Leiomyo-adenomatoid Tumor Research Articles

Leiomyo-adenomatoid Tumor of the Uterus: Finding the Rare in the Routine.

Leiomyo-adenomatoid tumour (LMAT) is a rare benign neoplasm and very few cases of LMAT of the uterus are documented in the literature. Uterine LMATs are usually detected incidentally during the histopathologic evaluation of routine myomectomy or hysterectomy specimens for leiomyomata. Thorough evaluation of the morphological features and a concise immunohistochemical panel allows for accurate classification of this benign neoplasm.

Leiomyoadenomatoid tumor of uterus: two case reports with literature review

BackgroundAdenomatoid tumors (AT) are benign neoplasms of mesothelial origin that occur more frequently in the genital tracts. In uterus, AT are usually located in the subserosa of the cornual myometrium. Microscopically, it is characterized by interanastomosing pseudoglands or pseudovascular spaces and striking smooth-muscle hypertrophy is often present. In some cases, the prominence of smooth muscle component simulates a leiomyoma and the lesion is denoted as a leiomyoadenomatoid tumor. The microscopic appearance of the adenomatoid component (AC) may mimic a malignant tumor due to irregular pseudoinfiltration with tubular formations. Just 16 cases with this morphological presentation were found in the literature review.Case presentationsThe first case, a 38-year-old female, showed lower abdominal pain, menorrhagia, postcoital bleeding and previous history of uterin leiomyoma. The second case, a 26-year-old female, had clinical complaint of metrorrhagia and received diagnostic hypothesis of leiomyoma after ultrasound image. Both underwent myomectomy. Microscopically, the uterine masses showed intersecting smooth muscle bundles and gland like areas lined by cuboidal epithelioid cells that stained positive for WT1, D2–40 and calretinin in immunohistochemical analysis.ConclusionsThe cases were diagnosed as leiomyoadenomatoid tumor of the uterus. This is a benign and rare entity that may mimic malignant tumors due to the pseudo infiltrative appereance of the adenomatoid component, possibly leading to misdiagnosis.

Leiomyoadenomatoid tumour of testicular tunica – A rare entity

Adenomatoid tumors are distinctive genital tract neoplasms that occur in both men and women. These are commonly located in epididymis, uterus, fallopian tubes, ovary, testicular tunica and spermatic cord. Rarely they are seen in extragenital locations like adrenal, bladder, pancreas, heart, pleura, mesentry, omentum and lymph nodes. Adenomatoid tumors arising from the testis are rare as compared to those arising from epididymis. Leiomyo-adenomatoid (LMAT) tumor is a variant of adenomatoid tumor with predominance of smooth muscle component. Twelve cases of Leiomyo-adenomatoid (LMAT) tumor of uterus and only three cases of LMAT of epididymis have been reported. We report an extremely rare case of LMAT arising from tunica of testis in a 58 year old male.

Uterine Adenomatoid Tumors: A Study of Five Cases Including Three Cases of the Rare Leiomyoadenomatoid Variant.

Adenomatoid tumor is a benign neoplasm of mesothelial origin encountered most often in the male and female genital tracts. This tumor has a distinct morphology and is characterized by anastomosing and variably sized tubules lined by epithelioid and flattened cells. Only 4 cases of the extremely rare leiomyoadenomatoid variant are on record. We report 5 cases of adenomatoid tumor including 3 cases of leiomyoadenomatoid tumor of the uterus, which is an extremely rare variant of adenomatoid tumor, difficult to recognize on morphology. A detailed histopathological review of all the uterine tumor diagnosed as fibroid and adenomatoid tumor over the period of 4years was done. A total of 5 cases of adenomatoid tumor were documented including 3 cases of leiomyoadenomatoid variant. Leiomyoadenomatoid variant of adenomatoid tumor often missed both on imaging and histopathological examination and hence needs to be recognized as a distinct morphological entity.

Leiomyo-Adenomatoid Tumor of the Uterus: Report of a Rare Entity

Abstract Background: A leiomyo-adenomatoid tumor in the anterior cervico-corporal junction of the uterus is reported in this article. Five previous cases in the uterus and 1 in the epididymis have been reported to date. Case: A 24-year-old woman presented with a sense of cervical descent and occasional dyspareunia among other symptoms. Transvaginal ultrasonography showed a 26×23–mm myoma, which was surgically removed. A microscopic examination revealed a myoma with an adenomatoid component intermingled between the smooth-muscle fascicles, consisting of groups of vacuolated cells, slit-like structures, and tubules lined by flattened-to-cuboidal cells with small and uniform nuclei, some with an apical brush border. Immunohistochemistry confirmed the diagnosis leiomyo-adnomatoid tumor of the uterus. Results: While the pathologic changes found represented a leiomyo-adenomatoid tumor of her uterus, she recovered from surgery and her symptoms were resolved. Conclusions: The coexistence of the tumor components f...

