Human Care Research Articles

Lactobacillus rhamnosus ZJUIDS07 ameliorates type 2 diabetes in mice through the microbiome-gut-pancreas axis

Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia, with its prevalence escalating. It exerts a profound impact on human health care and socio-economic development. Probiotics, known as natural, safe, and minimal side effects, have emerged as promising intervention agents to manage chronic diabetes. Our study aimed to explore the therapeutic potential of Lactobacillus rhamnosus ZJUIDS07 for mitigating T2D in mice induced by a high-fat diet (HFD) and streptozotocin (STZ). Administration of L. rhamnosus ZJUIDS07 led to a reduction in diabetic symptoms, including reversal of weight loss, improvement in hyperglycemia and insulin resistance, mitigation of disruptions in glucose and lipid metabolism, alleviation of pancreatic pathological damage, and reduction in oxidative stress and inflammation. Moreover, treatment with L. rhamnosus ZJUIDS07 could restore intestinal microbiota balance in T2D mice by altering the structure and composition of intestinal microbiota, and increased short-chain fatty acids (SCFAs) levels. Specifically, L. rhamnosus ZJUIDS07 significantly decreased the abundance of harmful bacteria like Staphylococcus, Corynebacterium, and Odoribacte, while increasing the abundance of beneficial bacteria (especially SCFAs-producing bacteria) such as Muribaculaceae_norank, Dubosiella, Clostridium sensu stricto 1, Lactobacillus, and Faecalibaculum. Our findings highlight that L. rhamnosus ZJUIDS07 represents a promising probiotic strategy for future treatment of T2D, and that the modulation of gut microbiota and their metabolites through the microbiome-gut-pancreas axis play a pivotal role for the antidiabetic effects of L. rhamnosus ZJUIDS07.

3D Printing‐Based Hydrogel Dressings for Wound Healing

AbstractSkin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of the best candidates for ideal wound dressings and the most feasible choices for printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic and mechanical properties, 3D printing can promptly and accurately create hydrogels with complex bioactive structures and the potential to promote tissue regeneration and wound healing. Herein, a comprehensive review of multi‐functional 3D printing‐based hydrogel dressings for wound healing is presented. The review first summarizes the 3D printing techniques for wound hydrogel dressings, including photo‐curing, extrusion, inkjet, and laser‐assisted 3D printing. Then, the properties and design approaches of a series of bioinks composed of natural, synthetic, and composite polymers for 3D printing wound hydrogel dressings are described. Thereafter, the application of multi‐functional 3D printing‐based hydrogel dressings in a variety of wound environments is discussed in depth, including hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, and machine learning‐assisted therapy. Finally, the challenges and prospects of 3D printing‐based hydrogel dressings for wound healing are presented.

A ATUAÇÃO DO ENFERMEIRO NA ASSISTÊNCIA HUMANIZADA EM UTI NEONATAL: REVISÃO DE LITERATURA

Objective: to understand the nurse's role in the humanization process of care in Neonatal Intensive Care Units (NICUs). Method: this literature review, following the integrative review approach, conducted a bibliographic search using a qualitative approach. Thirteen articles published in the Nursing Database (BDENF), Latin American and Caribbean Literature in Health Sciences (LILACS), and MEDLINE were selected, adhering to the temporal scope of the study (2013-2023). Articles were chosen based on the descriptors: neonatal nursing, humanization of care, and neonatal intensive care units. Results: it was evident that the nurse's relevance in a Neonatal ICU extends beyond technical procedures. The nurse plays an active role in creating an environment that prioritizes the humanization of care, acting multifacetedly as a caregiver, educator, communicator, and advocate for the rights of patients and their families. Conclusion: therefore, it is concluded that the nurse's involvement significantly contributes to the consolidation of humanized care in a Neonatal ICU. This is achieved through technical skills, the ability to establish meaningful connections with patients and their families, and a crucial role in promoting a caring environment that respects the dignity, individuality, and emotional needs of newborns and their families.

