Lead Levels In Excess Research Articles

Lead contamination status and assessment of potential risk to human health of commercial foods in Guangzhou City in 2017-2019

To investigate lead contamination in commercial foods in Guangzhou City, and to assess the health risk of dietary lead exposure in the residents. Food samples were collected in 11 districts in Guangzhou City from 2017 to 2019.The samples were tested for lead by using inductively coupled plasma mass spectrometry. The dietary exposure to lead of residents of different age groups in Guangzhou was calculated in combination with the intake of foods from the food consumption survey of Guangzhou residents in 2011, and the margin of exposure(MOE) method was used to evaluate the health risk of the population. A todal of 3130 food samples of 15 categories were collected. The overall lead detection rate was 82.11%, the exceeding rate was 0.13%, and the average lead content was 0.031 mg/kg. The highest lead levels were found in bivalve, edible fungi and flour and flour products. Excessive levels of lead were found in bivalve, eggs and egg products, and flour and flour products. The average daily dietary intake of lead in people aged 3-6, 7-17, 18-59 and over 60 in Guangzhou were 0.368, 0.377, 0.326 and 0.337 μg/kg, respectively. Daily lead exposure of population with high consumption(P95) in various age groups through foods were 1.091, 1.079, 0.906 and 0.925 μg/kg, respectively. Brassica and leafy vegetables, rice and its products and meat were the main sources of dietary lead exposure, accounting for 53.28% of the total dietary lead exposure. The average MOE of lead in all age groups were greater than 1, but the P95 of MOE value of people aged 3-6 and 7-17 were 0.55 and 0.56, respectively, which presented certain health risks. There was a certain amount of lead exceeding the standard in commercial foods in Guangzhou. The average level of dietary lead exposure for residents of all ages posed a low risk to population health, but the dietary lead exposure risk of high-food consumers aged 3-6 and 7-17 posed certain health risks that deserve significant attention.

Legacies of Lead: Estimating Home Buyer Response to Potential Lead Exposure

Excessive levels of lead in homes pose health hazards, but exposure is discerned ex post. As a precaution, local jurisdictions assign risk levels to neighborhoods based on contamination potential and require blood lead testing, leading to decreased desirability. This paper examines capitalization effects of lead risk disclosure from such an information-based policy, exploiting spatially varying implementation of a childhood lead reduction program identifying price effects via a triple-difference border discontinuity model. Information about lead risks lowers high-risk house prices by 7.7% while shifting neighborhood composition, suggesting the program altered risk perceptions, creating unintended consequences in the market.

Correlation of brain Magnetic Resonance Imaging of spontaneously lead poisoned bald eagles (Haliaeetus leucocephalus) with histological lesions: A pilot study

Six bald eagles with severe, acute lead poisoning based on blood lead values were analyzed by Magnetic Resonance Imaging (MRI) of the brain and histopathology. The aims of the study were to use MRI to locate brain lesions and correlate the changes in MRI signal with the histological character of the lesions at necropsy. All of the bald eagles presented with neurologic and non-neurologic signs suggestive of severe lead poisoning and had blood lead levels in excess of 1.0ppm. Areas of change in image intensity in the brainstem, midbrain and cerebellum were detected in the MRI scans. Histopathology confirmed the presence of all suspected lesions. The character of the lesions suggested vascular damage as the primary insult. MRI was useful for detecting lesions and defining their three-dimensional distribution and extent. Future studies are needed to evaluate the utility of MRI for detection of lesions in less severely lead poisoned eagles and determining prognosis for treatment.

Potential Environmental Impacts from the Metals in Incandescent, Compact Fluorescent Lamp (CFL), and Light-Emitting Diode (LED) Bulbs

