We propose a twin Pati-Salam (PS) theory of flavour broken to the G4321 gauge group at high energies, then to the Standard Model at low energies, yielding a TeV scale vector leptoquark {U}_1^{mu } (3, 1, 2/3) which has been suggested to address the lepton universality anomalies {R}_{K^{left(ast right)}} and {R}_{D^{left(ast right)}} in B decays. Quark and lepton masses are mediated by vector-like fermions, with personal Higgs doublets for the second and third families, which may be replaced by a two Higgs doublet model (2HDM). The twin PS theory of flavour successfully accounts for all quark and lepton (including neutrino) masses and mixings, and predicts a dominant coupling of {U}_1^{mu } (3, 1, 2/3) to the third family left-handed doublets. However the predicted mass matrices, assuming natural values of the parameters, are not consistent with the single vector leptoquark solution to the {R}_{D^{left(ast right)}} anomaly, given its current value.
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