A ATUAÇÃO DO FISIOTERAPEUTA NA ATENÇÃO PRIMÁRIA À SAÚDE NO CONTEXTO DA ESTRATÉGIA DE SAÚDE DA FAMÍLIA DO BRASIL

The physical therapist has been gradually integrated into the family health strategy (FHS), acting in a relevant role in the national healthcarenetwork. The objective of this studywas to investigate, through an integrative literature review, scientific evidence on the role of physical therapists in primary care within the context of the FHS. The literature search was conducted in the Google Scholar database, Pubmed, Scientific Electronic Library Online (SciElO), Literatura Latino-Americana e do Caribe em Ciências em Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Periódicos CAPES databases. A total of 45 articles published between 2014 and 2024 were included in the study.. The analysis of the studies demonstrated that the integration of physical therapists into the FHS, alongside the multidisciplinary team, is essential to providing comprehensive care and individualized attention, ensuring efficient assistance.. The study concludes that the role of physical therapists in Primary Health Care is of great importance to public healthgreat importance to public health, as these professionals contribute to the promotion, prevention, and recovery of both individual and collective health, restoring functionality, enhancing quality of life, and helping to reduce waiting times for care in the Unified Health System.. The expansion of the presence of physical therapists in Primary Care, specifically in the Family Health Strategy, is not onlybeneficial for the population but also enhances humanized care and functionality. Therefore, in addition to acknowledging the evidence, there is a need to recognize and support investments from health managers.

Navigating ethical considerations in the use of artificial intelligence for patient care: A systematic review.

To explore the ethical considerations and challenges faced by nursing professionals in integrating artificial intelligence (AI) into patient care. AI's integration into nursing practice enhances clinical decision-making and operational efficiency but raises ethical concerns regarding privacy, accountability, informed consent, and the preservation of human-centered care. A systematic review was conducted, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirteen studies were selected from databases including PubMed, Embase, IEEE Xplore, PsycINFO, and CINAHL. Thematic analysis identified key ethical themes related to AI use in nursing. The review highlighted critical ethical challenges, such as data privacy and security, accountability for AI-driven decisions, transparency in AI decision-making, and maintaining the human touch in care. The findings underscore the importance of stakeholder engagement, continuous education for nurses, and robust governance frameworks to guide ethical AI implementation in nursing. The results align with existing literature on AI's ethical complexities in healthcare. Addressing these challenges requires strengthening nursing competencies in AI, advocating for patient-centered AI design, and ensuring that AI integration upholds ethical standards. Although AI offers significant benefits for nursing practice, it also introduces ethical challenges that must be carefully managed. Enhancing nursing education, promoting stakeholder engagement, and developing comprehensive policies are essential for ethically integrating AI into nursing. AI can improve clinical decision-making and efficiency, but nurses must actively preserve humanistic care aspects through ongoing education and involvement in AI governance. Establish ethical frameworks and data protection policies tailored to AI in nursing. Support continuous professional development and allocate resources for the ethical integration of AI in healthcare.

Environmental Antimicrobial Resistance: Implications for Food Safety and Public Health

Antimicrobial resistance (AMR) is a serious global health issue, aggravated by antibiotic overuse and misuse in human medicine, animal care, and agriculture. This study looks at the different mechanisms that drive AMR, such as environmental contamination, horizontal gene transfer, and selective pressure, as well as the severe implications of AMR for human and animal health. This study demonstrates the need for concerted efforts across the scientific, healthcare, agricultural, and policy sectors to control the emergence of AMR. Some crucial strategies discussed include developing antimicrobial stewardship (AMS) programs, encouraging targeted narrow-spectrum antibiotic use, and emphasizing the significance of strict regulatory frameworks and surveillance systems, like the Global Antimicrobial Resistance and Use Surveillance System (GLASS) and the Access, Watch, and Reserve (AWaRe) classification. This study also emphasizes the need for national and international action plans in combating AMR and promotes the One Health strategy, which unifies environmental, animal, and human health. This study concludes that preventing the spread of AMR and maintaining the effectiveness of antibiotics for future generations requires a comprehensive, multidisciplinary, and internationally coordinated strategy.

