Left Frontal Cortical Activity Research Articles

The Effect of Induced Regulatory Focus on Frontal Cortical Activity.

The motivation-direction model has served as the primary framework for understanding frontal cortical activity. However, research on the link between approach/avoidance motivation and left/right frontal cortical activity has produced inconsistent findings. Recent studies suggest that regulatory systems may offer a more accurate explanation than the motivational direction model. Despite being regulatory systems, the relationship between regulatory focus and frontal cortical activity has received limited attention. Only one experimental study has explored this connection through correlational analysis, yet it lacks causal evidence. The present study aimed to address this gap by manipulating regulatory focus and measuring frontal cortical activity in 36 college students. Our results revealed that induced promotion focus led to increased left frontal cortical activity, whereas induced prevention focus led to increased right frontal cortical activity. These findings enhance our physiological understanding of regulatory focus and offer a deeper explanation of how regulatory focus influences alterations in psychology and behavior.

Neuropsychological Evidence Underlying Counterclockwise Bias in Running: Electroencephalography and Functional Magnetic Resonance Imaging Studies of Motor Imagery

We aimed to answer the question "why do people run the track counterclockwise (CCW)?" by investigating the neurophysiological differences in clockwise (CW) versus CCW direction using motor imagery. Three experiments were conducted with healthy adults. Electroencephalography (EEG) was used to examine hemispheric asymmetries in the prefrontal, frontal, and central regions during CW and CCW running imagery (n = 40). We also evaluated event-related potential (ERP) N200 and P300 amplitudes and latencies (n = 66) and conducted another experiment using functional magnetic resonance imaging (fMRI) (n = 30). EEG data indicated greater left frontal cortical activation during CCW imagery, whereas right frontal activation was more dominant during CW imagery. The prefrontal and central asymmetries demonstrated greater left prefrontal activation during both CW and CCW imagery, with CCW rotation exhibiting higher, though statistically insignificant, asymmetry scores than CW rotation. As a result of the fMRI experiment, greater activation was found during CW than during CCW running imagery in the brain regions of the left insula, Brodmann area 18, right caudate nucleus, left dorsolateral prefrontal cortex, left superior parietal cortex, and supplementary motor area. In the ERP experiment, no significant differences were found depending on direction. These findings suggest that CCW rotation might be associated with the motivational approach system, behavioral activation, or positive affect. However, CW rotation reflects withdrawal motivation, behavioral inhibition, or negative affect. Furthermore, CW rotation is understood to be associated with neural inefficiency, increased task difficulty, or unfamiliarity.

Scarcity Enhances Outcome Evaluation in the Present: Electroencephalography Evidence.

Scarcity goods have generally been perceived as high in value in real-world and empirical studies. However, few studies have investigated this value over time, such as performance in intertemporal decision making. This study's chief objective was to determine how scarcity evaluation changes temporally. We used the electroencephalogram technique and an outcome evaluation task with the valuation of scarcity and ordinary rewards delivered at different times to explore the effect of scarcity on delay discounting. The feedback-related negativity (FRN) results show that ordinary goods were associated with a more negative amplitude than scarcity goods, and that rewards delivered in the future evoked more negative deflection compared to those delivered immediately. The prominent FRN effect was derived mainly from ordinary trials rather than scarcity trials in the immediate condition and in the future rather than only in the immediate condition. The Frontal Asymmetry Index (FAI) results show that the scarcity condition was associated with greater relative left frontal cortical activity than the ordinary condition when delivered immediately. The frontal asymmetry indicated greater approach motivation. Our electrophysiology data indicate that scarcity goods have a perceived high value, particularly when delivered immediately.

Electroencephalographic Signature of Negative Self Perceptions in Medical Students.

