Assessment Of Left Ventricular Systolic Function Research Articles

Effect of exercise based cardiac rehabilitation on LV systolic function & exercise stress parameters in patients with ischemic cardiomyopathy post anterior STEMI

Background: Cardiovascular diseases are a leading cause of death worldwide. Multiple meta-analysis have demonstrated the benefit of exercise based cardiac rehabilitation. However, the effect of exercise training on left ventricular (LV) systolic function in patients with ischemic cardiomyopathy has been controversial in the literature. Objective: To study the effect of exercise-based cardiac rehabilitation (EBCR) on left ventricular (LV) systolic function and exercise stress parameters (METs achieved, HR recovery and HR reserve) in post anterior STEMI patients with ischemic cardiomyopathy (EF≤45%). Patients and methods: The study included 50 patients with ischemic cardiomyopathy (Post anterior STEMI successfully treated by 1ry PCI) referred for cardiac rehabilitation unit at Ain Shams University Hospitals. The patients were subjected to 3 months of formal exercise based cardiac rehabilitation. Before the CR program, they were subjected to a symptom-limited exercise test (modified Bruce protocol) to exclude any remaining ischemia and calculate enrolment HR reserve, baseline heart rate recovery in 1st minute and 2nd minute (HRR1 and HRR2). Another symptom-limited exercise test was done post CR program to assess the forementioned exercise parameters after completion of the program. Echocardiography was done at baseline and after completion of the CR program for assessment of LV systolic function by ejection fraction (assessed by 2D Simpson’s method) and peak longitudinal strain of the left ventricle (measured using speckle tracking echocardiography). Results: Exercise-based cardiac rehabilitation was associated with significant improvement in LV systolic function as reflected by significant improvement in Global longitudinal strain (GLS) (P-value = 0.0001) in patients with ischemic heart failure. CR was also associated with improvement in the functional capacity as reflected by the improvement in METs as well as in the HRR and HR reserve (P-value = 0.0001). However, there was no significant change regarding EF before and after cardiac rehabilitation (P-value= 0.4582).

Epicardial Adipose Tissue and Left Ventricular Systolic Function in Rheumatoid Arthritis Assessed by Two-Dimensional Speckle Tracking Echocardiography.

Introduction Epicardial adipose tissue (EAT) is an emerging cardiovascular biomarker. Subclinical left ventricular (LV) systolic dysfunction is common in rheumatoid arthritis (RA). The aim of this study was to assess LV systolic function using two-dimensional speckle tracking echocardiography (2D-STE) and investigate its association with EAT in RA patients without clinical cardiovascular disease (CVD). Methods 60 RA patients without manifestations of CVD and 60 age- and gender-matched healthy controls have been recruited for the study. We assessed LV systolic function and EAT in all subjects using conventional echocardiography and 2D-STE. EAT was measured as the relative echo-free region between the free wall of the right ventricle and the visceral layer of the pericardium at end-systole. Results Global longitudinal strain (GLS) was decreased and EAT was increased in the RA group compared to the control group. GLS was reduced as EAT increased in RA patients (r=-0.273, P=0.035). After adjusting for confounders, multivariate linear regression analysis revealed a weakened correlation between EAT and GLS.Age and disease activity scores28 were independent factors influencing GLS in RA. Conclusion RA patients have significantly thickened EAT compared with controls. 2D-STE can detect early LV myocardial systolic dysfunction in RA, as shown by lower GLS.Accumulation of EAT is associated with lower GLS, but older age and higher disease activity may play a greater role in LV myocardial systolic dysfunction in RA.

How to use MRI in cardiac disease with diastolic dysfunction?

Left ventricular (LV) diastolic dysfunction (DD) is an initially asymptomatic condition that can progress to heart failure, either with preserved or reduced ejection fraction. As such, DD is a growing public health problem. Impaired relaxation, the first stage of DD, is associated with altered LV filling. With progression, reducing LV compliance leads to restrictive cardiomyopathy. While cardiac magnetic resonance (CMR) imaging is the reference for LV systolic function assessment, transthoracic echocardiography (TTE) with Doppler flow measurements remains the standard for diastolic function assessment. Rather than simply replicating TTE measurements, CMR should complement and further advance TTE findings. We provide herein a step-by-step review of CMR findings in DD as well as imaging features which may help identify the underlying cause.

Quantitative assessment of left ventricular myocardial work in patients with different types of atrial fibrillation by non-invasive pressure-strain loop technique.

