Length Of Healing Research Articles

Effectiveness Of Bidara (Ziziphus mauritiana) Extract On The Long Wound Healing In White Rats (Rattus norvegicus)

Bidara have active compounds which affects in regenerating and repairing the skin’s epidermal layer. Examine the benefits of bidara (Ziziphus mauritiana) as a wounds cut treatment on white rats (Rattus Norvegicus). The type of research is quantitative research. Data collection using an observation of the length of wound healing in days and indicators of wound healing. The average wound healing time data was normally distributed and homogeneous with p>0.05. One Way ANOVA resulted p=0.16 means there is no difference between groups. Wound healing indicator data with the Nagaoka scale reached a p>0.05 means the data normally distributed and homogeneous. One Way ANOVA gave a value of p=0.00 means there is significant difference between groups and continued with Post Hoc and T-Test. The comparison of average wound healing time between groups with the intervention of 8% bidara extract ointment, 16%, and 25% influenced by the diversity. The administration of bidara extract ointment can be an alternative in post-incision wound care in obstetrics cases

THE EFFECTIVENESS OF RED BETEL LEAF AND ALOE VERA IN THE TREATMENT OF PERINEAL WOUNDS: LITERATURE REVIEW

Treatment of perineal wounds in postpartum women can be done by pharmacological and non-pharmacological methods, namely through complementary therapy with the use of herbs, which is betel leaf and aloe vera that have anti-inflammatory, anti-septic, anti-fungal and antibacterial effects. The purpose of this study was to determine the effectiveness of red betel leaf and aloe vera in the treatment of perineal wounds. This study uses a Literature Review, journal searches using Medline, PubMed, Tandfonline and Google Scholar databases for the last ten years. Analysis of the data used is descriptive statistics. Some literature discusses the treatment of perineal wounds using red betel leaf and aloe vera and has been shown to be effective in the perineum wound healing process in post artum mothers with an average length of healing that is faster than treatment without the intervention of red betel leaf and aloe vera. Conclusion, red betel leaf and aloe vera can be applied in the treatment of perineal wounds in postpartum.

Barriers and facilitators to use of compression therapy by people with venous leg ulcers: A qualitative exploration.

To explore barriers to, and facilitators of, adherence to compression therapy, from the perspective of people with venous leg ulcers. An interpretive, qualitative, descriptive study involving interviews with patients. Participants were purposively sampled from respondents to a survey exploring attitudes to compression therapy in people with venous leg ulcers. Sampling continued until data saturation: 25 interviews between December 2019 and July 2020. Inductive thematic analysis of interview transcripts was undertaken to create a framework for the data, followed by deductive analysis informed by the Common-Sense Model of Self-Regulation. A range of knowledge and understanding about the cause of venous leg ulcers and the mechanisms of compression therapy was demonstrated, which was not particularly related to adherence. Participants talked about their experience with different compression methods and their concerns about the length of time healing could take. They also spoke about aspects of the organization of services which affected their care. Identifying specific, individual barriers/facilitators to compression therapy is not simple, rather factors combine to make adherence more or less likely or possible. There was no clear relationship between an understanding of the cause of VLUs or the mechanism of compression therapy and adherence; different compression therapies presented different challenges for patients; unintentional non-adherence was frequently mentioned; and the organization of services could impact on adherence. Ways in which people could be supported to adhere to compression therapy are indicated. Implications for practice include issues relating to communication with patients; taking into account patients' lifestyles and ensuring that they know about useful 'aids'; providing services that are accessible and provide continuity of appropriately trained staff; minimizing unintentional non-adherence; and acknowledging that healthcare professionals will always need to support/advise those who cannot tolerate compression. Compression therapy is a cost-effective, evidence-based treatment for venous leg ulcers. However, there is evidence that patients do not always adhere to this therapy and there is limited research investigating reasons why patients do not wear compression. The study found no clear relationship between an understanding of the cause of VLUs or the mechanism of compression therapy and adherence; that different compression therapies presented different challenges for patients; that unintentional non-adherence was frequently mentioned and that the organization of services could impact on adherence. Attending to these findings offers the opportunity to increase the proportion of people undergoing appropriate compression therapy and achieving complete wound healing, the main outcome desired by this group. A patient representative sits on the Study Steering Group, contributing to the work from developing the study protocol and interview schedule to interpretation and discussion of findings. Members of a Wounds Research Patient and Public Involvement Forum were consulted about interview questions.