Artificial lighting systems are transitioning from incandescent to compact fluorescent lamp (CFL) and light-emitting diode (LED) bulbs in response to the U.S. Energy Independence and Security Act and the EU Ecodesign Directive, which leads to energy savings and reduced greenhouse gas emissions. Although CFLs and LEDs are more energy-efficient than incandescent bulbs, they require more metal-containing components. There is uncertainty about the potential environmental impacts of these components and whether special provisions must be made for their disposal at the end of useful life. Therefore, the objective of this study is to analyze the resource depletion and toxicity potentials from the metals in incandescent, CFL, and LED bulbs to complement the development of sustainable energy policy. We assessed the potentials by examining whether the lighting products are to be categorized as hazardous waste under existing U.S. federal and California state regulations and by applying life cycle impact-based and hazard-based assessment methods (note that "life cycle impact-based method" does not mean a general life cycle assessment (LCA) but rather the elements in LCA used to quantify toxicity potentials). We discovered that both CFL and LED bulbs are categorized as hazardous, due to excessive levels of lead (Pb) leachability (132 and 44 mg/L, respectively; regulatory limit: 5) and the high contents of copper (111,000 and 31,600 mg/kg, respectively; limit: 2500), lead (3860 mg/kg for the CFL bulb; limit: 1000), and zinc (34,500 mg/kg for the CFL bulb; limit: 5000), while the incandescent bulb is not hazardous (note that the results for CFL bulbs excluded mercury vapor not captured during sample preparation). The CFLs and LEDs have higher resource depletion and toxicity potentials than the incandescent bulb due primarily to their high aluminum, copper, gold, lead, silver, and zinc. Comparing the bulbs on an equivalent quantity basis with respect to the expected lifetimes of the bulbs, the CFLs and LEDs have 3-26 and 2-3 times higher potential impacts than the incandescent bulb, respectively. We conclude that in addition to enhancing energy efficiency, conservation and sustainability policies should focus on the development of technologies that reduce the content of hazardous and rare metals in lighting products without compromising their performance and useful lifespan.

A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities

A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities

CDC Advises Pregnancy Lead Screening That Targets Populations at Risk

Pregnant women who are more likely to have been exposed to lead should be routinely screened for excessive lead levels, according to a new guideline issued by the US Centers for Disease Control and Prevention (CDC).

Mattel, Lead Paint, and Magnets: Ethics and Supply Chain Management

Over a period of 19 months in 2006 and 2007, Mattel recalled approximately 14 million toys. The company was subjected to numerous lawsuits and regulatory actions and suffered severe damage to its reputation. Two issues were involved: excessive levels of lead in numerous toy surface paints and small detachable magnets in some toys, which could be swallowed. An examination of the facts shows that two different ethical situations were involved—one concerning product design and the other concerning manufacturing practices of Mattel's Chinese contractors and subcontractors. The ethical obligations of the company and individuals within the company in the two situations were quite different, and illustrate problems faced by companies in managing their global supply chains.

Face to Face with Toy Safety: Understanding an Unexpected Threat

Until March 2007, thousands of kids around the country could be found playing with toy trucks, helicopters, and soldiers sold under the Elite Operations brand name. The toys were fun, and they looked great with their thick coat of glossy paint. Trouble was, that paint was loaded with 5,000 ppm lead, a potent developmental neurotoxicant with no known safe exposure level. When the high lead levels were detected during a routine inspection, the Consumer Product Safety Commission (CPSC) issued a recall, the first for a lead-contaminated toy in 2007. Lead-triggered toy recalls were rare, but not unheard of in the United States, with just a handful issued in the last decade. Eventually, nearly 130,000 Elite Operations units—made by a Hong Kong company called Toy Century Industrial and imported by Toys R Us—would be recalled. In a typical year, the recall would have barely ruffled the $22 billion U.S. toy industry, which sells 3 billion units annually. But 2007 was far from typical as far as import recalls were concerned. Contaminated pet food, cough syrup, toothpaste, and other products—mostly made in China—were being yanked off store shelves under the full glare of the media. Given that most of its wares are made in China, the toy industry ramped up its inspections for lead, and found that high levels were a lot more common than they had assumed. By year’s end, 42 recalls involving nearly 6 million toys had been issued because of excessive lead levels. Lead-contaminated toys became one of the biggest environmental health stories of recent times. It was shocking to think of children being poisoned while playing, and by lead no less, a toxic metal that consumers assumed had been purged from products long ago. Now lead was back, sparking a furor over toy safety.