This study aimed to analyze myocardial work in patients with atrial fibrillation (AF) using a noninvasive pressure strain loop (PSL) technique to provide a basis for the quantitative assessment of left ventricular (LV) systolic function. LV myocardial work of 107 AF patients (56 with paroxysmal atrial fibrillation and 51 with persistent atrial fibrillation) and 55 healthy individuals were assessed by the noninvasive PSL and then compared. Global longitudinal strain (GLS) in absolute values, global work index (GWI), global constructive work (GCW), and global work efficiency (GWE) were significantly lower in the AF group than control group, whereas peak strain dispersion (PSD) and global wasted work (GWW) were significantly higher (P<.05). Further subdivision according to the AF type revealed that, compared with the controls, GLS in absolute values and GWE decreased significantly; PSD and GWW increased significantly in the paroxysmal AF group (P<.05). Nevertheless, GWI and GCW were not significantly different between paroxysmal AF and control groups (P>.05). Compared to paroxysmal AF, persistent AF induced a further decrease in absolute GLS and GWE and a further increase in GWW (P<.05), but PSD did not increase further (P>.05). Multiple linear regression analysis showed that GWI and GCW were independently associated with systolic blood pressure. GWW was associated with types of AF and left atrial volume index (LAVI). GWE was correlated with age, types of AF, disease duration, and LAVI. Receiver operating characteristic curve analysis showed that the area under the curve predicting myocardial injury was higher for GWE and GWW than for GLS (area under the curve: .880, .846, and .821, respectively). Non-invasive PSL can quantitatively assess LV systolic function in patients with different kinds of AF and detect early subclinical myocardial injury in patients with paroxysmal AF. GWE and GWW outperform GLS and LV ejection fraction when assessing myocardial injury. Systolic blood pressure, type of AF, LVAI, disease duration, and age may be associated with myocardial injury in patients with AF.

Diagnostic value of non-invasive indicators of myocardial function in patients after myocardial infarction

Aim. To study the diagnostic value of myocardial function parameters to assess their predictive ability in relation to left ventricular (LV) global contractility in patients after myocardial infarction (MI).Material and methods. The final analysis included 97 patients with MI aged 55,9±8,6 years. We performed standard two-dimensional echocardiography and speckle tracking echocardiography with analysis of following myocardial function parameters: global work index (GlobalWI, mm Hg %); global constructive work (GlobalCW, mm Hg %); global wasted work (GlobalWW, mm Hg %); global work efficiency (GlobalWE). The probability of ejection fraction (EF) reduction was analyzed using ROC curves using three criteria. The function parameters with the maximum sum of sensitivity and specificity were selected as the cut-off point.Results. On days 7-9 after MI, depending on the EF, patients were divided into 3 groups: "REF" — patients with EF &lt;40%); "MREF" — with EF from 40 to 49%, and "PEF" — patients with EF ³50%. By the 24th week, GlobalWI increased by 23% in the PEF group and by 33% in the MREF group. In the REF group, there was a gradual decrease in GlobalWI until the end of the study. In the PEF group, GlobalCW increased by 21% by week 24. By the end of follow-up, an increase in GlobalWW of 15% was observed in the REF group. GlobalWI, GlobalCW and GlobalWW were found to have the highest sensitivity values (60%) for reduced EF, ranging from 4049% at 24 weeks from the index event. GlobalWW had the highest specificity value (80%). With regard to a decrease in EF &lt;40% by week 24, the GlobalWW had the highest sensitivity (50%) and specificity (70%).Conclusion. Parameters of myocardial function have diagnostic and prognostic value for assessing LV systolic function after MI. Already in the acute period, myocardial function parameters can be used to determine the risk of decreased LV global contractility.

Myocardial Performance Index by Pulsed Wave Doppler versus Tissue Doppler Echocardiography in Left Ventricular Systolic Function Assessment

Myocardial Performance Index by Pulsed Wave Doppler versus Tissue Doppler Echocardiography in Left Ventricular Systolic Function Assessment

Evidence-Based Clinical Decision Support to Improve Care for Patients Hospitalized With Acute Myocardial Infarction.