Experiences and impact of moral injury in human trafficking survivors: a qualitative study.

Research in recent years has increasingly highlighted the relationship between exposure to potentially morally injurious events (PMIEs) and poor mental health outcomes. Human trafficking survivors often report exposure to many traumatic and PMIEs and given the complexities of trafficking exploitation, survivors may be especially vulnerable to moral injury. Despite this, no research has investigated experiences of PMIEs and moral injury in human trafficking survivors. The objective was to explore survivors' experiences of PMIEs, the impact of PMIEs on wellbeing and functioning and the factors that may influence outcomes following PMIEs. Participants were seven human trafficking survivors from diverse backgrounds who had settled in the UK. In-depth semi-structured interviews were conducted via telephone. Data were analysed using thematic analysis. Human trafficking survivors were found to experience multiple PMIEs, including transgressive acts committed by others and betrayal by trusted loved ones or those in positions of authority. Experiencing PMIEs contributed towards considerable psychological distress, including intense feelings of shame, anger and worthlessness, and negatively impacted survivors daily functioning. Formal support, especially practical help (e.g. warm clothing) and social support groups, were experienced as particularly beneficial. This study provides some of the first evidence that human trafficking survivors may be vulnerable to moral injury and indicates the impact that exposure to PMIEs can have on functioning. Future work is needed to ensure that statutory organisations consider the potential for causing moral injury when interacting with human trafficking survivors and clinical care teams are equipped to provide tailored guidance and support.

Development and Validation of Sensitivity for Needs of Elderly Scale Among Caregivers Based on Maslow’s Theory

The world currently lives in an aging society. Demand for elderly caregivers and services is rapidly rising. Elderly care encompasses not only medical care, but also the art of human care. Love and respect are usually considered the backbone of the modality of caregivers. This study aimed at developing a sensitivity for needs of elderly scale (SNES) among caregivers. Maslow’s theory of hierarchical needs, especially stage 3 (love and belongingness needs) and stage 4 (esteem needs), was used as a conceptual framework. This study consisted of four steps. The sample groups for the first two steps of item quality and exploratory factory analysis were 420 nursing students. A three-factor model emerged, which includes the sensitivity of needs for love and empathy, the sensitivity of needs for respect, and the sensitivity of needs for honor and dignity. The newly constructed measure consisted of 10 items, which explained the variance by 52.18%. The third step of confirmatory factor analysis, using a new group of 384 nursing students, indicated the model fit. In the final step, the scale was validated using 171 elderly caregivers. Moderate to strong absolute magnitudes of correlations between the new scale and psycho-moral strength, core self-evaluation, future orientation and self-control, moral disengagement, and caring behavior were found. Incremental validity was tested. Discussion and recommendations for further research and implications of the newly constructed measure were offered.