Antibiotic Evaluation Use towards Diabetic Foot Ulcer Inpatient at Hospital in Surakarta

A diabetic foot ulcer is one of diabetes mellitus type 2 complications indicated by open sores. Because it contains bacteria, it is treated with antibiotics. Improper use of antibiotics could harm patients due to the length of wound healing. This study aims to determine the appropriate of antibiotics in patients with a diabetic foot ulcers. This is a non-experimental research with descriptive analysis approach. The medical records of diabetic foot ulcer patients undergoing inpatient and antibiotic prescribing are observed. The data obtained were analyzed by comparing the use of antibiotics based on the National Health Service guidelines, the Indonesian National Drug Information, and the Drug Information Handbook. The results of this study showed antibiotics used are metronidazole (4.8%), vancomycin (4.8%) and antibiotics combination are ceftriaxone-metronidazole (47.6%), ceftriaxone-metronidazole-clindamycin (4,8%), levofloxacin-azithromycin-ceftriaxone (4.8%), cotrimoxazole-ciprofloxacin (4.8%), metronidazole-meropenem (4.8%), ceftriaxone-metronidazole-gentamicin (4.8%), metronidazole-clindamycin-ciprofloxacin (4.8%), ceftriaxone-levofloxacin (4.8%), and ceftriaxone-metronidazole-ciprofloxacin (9.5%). The evaluation results according to criteria appropriate usage of antibiotics that is 100% appropriate indication, 100% for appropriate of patients, 42.3% for appropriate drug, and 61.9% for the appropriate dose.

The Effect of Giving Boiled Chicken Eggs on the Healing of Perineal Wounds for Postpartum Mothers in the Independent Practice of Midwife Sumiariani in 2021

Postpartum infections still play a role as the main cause of maternal death, especially in developing countries like Indonesia. The aim of this study was to determine the effect of giving boiled chicken eggs on perineal wound healing in postpartum women. The type of research used in this study was a Quasi Experiment with a population of postpartum women with perineal wounds with a total sample of 10 respondents, 5 respondents (intervention group) and 5 respondents (control group). The results of the study showed that the average length of days healing of perineal wounds in postpartum women in the intervention group (given boiled eggs) was 5.4 days. The mean duration of perineal wound healing in the control group was 10.6 days. There is an effect of giving boiled chicken eggs on perineal wound healing in postpartum women with a p-value of 0.000 <0.05.

Development of a cocoa-based cream (Theobroma cacao), to take advantage of its anti-inflammatory properties in Ecuador

Ecuadorian cocoa is recognized worldwide for its marked characteristics of aroma and color. In addition, all derivatives are being given importance for their high health benefits. In this sense the objective of this work was: to develop a cream based on cocoa (Theobroma cacao), to take advantage of its anti-inflammatory properties. Therefore, bromatological analyses were made to the cocoa bean, in the same way the levels of flavonoids of the cocoa mass were analyzed. Also, different levels of cocoa butter were studied in combination with plantain infusion to obtain anti-inflammatory cream. Finally, the anti-inflammatory effect was studied by means of an analysis of the length of healing in wounds caused to young guinea pigs. After analysis, the physical and chemical characteristics of the raw material contrast with the data permitted by the NTE INEN 176 and 620 standards. In the analysis of total flavonoids such as quercetin, the 3 values obtained showed to have a great antioxidant potential. In the analysis of the anti-inflammatory effect, treatment 4 (A2B2) (54% cocoa butter + 27,89% Plantain infusion) proved to be the best, and even superior to traditional creams.