Lead and cadmium exposure in children living around a coal-mining area in Yatağan, Turkey

The study was designed to determine asymptomatic lead poisoning prevalence and cadmium exposure of preschool children living in a coal-mining area in Yatağan, Mugla, Turkey. The research was conducted between May and June 2002. The study included 236 children (53.4% female and 46.6% male) who were identified among the healthy children between the ages of 6 months and 6 years, using a systematic sampling method, from the records of the local medical centre of Yatağan. Assessments of the levels of blood lead and cadmium were performed by an atomic absorption spectrophotometer, in the Department of Biophysics, Cerrahpaşa Medical Faculty. The mean age of females and males were 49+/-18 and 43+/-19 months, respectively. The mean blood lead level was 33.8+/-15.6 microg/dL in females and 38.8+/-16.0 microg/dL in males. The mean blood lead level of the males was significantly higher than the females (P<0.05). Correlation analysis showed a statistically significant negative correlation between blood lead level and age in both sex groups (r= -0.367, P<0.001). The blood lead level was found to be > 10 microg/dL in 95.7% and >20 microg/dL in 87.6% of all children. The mean blood cadmium level of all children was 1.31+/-0.72 microg/dL. The blood cadmium level was found to be >0.5 microg/dL, which is considered to be toxic, in 85% of all children. The difference in blood cadmium levels between sexes was not significant. A statistically significant negative correlation was found between blood cadmium level and age of all children (r= -0.382, P<0.001). Although it is not possible to understand from this study what proportion of the biological lead and cadmium burden results from mining waste and what proportion comes from other sources, such as paint and gasoline residue deposited in soil and air, these results do indicate that asymptomatic lead poisoning and cadmium exposure are significant problems in children living in the Yatağan area. In conclusion, environmental lead measurements (house dust, soil, drinking water and air) must be performed, the results must be compared with the normal limits, and precautions must be taken if necessary in the Yatağan area. Future public health research efforts should focus on reducing the excessive levels of lead and cadmium in the environment.

Good News and Bad News: Blood Lead Levels in the US Go Down, but Higher Levels Are Still Associated with a Higher Burden of CKD: Continued Decline in Blood Lead Levels among Adults in the United States: The National Health and Nutrition Examination Survey. Arch Intern Med 165: 2155-2161, 2005.

Good News and Bad News: Blood Lead Levels in the US Go Down, but Higher Levels Are Still Associated with a Higher Burden of CKD: Continued Decline in Blood Lead Levels among Adults in the United States: The National Health and Nutrition Examination Survey. Arch Intern Med 165: 2155-2161, 2005.

Lead leaching from inline brass devices: A critical evaluation of the existing standard

The American National Standards Institute/NSF Standard 61, Section 8, is intended to protect the public from inline brass plumbing products that might leach excessive levels of lead to potable water. Experiments were conducted to examine the practical rigor of this test. Contrary to expectations, the test was not highly protective of public health. In fact, results indicated that small devices made of pure lead—which pose an obvious public hazard—can easily pass the leaching protocol. Reforms are needed to help prevent such unacceptable outcomes in the future. Brass devices passing the test can contribute to lead levels at the tap in residences, schools, and other buildings.

Lead-contaminated drinking waters in the public schools of Philadelphia.

Lead exposure is a preventable environmental health concern. Young children between the ages of 1 to 6 are most susceptible to its clinical effects. This article reports the results of lead level determinations in the drinking water of Philadelphia's public school buildings and remediation efforts aimed at dealing with this public health concern. Water samples were collected from drinking sources in 292 school buildings in Philadelphia from May 2000 through January 2001. These samples were collected and sent to reference laboratories for determination of lead levels. A total of 42.5% (124) of schools had water lead levels not exceeding the action level of 20 ppb, of which 3.1% had nondetectable levels or levels less than 5 ppb. A total of 28.7% of buildings had water lead levels ranging from 20 to 50 ppb, 11.6% had levels between 50-100 ppb, and 17.1% had water lead levels of 100 ppb or more. A total of 57.4% of Philadelphia's public school buildings had water lead levels exceeding the Environmental Protection Agencies (EPA) action level of 20 ppb, and 28.7% of school buildings had water with mean lead levels in excess of 50 ppb. Depending on the volume of water consumed, drinking water from school buildings may be a significant source of lead exposure for children in their formative years of development. Although Philadelphia's public school buildings were evaluated, lead-contaminated drinking water in schools is not only an urban concern. School buildings in suburban and rural areas may have similar water lead levels, and testing programs are desirable.