Clinical decision support in the EHR is an innovation that can support guideline adherence in acute myocardial infarction. Cardiac rehabilitation referral and left ventricular systolic function assessment are part of evidence-based clinical practice guidelines associated with reduced morbidity and mortality following acute myocardial infarction. Effective clinical decision support is sustained by evidence-based principles for design and implementation. This quality improvement project evaluated the impact of practice advisories designed using principles of effective clinical decision support design to improve performance of left ventricular systolic function assessment and ambulatory referral to cardiac rehabilitation for patients hospitalized with acute myocardial infarction. Performance in cardiac rehabilitation referral and left ventricular systolic function assessment was measured for a 3-month interval pre- and post-intervention. Pre-implementation, cardiac rehabilitation referral or valid documented reason for non-referral was 80.3%. Rehabilitation referral or documented valid reason for non-referral increased to 98.4% post-implementation (P < .001). Left ventricular systolic function assessment increased from 94.2% to 100% following clinical decision support implementation (P = .120). This quality improvement project supports the positive impact of effective clinical decision support design and implementation to improve outcomes for patients hospitalized with acute myocardial infarction.

Evaluation of echocardiographic abnormalities in children with end-stage renal disease (CKD stage 5): A single-center experience

BackgroundChronic Kidney disease (CKD) stage V might gradually induce the occurrence of morphological and functional cardiac disturbances; these cardiac disturbances make up supplementary risk factors. ObjectiveThe study aimed to describe electrocardiographic (ECG) and Echocardiographic (Echo) findings in dialysis patients. Also, to define the correlation between Echo findings and dialysis modality. MethodsWe studied 27 dialysis patients aged 3 years and one month to 25 years (163 ± 77 months. Boys accounted for 59.3 % of the patients. The modality of dialysis was peritoneal dialysis (PD) in 33.3 % and hemodialysis (HD) in 51.9 % of cases. Four patients (14.8 %) had undergone both modalities at different times. All patients were taken ECG and Doppler 2D echocardiography (Echo). Assessment of LV systolic function was done according to ejection fraction (EF) and categorized as normal (≥55 %), mild systolic dysfunction (45–54 %), moderate systolic dysfunction (30–44 %), and severe systolic dysfunction (<30 %) . ResultsThe most common abnormalities in ECG were left ventricular hypertrophy (70.4 %), prolonged QTC interval (33.3 %), and first-degree atrioventricular block (25.9 %), respectively. Based on the ejection fraction, 40.7 %, 33.3 %, and 26 % of the patients had normal systolic function, mild systolic dysfunction, and moderate systolic dysfunction, respectively. Also, left ventricular (LV) volume in both diastole and systole were significantly lower in PD compared to HD cases (P = 0.006 and 0.004). ConclusionsWe found that abnormal findings in ECG are common among pediatric dialysis patients. Additionally, Echo's assessment noted that systolic dysfunction was common. Significantly lower LV volume in diastole and systole in PD compared to HD cases may suggest that PD patients encounter less pressure and volume loads. These findings can be considered a positive point of PD modality.

Left ventricular systolic function in subjects conceived through assisted reproductive technologies.

Over the past decades, assisted reproductive technologies (ART) have gained remarkable influence in the treatment of infertility and account for more than 2 % of births in European countries nowadays. Accumulating evidence suggests ART to cause cardiovascular alterations, including left ventricular (LV) dysfunctions, within its offspring. The aim of this study was to assess LV systolic function in subjects conceived through ART in comparison to spontaneously conceived peers. For the assessment of LV morphology and LV function, M-Mode echocardiography, pulsed wave Doppler and two-dimensional speckle tracking echocardiography (2DSTE) were applied. LV ejection fraction (EF) and fractional shortening (FS) were assessed in M-Mode and calculated by Teichholz formula. EF was additionally assessed semiautomatically through 2DSTE. In total, 64 ART subjects and 83 spontaneously conceived controls with no significant differences in age (12.52 ± 5.64 years vs. 13.20 ± 5.95 years, p = 0.486) and sex were included in the analysis. In the ART cohort, significantly lower values were observed for M-Mode assessed EF (63.63 ± 5.17 % vs. 65.35 ± 5.10 %, p = 0.046) and FS (34.26 ± 3.87 % vs. 35.60 ± 3.84 %, p = 0.038). However, after the adjustment for birth weight percentile and gestational age, M-Mode assessed EF and FS displayed no significant differences between both groups. LV morphology and remaining systolic function parameters, such as mitral annular plane systolic excursion, aortic velocity time integral, global peak longitudinal strain and 2DSTE measured EF, were comparable between both groups. This study suggests a lower LV systolic function in ART subjects, visualized by significantly lower values for M-Mode assessed EF and FS, compared to spontaneously conceived peers. The clinical relevance of these findings has to be investigated as the above-mentioned parameters were in normal reference range. In addition, LV systolic function parameters evaluated by other echocardiographic imaging modalities were comparable between both groups. Therefore, further studies will be required to evaluate the influence of ART on LV systolic function and cardiovascular morbidity in the future.