Frontal alpha asymmetry (fAA) is purported to be a neurophysiological marker for anxiety and depression. Higher left frontal alpha EEG voltage is associated with lower left and higher right frontal cerebral cortical activation, indicative of right-sided fAA. This pilot study tests the hypothesis that greater left-sided frontal alpha voltage is associated with negative thoughts about oneself. A group of eight healthy 28-41-year-old right-handed male medical students were subjected to an extensive interactive self-report inventory (ISI) evaluating perceptions of their psychosocial interactions. Quantitative EEG (qEEG) was performed with eyes closed. Computations of fAA and related parameters were based on measurements in the alpha bandwidth (8-13 Hz) at the left frontal F7 and right frontal F8 scalp electrodes. fAA was the percent difference between mean voltages at F8 minus that at F7. Significance of associations between fAA and the ISI scores was determined by Pearson’s product-moment correlation coefficient, at P≤0.05. “Depressed” scores were positively correlated with right-sided fAA (P=0.01). “Relaxed” (P=0.05), “regulated” (P=0.02), “cooperative” (P=0.05) and “dependent scores” (P=0.004) were negatively correlated with right-sided fAA. These findings imply that right-sided fAA may be associated with more perceptions of “depressed” psychosocial interactions involving negative thoughts about oneself, as well as, more reliance on others (“dependence” score), less sharing (“cooperative” ISI score), less trust (“regulated” ISI score) and less initiative (“relaxed” ISI score). These results support the hypothesis that right-sided fAA may identify individuals with a predilection for negative thoughts about themselves and other negatively-valenced perceptions of their psychosocial interactions.

EEG neurofeedback improves cycling time to exhaustion

ObjectiveThe role of the brain in endurance performance is frequently debated; surprisingly, few investigations have attempted to improve endurance performance by directly targeting brain activity. One promising but untested approach to modifying brain activity is electroencephalogram (EEG) neurofeedback. Consequently, our experiment is the first to examine an EEG neurofeedback intervention for whole-body endurance performance. MethodWe adopted a two-part experiment. The first consisted of a randomized parallel controlled design. Forty participants were allocated to three experimental groups; increase relative left cortical activity (NFL), increase relative right (NFR), and passive control (CON). They performed a depleting cognitive task, followed by either six 2-min blocks of EEG neurofeedback training (NFL or NFR) or time-matched videos of the neurofeedback display (CON). Next, they performed a time-to-exhaustion (TTE) test on a cycle-ergometer. We then tested participants of NFL and NFR groups in an additional experimental visit and administered the opposite neurofeedback training within a fully repeated-measures protocol. ResultsEEG neurofeedback modified brain activity as expected. As hypothesized, the NFL group cycled for over 30% longer than the other groups in the parallel controlled design, NFL: 1382 ± 252 s, NFR: 878 ± 167, CON: 963 ± 117 s. We replicated this result in the repeated-measures design where NFL: 1167 ± 831 s performed 11% longer than NFR: 1049 ± 638 s. There were no differences in pre-exercise fatigue, vigor or self-control; area under the curve group-differences for perceived effort were interpreted within a goal persistence framework. ConclusionThe brief EEG neurofeedback intervention elicited greater relative left frontal cortical activity and enhanced endurance exercise performance.

Electrocortical brain oscillations and social anxiety disorder: a pilot study of frontal alpha asymmetry and delta-beta correlation

The main objective of the present study is to investigate whether socially anxious individuals and healthy control show recognizable electroencephalographic (EEG) patterns in the frontal brain during baseline and recovery states. Towards this goal, this study recruited eight participants to examine the severity of social anxiety disorder (SAD) on EEG oscillations through the study of electrocortical frontal alpha asymmetry (FAA) and delta–beta correlation. A group of healthy male participants was chosen (consisting of 4 SAD and 4 HC individuals), and they were assessed by using Social Interaction Anxiety Scale (SIAS) to determine the level of social anxiety. Frontal EEG oscillations were measured to investigate the delta-beta correlation and frontal alpha asymmetry in baseline tasks (eyes opened and eyes closed) and recovery from social tasks (speaking in front of camera). As an outcome, Delta-beta coupling in SAD has shown greater correlation in baseline condition (eyes closed, and eyes open) than the recovery task, unlike HC individuals who exhibited greater correlation in recovery state more than baseline state. For frontal alpha asymmetry, SDA participant have shown greater left frontal cortical activity, whereas HC participants have demonstrated greater right frontal cortical activity. Taking all together, the reported findings indicate that delta-beta correlation and alpha asymmetry are presumptive EEG biomarkers of social anxiety.

