Objectives: To evaluate therapeutic effect of CPAP therapy in patients presenting the association of severe sleep apnea syndrome and heart failure following myocardial infarction (MI). Materials and methods: Twelve patients with heart failure (III functional class) after myocardial infarction were examined. Echocardiography, cardiorespiratory monitoring (CRM) and 6 min walking test were evaluated for all patients. All patients received standard therapy with ACE-inhibitors, blockers, diuretics, antiaggregants and statins. Six patients were treated with CPAP therapy, the other six patients formed the control group. Results: At the beginning of the study all patients displayed the equal contractile left ventricular ejection fraction (EF), diastolic left ventricle volume (LVd), apnea– hypopnea index (AHI), and tolerance to physical exercises. By the 11th month of the study the patients of the CPAP group had showed the increased contractile ability of the left ventricle in comparison with the control (EF 49.6 ± 9.0% and 56.6 ± 9.9%, accordingly) and significant decrease in LVd (50.1 ± 1.5 mm and 55.1 ± 2.2 mm in CPAP and control groups correspondingly). Moreover, control patients displayed lower tolerance to physical exercises. Conclusion: The correction of impaired breathing in patients with cardiac insufficiency at the background of myocardial infarction history, significantly improved left ventricle function and patients’ tolerance to physical exercises, improving thus their life quality.