Graph-based methods have demonstrated exceptional performance in semi-supervised classification. However, existing graph-based methods typically construct either a predefined graph in the original space or an adaptive graph within the output space, which often limits their ability to fully utilize prior information and capture the optimal intrinsic data distribution, particularly in high-dimensional data with abundant redundant and noisy features. This paper introduces a novel approach: Semi-Supervised Classification with Optimized Graph Construction (SSC-OGC). SSC-OGC leverages both predefined and adaptive graphs to explore intrinsic data distribution and effectively employ prior information. Additionally, a graph constraint regularization term (GCR) and a collaborative constraint regularization term (CCR) are incorporated to further enhance the quality of the adaptive graph structure and the learned subspace, respectively. To eliminate the negative effect of constructing a predefined graph in the original data space, we further propose a Hybrid Subspace Ensemble-enhanced framework based on the proposed Optimized Graph Construction method (HSE-OGC). Specifically, we construct multiple hybrid subspaces, which consist of meticulously chosen features from the original data to achieve high-quality and diverse space representations. Then, HSE-OGC constructs multiple predefined graphs within hybrid subspaces and trains multiple SSC-OGC classifiers to complement each other, significantly improving the overall performance. Experimental results conducted on various high-dimensional datasets demonstrate that HSE-OGC exhibits outstanding performance.