Possibilities of a portable electrocardiogram and pulse wave recorder in detecting left ventricular systolic dysfunction

Highlights. The article presents a novel and unique method for assessment of left ventricular systolic disfunction using electrocardiography and photoplethysmography data. This method will improve and simplify the detection of cardiovascular diseases.Aim. To evaluate left ventricular (LV) systolic function using electrocardiogram (ECG) and photoplethysmogram (PPG) signals recorded by a single-channel ECG and PPG-based monitor.Methods. The prospective study included 489 patients over 18 years old with various cardiovascular diseases. All participants underwent echocardiography to determine the main indicators of LV systolic function: LV ejection fraction (EF), LV outflow tract velocity time integral (LVOT VTI), and global longitudinal strain (GLS). Moreover, all patients underwent 1-lead ECG and PPG recording using a single-channel ECG and PPG-based monitor (CardioQvark). The obtained data were analyzed, and ROC curve analysis was performed.Results. We have identified ECG and PPG parameters associated with a decrease in LV contractile function. During the analysis, the ECG, T-wave amplitude (TA) and RonsF parameters showed the highest diagnostic accuracy. With EF below 55%, the area under the ROC curve (AUC) was 0.822, sensitivity (Se) 80%, specificity (Sp) 69% in EF below 55% in TA; in RonsF AUC was 0.743, Se 81%, Sp 77%. With EF below 40%, AUC was 0.915, Se 85%, Sp 83% in TA, and in RonsF AUC was 0.844, Se 82%, Sp 82%. Diagnostic accuracy of ECG signals in case of LVOT VTI lower than 16 cm was measured: TA (AUC 0.755, Se 82%, Sp 70%), RonsF (AUC 0.620, Se 77%, Sp 72%). PPG signals were not significantly associated with reduced EF; however, the pulse wave parameters were associated with lower LVOT VTI: in DP-B0 AUC was 0.687, Se 71%, Sp 74%. The combination of ECG and PPG signals was significantly associated with EF below 40% (RonsF * DP-SEP (AUC 0.877, Se 86%, Sp 85%). ECG and PPG signals were not associated with LV GLS.Conclusion. Assessment of LV systolic function can be performed by analyzing ECG and PPG signals recorded using a portable single-channel CardioQvark monitor.

Echocardiographic Assessment of Left Ventricular Myocardial Work

Prognosis in cardiac disorders is determined by left ventricular (LV) function and hence, its precise estimation is of utmost importance. Myocardial work is a new advanced technique based on computation by incorporating systolic blood pressure into strain analysis. The aim of this review article is to provide an overview and additive value of this technique for the assessment of LV systolic function. The article includes the evolution of this technique from invasive to noninvasive mode, the method of acquiring and measuring it, normal reference values, its role in various cardiac conditions as described in the current literature, and potential limitations.

Impact of Left Ventricular Global Longitudinal Strain on Outcomes After Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation

Assessment of left ventricular (LV) systolic function is essential in patient selection for transcatheter edge-to-edge repair (TEER) in secondary mitral regurgitation (MR). Although LV ejection fraction (EF) is mostly used for assessing LV function, it represents the change of LV chamber size, but not myocardial contractility. LV global longitudinal strain (GLS) provides an alternative to assess LV systolic function in patients with secondary MR. This study included 380 patients with secondary MR (mean age 71.0 ± 13.0 years; 61.1% male) who underwent TEER. Patients were dichotomized based on baseline LV GLS (more impaired GLS [<7.0%] vs less impaired GLS [≥7%]) based on existing literature. The primary outcome was all-cause mortality, whereas the secondary outcome was the composite end point of all-cause mortality and heart failure hospitalization. The mean LV GLS was 8.1 ± 3.8%, and 162 patients had GLS <7%. Patients with more impaired GLS (<7%) were more likely to be male (68.5% vs 55.5%; p=0.01) and have larger LV end-diastolic volume (110.5 ± 36.5 ml/m2 vs 92.9 ± 34.3 ml/m2; p <0.001) and lower LVEF (22.2 ± 8.9% vs 36.4 ± 14.5%; p <0.001) than those with less impaired GLS (≥7%). The number of clips used and residual MR were similar between the 2 groups. Patients with more impaired LV GLS (<7%) had significantly higher 2-year event rates of the primary outcome (38.2% vs 25.9%; log-rank p=0.003) and the secondary outcome (52.5% vs 36.3%; log-rank p <0.001). Multivariate analysis showed that LV GLS (<7%) was independently associated with the primary outcome (hazard ratio 1.65, 95% confidence interval 1.16 to 2.34, p=0.005) and the secondary outcome (hazard ratio 1.54, 95% confidence interval 1.08 to 2.20, p=0.016) whereas such associations were not observed with LVEF. In conclusion, LV GLS (<7%) was independently associated with a higher risk of adverse events in patients with secondary MR who underwent TEER.