The influence of maternal anxiety and depression symptoms on fNIRS brain responses to emotional faces in 5- and 7-month-old infants

Greater relative right (versus left) frontal cortical activation to emotional faces as measured with alpha power in the electroencephalogram (EEG), has been considered a promising neural marker of increased vulnerability to psychopathology and emotional disorders. We set out to explore multichannel fNIRS as a tool to investigate infants’ frontal asymmetry responses (hypothesizing greater right versus left frontal cortex activation) to emotional faces as influenced by maternal anxiety and depression symptoms during the postnatal period. We also explored activation differences in fronto-temporal regions associated with facial emotion processing. Ninety-one typically developing 5- and 7-month-old infants were shown photographs of women portraying happy, fearful and angry expressions. Hemodynamic brain responses were analyzed over two frontopolar and seven bilateral cortical regions subdivided into frontal, temporal and parietal areas, defined by age-appropriate MRI templates. Infants of mothers reporting higher negative affect had greater oxyhemoglobin (oxyHb) activation across all emotions over the left inferior frontal gyrus, a region implicated in emotional communication. Follow-up analyses indicated that associations were driven by maternal depression, but not anxiety symptoms. Overall, we found no support for greater right versus left frontal cortex activation in association with maternal negative affect. Findings point to the potential utility of fNIRS as a method for identifying altered neural substrates associated with exposure to maternal depression in infancy.

I'm tired and feel like drinking: Viewing alcohol cues after exerting self-control increases approach motivation among individuals lower in alcohol sensitivity.

Exerting self-control depletes capacity for future self-control, which can promote greater alcohol use. However, certain populations may be more susceptible to these effects of depleted self-control capacity. For example, individuals with lower alcohol sensitivity (i.e., requiring more drinks to experience the effects of alcohol) are a high-risk group who are likely to engage in hazardous alcohol use and develop an alcohol use disorder. Those lower in alcohol sensitivity also exhibit heightened motivational reactivity in response to alcohol-related cues, which may be enhanced following exertion of self-control. However, whether drinkers lower in alcohol sensitivity are at higher risk for exhibiting greater motivations toward alcohol-related cues after exerting self-control is unclear. The current research examined the role of alcohol sensitivity in predicting approach motivation following exertion of self-control. It was expected drinkers exerting self-control would exhibit greater orientation toward rewarding cues, particularly after viewing alcohol-related cues. However, we predicted this pattern would be most prominent among drinkers lower in alcohol sensitivity. Experiment 1 supported these hypotheses, with lower alcohol sensitivity predicting greater approach motivation among drinkers required to exert self-control prior to viewing alcohol-related compared to neutral cues. Experiment 2 aimed to replicate these findings by assessing asymmetrical frontal cortical activation, an index of approach motivation. Drinkers with lower alcohol sensitivity exhibited greater relative left frontal cortical activation, consistent with approach motivation, while viewing alcohol-related cues following exertion of self-control. Results have implications for interventions aimed at identifying those at risk for greater alcohol motivations during states of mental exhaustion. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Effortful control of motivation, not withdrawal motivation, relates to greater right frontal asymmetry

