Catch-and-release (C&R) has become a popular practice in many fisheries, but especially in muskellunge Esox masquinongy fisheries where voluntary release rates of legal-sized fish have approached 100%. Because muskellunge are a coolwater species, muskellunge anglers and biologists have expressed concerns regarding the population-level effects of additional mortality from C&R during periods of elevated water temperatures. Therefore, we used a combination of a radio telemetry study and individual-based growth model simulations to evaluate the effects of warm-water C&R mortality on the length potential of muskellunge in the James River, Virginia. We implanted radio transmitting tags in muskellunge ≥ 650 mm in winter 2020 (N = 45) and 2021 (N = 50) to monitor fates of fish that were subsequently caught and released during the warm-water period (July – August). Twelve tagged fish were caught and released in the warm-water period, of which four died (33%). Despite a high rate of mortality compared to studies conducted during cooler temperatures, our simulations indicated that a closed season during the warm-water period on the James River would result in little to no increase in the proportions of muskellunge reaching preferred (≥1020 mm) and memorable (≥1140 mm) size classes because (1) thermally stressed fish were not susceptible to angling, and (2) growth potential beyond the memorable size class is currently limited in the James River. Given the growing popularity of muskellunge angling in the southern portion of their distribution and projected increases in water temperature throughout the muskellunge’s distribution, results from this study will provide managers with the information necessary for developing more comprehensive muskellunge management plans.