A survey of blood lead levels in Mute Swans Cygnus olor

Following bans on the use of most lead angling weights, the incidence of lead poisoning cases in Mute Swans started to fall and the population started to increase. However, surveys of lead levels in blood of rescued swans continue to show that a high proportion of the birds are carrying levels in excess of 1.21 mol/l. Since rescued swans, although rescued for many different reasons, might be a biased sample, a survey was made of apparently healthy birds living in flocks in the summer. These too showed that a high percentage of the birds in most of the flocks sampled had blood lead levels in excess of 1.21 mol/l. No source of this lead has been identified other than lead fishing weights; these may be long-lost leads, current, but illegally used weights or "dust-shot" which it is still legal to use. Although many of the birds sampled are carrying lead burdens that are probably not harmful, others are seriously affected. Except in the most serious cases, it is not possible to recognise birds with elevated lead levels without taking a blood sample for assay.

Children's blood lead levels after the phasing out of leaded gasoline in Shantou, China.

Shantou, a city in the People's Republic of China, has a central urban population of approximately 700,000 and a large number of registered vehicles (motorcycles = 256,600; other motor vehicles = 261,000). Shantou is designated as 1 of the 5 Special Economic Zones in China. The use of leaded gasoline was prohibited in the city at the end of 1998. Blood samples for lead analysis were collected from children aged 1-5 yr during the summers of 1999-2001, and the samples were analyzed using graphite furnace atomic absorption spectrometry. In 1999, 44.3% (147/332) of the children had mean blood lead levels in excess of 100 microg/l. The percentage of children with blood lead levels that exceeded 100 microg/l was reduced to 35.8% (227/635) and 23.0% (105/457) in 2000 and 2001, respectively. Average blood lead levels declined from 104 microg/l, to 94 microg/l, and 79 microg/l during the 3-yr period, respectively; the respective concordant geometric means were 97 microg/l, 85 microg/l, and 71 microg/l. Mean blood lead levels for the children studied decreased significantly (p < 0.05) every year. Among all children tested during the 3-yr period, there were no significant differences by gender and no significant differences between children who were between the ages of 2 and 3 yr; however, those who were 4 yr of age had blood lead levels that were significantly (p < 0.05) higher than levels in those 2 and 3 yr of age.

Prevalence of elevated blood lead levels in nigerian children

ABSTRACTObjectiveTo determine the prevalence and risk factors of elevated blood lead levels in young, urban Nigerian children.DesignA randomized cluster sample of children aged 6–35 months.SettingJos, a community in north central Nigeria.Outcome measurementBlood lead level.ResultsOf 218 children evaluated, 70% of the children had blood lead levels in excess of 10 μg/dL. Mean blood lead levels were 15.2 ± 1.4 μg/dL; median blood lead concentration was 12.0 (range 1– &gt; 60 μg/dL). Mean lead concentrations were higher in those who professed the Islamic faith, used eye cosmetics, lived near a battery smelter, or lived in a certain geographical area. Pica was not associated with increased blood lead concentrations. Forward stepwise regression analysis revealed religion, area of residence, and proximity to a battery smelter as the variables which jointly predicted increased blood lead concentrations.ConclusionA majority of the studied children in Jos, Nigeria have lead levels placing them at risk for intellectual impairment. The cause of lead intoxication appears to be multifactoral. Further studies should investigate the causality of these associations prior to the implementation of a primary preventive public health measure.

Coordinating Federal and State Lead Control Activities: The Connecticut Model for Integrated Lead Exposure Enforcement

Abstract Activities related to lead exposure control and enforcement occur at various levels of state and federal government. Many states have blood lead surveillance programs requiring laboratories and clinicians to report elevated blood lead levels to state lead registries. In Connecticut, the Adult Blood Lead Registry, operated by the Department of Public Health and Addiction Services, receives reports of blood lead levels in excess of 10 μg/dl from clinical laboratories. Further, the U.S. Department of Labor-Occupational Safety and Health Administration, through the General Industry and Construction Lead Standards, requires biological monitoring of workers. In Connecticut, the Department of Transportation, through the Connecticut Road Industry Surveillance Project, requires monitoring of worker blood lead levels by contract specification. In 1993 these four agencies joined together to form a single integrated enforcement network designed to control lead toxicity in workers throughout Connecticut. Usin...