Past models of frontal asymmetry have associated greater relative right frontal cortical activity with greater withdrawal motivation and greater relative left frontal cortical activity with greater approach motivation. However, this traditional model of frontal asymmetry leaves little to no room for the control processes that engage and regulate these emotional and motivational systems. A growing body of literature suggests that greater relative right frontal activation may be associated with greater regulatory control (Gable et al. 2018). However, this work confounded regulatory control and motivational direction. The current studies sought to test the competing hypotheses that currently exist in the literature by examining whether greater right frontal activation is more closely associated with regulatory control or withdrawal motivation. In Study 1, participants listened to negative and neutral sounds while suppressing their emotional reactions or listening naturally. Greater relative right frontal activation during the sound clips was associated with participants' reported effort when attempting to suppress their motivational responses to negative stimuli. Greater relative right frontal activation did not relate to experiencing negative affect. In Study 2, participants could win money by looking at a negative or neutral image or escape from looking at them for no reward. Greater relative right frontal activation was associated with looking at the negative pictures longer when there was a possibility of reward, but not when the possibility of reward was absent. Together, these studies suggest that it is the affective control of emotion rather than negative affect driving greater relative right frontal asymmetry. Additionally, these studies suggest that motivational conflicts engage effortful control.

Resting frontal EEG asymmetry in adolescents with major depression: Impact of disease state and comorbid anxiety disorder

ObjectiveGreater relative right- than left-frontal cortical activity has been frequently found in adults with major depression (MD). As the few studies in adolescents with MD have been inconclusive, the aim of this study was to assess frontal alpha asymmetry (FAA) in an adolescent sample with MD whilst taking into account possible confounding variables such as disease state and comorbid anxiety disorder. MethodsAn 8-minute resting frontal EEG was assessed in 34 healthy controls (HCs), 16 adolescents with MD in remission without comorbid anxiety disorder (rMDa−), 22 adolescents with acute depression without comorbid anxiety disorder (MDa−), and 23 adolescents with acute depression and comorbid anxiety disorder (MDa+). Alpha power was analyzed over corresponding frontal Regions of Interests. ResultsCompared to HCs, MDa+ adolescents demonstrated more left- than right-sided EEG alpha power, indicating greater right-than left-frontal cortical activity. No other group differences emerged. ConclusionsThe results suggest that greater relative right-frontal cortical activity in adolescent MD is not a result of disease state but can be attributed to comorbid anxiety disorder. SignificanceResults suggest that FAA is not linked to adolescent depression per se and highlight the importance of considering comorbid disorders when examining asymmetry patterns in adolescent MD.

Social power and frontal alpha asymmetry

ABSTRACTRecent studies have shown that the states of high and low social power (the ability to control or influence another’s thoughts, feelings, or behaviours) are related to left and right frontal hemisphere activity, respectively, suggesting a connection with two neurobiological motivational systems—the Behavioural Activation and Inhibition Systems. However, an important and outstanding question is which state of social power is associated with differences in hemispheric activity. In the current study, we addressed this outstanding issue by examining differences in frontal alpha asymmetry while participants engaged in an established episodic recall task, priming states of high, low, or neutral social power. Our results showed that it was the low social power state that was associated with hemispheric differences; that is, the low social power state was associated with significantly less left-frontal cortical activity relative to both the high and neutral social power states, while the latter two states did not differ. We discuss our results considering previous work on social power and the notion that different social power states are associated with different cognitive and behavioural tendencies.

Positive and Negative Emotionality at Age 3 Predicts Change in Frontal EEG Asymmetry across Early Childhood.

Depression is characterized by low positive emotionality (PE) and high negative emotionality (NE), as well as asymmetries in resting electroencephalography (EEG) alpha power. Moreover, frontal asymmetry has itself been linked to PE, NE, and related constructs. However, little is known about associations of temperamental PE and NE with resting EEG asymmetries in young children and whether this association changes as a function of development. In a longitudinal study of 254 three-year old children, we assessed PE and NE at age 3 using a standard laboratory observation procedure. Frontal EEG asymmetries were assessed at age 3 and three years later at age 6. We observed a significant three-way interaction of preschool PE and NE and age at assessment for asymmetry at F3-F4 electrode sites, such that children with both low PE and high NE developed a pattern of increasingly lower relative left-frontal cortical activity over time. In addition, F7-F8 asymmetry was predicted by a PE by time interaction, such that the frontal asymmetry in children with high PE virtually disappeared by age 6. Overall, these findings suggest that early temperament is associated with developmental changes in frontal asymmetry, and that the combination of low PE and high NE predicts the development of the pattern of frontal symmetry that is associated with depression.

