Levels Of Asbestos Research Articles

Abstract 838: Population attributable fraction of occupational carcinogens for cancer incidence among Korean adults in 2020

Abstract Assessing the level and scope of exposure to occupational carcinogens on a country-specific basis presents challenges, and as a result, it has been appraised as uncertain when compared with other factors in the estimation of the burden of cancer. The Korean CARcinogen Exposure (K-CAREX) developed in 2021 is utilized to estimate the population at risk in industrial work environments in Korea (Koh et al., 2021). Our goal is to estimate preventable cancer incidence attributable to occupational carcinogens in Korea, utilizing the K-CAREX program and employing appropriate methodology. Among the exposures classified as Group 1 factors by IARC, considering the possibility of occupational exposure. Population attributable fractions (PAFs) were computed using Levin's Formula (1953), considering a latency period of 15 years between exposure and cancer in our assessment. The prevalence of exposure was calculated using K-CAREX program and census data. The relative risk (RR) for incidence was derived from a meta-analysis of literature. It was possible to calculate PAFs for 11 occupational factors linked with 8 cancer types. This estimation was chosen based on a combination of exposure and sufficient evidence of human carcinogenicity. As a result, Population attributable fractions (PAFs) for cancer incidence associated with occupational carcinogens was estimated at 1% in 2020. Lung cancer (approximately 90%) was found to be the most prevalent type of cancer attributable to occupational factors, as widely acknowledged. The prevalence of exposure to occupational carcinogens was 22%, with Diesel engine exhaust being the most significant source for both genders. Since the early 2000s, the exposure levels of asbestos, subject to usage prohibition and restriction measures, were estimated to be at a lower level compared to other countries. It is evident that these estimates reflect the characteristics of the Korean industry. This is anticipated to provide a foundation for the development of methodologies and indicators essential for measuring the burden of occupational cancer in the country. Citation Format: Eun Mi Kim, Dong-Hee Koh, Sue K Park, Yoon-Jung Choi, Hong Gwan Seo, Inah Kim, Jeong-Soo Im. Population attributable fraction of occupational carcinogens for cancer incidence among Korean adults in 2020 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 838.

Assessment of worst-case potential airborne asbestos exposure associated with the use of cosmetic talc: application of an exponential decay model.

Talc is used in cosmetic products to confer desirable properties, such as moisture absorption and smooth texture, to the finished products. Concerns have been raised about the potential presence of asbestos in products containing cosmetic talc. Reconstruction of potential asbestos exposure from the use of cosmetic talc products (assuming a trace level of asbestos) requires consideration of consumer use patterns. Although application generally only lasts seconds, exposure theoretically may continue if the consumer remains in the immediate vicinity. Most published exposure measurements have not adequately characterized the potential for continued exposure. In this analysis, estimates and measurements of airborne asbestos fiber concentrations associated with cosmetic talc use from 10 published studies were used as inputs to an exponential decay model to estimate "worst-case" exposure during and following application. The resulting geometric mean 30-min time-weighted average (TWA) concentrations were 0.006 f/cc for both puff and shaker application, for diapering, 0.0001f/cc (adult applying baby powder) and 0.0002 f/cc (infant), and for makeup application, 0.0005 f/cc. Application of an exponential decay model to measured or estimated asbestos concentrations associated with the use of cosmetic talc products yields a conservative means to comprehensively reconstruct such exposures. Moreover, our results support that, if a cosmetic talc powder product contained a trace level of asbestos fibers, the "worst-case" airborne asbestos exposure associated with its application is low.

Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study.