HUMANIZED PRENATAL CARE

Humanized prenatal care is a concept that aims to ensure that pregnant women receive respectful and personalized care, promoting an emotionally supportive and welcoming environment during pregnancy. This approach aims not only to ensure the physical health of the mother and fetus, but also to improve the psychological and emotional well-being of women during pregnancy, which can have a positive impact on maternal and fetal outcomes. Studies have shown that a humanized approach is a determining factor in reducing complications during pregnancy and childbirth, as well as strengthening the bond between mother and baby. This summary seeks to analyze the influence of humanized care during prenatal care on maternal and fetal outcomes, discussing the importance of welcoming and personalized practices for increasing the quality of care. It also examines how humanized care can have a positive impact on both the physical and emotional health of pregnant women, promoting more favorable outcomes for mother and baby. This study used a qualitative methodology based on a literature review, focusing on humanization practices in prenatal care, exploring their impact on maternal and fetal health and public policy guidelines in Brazil. Humanized prenatal care involves practices such as respect for the autonomy of the pregnant woman, active listening, inclusion of the family in the process and psychological support, as well as comprehensive care for the woman’s physical health. Research shows that pregnant women who receive this type of care have lower rates of anxiety and depression, factors that are associated with obstetric complications and negative outcomes. In addition, humanized care contributes to pregnant women’s adherence to prenatal appointments and tests, reducing the risks of premature births, low birth weight and neonatal mortality. Care that respects a woman’s individuality also facilitates the control of conditions such as hypertension and gestational diabetes, promoting a safer pregnancy. Humanized prenatal care therefore plays a crucial role in maternal and fetal outcomes, promoting a healthier pregnancy and reducing the risks associated with labour and birth. In addition to improving the physical health of the mother and fetus, humanized care strengthens the emotional health of the pregnant woman and facilitates the mother-baby bond, factors that are essential for the healthy development of the newborn. The implementation of humanized practices in health services is therefore a fundamental strategy for improving the quality of prenatal care and promoting better outcomes for mothers and babies.

Agenda of Early Life Experience and Its Association with Sensitivity to Human Presence and Familiarity in Wild-Born Orphaned Captive Cheetahs

It has been argued that domestication explains the ability of domestic animals to use human cues, but similar abilities exist in wild animals repeatedly exposed to humans. Little is known on the importance of the developmental stage of this exposure for developing such abilities. Orphancy and subsequent hand-rearing constitute a quasi-experimental situation for investigating this question. Cheetahs (Acinonyx jubatus) are interesting as they present a two-step development, spending their first two months of life in a den with occasional visits from the mother, and then accompanying their mother outdoors. Mother loss may occur at any of these stages, and the orphaned cheetahs are then taken under human care. We tested the importance of the stage of development on their long-term perception of humans by comparing the reactions of adult wild-born cheetahs, orphaned at “den-age” (Early-Orphaned, 0–2 months) or at a later stage (Late-Orphaned, 2–6 months), to motionless humans (familiar vs. unfamiliar). The results showed that Early-Orphaned, but not Late-Orphaned cheetahs, produced affiliative calls (purrs) towards humans and discriminated familiar and unfamiliar humans. Taken together, these results suggest that the timing in which an emotional bond is created with the primary caregiver (humans in the case of Early-Orphaned cheetahs and the mother in the case of Late-Orphaned cheetahs) is crucial in determining the reaction towards the species of the early caregiver throughout life.

CUIDADOS PALIATIVOS NO ENFRENTAMENTO DE DOENÇAS QUE AMEACEM A CONTINUIDADE DA VIDA

This article aims to discuss the topic of palliative care, jointly comprising other issues that made up this work, such as: the possible emotional reactions of a chronic patient whose disease is no longer responsive to treatment; the systemic psychology approach, in which some action strategies include family involvement; active listening and communication; and psychoeducation, which is a guiding resource. The work was a bibliographical review of several authors with significant concepts adding positively to the construction of this article. Palliative care is a right of care for everyone, although its provision is still limited. The role of the psychologist within the multidisciplinary team is to offer adequate and humanized care.

Positive Correlation Between Fecal Estrogen and Glucocorticoid Metabolites in a Female Clouded Leopard.

Clouded leopards are notoriously difficult to manage under human care due to their tendency toward high stress, intersex aggression, and limited reproductive success. This case study investigated the endocrinological interplay between adrenal and ovarian steroids and describes a positive correlation between concentrations of fecal estrogen and glucocorticoid metabolites in a female clouded leopard. The female was monitored through two sampling periods approximately 16 months apart, and each data set yielded similar results using a simple linear regression model. The finding of a significant positive correlation between the two steroids represents a novel finding in felids and a hitherto unidentified potential interplay between adrenal and ovarian steroid activity. It also adds to our collective understanding of the effects of estrus on female clouded leopards, impacting conservation efforts as we encourage reproduction in this vulnerable species.