Risky economic choices and frontal EEG asymmetry in the context of Reinforcer-Sensitivity-Theory-5.

This study investigated individual risky choice behavior in a gambling task and its relation with traits proposed by the Reinforcer-Sensitivity-Theory-5 (RST-5; Corr & McNaughton in Neuroscience and Biobehavioral Reviews, 36(10), 2339-2354, 2012) as well as with frontal EEG asymmetry. As assumed by the RST-5, the results showed independent influences of approach/avoidance and gain/loss sensitivities on participants' behavior in risky choices. Individual approach/avoidance sensitivity was predicted by trait measures of the behavioral approach system (BAS) and the behavioral inhibition system (BIS), while no such correlation was present for gain/loss sensitivity. EEG recordings revealed relatively stronger left-frontal cortical activity for trials with approach motivation compared to conflict and avoidance motivation. On the individual level, relatively stronger left-frontal cortical activity was associated with trait BAS. In addition, activity changes in frontal EEG asymmetry were associated relatively higher behavioral approach sensitivity. We conclude that frontal EEG asymmetry is an especially useful neuronal marker of BAS sensitivity and that the traits proposed by the RST-5 (measured by frontal EEG asymmetry and self-report) can be used to explain individual differences in risky choice behavior.

Depression symptom dimensions and asymmetrical frontal cortical activity while anticipating reward.

Unipolar depression has been characterized as involving diminished approach motivation and reward sensitivity. A psychophysiological indicator of approach motivation involves an asymmetry in frontal EEG activity, such that greater left relative to right frontal cortical activity indicates increased approach motivation. Consistent with the perspective of reduced approach motivation tendencies, depression has been associated with decreased relative left frontal cortical activity. To date, supporting research has primarily relied on categorical diagnoses or composite symptom counts. However, given the heterogeneity in depression, it is unclear what specific symptom dimensions relate to decreased relative left frontal cortical activity. The present study examined the association between multiple depression symptom dimensions and asymmetrical frontal cortical activity while anticipating reward in separate undergraduate (n = 75) and clinical samples (current major depressive disorder [n = 68] and never depressed controls [n = 67]). All participants completed the Inventory of Depression and Anxiety Symptoms, a self-report measure of factor-analytically derived symptom dimensions. Frontal cortical activity was assessed during a computerized slot machine task while participants anticipated potential monetary reward or no incentive. In undergraduates with low depression symptoms and never depressed controls, reward trials relative to no-incentive trials elicited greater relative left frontal cortical activity. Furthermore, in both samples across all participants, increased dysphoria and lassitude symptoms were associated with decreased relative left frontal cortical activity while anticipating reward. The present study suggests that depression symptoms consistent with motivational disengagement are associated with decreased relative left frontal cortical activity.

On the role of asymmetric frontal cortical activity in approach and withdrawal motivation: An updated review of the evidence.

We review conceptual arguments and research on the role of asymmetric frontal cortical activity in emotional and motivational processes. The current article organizes and reviews research on asymmetrical frontal cortical activity by focusing on research that has measured trait (baseline) frontal asymmetry and related it to other individual differences measures related to motivation (e.g., anger, bipolar disorder). The review also covers research that has measured state frontal asymmetry in response to situational manipulations of motivation and emotion and as an intervening variable in motivation-cognition interactions. This review concludes that much research supports the view that greater left than right frontal cortical activity is associated with greater positively or negatively valenced approach motivation. The view that greater right than left frontal cortical activity is associated with withdrawal motivation, although supported, has received less empirical attention. In addition to reviewing research on the emotive functions of asymmetric frontal cortical activity, the reviewed research illustrates the need to consider motivational direction as separate from affective valence in conceptual models of emotional space.

Effects of positive emotion, extraversion, and dopamine on cognitive stability-flexibility and frontal EEG asymmetry.

