Objectives There is a lack of an accepted standard of care for dental treatment before hematopoietic stem cell transplantation (HSCT). Therefore, in this international, prospective multicenter study (OraStem), we evaluated the differences in dental diseases, oral hygiene practices, and dental treatments before HSCT. Study Design Enrollment sites included Vancouver, BC (Canada); Gothenburg and Huddinge (Sweden); Nijmegen and Amsterdam (The Netherlands); and Charlotte, NC (USA). The frequency of dental diseases, oral hygiene practices, and dental treatments before HSCT are reported here. Results Data on the number, mean age, and gender (%) of the cohort included the following: Overall: n = 269, age 53.6 years, males 56%; Vancouver: n = 58, age 52.3 years, males 57%; Sweden: n = 29, age 57.2 years, males 56%; Nijmegen: n = 81, age 55.1 years, males 54%; Amsterdam: n = 43, age 55.2 years, males 59%; and Charlotte: n = 58, age 49.6 years, males 57%. Overall, the most frequent medical diagnoses necessitating HSCT were as follows: myeloma = 74 (27%), acute myelogenous leukemia = 67 (24%); lymphoma = 37 (13%), myelodysplastic syndrome = 19 (7%); and acute lymphoblastic leukemia = 17 (6%). Overall, most transplants were allogeneic (61%) versus autologous (36%). The numbers of patients reporting brushing 2 or more times per day were as follows: overall = 200 (73%); Vancouver = 40 (67%); Sweden = 27 (87%); Nijmegen = 63 (78%); Amsterdam = 34 (77%); and Charlotte = 36 (59%). The numbers of patients reporting seeing a dentist or dental therapist routinely were as follows: overall = 202 (73%); Vancouver = 41 (71%); Sweden = 24 (77%); Nijmegen = 70 (86%); Amsterdam = 37 (84%); and Charlotte = 30(49%). Conditions of teeth were recorded before and after dental treatment provided before HSCT. Upon enrollment, mean numbers of teeth with a natural root (with or without crown) were as follows: overall = 24.2; Vancouver = 23.2; Sweden = 26.3; Amsterdam = 23.5; Nijmegen = 23.8; and Charlotte = 25.5. The numbers of people who underwent tooth extraction and the numbers of dental extractions (% of existing teeth) before transplantation were as follows: overall: n = 44, 126 teeth (0.5%); Vancouver: n = 4, 5 teeth (0.1%); Sweden: n = 5, 28 teeth (0.32%); Nijmegen: n = 10, 41 teeth (0.5%); Amsterdam: n = 8, 14 teeth (0.3%); and Charlotte: n = 17, 59 teeth (1%). The numbers of teeth with periodontal pocketing greater than 5 mm left untreated were as follows: overall = 102 (0.4%); Vancouver = 23 (0.5%); Sweden = 25 (0.3%); Nijmegen = 25 (0.3%); Amsterdam = 12 (0.3%); and Charlotte = 35 (0.8%). The numbers of teeth with 1 or more carious lesions to dentin left untreated were as follows: overall = 246 (1.0%); Vancouver = 11 (0.2%); Sweden = 27 (0.3%); Nijmegen = 118 (1.5%); Amsterdam = 11 (0.3%); and Charlotte = 99 (1.7%). Conclusions This baseline report reveals variations in dental diseases, oral hygiene practices, and dental treatments rendered before HSCT among different study centers. Establishment of an international standard of care for dental treatment before HSCT is needed. Prospective OraStem study data will increase the understanding of risk factors related to oral complications during HSCT.
Read full abstract