A Systematic Review of Point-of-View Video Prompting to Teach Daily Living Skills to Individuals With Autism

The acquisition of daily living skills (DLS) represents an important component in establishing independence and increasing the quality of life for individuals diagnosed with autism spectrum disorder. Video prompting has become a popular intervention to teach DLS and researchers have used different perspectives when filming the video (e.g., point-of-view, spectator view). This literature review sought to systematically examine research on the use of the point-of-view perspective when using video prompting to teach DLS to individuals with autism. This review investigated the overall quality of the evidence, based on the What Works Clearinghouse standards for single-case experimental design and used Tau-U to calculate the effects of the interventions. Additionally, the researchers examined and summarized various descriptive variables found within this literature. Overall, point-of-view video prompting produced larger to very large effects. Suggestions for future research and considerations are discussed.

DESEMPENHO FÍSICOS EM IDOSOS SEDENTÁRIOS

In the study with 30 sedentary elderly individuals between 60 and 80 years of age, physical and functional capacity tests were performed. In the 6-Minute Walk Test, the elderly individuals aged 60 to 69 years walked an average of 4 meters, while those aged 70 to 79 and 80 years walked 5 and 6 meters, respectively. In the Lawton Scale, which assesses independence in instrumental activities, most elderly individuals showed a need for help, showing that dependence increases with age. In the Katz Scale, 37% of the elderly individuals aged 60 to 69 years, 43% of those aged 70 to 79 years and 20% of those aged 80 years maintained independence in basic self-care activities.

Clinical Humanistic Needs of Chinese Medicine Treatment for Patients with Chronic Urticaria from the Perspective of Narrative Medicine

Abstract: The curative effect of traditional Chinese medicine (TCM) in the treatment of chronic urticaria has gradually been recognized by the clinic, but the physical symptoms and psychological symptoms of this disease in the clinic are equal, how to play the effect of traditional Chinese medicine more effectively is worth exploring. Narrative medicine is a medical model that attaches great importance to humanistic care. There is a certain correlation between the concept of “holism of body and spirit (形神一体观)” embodied in TCM treatment of chronic urticaria and the key concepts of "narrative lock", "narrative adjustment" and "narrative intervention" in Chinese narrative medicine system. Based on the Chinese narrative medicine system, this paper connects the concept of narrative medicine with the TCM treatment of chronic urticaria, and discusses the clinical humanistic needs of TCM diagnosis and treatment of chronic urticaria patients from the perspective of narrative medicine.

Analysis of Users’ Perception of Home Care Provided by the Family Health Strategy Team: A Quali–Quantitative Approach

Background/Objective: Home care involves actions and services aimed at promoting health. Despite being an important strategy for humanized care, strengthening bonds, and improving access, there is a lack of scientific evidence regarding users’ perceptions of home care. The objective of this study was to analyze the perception of users regarding the home care provided by the Family Health Strategy team. Methodology: A descriptive, quali–quantitative approach was used, with a sample of 60 patients who required home care. Interviews were conducted using a semi-structured guide, and the analysis applied the Collective Subject Discourse. Results: Most participants were female (60%) and aged between 71 and 85 years (45%). The duration of home care varied, with 41.6% receiving care for 13 to 24 months. The majority of participants (61.6%) received home care weekly, while 33.4% were visited every 15 days, and 5% monthly. The most present professionals were community health agents (45%), followed by nursing assistants (18.3%), nurses (15%), and doctors (15%). Dentists and physiotherapists made fewer visits (3.3%). Regarding the care received, 36.6% valued the continuity of treatment, 31.6% were satisfied with the quality, and 25% highlighted the humanization of care. Only 6.6% desired more frequent visits. Conclusions: The analysis of perceptions revealed that participants valued the continuity of treatment and the quality of care received. Home visits were predominantly carried out by community health agents.