The influence of positive emotions on the balance between cognitive stability and flexibility has been suggested to (a) differ among various positive emotional/motivational states (e.g., of varying approach motivation intensity), and (b) be mediated by brain dopamine (DA). Frontal EEG alpha asymmetry (ASY) is considered an indicator of approach motivational states and may be modulated by DA. The personality trait of extraversion is strongly linked to positive emotions and is now thought to reflect DA-based individual differences in incentive/approach motivation. The present study independently manipulated positive emotion (high approach wanting-expectancy [WE] vs. low approach warmth-liking [WL]) and dopamine (placebo vs. DA D2 blocker sulpiride) to examine their effects on both cognitive stability-flexibility and emotion-related ASY changes. The results showed numerically lower stability-flexibility in WE versus WL under placebo and a complete reversal of this effect under the D2 blocker, no differentiation between WE and WL groups in terms of emotion-related ASY change, but an association between self-reported WE and WL and ASY changes toward left and right frontal cortical activity, respectively. Finally, extraversion was positively associated with both stability-flexibility and ASY changes toward left frontal cortical activity under placebo, and these associations were completely reversed under the D2 blocker. The results (a) support a dopaminergic basis for frontal EEG asymmetry, extraversion, and the modulating effect of positive emotions on stability-flexibility, and (b) extend previous reports of cognitive differences between introverts and extraverts.

The relationship of approach/avoidance motivation and asymmetric frontal cortical activity: A review of studies manipulating frontal asymmetry

The balance between activity in the left and right frontal cortex, commonly referred to as asymmetric frontal cortical activity, has served as a proxy for an organism's motivational direction (i.e., approach vs. avoidance). Many studies have examined the influence of the manipulation of motivational direction on asymmetrical frontal cortical activity and found results consistent with the idea that greater relative left (right) frontal cortical activity is associated with approach (avoidance) motivation. We critically review literature employing physical (versus psychological) manipulations of frontal asymmetry using a variety of methodologies including neurofeedback training, muscular contractions, and non-invasive brain stimulation. These reviewed methods allow us to make stronger causal inferences regarding the role of asymmetric frontal cortical activity in approach and avoidance motivation.

Individual differences in relative left frontal cortical activity and willingness to expend effort for reward

Individual differences in relative left frontal cortical activity and willingness to expend effort for reward

Jealousy increased by induced relative left frontal cortical activity.

Asymmetric frontal cortical activity may be one key to the process linking social exclusion to jealous feelings. The current research examined the causal role of asymmetric frontal brain activity in modulating jealousy in response to social exclusion. Transcranial direct-current stimulation (tDCS) over the frontal cortex to manipulate asymmetric frontal cortical activity was combined with a modified version of the Cyberball paradigm designed to induce jealousy. After receiving 15 min of tDCS, participants were excluded by a desired partner and reported how jealous they felt. Among individuals who were excluded, tDCS to increase relative left frontal cortical activity caused greater levels of self-reported jealousy compared to tDCS to increase relative right frontal cortical activity or sham stimulation. Limitations concerning the specificity of this effect and implications for the role of the asymmetric prefrontal cortical activity in motivated behaviors are discussed.

Exercising self-control increases relative left frontal cortical activation.

Self-control refers to the capacity to override or alter a predominant response tendency. The current experiment tested the hypothesis that exercising self-control temporarily increases approach motivation, as revealed by patterns of electrical activity in the prefrontal cortex. Participants completed a writing task that did vs did not require them to exercise self-control. Then they viewed pictures known to evoke positive, negative or neutral affect. We assessed electroencephalographic (EEG) activity while participants viewed the pictures, and participants reported their trait levels of behavioral inhibition system (BIS) and behavioral activation system (BAS) sensitivity at the end of the study. We found that exercising (vs not exercising) self-control increased relative left frontal cortical activity during picture viewing, particularly among individuals with relatively higher BAS than BIS, and particularly during positive picture viewing. A similar but weaker pattern emerged during negative picture viewing. The results suggest that exercising self-control temporarily increases approach motivation, which may help to explain the aftereffects of self-control (i.e. ego depletion).