Epidemiological characteristics and treatment outcome analysis of 229 patients with hydrofluoric acid burns in hands

Epidemiological characteristics and treatment outcome analysis of 229 patients with hydrofluoric acid burns in hands

Reviewing the Physiology of Cutaneous Wound Healing and Evaluating the Effect of Exercise on It: A Narrative Review Article

Context: The skin is the most important organ of the body, and maintaining its integrity is important for health. Severe skin damage is life-threatening, and wound healing restores its integrity. One of the main health problems is impaired cutaneous wound healing. According to the importance of wound healing and the fact that unrepaired skin decreases the quality of life, many studies have investigated the effect of some natural and chemical substances on the length and quality of wound healing to find beneficial interventions for rapid and economical treatment. Objectives: This review was conducted to describe the physiology of cutaneous wound healing and some positive and negative factors affecting it with a focus on exercise. Evidence Acquisition: An electronic search without any time limitation was performed on the PubMed, Google Scholar, and Web of Science databases. The keywords were ‘wound’, ‘healing’, and ‘exercise’. Finally, according to the similarities or differences between the results and the relationship with the subject, 53 papers were selected and reviewed. Results: Wound healing is a complex physiological process with four overlapping processes. It seems that disturbance in the inflammatory phase of wound healing is the main factor in the impairment of healing. Traditionally, many chemical and herbal medicines and compounds have been used to speed up wound recovery due to their anti-inflammatory and antioxidative properties. Many studies have evaluated the effect of exercise, as complementary medicine, on wound healing, and they have examined the effect of different protocols of exercise on the speed of wound healing. According to the results of these studies, aerobic exercise, due to its anti-inflammatory and antioxidative effects, is a beneficial method in shortening the length of healing, especially in aged, obese, and diabetic individuals. Conclusions: Exercise as a low-cost intervention is a good strategy in the treatment of impaired and chronic wounds.

Modern Wound Care Application: A Literature Review

Wounds are damage to tissue structures and normal anatomical functions as a result of pathological processes originating from internal and external that hit certain organs. Wounds can be classified based on anatomical structure, properties, the healing process, and length of healing. The literature review aims to find out the modern application of the wound care-related wound healing process. Literature review through several stages, namely making questions, identification, eligibility, selection of article inclusion, and screening. The Selection Process is listed in the framework of the review literature and obtained the results of article 7 articles. The data showed different results adjusted to the system and the conditions of where the research was conducted. The results of the reviewed article focus on explaining the patient's comfort level and more significant healing process. Modern wound care application has been proven to provide comfort to patients in carrying out the wound healing process, and is very helpful for nurses in providing nursing services. The application of modern wound care is a wound care technique that will develop at any time based on the development of nursing science, in which case it focuses on the level of comfort of patients in receiving health services related to wound care. So nurses urgently need to improve and develop science related to the application of modern wound care that will support patient comfort in wound care and accelerate the wound healing process well.

Identifying wound infections for veterinary nurses

Heavily contaminated wounds are a common occurrence in both referral and primary care practice, with traumatic and bite wounds being among the most typical aetiologies seen. Each type of wound can be affected by numerous factors that can inhibit the healing process, one of these major factors is infection.Wound infections and the formation of biofilms can present veterinary nurses with a variety of challenges, which is why it is important that we understand the difference between normal inflammatory signs and the signs of infection. The early identification of infection and biofilms within a wound can influence healing times, scar tissue formation and length of healing. This article aims to highlight the difference between inflammation and infection, the different levels of contamination within a wound, and ways to decipher between superficial and deep tissue infections.