The mediating role of resilience in the relationship between meaning in life and attitude toward death among ICU nurses: a cross-sectional study

BackgroundThe majority of elderly individuals prefer to spend their final days in the Intensive Care Unit (ICU). ICU nurses are key providers in hospice care, and their attitudes toward death influence the quality of end-of-life nursing. Positive psychology emphasizes promoting positive attitudes toward death. A sense of meaning in life and resilience are critical aspects of positive psychology, which are essential for shaping ICU nurses’ attitudes toward death.ObjectiveThis study aims to investigate whether a sense of meaning in life indirectly affects attitudes toward death through the mediation of resilience.MethodA total of 212 ICU nurses from four tertiary general hospitals in Guangdong and Fujian provinces, China, participated in this study. They completed an online questionnaire, including the Death Attitude Profile-Revised, the Connor-Davidson Resilience Scale, and the China Meaning in Life Questionnaire for ICU nurses.ResultsICU nurses scored highest in natural acceptance (3.26 ± 0.53), followed by escaping acceptance (2.54 ± 0.59), and fear of death (2.53 ± 0.78). The proposed model fit the data well. Both the presence of meaning and the search for meaning were positive predictors of resilience (β = 0.313, p < 0.05; β = 0.256, p < 0.05). Resilience, the presence of meaning, and the search for meaning positively predicted natural acceptance (β = 0.299, p < 0.05; β = 0.294, p < 0.05; β = 0.177, p < 0.05). Conversely, these factors negatively predicted fear of death (β = −0.179, p < 0.05; β = −0.251, p < 0.05; β = −0.192, p < 0.05) and escaping acceptance (β = −0.208, p < 0.05; β = −0.208, p < 0.05; β = −0.219, p < 0.05). Mediation analysis indicated that resilience had a partial mediating role.ConclusionThe presence of meaning and the search for meaning influence attitudes toward death, with resilience serving as a partial mediator. It is recommended that nursing administrators consider ICU nurses’ attitudes toward death and emphasize the importance of meaning in life and resilience in death education. This approach can help protect the psychological well-being of ICU nurses, promote a deeper understanding of life’s meaning, and develop a scientific perspective on death. Such measures are crucial for providing better humanistic care and psychological comfort to terminally ill patients and their families, thereby improving the quality of end-of-life care.

Lyme borreliosis in Brazil: a critical review on the Baggio-Yoshinari syndrome (Brazilian Lyme-like disease).

SUMMARYLyme borreliosis or Lyme disease is the most frequently reported tick-borne disease in the Northern Hemisphere. In countries of the Southern Hemisphere, such as Brazil, since the early 1990s, some researchers have argued for the existence of an autochthonous Lyme-like borreliosis, known locally as the Baggio-Yoshinari syndrome (BYS), an alleged "Brazilian borreliosis" supposedly caused by a different strain of Borrelia burgdorferi and transmitted by hard ticks. Currently, the existence of BYS in Brazil is still accepted by a large part of the human health care workers, scientists, medical societies, and patients. In fact, this alleged "Brazilian borreliosis" has been the tick-borne zoonotic disease with the greatest number of reported cases and published studies in Brazil during this century, second only to Brazilian spotted fever. In this manuscript, we reviewed all manuscripts directly related to BYS that have been published in Brazil during the last 35 years. This analysis included 199 individual human cases that have been reported in Brazil since 1989, plus multiple studies on ticks, domestic, and wild animals. Our revision aimed to provide a critical opinion on whether the current published works allow healthcare workers, public health agencies, and patients to accept the existence of Lyme disease, BYS, or other Lyme borreliosis-related disease in Brazil. For this purpose, we evaluated the strengths and weaknesses of each published study, considering the diagnostic methods used, such as serological, microbiological, and molecular analyses. Based on these evaluations, we conclude that there is not enough evidence to support the occurrence of Lyme borreliosis in Brazil or that BYS (Brazilian Lyme-like disease) is caused by a bacterium of the genus Borrelia. This assumption is based on the inaccuracy, unreliability, and misinterpretation of the different diagnostic methods that have been used in Brazil. Recognizing the lack of technical evidence for the occurrence of Lyme borreliosis in Brazil has highly relevant implications. For example, it becomes imperative to raise awareness among the country's medical profession, as they have adopted unnecessary and extreme therapies recommended for patients with a supposed borrelial infection, including BYS, in Brazil. Finally, the technical analyses carried out in this study could be applied to other countries in the Southern Hemisphere (e.g., Argentina, South Africa, Australia), where cases classified and alleged as Lyme disease have been reported.