The causal attribution of asbestos-related diseases to past asbestos exposures is of crucial importance in clinical and legal contexts. Often this evaluation is made based on the history of exposure, but this method presents important limitations. To assess past asbestos exposure, pleural plaques (PP), lung fibrosis and histological evidence of ferruginous bodies (FB) can be used in combination with anamnestic data. However, such markers have never been associated with a threshold value of inhaled asbestos. With this study we attempted to shed light on the dose-response relationship of PP, lung fibrosis and FBs, investigating if their prevalence in exposed individuals who died from malignant mesothelioma (MM) is related to the concentration of asbestos in lungs assessed using scanning electron microscopy equipped with energy dispersive spectroscopy. Moreover, we estimated the values of asbestos concentration in lungs associated with PP, lung fibrosis and FB. Lung fibrosis showed a significant positive relationship with asbestos lung content, whereas PP and FB did not. We identified, for the first time, critical lung concentrations of asbestos related to the presence of PP, lung fibrosis and FB at histology (respectively, 19 800, 26 400 and 27 400 fibers per gram of dry weight), that were all well-below the background levels of asbestos identified in our laboratory. Such data suggest that PP, lung fibrosis and FB at histology should be used with caution in the causal attribution of MM to past asbestos exposures, while evaluation of amphibole lung content using analytical electron microscopy should be preferred.

Microscopy in the Study of Asbestos-Containing Joint Compound and Patching Products, Including Spackling

Drywall (wallboard, plasterboard, gypsum board) became the common construction material for interior walls in buildings in the later 1940s. Joint compound (mud, spackling, taping compound, joint treatment material) and patching products such as spackle or spackling were used to seal the seams between the boards and cover cracks and nail indentations. Most joint compounds from the 1940s into the later 1970s contained chrysotile asbestos in various formulations. Analyses by microscopy determined the chrysotile asbestos content of samples of Bondex, Georgia-Pacific, and Reardon products to be 1–5%, 3–8%, and 1–2% asbestos, respectively. Information compiled from several sources, including corporate responses to the U.S. EPA Asbestos Information Act of 1988 and other documents, suggest that asbestos-containing joint compounds and patching products from the 1930s into the late 1970s contained chrysotile in the range of 0.5% to 23%, with one company having a few formulations with asbestos levels as high as 45.2%. Although there were no documents showing that amphibole asbestos was intentionally added to joint compounds, there is some evidence of amphibole asbestos fibers in certain joint compound products, probably as accessory minerals with added chrysotile, talc, or limestone. No amphibole asbestos fibers were found in a Georgia-Pacific joint compound product tested using the acid/base digestion preparation procedure. During simulation testing, the asbestos level in the breathing zone of a worker during the mixing of Bondex Joint Compound ranged from 6.9 to 12 asbestos fibers per cubic centimeter of air (F/cc) (phase contrast microscopy modified by transmission light microscopy). The level was below detection during application. During sanding, the asbestos level in the breathing zone of the worker ranged from 1.9 to 5.5 asbestos F/cc. The simulations showed results that were within the ranges reported in the scientific literature for airborne asbestos levels caused by dry mixing and sanding of asbestos-containing joint compound. The sale of joint compound and spackling sold for consumer use with intentionally added asbestos was banned by the Consumer Product Safety Commission in 1977.

Environmental Assessment of Friable Asbestos from Soil to Air Using the Releasable Asbestos Sampler (RAS).

The objectives of this study are to examine the feasibility of the releasable asbestos sampler (RAS) equipment for laboratory tests as an alternative to activity-based sampling (ABS), and to apply the equipment controlled by wind velocity and water contents in the field to asbestos-contaminated soils. Two asbestos-contaminated mines (the Jecheon mine and the Jongmin-ri mine) were selected. At each mine, 21 surface soils (0~15 cm) were sampled, the asbestos concentrations were analyzed, and then three representative sites, containing 0.25%, 0.50%, and 0.75% of asbestos in soils, were chosen to evaluate the amount of releasable asbestos by the modified RAS with wind velocity and water contents. The results showed that the levels of releasable asbestos from soil to air increased with higher wind velocities and lower water content. In addition, the application of risk assessment of releasable asbestos in the soils as an alternative to the activity-based sampling (ABS) method was established at each site, and an estimation of the excess lifetime cancer risk (ELCR) was also calculated. According to the calculation, the estimated ELCR values did not exceed the threshold value (1 × 10-4) in the Jecheon mine for all the soils, while some samples from the Jongmin-ri mine exceeded the threshold value. Therefore, proper remediation work is needed to control friable asbestos from soils to air in the vicinity of the mines.