PENGARUH JUMLAH TOPIKAL AIR SUSU IBU TERHADAP LAMA PELEPASAN TALI PUSAT

The length of time that the cord is removed will allow infection which is the cause of death. WHO recommends treatment based on aseptic principles, but there is insufficient evidence to recommend routine use of topical antimicrobials for treatment. The incidence of tetanus neonatorum due to umbilical cord infection continues to increase and is at risk of causing death. Several studies have shown that breast milk is an alternative material for cord care because it is sterile, contains antiinflammatory and anti-infective properties. This study aims to determine the effect of the topical amount of breast milk on the duration of release. The research design used a quasi-experiment with a cohort approach. The sample in this study was 43 babies who were selected using consecutivesampling. Samples were divided into 3 treatment groups, namely newborns who met the inclusion criteria were given 5 drops, 7 drops, and 10 drops of breast milk to observe the duration of wound healing. Data collection using the observation sheet. The results showed the fastest wound healing time was given 5 drops of breast milk for 164,931 hours (164 hours 56 minutes), 10 drops for 170,173hours (170 hours 10 minutes), and 7 drops for 171,807 hours (171 hours 48 minutes). The results of the analysis using one-way ANOVA showed that the treatment of topical breastfeeding had no significant effect on the length of healing of cord wounds (F-count 0.393 with p-value 0.678). Topical breastfeeding responds differently to the healing of the baby's cord wound. Keywords: breast milk, length of umbilical cord release

Prophylactic negative-pressure wound therapy after ileostomy reversal for the prevention of wound healing complications in colorectal cancer patients: a randomized controlled trial

BackgroundThe aim of this study was to assess the usefulness of protective negative-pressure wound therapy (NPWT) in the reduction of wound healing complications (WHC) and surgical site infections (SSI) after diverting ileostomy closure in patients who underwent surgery for colorectal cancer.MethodsIn this prospective randomized clinical trial in a tertiary academic surgical center, patients who had colorectal cancer surgery with protective loop ileostomy and were scheduled to undergo ileostomy closure with primary wound closure from January 2016 to December 2018 were randomized to be treated with or without NPWT. The primary endpoint was the incidence of WHC. Secondary endpoints were incidence of SSI, length of postoperative hospital stay (LOS), and length of complete wound healing (CWH) time.ResultsWe enrolled 35 patients NPWT (24 males [68.6%]; mean age 61.6 ± 11.3 years), with NPWT and 36 patients (20 males [55.6%]; mean age 62.4 ± 11.3 years) with only primary wound closure (control group). WHC was observed in 11 patients (30.6%) in the control group and 3 (8.57%) in the NPWT group (p = 0.020). Patients in the NPWT group had a significantly lower incidence of SSI (2 [5.71%] vs. 8 [22.2%] in the control group; p = 0.046) as well as significantly shorter median CWH (7 [7–7] days vs. 7 [7–15.5] days, p = 0.030). There was no difference in median LOS between groups (3 [2.5–5] days in the control group vs. 4 [2–4] days in the NPWT group; p = 0.072).ConclusionsProphylactic postoperative NPWT after diverting ileostomy closure in colorectal cancer patients reduces the incidence of WRC and SSI.Clinical trial registrationclinicaltrials.gov (NCT04088162).

Naringenin Sensitizes Resistant C6 Glioma Cells with a Repressive Impact on the Migrating Ability.

Background:Glioma, the most common form of a malignant brain tumour is characterised by a poor prognosis, which is attributable to its resistance against current therapeutic approaches. Temozolomide (TMZ), a DNA alkylating agent, is the first-line drug for glioma treatment. Long-term treatment using TMZ was reported to culminate in the development of resistance with overexpression of multidrug resistance 1 gene coded protein P-glycoprotein, which in turn releases the drugs from the tumour cells.Purpose:Thus, to circumvent such resistance issues, the current study attempted to explore the effect of naringenin (a flavanone) with proven antiglial tumour potential, in mitigating the features of TMZ resistance.Methods:Colony-forming assay, invasion assay and scratch wound assay were performed among the groups, namely tumour control (C6), vehicle control (V), naringenin (NGEN)-treated, drug-resistant tumour cells (C6R), and drug resistance cells added with NGEN (C6R+NGEN), to examine the impact of NGEN on migration and invasion. The effect of NGEN on filopodia length and density during cell migration was also studied in addition to the matrix metalloproteinases (MMP-2 and MMP-9) and p-ERK levels.Results and Conclusion:NGEN and C6R+NGEN groups had shown significant reduction (P < .01) in length and density of filopodia, colony formation, invasion and wound healing. Further, NGEN could also modify the assessed protein levels (P < .001), which were involved in migration and invasion in sensitive and resistant cells. Our study had provided the first evidence on NGEN-induced enhanced sensitivity against TMZ resistance with profound influence as an antimigratory and anti-invasive agent.

