Background: Based on the theoretical foundations of social support theory, empowerment theory and endogenous development theory, this study examines the relevant literature on "quality of life", "social services access", "socio-economic status", "organizational cooperation", "rehabilitation strategy" and "self-esteem" and other related literatures were sorted out. An exploratory study of the relationship between social service access, socioeconomic status, organizational cooperation, rehabilitation strategies, self-esteem and quality of life was conducted. Latent and observed variables are extracted to construct a model of factors influencing the quality of life of rural left-behind women in Guangxi, and relevant research hypotheses are proposed. This study attempts to clarify the relationship and interactions between social service access, socioeconomic status, organizational cooperation, rehabilitation strategy, self-esteem and quality of life, in order to explore the overall quality of life of rural left-behind women in Guangxi and related influencing factors, and to improve the quality of life of rural left-behind women in Guangxi. Objective: The objective was to find influencing factors to improve quality of life rural left behind women. Theoretical Framework: Through the above analysis, this study establishes a model of factors influencing the quality of life of rural left-behind women in Guangxi, China. Th(Wu Jing & Lang Ying, 2021)e model includes five independent variables: access to social services, socioeconomic status, organizational cooperation, rehabilitation strategies, and self-esteem, and one dependent variable, quality of life of left-behind women. The research framework model is shown in Figure 1 for reference: Method: This was a conceptual study Results and Discussion: The study found that social services access, socioeconomic status, organizational cooperation, rehabilitation strategies, and self-esteem have an impact on the quality of life of rural left-behind women in Guangxi. Social support, including government support, support from social organizations, support from other kinds of cooperative organizations, and support from the families of left-behind women, is very important to improve the quality of life of rural left-behind women. At the same time, the development of left-behind women themselves, including self-esteem and socio-economic status, is also important to improving their quality of life. Research Implications: The framework can help in human capital development of China with respect to women population who are left behind in rural area. Originality/Value: This study is not conducted yet in context of Guangxi province