An atypical leiomyoadenomatoid tumor of the uterus – a case report and literature review

In this study, we describe morphological and immunohistochemical features of a mixed tumor (atypical leiomyoadenomatoid tumor - LMAT) localized in the body of the uterus. LMAT-type tumors are very rare and only 5 cases have been described in the literature so far therefore this case report seems particularly noteworthy. A 57-year-old patient was admitted to the Gynecology and Obstetrics Unit, Brothers of Mercy Hospital in Katowice for hysterectomy with bilateral salpingo-oophorectomy due to uterine myomata. The macroscopic examination of the surgical material revealed a polycystic tumor 5 cm in diameter with gelatinous contents and grey fibrous areas. The patient was discharged on postoperative day 4, in good general condition. A histological diagnosis of an atypical leiomyoadenomatoid tumor was established on the basis of the tissue material.

Leiomyo-adenomatoid tumor of the uterus: a distinct morphological entity?

The morphologic and immunohistochemical findings of a well-circumscribed leiomyoadenomatoid tumor located in the posterior uterine wall are reported. The patient was a 55-year-old white woman who complained of peri/postmenopausal and irregular bleeding during the past 4 months. The adenomatoid component was intermingled with bland smooth muscle fascicles and was composed of vacuolated cells, tubules, and slit-like structures crossed by epithelial bridges. Immunohistochemistry revealed positivity to epithelial and mesothelial markers in the adenomatoid component and strong immunoreaction for smooth muscle markers in the leiomyomatous one. The well-defined circumscription and the presence of mesothelial component intermingled with the leiomyomatous proliferation favors the hypothesis that a leiomyo-adenomatoid tumor should be considered as a subtype of adenomatoid tumor with distinctive morphological features. Only four previous cases of this rare neoplasm have been reported to date, one in the epydidimis and the other three cases in the uterine wall, one of them affecting also to the right ovary.

Leiomyoadenomatoid tumor of the uterus

Adenomatoid tumors are benign, usually small lesions with a predilection for the male and female genital tracts. In the female genital tract, they may be found within the wall of fallopian tubes or beneath the uterine serosa near the uterine cornu. The term leiomyoadenomatoid tumor is used to describe a variant of adenomatoid tumor with a prominent smooth muscle component. In the present case report we describe a rare case of leiomyoadenomatoid tumor which was incidentally found in a hysterectomy specimen performed for symptomatic fibroid. We report a case of leiomyoadenomatoid tumor of the uterus in a 51 year old female who presented with symptomatic fibroid. extensive literature search has resulted in only 3 cases of leiomyoadenomatoid tumors of the uterus. We would like to report an additional case of this rare tumor.

Leiomyo-adenomatoid Tumor of the Epididymis

Primary tumors of the epididymis are rare. Adenomatoid tumors are the most frequently diagnosed benign tumors of the epididymis and are well known, while leiomyomas are uncommon. We report a case of combined leiomyo-adenomatoid tumor of the right epididymis, which was difficult to diagnose. CASE REPORT A 44-year-old white man presented with a painful right scrotal mass 2 months in duration. History was unremarkable and no other symptoms were reported. Physical examination revealed a 2 3 3 cm. mass at the lower pole of the right testicle. Ultrasound showed a 3 2 cm. combined hypodense and hyperdense mass of the right epididymal tail, which was not clearly separable from the testicle. The right testicle and contralateral scrotal contents were normal. Doppler ultrasound demonstrated enhanced signals of the right rete testis when compared to the contralateral testis. Blood studies, including the tumor markers -fetoprotein, human chorionic gonadotropin, placental alkaline phosphatase and lactate dehydrogenase, revealed normal parameters. Primarily, the patient was thought to have epididymitis and conservative treatment was started. After an initial decrease in symptoms, the patient was referred to our department with recurrent pain and unchanged clinical and sonographic findings 1 month later. Subsequently, right inguinal exploration was performed, during which a firm solid mass arising from the tail of the epididymis was found. Although the mass was firmly adherent to the testicle, epididymectomy was easy to perform. Fresh frozen sections of the tumor were interpreted as leiomyoma of the epididymis. Biopsies of the adjacent testicle were normal. Due to the histological findings, radical orchiectomy was not performed. However, after epididymectomy, routinely processed histological sections of different tumor sites showed a leiomyo-adenomatoid tumor of the epididymis. At 8-month followup the patient was well and without evidence of disease. DISCUSSION