SKRINING FITOKIMIA DAN UJI AKTIVITAS EKSTRAK ETANOL RUMPUT LAUT MERAH (Gracilaria verrucosa) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH JANTAN GALUR WISTAR

Wound is defined as the disruption of the anatomic and cellular continuity of tissue caused by chemical, thermal ,physical, immunological and microbial, or injury to the tissue. Seaweed contains secondary metabolites such as flavonoids and saponins. Red seaweed contains albumin which can accelerate the process of wound healing. This study aims to determine the concentration of red seaweed ethanol extract which has an effect as a wound wound healing and to determine the length of wound healing from each concentration. A total of 25 rats were divided into 6 groups consisting of positive control given 10% povidone iodine ointment, negative control given vaseline albumin, Group 1 (Concentration 7.5% ethanol extract of red seaweed), group 2 ( Concentration 15 % ethanol extract of red seaweed, group 2 ( Concentration 30% ethanol extract of red seaweed). Phytochemical screening on ethanol extracts of red seaweed showed the presence of secondary metabolites such as flavonoids, saponins, quinones, monoterpenes and sesquiterpenes. Albumin identification shows positive results. Changes in wound area or wound surface were observed by measuring the diameter of the wound from days 1 to 16, and the diameter of the wound was converted into percent using the Morton method. Data analysis using non-parametric tests. The analysis showed a significant difference (p &amp;lt;0.05) between the positive and negative control groups, and there was no difference between positive controls with concentrations of 7.5%, 15%, 30% on the 4 day. The 30% concentration is the group that provides the fastest wound healing effect on the 12 day when compared to the 7.5% and 15% concentration groups . The results of this study indicate that ethanol extract of red seaweed has a healing effect on the wound.

Initial experience with minimally invasive treatment of pilonidal sinus in children.

IntroductionSinus pilonidalis (SP) is an acquired inflammatory disease, which is relatively common in the paediatric population. Surgery is indicated in symptomatic patients. In 2017, minimally invasive pilonidal sinus treatment (EPSiT) was adapted to the paediatric population.AimTo evaluate the first experience with minimally invasive endoscopic treatment of SP (PEPSiT) in children and adolescents in the Czech Republic.Material and methodsA retrospective review of all consecutive paediatric patients who underwent PEPSiT from November 2018 to February 2020. The monitored parameters were demographics, perioperative course of the disease, surgery, length of hospitalisation, postoperative complications, healing, disease recurrence, and follow-up.ResultsSeventeen patients were enrolled in the study. The median age at surgery was 17.1 years (range: 12.5–18). The subjects comprised 76% males, and the median body mass index was 25.6 kg/m2 (range: 17–30.3 kg/m2). Thirteen patients underwent previous surgical treatment (76%) under local anaesthesia. The median duration of PEPSiT was 50 min (range: 30–85 min). The subjective evaluation of pain by patients on the VAS scale was 0 on the day of discharge. There were no postoperative complications up to the 30th postoperative day. Two disease recurrences were successfully managed by re-PEPSiT. By the end of follow-up, 14/15 patients had healed. Two patients are still within 3 months of surgery, which is too soon to definitively evaluate possible recurrence of the disease.ConclusionsThese preliminary results show that PEPSiT is a highly promising method. It is safe and well-tolerated by patients (short hospital stay, quick return to normal life, low pain and analgesic consumption). Two recurrences of disease were treated by re-PEPSiT.

