This article constructs a brief history of how lesbian, gay, bisexual, transgender and intersex (LGBTI) issues have intersected with South African psychology at key sociopolitical moments, filling a gap in current histories. Organized psychology-a primary focus of this analysis-since its first formations in 1948, mostly colluded with apartheid governments by othering queerness as psychopathology or social deviance. The National Party, both homophobic and racist, ruled the country from 1948 until the first democratic elections in 1994. The acceleration of antiapartheid struggles in the 1980s saw progressive psychologists develop more critical forms of theory and practice. However, LGBTI+ issues remained overshadowed by the primary struggle for racial equality and democracy. Psychology's chameleon-like adaptation to evolving eras resulted in a unified organization when apartheid ended: the Psychological Society of South Africa (PsySSA). Democratic South Africa's Constitution took the bold step of protecting sexuality as a fundamental human right, galvanizing a fresh wave of LGBTI+ scholarship post-1994. However, LGBTI+ people still suffered prejudice, discrimination, and violence. Additionally, psychology training continued to ignore sexual orientation and gender-affirmative health care in curricula. PsySSA therefore joined the International Psychology Network for Lesbian, Gay, Bisexual, Transgender and Intersex Issues (IPsyNet) in 2007, catalyzing the PsySSA African LGBTI+ Human Rights Project in 2012 and two pioneering publications: a position statement on affirmative practice in 2013, and practice guidelines for psychology professionals working with sexually and gender-diverse people in 2017. This article traces a neglected history of South African psychology, examining the political, social, and institutional factors that eventually enabled the development of LGBTI+ affirmative psychologies. (PsycINFO Database Record (c) 2019 APA, all rights reserved).