The Narrative Medicine Practice of Traditional Chinese Medicine for the Treatment of Ben Tun Qi

Abstract: This article takes the narrative medicine practice of traditional Chinese medicine (TCM) in the treatment of Ben Tun Qi (奔豚气) as an example to illustrate the characteristics of narrative medicine in TCM diagnosis and treatment, and strives to form a simple, easy to implement, and practical process of narrative medicine of TCM, which can help doctors provide more comprehensive, detailed, and humanistic care for diagnosis and treatment activities, and achieve doctor-patient harmony.

Benefits of an educational intervention on functional capacity in community-dwelling older adults with frailty phenotype: A randomized controlled trial

BackgroundThere is an urgent demand for nurses to expand their knowledge and skills in managing frailty in primary care. Frailty is a multifaceted condition that is prevalent among older adults and often leads to reduced functional capacity. Currently, there is a limited understanding of the effectiveness of educational interventions aimed at improving functional capacity among community-dwelling frail older adults in a primary care setting. ObjectiveThis study aimed to evaluate the impact of an educational program on functional capacity among pre-frail and frail older adults living in the community. DesignA 12-month, multicenter, randomized controlled trial. SettingsThe FRAGSALUD study was conducted across 14 healthcare centers situated within the regions of Cadiz and Malaga, Spain. ParticipantsA total of 199 frail/pre-frail community-dwelling older adults (74.2 ± 6.4 years). MethodsParticipants who met at least one Fried's criteria were assigned to either the control group (n = 90), which received usual healthcare assistance, or the intervention group (n = 109). The 6-month intervention comprised four group sessions and six telephone calls conducted by professional nurses, sport scientists, and nutritionists. This educational program focused on guidelines for physical activity, nutritional habits, cognition, and psychosocial well-being. Functional capacity was assessed using questionnaires for basic (Barthel Index) and instrumental (Lawton & Brody Scale) activities of daily living. All outcome measures were evaluated at baseline, immediately after the intervention (6-month), and six months after the intervention as a follow-up (12-month). Differences in functional capacity (Barthel Index and Lawton and Brody Scale scores) across the three time points were analyzed using Friedman's ANOVA, with Wilcoxon signed-rank test for pairwise comparisons. ResultsAt both 6-month and 12-month assessments, the control group showed a statistically significant decline in basic and instrumental activities of daily living compared to the intervention group, which maintained similar levels, preventing this age-related decline. ConclusionsThe educational intervention, designed for easy implementation within healthcare systems, especially for nurses, successfully maintained levels of functional capacity in basic and instrumental activities of daily living, while the control group experienced a decline in functional capacity during the 12-month follow-up. Thus, educational interventions are encouraged for preserving the functional independence of frail/pre-frail older adults living in the community. RegistrationThis trial was registered at ClinicalTrials.gov (Identifier: NCT05610605) and the first participant was registered in March 2022.Tweetable abstract: The FRAGSALUD educational intervention prevents the age-related decline in functional independence over 12 months in frail older adults.