Posterior lens capsule opacification (PCO) is the most common complication after cataract surgery. Its treatment comprises Nd:YAG laser capsulotomy, which is also indicated in cases of capsular contraction syndrome, capsular bag distension syndrome, and negative dysphotopsia. Although it is a safe procedure, many complications occur when it is applied to patients with PCO. These complications include marks or fissures on the intraocular lens (IOL), increased intraocular pressure, displacement of the IOL, uveitis, cystoid macular edema, retinal detachment, macular hole, retinal hemorrhage, and endophthalmitis. Meticulous cortical cleaning, the IOL inside the capsular bag, continuous curvilinear capsulorhexis (which overlaps the optical edge of the 360° IOL), and changes in IOL designs and materials have all helped to decrease the rate of complications associated with PCO treatment. Antiglaucomatous eye drops and topical corticosteroids have also been used to prevent and treat complications associated with the use of Nd:YAG laser.