RELATIONSHIP OF PERSONAL HYGIENE AND EARLY MOBILIZATION WITH PERINEUM WOUND HEALING

Postpartum mothers who have perineal wounds are susceptible to infection because they are not clean and will affect the length of healing of the perineum. Early mobilization is a policy to quickly guide postpartum mothers out of their beds and walk and can smooth blood flow so as to accelerate the healing of perineal wounds. Perineal wounds due to rupture or laceration are areas that are not easy to keep clean and dry. If healing of wounds is not handled properly it will cause imperfect rupture wound healing. Perineal rupture is a birth canal injury that occurs at the time of the baby's birth, either using or not using a tool. The aim was to determine the relationship of personal hygiene and early mobilization with healing of perineal wounds on postpartum 7th day mothers in Pasanggar Pamekasan Village. Method Analytic, cross-sectional, purposive sampling, population of 38 postpartum mothers, 34 samples of postpartum mothers.The results of the study good day-to-day personal hygiene of postpartum mothers (67.6%), good early mobilization (61.8%), good perineal wound healing (58.8%), good personal hygiene, good perineal wound healing (87 %), early mobilization of good perineal wound healing is good (76.2%). Rank Spearman test, personal hygiene with perineal wound healing p = 0,000 <α 0,05 and mobilization with wound healing p = 0,002 <α 0,05 means that there is a significant relationship. Conclusion there is a relationship between personal hygiene and early mobilization with healing of perineal wounds in postpartum mothers on the 7th day .

Collagen-Chitosan- Glycerol-HPMC Composite as Cornea Artificial Candidate

The number of blindness is tend to be increased year by year. One of the blindness cause is cornea ulcer.The cause of cornea ulcer is bacteria, fungi, and herpes simplex virus. Cornea transplantation is the only treatment which could widely accepted for blindness. Transplant by donor network becomes the only treatment that is acceptable on a large for blindness. However, treatment donor transplants have many shortcomings in complications post surgery such as host response, donor limitations, incompatibility and the length of time healing. As technology develops, there are many corneal substitutes based on natural ingredients derived from collagen or their derivatives because they promise better properties in biocompatibility. The aim of research are to conduct the synthesis and characterization of collagen- chitosan- glycerol - HPMC as artificial cornea such functional cluster test, cytotoxycity test, morphological test and antibacterial test. Based on functional cluster test, there are functional groups of all components of composite materials. While from cytotoxicity test, all samples have a percentage of living cells above 85%. The morphology test is showed that the pore size of sample B with composition collagen-chitosan-glycerol-HPMC is in accordance with the standard pore size for keratoprothesis. Sample A (collagen-chitosan-glycerol) and sample B (collagen-chitosan-glycerol-HPMC) have strong antibacterial properties.Biocomposite of collagen-chitosan-glycerol could be considered as artificial cornea due to the proximity with the corneal characteristics.

Effects of minimally invasive tangential excision in treating deep partial-thickness burn wounds on trunk and limbs in pediatric patients in the early stage post burn

Objective: To observe the effects of minimally invasive tangential excision in treating deep partial-thickness burn wounds on trunk and limbs in pediatric patients in the early stage post burn. Methods: Clinical data of 40 children with deep partial-thickness burn wounds on trunk and limbs, admitted to our burn ward from January 2016 to June 2017, conforming to the study criteria, were retrospectively analyzed. They were divided into conventional treatment group (CT, n=19) and minimally invasive tangential excision group (MITE, n=21) according to the different treatments. The patients in group CT were treated with eschar-reserving therapy firstly. When tangential excision was performed, the roller knife was used, and no necrotic tissue left on the wound bed was considered the proper depth of excision. Razor-thickness skin grafting was performed to cover the wound when adipose tissue exposed markedly after tangential excision. Dressing change was performed within 48 h after the operation and repeated every 2 days. Unhealed wounds were covered by razor-thickness skin grafting. The patients in group MITE were treated with tangential excision in the early stage post burn. The tangential excision was operated with electric dermatome, and the thickness was set at 0.1 mm to excise the surface of eschar until the sporadic punctate hemorrhage on wound surface was observed and some necrotic tissue was left on the wound bed. Porcine acellular dermal matrix was applied after tangential excision. The first dressing change was often performed about 1 week after the operation. Razor-thickness skin grafting was performed to cover the unhealed wounds. The length of wound healing, high fever, antibiotic usage, and hospital stay, times of later operation, and hospitalization expenses of patients in the 2 groups were recorded. The excisional eschar and wound bed tissue of patients in group MITE were harvested for pathological observation. Data were processed with t test and Fisher's exact probability test. Results: (1) There were no statistically significant differences in length of high fever and length of hospital stay and hospitalization expenses between patients in the 2 groups (t=-1.67, -1.93, 0.31, P>0.05). The lengths of wound healing [(24.8±2.5) d] and antibiotic usage [(4.4±0.7) d] of patients in group MITE were significantly shorter than those in group CT [(33.3±2.5) and (7.0±0.7) d, t=-2.44, -2.44, P<0.05], and times of later operation of patients in group MITE [(0.29±0.14) times] were significantly less than those in group CT [(0.79±0.21) times, t=-2.03, P<0.05]. (2) The thickness of the excisional eschar of patients in group MITE was about 150 μm. The eschar has epidermis and upper dermis. Some necrotic tissue was left on the wound bed. Conclusions: The treatment for pediatric deep partial-thickness burn wounds on trunk and limbs with minimally invasive tangential excision using electric dermatome in the early stage post burn can accelerate wound healing, shorten length of antibiotic usage, and reduce times of later operations.