Investigation of asbestos concentration in ambient and lavage fluids of patients referred for bronchoscopy, Ahvaz.

The amount of fibers in the lungs is considered to reflect the cumulative intensity of past asbestos exposure, and bronchoalveolar lavage (BAL) has been proposed to be a good indicator of the presence and quantity of asbestos particles in the lungs. This study evaluated the asbestos concentration in BAL fluids of asbestos-exposed and unexposed pulmonary patients and the environment of Ahvaz city. This prospective study was conducted on 80 patients underwent diagnostic fiberoptic bronchoscopy referred to Imam Khomeini Hospital in Ahvaz, Iran, in 2019. Patients with Lung diseases were divided into three groups based on CT scan results: normal (n = 32), lung cancer (n = 40) and Interstitial lung disease (n = 8). The analysis of asbestos fiber concentration in BAL fluid was carried out by Scanning Electron Microscope (SEM). The positive asbestos test was detected in 69% of all subjects, including 64% of whom had asbestos-related jobs and 74.5% of those with non-related jobs (p = 0.240). The concentrations of asbestos fiber in the BAL in normal patients, lung cancer and interstitial fibrosis (ILD) were 8.13 ± 5.38, 9.66 ± 7.30 and 6.31 ± 1.98 f/ml, respectively (P = 0.492). There was no significant difference between the asbestos levels and exposure history (P = 0.877). The mean concentration of asbestos in the ambient air during the current year was 2.69 ± 0.57 f/ml (2.26-3.70), and the correlation between asbestos levels in BAL and the air was not significant (r = 0.147; P = 0.243). The exposure of different occupational and non-occupational groups to this carcinogenic substance indicates the need for environmental and individual control measures to reduce and prevent asbestos exposure.

ELASTOMERIC COMPOSITIONS WITH A HIGH CONTENT OF CHRYSOTILE ASBESTOS

The studies have shown the possibility of increasing the safety level of chrysotile asbestos (AX) in the technological process of its use in elastomeric compositions. This is achieved by dispersing ACh in a lactam-containing melt. As a result, dispersed ACh almost completely eliminates dusting, which is the main essence of increasing its safety level and allows solving the problem of its maximum content in elastomeric compositions, which in turn provides the necessary level of swelling of the elastomeric composition as a whole upon its contact with working fluids. drilling wells.

Burden of Mortality from Asbestos-Related Diseases in Italy.

Asbestos is one of the major worldwide occupational carcinogens. The global burden of asbestos-related diseases (ARDs) was estimated around 231,000 cases/year. Italy was one of the main European asbestos producers until the 1992 ban. The WHO recommended national programs, including epidemiological surveillance, to eliminate ARDs. The present paper shows the estimate of the burden of mortality from ARDs in Italy, established for the first time. National standardized rates of mortality from mesothelioma and asbestosis and their temporal trends, based on the National Institute of Statistics database, were computed. Deaths from lung cancer attributable to asbestos exposure were estimated using population-based case-control studies. Asbestos-related lung and ovarian cancer deaths attributable to occupational exposure were estimated, considering the Italian occupational cohort studies. In the 2010–2016 period, 4400 deaths/year attributable to asbestos were estimated: 1515 from mesothelioma, 58 from asbestosis, 2830 from lung and 16 from ovarian cancers. The estimates based on occupational cohorts showed that each year 271 deaths from mesothelioma, 302 from lung cancer and 16 from ovarian cancer were attributable to occupational asbestos exposure in industrial sectors with high asbestos levels. The important health impact of asbestos in Italy, 10–25 years after the ban, was highlighted. These results suggest the need for appropriate interventions in terms of prevention, health care and social security at the local level and could contribute to the global estimate of ARDs.

Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up

ObjectiveTo update the analysis of mortality of a cohort of talc miners and millers in Northern Italy. MethodsWe analyzed overall mortality and mortality from specific causes of death during 1946–2020 of 1749 male workers in a talc mine where asbestos was not detected (1184 miners and 565 millers) employed during 1946–1995. ResultsThe overall standardized mortality ratio (SMR) was 1.21 (95 % confidence interval [CI] 1.14–1.28); no deaths were observed from pleural cancer. Mortality from lung cancer was not increased (SMR = 1.02 95 % CI 0.82–1.27), while mortality from pneumoconiosis was (SMR 9.55; 95 % CI 7.43–12.08), especially among miners (SMR 12.74; 95 % CI 9.79–16.31). There was a trend in risk of pneumoconiosis with increasing duration of employment in the overall cohort, and the SMR for 25+ years of employment was 15.12 (95 % CI 10.89–20.43). ConclusionsThis uniquely long-term follow up confirms the results of previous analyses, namely the lack of association between exposure to talc with no detectable level of asbestos and lung cancer and mesothelioma. Increased mortality from pneumoconiosis among miners is related to past exposure to silica.

Predicting Long-Term Asbestos Prevalence in Human Lungs, Lymph Nodes, and Remote Organs from Short-Term Murine Experiments.

Inhalation of asbestos fibers leads to a suite of fatal diseases that can manifest years, if not decades, after cessation of exposure. The first phase of disease progression occurs as fibers are transported from point of entry in the lungs throughout the entire body. A mathematical model is developed for the disposition of non-chrysotile asbestos in the body and, except for exposure levels, is parameterized by published data on short-term rat experiments. Asbestos exposure in individual humans is determined by matching published long-term lung data for nine patients. The resulting model predicts transport of fibers within the lymphatic system and prevalence of fibers in lymph nodes for these patients with reasonable accuracy. Model predictions for remote organs are compared against published observations. The model consists of a system of globally stable differential equations, and a sensitivity analysis was conducted. The model indicates that fiber density in lymph nodes is correlated with total exposure, level times duration, no matter whether there is a long-term, low-level exposure or short-term, high-level exposure. The model predicts that levels of sequestered asbestos reach steady state within five years of cessation of exposure, a timeline previously not known. The model suggests that the time to steady state is short compared to onset of disease, and that delayed onset of related disease may be a function of chemical and biological processes not in this model.

Management of Naturally Occurring Asbestos Area in Republic of Korea

ABSTRACT The Republic of Korea Government has adopted a whole-of-government approach in the management of naturally occurring asbestos (NOA) through a nationwide asbestos management plan. Regional and detailed mapping, and examination of NOA effects are still ongoing for NOA management by indoor air, noise and asbestos management division, Ministry of Environment. Plans by the Korea Rail Network Authority are under way to rebuild the Janghang double-track railway. The proposed Jannghang double-track railway route is through an area of high NOA probability that has serpentine and ultramafic rock. Chrysotile, tremolite, and actinolite asbestos were among the rocks identified within the project site (initial planning line and the operational design line). The level of asbestos in most soils was low (≤0.25 percent), while some soils contained 0.75 percent asbestos. Monitoring and analyses of air quality revealed below 0.01 fibers per cm3 (f/cc). However, there were no traces of asbestos detected in the groundwater and stream water. Despite the low asbestos content of the soil and rock, the disturbance of NOA-containing soils and rocks during railway construction could trigger the release of asbestos fibers into the air. NOA mitigation plans and measures are necessary for workers and residents during the construction of the railway.