The Value of Mitral valve E point septal separation as an index of assessment of left ventricular systolic function

Background and objectives: There are several methods of assessment of left ventricular function utilizing M-mode echocardiography, the most popular one being geometrically derived ejection fraction, for which its validity is compromised in case of abnormal geometry or regional wall motion abnormalities. Mitral valve E septal separation estimated by M mode echocardiography or cardiac magnetic resonance imaging can be used as an index of left ventricular systolic function assessment. The aim of this study is to assess the value of mitral valve E septal separation estimated by M mode echocardiography in evaluation of left ventricular systolic function in patients assessed in two hospitals in Erbil city. Methods: from March 2016 to May 2019, 564 patients were randomly selected in Rizgary and Erbil teaching hospitals were included in this study. For all cases; demographic data were recorded, echocardiography performed by cardiologists, ejection fraction estimated by the most appropriate method and mitral valve E septal separation estimated by M mode scanning. Results: Means of age, ejection fraction, mitral valve E septal separation were 52.4±14.8, 65.4±10.4% and 3.87±4.1 respectively. Male to female ratio was 0.64 (220/344). There was strong highly significant negative correlation between ejection fraction and E septal separation, value of 6.9 mm was the upper normal level representing ejection fraction of 55%. The sensitivity and specificity of mitral valve E septal separation more than 7 mm as a reference to low left ventricular systolic function were 100% and 99%. Conclusions: Mitral valve E septal separation is reliable and easily measurable index of assessment of left ventricular systolic function; value more than 7 mm is indicating abnormal systolic function with sensitivity of 100% and specificity of 99%.

Quantitative Echocardiography Improves Resident Assessment of Left Ventricular Systolic Function.

The use of echocardiography to assess left ventricular ejection fraction (LVEF) is an important component of anesthesiology resident education; however, there is no consensus on the most effective method for teaching this skill set. This study investigates the impact and feasibility of teaching a quantitative LVEF assessment method to anesthesiology residents, compared with teaching visual estimation techniques. We included all anesthesiology residents rotating through cardiac anesthesia at our institution from August 2020 through March 2021. Participants completed a pretest to assess baseline ability to accurately estimate LVEF. All tests consisted of transthoracic echocardiography images with standard views from 10 patients. Participants were assigned to either a control group that received teaching on visual estimation of LVEF or an intervention group that was taught quantitative LVEF assessment with the Simpson biplane method of discs. After 4 weeks, all participants were administered a postteaching exam. A retention exam was administered an additional 4 weeks later. LVEF accuracy was measured as the absolute difference between their LVEF estimation and the reference value. Control and intervention groups performed similarly on the preteaching exam of LVEF estimation accuracy. Intervention-group residents demonstrated significantly improved accuracy in LVEF assessment on the postteaching exam (3.6% improvement in accuracy, confidence interval [CI], 1.23-5.97; P = .03) compared with the control group (0.60% improvement inaccuracy, CI, -1.77-2.97; P = .62). The observed improvement was not maintained through the retention exam.Conclusions: Addition of quantitative LVEF assessment to traditional teaching of visual LVEF estimation methods significantly improved the diagnostic accuracy of anesthesiology residents' left ventricular systolic function assessment.