Skin Laceration in Collagenase Clostridium histolyticum Treatment for Dupuytren's Contracture.

Dupuytren's contracture produces a progressive flexion contracture of the affected fingers. Collagenase Clostridium histolyticum produces breakdown of the cord in the hand and/or finger(s) that tightens as a result of the disease creating a contracture, allowing manual traction and cord rupture. One of the side effects is spontaneous skin laceration when the finger is extended. To evaluate the development of skin lacerations in Dupuytren's contracture treated with collagenase Clostridium histolyticum, to determine predisposing factors, and evaluate the effectiveness of 2 different treatments (antiseptic and non-antiseptic dressings). Included 157 patients diagnosed with Dupuytren's contracture and treated with collagenase Clostridium histolyticum. Analysis of variables and logistic regression model were applied to determine their possible relationship with skin lacerations. The effectiveness of the type of treatment used was evaluated by comparing the amount of time required for healing. Skin lacerations were present in 33.1% (n = 52) of patients, with an average laceration length of 1.12 (SD: 0.70) cm. Characteristics that were significant predisposing factors for lacerations were disease bilateralism (p = .002), previous surgical intervention (p = .003), and initial matacarpophalangeal joint contracture (p < .001). Worse initial contracture (Z = 5.94; p < .001) had a greater risk of laceration as did those who had prior hand surgery, or whose little finger was affected. Average treatment length of healing was 11.24 days (SD: 8.13). All wounds healed successfully. There were no significant differences (p = .511) in healing between different dressings evaluated. Skin lacerations as a consequence of treating Dupuytren's contracture with collagenase Clostridium histolyticum occur often and are moderately serious. For all cases, evolution is satisfactory in less than 2 weeks, and the type of treatment does not appear to make any difference in healing time.

Evaluation of the mobility of the shoulder and quality of life after perforator flaps for recalcitrant axillary hidradenitis

Hidradenitis suppurativa is a very debilitating disease, treated by antibiotics and excision. The reconstruction is usually done by secondary wound healing and/or split-thichness skin graft. The aim of this study was to evaluate the reconstruction of the axilla with local perforator flaps as a single stage surgical treatment. This was a monocentric retrospective study conducted between November 2013 and June 2015. We included the patients with a severe axillary localization of the disease. Between 6 months and 1 year postoperatively, we noted length of complete healing, complications, patients satisfaction score about the surgery, DASH functional score, maximum abduction angle of the arm, and recurrence of the disease. Thirteen patients were included, for a total of seventeen affected axillae. We performed seven thoracodorsal artery perforator flaps, seven lateral intercostal artery perforator flaps and three serratus anterior artery perforator flaps. The mean duration of follow-up was 279.1±84.1 days (180-365). The average complete healing time was 20.5±13.5 days (10-60). Six axillae were compounded (35%). The average recurrence rate of HS was 0%. The average score in the DASH questionnaire was 68.6±35.3 points (39-152) and the average maximum abduction angle of the arm was 160.6±18.5 degrees. The average score on the satisfaction questionnaire was 36.5±5.6 points (25-43). This is a single stage, reliable and effective surgical procedure. The results are very encouraging, with a good quality of life, a low functional disability and a shorter healing time.