The association of asbestosis and autoantibody titer among former asbestos textile workers

TPS 791: Occupational health 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background: Asbestos is a well-known hazardous substance which causes environmental diseases including asbestosis (lung fibrosis). Although silica exposure which causes silicosis (another type of lung fibrosis) were well known to be related with autoimmune disease, the association between asbestos exposure and autoimmune diseases are not much studied. Methods A total of 54 individuals who had worked in former asbestos textile factory performed autoantibody-related blood tests, chest X-ray and pulmonary function tests. Based on the Job Exposure Matrix, the estimated asbestos exposure concentrations were determined and the presence of asbestosis was determined by chest radiography. Results The severity of asbestosis tended to increase as the estimated exposure level of asbestos increased (p = 0.002). Subjects were classified into two groups according to the presence or absence of asbestosis: the titer of Scl-70 Ab (0.02 ± 0.03 vs. 0.11 ± 0.13, p = 0.001), SSB-Ab (0.03 ± 0.07 vs. 0.10 ± 0.13, p = 0.013), and Sm-RNP Ab (0.10 ± 0.07 vs. 0.21 ± 0.31, p = 0.027) was significantly lower in asbestosis group. When stratified with the type of treated asbestos, Scl-70 Ab (p = 0.014) had inverse association with the presence of asbestosis in chrysotile exposed group. In case of crocidolite exposed group, Scl-70 Ab (p = 0.012) and Smith-Ab (p = 0.042), SSB ab (p = 0.006) and SmRNP Ab (p = 0.038) had inverse association with the asbestosis, respectively. Conclusion On the contrary of our expectation, the asbestosis and some autoantibidies were inversely related. But as majority of the titers were in normal range, the clinical meanings are uncertain. However, cautions are needed to the interpretation of the results due to the small number of subjects. Further well-designed research such as case-control study or cohort study is required.

Does Simian Virus 40 (SV40) Have a Role in UK Malignant Pleural Mesothelioma? No Role is Identified in a Sensitive RNA In Situ Hybridization Study on Potentially Affected Birth Cohorts.

Simian virus 40 (SV40)-contaminated polio vaccine was accidentally administered to about one-third of the UK population receiving polio vaccines between 1956 and 1962. SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. Since then, the SV40 oncogenic protein large T antigen (SV40 Tag) has been shown to cause malignant transformation of asbestos-treated human pleural mesothelial cells and malignant pleural mesotheliomas in asbestos-exposed SV40 Tag transgenic mice. The present study was designed to investigate the possible association of SV40 Tag with human malignant pleural mesothelioma samples from birth cohorts of the UK population exposed to combined peak levels of asbestos and SV40-contaminated polio vaccines. Tumor and background lung tissue microarrays prepared from archival surgical specimens of 139 pleural mesothelioma cases, collected over a period of 8 years (1998 to 2005), were analyzed. These represented birth cohorts overlapping with the period 1950 to 1960, exposed to a high level of both asbestos and SV40-contaminated live polio vaccines. SV40 Tag mRNA expression was investigated using a highly sensitive and specific SV40 Tag RNA in situ hybridization detection method on the basis of the novel RNAscope technology. SV40 Tag RNA was not detected in any of the 127 evaluable tumor cases, despite appropriate results obtained for the external positive and negative controls included. The complete absence of SV40 Tag mRNA in this large series of cases contradicts experimental evidence suggestive of SV40 link with asbestos-exposed malignant pleural mesotheliomas in the UK population. Alternative explanations of the negative findings are discussed to exclude possible confounding factors.

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma.

BackgroundMalignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic variability of proteins involved in DNA repair mechanisms affects the risk of MM. This study investigated the influence of functional polymorphisms in ERCC1 and XRCC1 genes, the interactions between these polymorphisms as well as the interactions between these polymorphisms and asbestos exposure on MM risk.Patients and methodsIn total, 237 cases with MM and 193 controls with no asbestos-related disease were genotyped for ERCC1 and XRCC1 polymorphisms.ResultsERCC1 rs3212986 polymorphism was significantly associated with a decreased risk of MM (odds ratio [OR] = 0.61; 95% confidence interval [CI] = 0.41–0.91; p = 0.014). No associations were observed between other genetic polymorphisms and MM risk. Interactions between polymorphisms did not significantly influence MM risk. Interaction between ERCC1 rs11615 and asbestos exposure significantly influenced MM risk (OR = 3.61; 95% CI = 1.12–11.66; p = 0.032). Carriers of polymorphic ERCC1 rs11615 allele who were exposed to low level of asbestos had a decreased risk of MM (OR = 0.40; 95% CI = 0.19–0.84; p = 0.016). Interactions between other polymorphisms and asbestos exposure did not significantly influence MM risk.ConclusionsOur findings suggest that the genetic variability of DNA repair mechanisms could contribute to the risk of developing MM.

