Little is known about how young children with orofacial cleft grow over time. To characterize longitudinal growth patterns from 0-36 months of age in U.S. children with an orofacial cleft. A retrospective cohort study. Children with cleft lip (CL), cleft lip and palate (CLP), or cleft palate (CP) who were <36 months of age at a hospital encounter between 2010-2019 (N=1334) were included. The setting was a U.S. tertiary care children's hospital with a cleft center that serves a 5-state region. Weight-for-age z-scores (WAZ) and length-for-age z-scores (LAZ). Longitudinal growth patterns were characterized using generalized linear mixed models to estimate mean WAZ and LAZ from 0 to 36 months of age. Growth in infants with cleft slowed dramatically in the first 3 to 4 months of life, rebounded with catch-up growth until 12 months of age for CL and CP and until 36 months for CLP. When comparing populations, children with any type of cleft demonstrated subpar growth compared to WHO standards. Growth deficits were more common in those with CLP and CP compared to those with CL. The intraclass coefficient (ICC) showed that most of the variability in the WAZ (65%) was between individuals while 35% was within an individual. The ICC for LAZ showed that most of the variability in the LAZ (74%) was between individuals while 26% was within an individual. The proportion of variance attributable to cleft type and/or comorbidities accounted for less than 5% of the variance for WAZ and LAZ. WAZ and LAZ were lower in children with comorbidities than those without comorbidities with cleft and WHO standards. Infants with CLP and CP, and cleft plus comorbidities have higher rates of poor growth than their peers with CL and no comorbidities, respectively.