SYSTOLIC AND DIASTOLIC LEFT VENTRICULAR DYSFUNCTION IN CHILDREN WITH PRIMARY HYPERTENSION: A SYSTEMATIC REVIEW

Objective: Evaluation of left ventricular (LV) function provides important insights about target-organ damage in children with primary hypertension (PH). We aimed to summarize evidence about LV systolic and diastolic function in pediatric PH by performing a systematic review. Design and method: 718 papers (published between 2000–2021) retrieved by a liberal search strategy in PubMed database using keywords relevant to pediatric hypertension and LV underwent abstract and title screening and 37 underwent full-text review. 22 articles providing comparison of LV function parameters between children with PH and normotensive controls were selected. Results: Analysis included a total of 1430 children (age range: 5–21 years) with PH (6.7% white-coat). Reported prevalence of LV hypertrophy was 7.7–48% (n = 15 studies). Majority of studies used ultrasound and 1 used magnetic resonance imaging for LV function evaluation. None of 15 studies reporting systolic parameters such as fractional shortening or ejection fraction (EF) reported differences from controls except for 2 studies with lower EF within normal range. 5 studies used strain analysis for LV systolic function assessment with lowered strain in 60%. Strain parameters correlated with LV mass (n = 2), obesity indices (n = 2), blood pressure (BP) (n = 2) and other (age, sex, race and antihypertensive therapy; all n = 1). 5 studies evaluated Tei index with increased values in 60%. 1 study assessed first-phase EF (EF1) which was lower in children with PH and higher LV mass. Most studies evaluated diastolic function by E/A (n = 19) and E/e‘ (n = 16) that were impaired compared to controls in 47% and 94%, respectively. Measures of diastolic function correlated with LV mass (n = 3), obesity indices (n = 3), BP (n = 2), insulin resistance (n = 2), age (n = 2) and other (neutrophile-lymphocyte ratio, puberty, heart rate and EF1; all n = 1). Conclusions: Children with PH exhibit signs of impaired LV function with predominance of diastolic dysfunction. Conventional ultrasound measures appear to lack sensitivity, thus tissue Doppler imaging and strain analysis may be preferred measures to quantify subclinical LV dysfunction in children with PH.

Effects of late, repetitive remote ischaemic conditioning on myocardial strain in patients with acute myocardial infarction

Late, repetitive or chronic remote ischaemic conditioning (CRIC) is a potential cardioprotective strategy against adverse remodelling following ST-segment elevation myocardial infarction (STEMI). In the randomised Daily Remote Ischaemic Conditioning Following Acute Myocardial Infarction (DREAM) trial, CRIC following primary percutaneous coronary intervention (P-PCI) did not improve global left ventricular (LV) systolic function. A post-hoc analysis was performed to determine whether CRIC improved regional strain. All 73 patients completing the original trial were studied (38 receiving 4 weeks’ daily CRIC, 35 controls receiving sham conditioning). Patients underwent cardiovascular magnetic resonance at baseline (5–7 days post-STEMI) and after 4 months, with assessment of LV systolic function, infarct size and strain (longitudinal/circumferential, in infarct-related and remote territories). At both timepoints, there were no significant between-group differences in global indices (LV ejection fraction, infarct size, longitudinal/circumferential strain). However, regional analysis revealed a significant improvement in longitudinal strain in the infarcted segments of the CRIC group (from − 16.2 ± 5.2 at baseline to − 18.7 ± 6.3 at follow up, p = 0.0006) but not in corresponding segments of the control group (from − 15.5 ± 4.0 to − 15.2 ± 4.7, p = 0.81; for change: − 2.5 ± 3.6 versus + 0.3 ± 5.6, respectively, p = 0.027). In remote territories, there was a lower increment in subendocardial circumferential strain in the CRIC group than in controls (− 1.2 ± 4.4 versus − 2.5 ± 4.0, p = 0.038). In summary, CRIC following P-PCI for STEMI is associated with improved longitudinal strain in infarct-related segments, and an attenuated increase in circumferential strain in remote segments. Further work is needed to establish whether these changes may translate into a reduced incidence of adverse remodelling and clinical events. Clinical Trial Registration: http://clinicaltrials.gov/show/NCT01664611.

Assessment of novel echocardiographic indices of myocardial function in patients with significant primary mitral regurgitation

