive processes such as emotion. Research has found that subjects with greater levels of executive control are more likely to be able to control their reactions to stressful events and are less likely to develop depressive symptoms. As a result of these findings, cognitive control training has been suggested as a possible new treatment for depression. Further research in this field would be highly beneficial for the development of new and effective treatments for depression.

Bilingual effects on deployment of the attention system in linguistically and culturally homogeneous children and adults

We investigated the impact of early childhood and adulthood bilingualism on the attention system in a group of linguistically and culturally homogeneous children (5- and 6-year olds) and young adults. We administered the child Attention Network Test (ANT) to 63 English monolingual and Korean–English bilingual children and administered the adult ANT to 39 language- and culture-matched college students. Advantageous bilingual effects on attention were observed for both children and adults in global processing levels of inverse efficiency, response time, and accuracy at a magnitude more pronounced for children than for adults. Differential bilingualism effects were evident at the local network level of executive control and orienting in favor of the adult bilinguals only. Notably, however, bilingual children achieved an adult level of accuracy in the incongruent flanker condition, implying enhanced attentional skills to cope with interferences. Our findings suggest that although both child and adult bilinguals share cognitive advantages in attentional functioning, age-related cognitive and linguistic maturation differentially shapes the outcomes of attentional processing at a local network level.

Executive and attentional contributions to Theory of Mind deficit in attention deficit/hyperactivity disorder (ADHD)

Attention deficit/hyperactivity disorder (ADHD) in children has been associated with attentional and executive problems, but also with socioemotional difficulties possibly associated with deficits in Theory of Mind (ToM). Socioemotional problems in ADHD are associated with more negative prognoses, notably interpersonal, educational problems, and an increased risk of developing other psychiatric disorders that emphasize the need to clarify the nature of their ToM deficits. In this study, we hypothesized that ToM dysfunction in children with ADHD is largely attributable to their attentional and/or executive deficits. Thirty-one children with ADHD (8–12 years, IQ > 85) and 31 typically developing (TD) children were assessed using executive functions (inhibition, planning, and flexibility) and attentional tasks, as well as two advanced ToM tasks (Reading the Mind in the Eyes and Faux Pas) involving different levels of executive control. Children with ADHD performed more poorly than TD children in attentional, executive function, and ToM tasks. Linear regression analyses conducted in the ADHD group indicated that inhibition scores predicted performance on the “Faux Pas” task the best, while attention scores were the best for predicting performance on the Reading the Mind in the Eyes task. When controlled for inhibition and attentional variables, ToM performance in children with ADHD was actually similar to TD children. Contrarily, controlling for ToM scores did not normalize performance for inhibition and attentional tasks in children with ADHD. This unidirectional relationship suggests that deficits in the EF and attentional domains are responsible for ToM deficits in ADHD, which therefore may contribute to their socioemotional difficulties.