Smart buildings can store various types of data, analyze data at a faster speed, and quickly provide users with the most accurate and high-quality intelligent services through technical means. The main purpose is to meet the needs of users, to provide communication and a series of knowledge services for all professional participants, and to provide comfortable working resources and working environment for all professional participants to ensure the smooth implementation of the project and meet the construction engineering requirements. In this study, the spatial layout and optimization of intelligent buildings are carried out based on biological population simulation, and the following conclusions are drawn: (1) The emergence of multicore or multicore graphics converters reduces the cost and popularity of high-performance software platforms, and provides faster computing speeds for applications. A new platform and implementation method have been developed. Comparing marine biopopulation models relies on the i4Ocean platform. The i4Ocean platform is a computer platform for seascape information and virtual reality applications, including view management, production engine, and MVC core framework. (2) The swarm model simulates the movement of fish in a virtual ocean. Determine their behavioral changes based on determined behavioral conditions (e.g., in position, position, and velocity). As everyone in the group moves, the entire group is monitored for behavior. (3) Intelligent buildings involve many aspects of the social machine, such as building construction, which not only affects architecture, but also design. Smart construction helps improve quality, shorten production time, save resources, and control costs. It is an important part of the structural transformation of the supply side of the construction industry, and an important tool for the structural adjustment and modernization of the construction industry and greenhouses. (4) X2View is like the most popular configuration king, with integrated functions. Project software is placed on the X2View and sent to the door or touch screen for processing and monitoring. In the driver configuration interface, you can set the application frame time of the monitoring node and the real-time measurement time of the record value recording time frame.