Blockage of leachate drainage facilities is a common engineering problem in landfill operation. The key factors that cause blockage of drainage facilities in landfill leachate are the deposition of suspended solids (SS) with colloids and the precipitation of inorganic salts. To determine the combined sedimentation law of SS, colloids and inorganic salts, a combined sedimentation test of suspended solids, colloids and inorganic salts was conducted. To further clarify the resulting clogging characteristics of the water-conducting sand layers, a sand column blocking test were conducted, and mineral composition and grain characteristics of sediments were determined. The experimental results shown that the colloids (silver iodide) and inorganic salts (calcium chloride or aluminum sulfate) increased the sedimentation rate of SS by 8 to18 times. Among them, the effect of AgI colloid was the most significant, followed by effect of calcium chloride, while effect of aluminum sulfate was the weakest. Compared with sand column clogging caused by SS, this combined migration shortened the sand column clogging time by more than half and reduced hydraulic conductivity by nearly two to three orders of magnitude. This study contributes to the accurate assessment of the service performance of landfill leachate drainage systems.