Lead exposure among automobile radiator repair workers and their children in New York City.

Despite a comprehensive Occupational Safety and Health Administration lead standard, exposure to lead continues in many industries. This paper describes a blood lead screening and education program for automobile radiator repair workers and their families in New York City. Results showed that 67% of automobile radiator repair workers (n = 62) in 89% of the shops tested (n = 24) had blood lead levels in excess of 25 micrograms/dl. The vast majority of workers had never been tested previously, and none had received health and safety training regarding occupational lead exposure. Although none of the workers' children's blood lead levels were in excess of then-current guidelines, several had levels which may be associated with subclinical toxicity and in excess of the revised Centers for Disease Control guidelines of 10 micrograms/dl. This project demonstrates that lead exposure in the automotive radiator repair industry continues to be widespread and that local health departments can assist in hazard identification and remediation.

Court overturns fetal protection policies

The Supreme Court has unanimously ruled that cannot be barred from jobs that expose them to hazardous chemicals on the grounds that such exposure might harm potential fetuses. Several chemical companies, including Monsanto and Du Pont, have fetal protection policies. At issue was a policy established by Johnson Controls Co., a Milwaukee, Wis., battery manufacturer, in 1982 after eight female employees became pregnant while maintaining blood lead levels in excess of 30 g per deciliter. That policy stated, Women who are pregnant or who are capable of bearing children will not be placed into jobs involving lead exposure or which could expose them to lead through the exercise of job bidding, bumping, transfer, or promotion rights/' The company defined capable of bearing children as all women except those whose inability to bear children has been medically documented/' The court ruled that the policy was a clear violation of ...

Lead poisoning in adults from renovation of an older home

Presented is the case of a group exposure to lead occurring during the removal of lead-based paint from an older home. One patient had symptoms from the time of exposure to the time of presentation, when he was acutely ill and encephalopathic. The patient was treated successfully with an initial course of British Anti-Lewisite agent and calcium disodium versenate (CaEDTA) chelation, and two subsequent chelations with CaE-DTA alone. The other two patients had elevated lead levels but were asymptomatic. They were followed closely, and their lead levels steadily declined over several months. The evaluation and treatment of lead poisoning and excessive lead levels in adults is discussed, as is the need for physicians and the lay public to become aware of the hazards of renovating older homes.

Cardiovascular Actions of Lead and Relationship to Hypertension: A Review

Chronic and acute lead poisoning cause overt, clinical symptoms of cardiac and vascular damage with potentially lethal consequences. Morphological, biochemical, and functional derangements of the heart have all been described in patients following exposure to excessive lead levels. Disturbances in cardiac electrical and mechanical activity and postmortem evidence of morphological and biochemical derangements of the myocardium have all been reported following excessive exposure to lead in humans. In addition, signs of vascular degeneration, abnormal vascular smooth muscle function, and altered vessel compliance have been described in humans chronically and acutely exposed to toxic lead levels. Similar cardiovascular complications have been detected following excessive lead exposure in experimental animals. Myocarditis, electrocardiographic disturbances, heightened catecholamine arrhythmogenicity, altered myocardial contractile responsiveness to inotropic stimulation, degenerative structural and biochemical changes affecting the musculature of the heart and vasculature, hypertension, hypercholesterolemia, atherosclerosis, and increased vascular reactivity to alpha-adrenergic agonists have been among the reported cardiovascular disturbances linked to lead poisoning. Less certain are the cardiovascular effects of subclinical lead poisoning. Although controversial, chronic low-level lead exposure has been linked to hypertension and other cardiovascular disturbances in both clinical and experimental studies. In general, it can be concluded that lead over a wide range of exposure intensities can induce significant changes in the function of the cardiovascular system. Evidence points to the involvement of multiple sites of action. Cardiac and vascular sites, as well as sites within the central nervous system, have all been implicated in the sequelae of cardiovascular effects. The exact pathogenic mechanisms that underlie the actions of lead in the cardiovascular system, however, have yet to be elucidated definitively.(ABSTRACT TRUNCATED AT 250 WORDS)