Is there an acceptable level of asbestos use?

Is there an acceptable level of asbestos use?

Evaluation of Asbestos Exposure Associated with Research Laboratories

Asbestos containing materials (ACM) have been used for decades in research laboratory products including gloves, tong sleeves, Transite board, and other materials. These materials typically contain chrysotile asbestos with concentrations ranging up to 80%. The objective of this research was to evaluate asbestos exposure from gloves, tong sleeves, and Transite board with simulated laboratory use. An environmental chamber was used to simulate laboratory application of the products. Bulk samples of various products were tested before and after use. Personal breathing zone air samples as well as one cumulative air sample were collected during testing and followed the National Institute for Occupational Safety and Health (NIOSH) 7400/7402 methodologies. Phase contrast microscopy (PCM) and transmission electron microscopy (TEM) were used for sample analyses. Analysis of air samples using PCM, showed airborne fiber concentrations as high as 0.058 f/cc during use of tongs fitted with asbestos sleeves. Further analysis using TEM showed that the highest airborne fiber concentration was 0.0036 f/cc. Manipulation of Transite board resulted in 8-hour time-weighted-average (TWA) asbestos levels as high as 0.02 f/cc. Testing of various asbestos containing materials used in research laboratories indicate low potential for asbestos fiber exposures.

Does exposure to asbestos cause prostate cancer? A systematic literature review and meta-analysis: Retraction

The relationship between asbestos and prostate cancer (PCa) is not well understood due to small number of cases. This study aimed to determine the incidence and mortality of PCa among workers or residents exposed to asbestos based on a systematic review and meta-analysis METHODS: All published studies citing the standardized mortality ratio (SMR) or standardized incidence ratio (SIR) of PCa in workers or residents exposed to asbestos were collected by conducting a search on PubMed, EMBASE, Cochrane Library, and Web of Science before April 2018. Standardized mortality rate for PCa with its 95% confidence interval (CI) was pooled using a fixed-/random-effect model in STATA (Version14.0). This study is registered with PROSPERO, number CRD42018095195. A total of 17 independent studies were included for the analysis. The overall pooled SMR of PCa was 1.22, with a 95% CI of 1.13 to 1.32, with no heterogeneity across the studies (I = 18.8%, P = .234). Subgroup analysis shows that exposure to crocidolite, cement, studies conducted in Europe and Oceania, and long study follow-up (≥25 years) all contribute to significantly higher SMR, and we found no evidence of publication bias (Begg test P value = .592, Egger test P value = .874). This meta-analysis suggested that exposed to asbestos might be associated with an increased risk of PCa. High-exposure level of asbestos could contribute to significantly higher risk of PCa mortality.

Past and current asbestos exposure and future mesothelioma risks in Britain: The Inhaled Particles Study (TIPS)