Abstract Funding Acknowledgements Type of funding sources: None. INTRODUCTION Assessment of left ventricular (LV) function in primary mitral regurgitation remains challenging due to ejection fraction preservation, even in late stages of the disease. Global longitudinal strain (GLS) remains a valuable tool for the assessment of systolic function which is affected, like ejection fraction, by loading conditions. Lately, novel methods, such as myocardial work estimated by echocardiography, have been developed in assessment of LV systolic function, along with left atrial strain in assessment of diastolic function. Early identification of systolic or diastolic dysfunction in primary mitral regurgitation is crucial for further management of these patients. PURPOSE In this study we assessed several indices of LV systolic and diastolic function, such as myocardial work, global longitudinal strain and left atrial strain, in patients with significant primary mitral regurgitation, in order to evaluate early myocardial dysfunction. METHODS We retrospectively assessed echocardiograms of 64 patients, referred to an echocardiography laboratory of a tertiary hospital between 2019 and 2021 with the diagnosis of significant primary MR. Measurements included several echocardiographic indices of LV anatomy and function, such as left atrial volume indexed (LAVi), left atrial strain, global longitudinal strain (GLS), pulmonary hypertension and global myocardial work. Finally we correlated various indices of systolic and diastolic function with severity of mitral regurgitation. RESULTS We analyzed echocardiograms of 64 patients (50 men, mean age 60 ± 13,8) with at least moderate organic MR, 75,8% of which had severe MR, and normal ejection fraction (mean EF 63%±4,9). We identified negative correlation between left atrial strain (reservoir) and pulmonary hypertension measurements (correlation coefficient -358, p &amp;lt; 0,05) in patients with at least moderate MR. However, we were not able to find any statistically significant differences in GLS (21,98 vs 22,26) or myocardial work, even though we noticed a difference in myocardial work between patients with moderate and severe MR (Global Work Index 2302mmHg% vs 2262mmHg% with normal values 2209 ± 307mmHg% in STAAB cohort, Global Constructed Work 2540mmHg% vs 2327mmHg%, Global Waste Work 136,89mmHg% vs 136,43mmHg%, Global Work Efficiency 94,22% vs 93,76%). CONCLUSIONS These data suggest that an early assessment of indices of diastolic function, such as left atrial strain linked to pulmonary hypertension, can guide to a more effective evaluation of patients with severe MR and normal systolic function. Additionally, novel indices of LV function less load-dependent, such as myocardial work, are promising tools in the assessment of left ventricle and early recognition of myocardial dysfunction in patients with severe organic MR, but more prospective studies are needed. Abstract Figure. Abstract Figure.

Comprehensive Assessment of the Left Ventricular Systolic Function in the Elderly with Acute Myocardial Infarction Using Echocardiography.

AimTo evaluate the left ventricular (LV) systolic function in elderly with non-ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI) using real-time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking imaging (STI).MethodsForty NSTEMI and forty STEMI patients after undergoing percutaneous coronary artery intervention (PCI) were enrolled. The myocardial segments were supplied by the infarct-related artery (Myo-IRA) which were indicated by the selective coronary arteriography (SCA). The LV end-diastolic volume (LVEDV), end-systolic volume (LVESV), stroke volume (LVSV) and ejection fraction (LVEF) were acquired by 4D LV Volume Tom Tec. LV longitudinal peak systolic strain (LPSS), radial peak systolic strain (RPSS), circumferential peak systolic strain (CPSS) of Myo-IRA segments, LV rotational peak degree in the base (rot-base) and in the apex (rot-apex), and twist were acquired by strain analysis software. Forty older healthy individuals were included as normal controls.ResultsThe LVEF of the NSTEMI and STEMI patients at 1 week after PCI were significantly lower (P<0.05), then, this parameter was improved in both groups after 3 months, but was still significantly lower than that of the controls (P<0.05). The LPSS, RPSS, CPSS of the Myo−IRA segments, rot−Base, rot−Apex and twist in both groups were significantly lower than those in the controls. The LPSS and CPSS of the Myo-IRA segments, rot−Base, rot−Apex and twist in NSTEMI patients were obviously higher than those in STEMI patients in 1 week and 3 months after PCI (P<0.05). After 3 months, the RPSS of NSTEMI patients was improved notably and was obviously higher than that of STEMI patients (P<0.05). All these values in STEMI and NSTEMI patients were improved after 3 months, apart from LPSS in STEMI patients (P>0.05), but were still significantly lower than those in the controls (P<0.05).ConclusionRT-3DE and STI can sensitively assess LV systolic function with different extents of transmural damage.

A narrative review of clinical applications of systolic time intervals

Systolic time interval (STI) estimation is an established noninvasive method for the quantifiable assessment of left ventricular (LV) performance in well-being and disease states; it stays valuable for clinical application and forms no burden to the subjects. This manuscript reviews the potential clinical applications and prognostic value of STI for the assessment of LV systolic function in cardiovascular disease (CVD). STIs could be obtained by several noninvasive imaging modalities such as transthoracic echocardiography, tissue Doppler imaging M-mode echocardiography, conventional echocardiography, and so on. In view of that, a literature review for studies reporting the clinical applications of STI in assessing LV systolic function among CVD patients was carried out using PubMed search. Accordingly, the current review describes how STI can be measured; reliability of cardiac time interval measurement in patients with CVD and its role in a clinical setting. With the advent of modern techniques, STI could be easily measured in a clinical setting. Likewise, STI parameter, particularly preejection period and LV ejection time ratio (PEP/LVET), has got the highest degree of correlation with LV ejection fraction (LVEF) in assessing LV performance. Furthermore, reproducibility of systolic ejection time (SET) achieved by the TDI M-mode method is outstanding and better when compared with the reproducibility of SET obtained by the conventional pulsed Doppler method. Furthermore, prolonged SET is independently related with enhanced outcomes among heart failure with reduced EF (HFrEF, i.e., EF ≤40%) but not HF with preserved EF (HFpEF, i.e., EF >40%) patients, indicating that stabilizing SET would be helpful in the case of systolic dysfunction. Clinically, tissue Doppler-derived time intervals could be beneficial to analyze abnormal cases in comparison with other invasive and noninvasive methods of ventricular function examination. Furthermore, phonoelectrocardiography-derived STI parameters, particularly electromechanical activation time-to-LVET ratio, may have a significant role in the diagnostic approach of heart failure (HF) in patients with undifferentiated dyspnea. In addition, in HF patients, PEP/LVET of >0.43 helps to detect LVEF <35% by pulsed Doppler echocardiography. Moreover, LVET continues to be an independent predictor of incident HF and provides incremental prognostic value on the future HF risk and death but not myocardial infarction. In conclusion, STI measurement could be useful, particularly in identifying LVEF <35% in the case of refractory HF patients. This could be beneficial in the selection of patients requiring cardiac resynchronization, specifically when accurate LVEF evaluation by echocardiography proves challenging in atrial fibrillation or if the evaluation is done by a trainee echocardiographer. Furthermore, the cardiac time intervals including SET can be acquired irrespective of rhythm. Good image quality is required for the assessment of LVEF. In contrast, evaluation of SET could be useful in the case of echocardiograms with poor quality images. As a final point, the present review suggests using an echocardiographic parameter like STIs to procure additional information regarding the risk of mortality in patients with HFrEF along with LVEF measurement.

Longitudinal strain measurement by 3D modelling from cine CMR: feasibility and comparison to 2D speckle tracking echocardiography

Abstract Background Global longitudinal strain (GLS) has emerged as a sensitive index of left ventricular (LV) systolic function with greater prognostic value than LV ejection fraction (LVEF) in a variety of cardiac disorders. While GLS is routinely derived from 2D speckle tracking echocardiography (STE) and feature tracking in cardiac magnetic resonance (CMR) imaging, calculation of strain via 3D geometric modelling enables analyses of deformation that are independent of 2D image plane constraints. Purpose We sought to compare longitudinal strain measurements extracted from geometric 3D analysis of CMR against values obtained from conventional 2D-STE. Methods Consecutive 2D-echocardiography (2D-echo) and steady-state free precession multiplanar cine CMR scans were performed in 80 prospectively recruited participants (48 healthy controls with LVEF range 53–74%, 30 patients with non-ischaemic cardiac disease with LVEF range 25–77%, and 2 heart transplant recipients with LVEF 53% and 58%), &amp;lt;1 hour apart. Average endocardial peak GLS from 2D-STE was calculated offline using vendor-independent clinical software from apical triplane (2, 3 and 4-chamber) images for each of the standardised LV walls (anterior, anteroseptal, inferoseptal, inferior, inferolateral, anterolateral). Dynamic 3D geometric models of the LV were reconstructed from 3 long- and 6 short-axis CMR slices over one cardiac cycle. Corresponding longitudinal strain measurements were then evaluated by extracting analogous endocardial arc lengths (apex to base of each LV wall) from the 3D LV model. Finally, an average peak GLS was calculated as the mean of the peak longitudinal strains in each LV wall. Results GLS measured by 2D-STE ranged between −6.5% and −27.9% for the study population. A two-way mixed-effects intraclass correlation coefficient (ICC) for absolute agreement of 0.820 (95% CI: [0.720, 0.885]) demonstrated good correlation between average GLS obtained from 2D-STE and CMR. A Bland-Altman analysis revealed a minimal bias (&amp;lt;1%) and 95% limits of agreement (LOA) between −6.3% and 5.5% (Fig. 1), with no apparent proportional bias. Comparatively lower correlation and wider LOA between longitudinal strains from 2D-STE and CMR were observed for each LV wall (Table I). Conclusions Fully automated calculation of LV GLS can be obtained from geometric 3D CMR analysis. Average peak GLS from cine CMR exhibits good agreement with 2D-STE, despite showing only moderate agreement at each LV wall. The increased discrepancy in regional longitudinal strain may be attributed to subjective plane positioning in 2D-echo, which can be expected to improve with advances in 3D-STE. The calculation of GLS by 3D geometric modelling may enhance the diagnostic value of routine cine CMR examinations for LV systolic function assessment. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Health Research Council (HRC) of New Zealand and National Heart Foundation (NHF) of New Zealand Figure 1. Bland-Altman analysisTable I. Regional correlations