BackgroundOccupational and environmental airborne asbestos concentrations are too low and variable for lifetime exposures to be estimated reliably, and building workers and occupants may suffer higher exposure when asbestos in older buildings is disturbed or removed. Mesothelioma risks from current asbestos exposures are therefore not known.MethodsWe interviewed and measured asbestos levels in lung samples from 257 patients treated for pneumothorax and 262 with resected lung cancer, recruited in England and Wales. Average lung burdens in British birth cohorts from 1940 to 1992 were estimated for asbestos-exposed workers and the general population.ResultsRegression analysis of British mesothelioma death rates and average lung burdens in birth cohorts born before 1965 suggests a lifetime mesothelioma risk of approximately 0.01% per fibre/mg of amphiboles in the lung. In those born since 1965, the average lung burden is ∼1 fibre/mg among those with no occupational exposure.ConclusionsThe average lifetime mesothelioma risk caused by recent environmental asbestos exposure in Britain will be about 1 in 10 000. The risk is an order of magnitude higher in a subgroup of exposed workers and probably in occupants in the most contaminated buildings. Further data are needed to discover whether asbestos still present in buildings, particularly schools, is a persistent or decreasing hazard to workers who disturb it and to the general population, and whether environmental exposure occurs predominantly in childhood or after beginning work. Similar studies are needed in other countries to estimate continuing environmental and occupational mesothelioma hazards worldwide, including the contribution from chrysotile.

Evaluation of the presence of asbestos in cosmetic talcum products

Talc has been used for over a century in a variety of cosmetic products. While pure cosmetic talc (free of asbestos) is not considered a risk factor for mesothelioma, it has been recently suggested that inhalation of cosmetic talc containing trace levels of asbestos is a risk factor for mesothelioma. Bulk analyses of cosmetic talcum products were performed in the 1960s and 1970s, however, the analytical methods used at that time were incapable of determining whether asbestos minerals were present in the asbestiform versus non-asbestiform habit. The distinction between these two mineral habits is critical, as non-asbestiform amphibole minerals do not present an asbestos-related cancer risk via inhalation. As such, we evaluated six historical talcum powders using modern-era analytical methods to determine if asbestos is present, and if so, to identify the mineral habit (asbestiform versus non-asbestiform) of the asbestos. Based on their labels, the products were produced by four manufacturers and sold between 1940 and 1977. The products were analyzed in duplicate by two laboratories using standard protocols. Laboratory A analyzed samples using X-ray diffraction (XRD) and polarized light microscopy (PLM), and Laboratory B analyzed samples using PLM and transmission electron microscopy (TEM) with energy dispersive X-ray analysis (EDX) and selected area electron diffraction (SAED). No asbestiform minerals were found in any of the products. Nonetheless, even if some historical cosmetic talcum products contained trace amounts (≤0.1%) of asbestiform minerals, any resulting asbestos exposure would be expected to be exceedingly low, and comparable to exposures from breathing ambient air.

Asbestos knowledge and awareness level in central part of Anatolia.

Background Asbestos-contaminated soil has been used by people for many years in the rural part of Anatolia. However, there is no program to control usage of asbestos in this region. Objective To determine the knowledge and awareness level about asbestos in a region where asbestos-related diseases are endemic due to environmental exposure to asbestos in the rural setting. Methods This study included 760 participants, recruited using non-probability sampling, who were classified into four groups according to residence and asbestos exposure type (urban, rural; asbestos-exposed, asbestos-unexposed). Asbestos knowledge and awareness was measured via the Asbestos Knowledge and Awareness Questionnaire (AKAQ). The cut-off value of questionnaire was determined by the K-means cluster analysis for sufficient and insufficient knowledge and awareness level. A multiple logistic regression analysis was performed to determine independent factors affecting sufficient knowledge and awareness of participants about asbestos. Results The median and mean score of the AKAQ in study group were 30 and 33.9, respectively. The urban asbestos-exposed group had a higher score than the urban asbestos-unexposed and both rural groups (p<0.001). Factors affecting asbestos knowledge and awareness were education status (p=0.035), asbestos exposure (p=0.003) and living in the rural area (p=0.005). Sufficient knowledge and awareness (score>45) was higher among participants who had graduated from university and had asbestos exposure. Insufficient knowledge and awareness level was higher among participants living in rural areas. Conclusion In this region of Anatolia, knowledge and awareness level of asbestos was low among people at risk for environmental asbestos exposure. People should be aware of asbestos and its hazards by a well-designed training program and be monitored for asbestos-related diseases.