Lavender Essential Oil Research Articles

Lavandula angustifolia oil induces oxidative stress, stiffening of membranes, and cell wall in Cryptococcus spp.

The Cryptococcus neoformans and Cryptococcus gattii species complexes are the etiological agents of cryptococcosis, a disease responsible for 181 000 deaths annually worldwide due to late diagnosis and limited treatment options. Studies focusing on the identification of new substances with antifungal activity, such as essential oils (EOs), are urgently needed. While the antifungal effects of EO have already been suggested, their mechanism of action at the molecular level still requires evaluation. In this work, we assessed the molecular changes induced by the exposure of Cryptococus neoformans (H99) and Cryptococcus deuterogatti (R265) to lavender essential oil (LEO) using a morphological and proteomics approach. The identified proteins were categorized by Gene Ontology according to biological processes and molecular functions, and Kyoto Encyclopedia of Genes and Genomes pathway analysis was also conducted. Our findings indicate that LEO creates a stressful environment in both strains; however, the response to this stimulus differs between the two species. In C. neoformans, changes were observed in energy metabolism and pathways related to alternative sources of energy and oxidative stress response. In C. deuterogatti, changes were identified in pathways related to cellular architecture, implying that the cell underwent morphological changes such as membrane and cell wall stiffening.

Analysis of the Chemical Composition, Antimicrobial, and Antioxidant Qualities of Microwave and Supercritical CO2-Extracted Lavender Essential Oils Cultivated in a Hyperarid Region of Türkiye

This study compares the chemical composition, antioxidant capacity, and antibacterial properties of lavender essential oils extracted using microwave-assisted extraction (MAE) and supercritical CO2 extraction (SCDE). Gas chromatography–mass spectrometry analysis revealed that the MAE oil contained higher levels of linalyl acetate (36.19%) and linalool (28.29%) compared with the SCDE oil, which had values of 28.72% and 27.48%, respectively. The MAE oil also showed superior antioxidant activity, with DPPH IC50 values of 72.99 mg/mL and FRAP values of 1.31 mM Fe2+/g, compared with 80.84 mg/mL and 1.14 mM Fe2+/g for the SCDE oil. Antibacterial tests indicated that the MAE oil exhibited lower MIC values, demonstrating twice the antibacterial activity against Bacillus cereus NRRL B3711, Bacillus subtilis PY79, and Enterococcus faecalis ATCC 29212 compared with the SCDE oil. These results highlight the superior bioactivity of MAE-extracted lavender oil, making MAE a preferred method for high-quality oil extraction from drought-affected lavender plants.

Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound.

Aim: To treat diabetic wound healing with a novel Thymoquinone (TQ) loaded nanoformulation by using combination of essentials oils.Methods: TQ nanoemulsion (NE) was developed with seabuckthorn & lavender essential oils by phase inversion method and mixture design. Further, DIAGEL is obtained by incorporating NE into 1% carbopol®934. Furthermore, particle size, polydispersity index, thermodynamic stability studies, rheology, spreadability, drug content, in-vitro drug release, ex-vivo permeation, anti-oxidant assay, antimicrobial studies, angioirritance, HAT-CAM assay, in-vitro and in-vivo studies were determined.Results: NE has a particle size of 17.79±0.61nm, 0.206±0.012 PDI & found to be thermodynamically stable. DIAGEL exhibited pseudoplastic behavior, sustained drug release, better permeation of TQ and a drug content of 98.54±0.08%. DIAGEL stored for 6months at room temperature and 2-8°C showed no degradation. Further, an improved angiogenesis, absence of angio-irritancy, remarkable antioxidant and antimicrobial activities against Candida albicans & S. aureus were observed. Cytotoxicity analysis revealed nearly 2.28 -folds higherIC50 value than drug solution. Furthermore, inflammatory mediators were reduced in DIAGEL treated animal groups. The histopathological studies confirmed skin healing with regeneration and granulation of tissue.Conclusion: The novel formulation has strong anti-inflammatory, angiogenesis, antioxidant and appreciable diabetic wound healing properties.

Aromatic Serenity: How Lavender Eases Stress and Anxiety - A Literature Review

In today's fast-paced society, rising stress levels necessitate effective management strategies. While pharmacological treatments are common, their side effects have spurred interest in alternative therapies, particularly those rooted in natural remedies. Lavender (Lavandula angustifolia), long esteemed for its calming properties, has emerged as a promising non-pharmacological option. Historical use in herbal medicine for anxiety and stress-related disorders has inspired modern scientific research to explore its potential. This review synthesizes recent studies on lavender essential oil, examining its mechanisms—such as neurotransmitter modulation—and its effectiveness in diverse settings, from reducing stress among healthcare professionals to improving sleep quality. Despite promising results, limitations like small sample sizes and variability in application methods highlight the need for more rigorous research to establish lavender's efficacy and optimize its therapeutic use in stress management and mental health care.

Development of Alginate Hydrogels Incorporating Essential Oils Loaded in Chitosan Nanoparticles for Biomedical Applications.

A hybrid alginate hydrogel-chitosan nanoparticle system suitable for biomedical applications was prepared. Chitosan (CS) was used as a matrix for the encapsulation of lavender (Lavandula angustifolia) essential oil (LEO) and Mentha (Mentha arvensis) essential oil (MEO). An aqueous solution of an acidic Natural Deep Eutectic Solvent (NADES), namely choline chloride/ascorbic acid in a 2:1 molar ratio, was used to achieve the acidic environment for the dissolution of chitosan and also played the role of the ionic gelator for the preparation of the chitosan nanoparticles (CS-NPs). The hydrodynamic diameter of the CS-MEO NPs was 130.7 nm, and the size of the CS-LEO NPs was 143.4 nm (as determined using Nanoparticle Tracking Analysis). The CS-NPs were incorporated into alginate hydrogels crosslinked with CaCl2. The hydrogels showed significant water retention capacity (>80%) even after the swollen sample was kept in the aqueous HCl solution (pH 1.2) for 4 h, indicating a good stability of the network. The hydrogels were tested (a) for their ability to absorb dietary lipids and (b) for their antimicrobial activity against Gram-positive and Gram-negative foodborne pathogens. The antimicrobial activity of the hybrid hydrogels was comparable to that of the widely used food preservative sodium benzoate 5% w/v.

Improving Egg Production, Quality and Eggshell Hygiene by Supplementation of Sage (Salvia officinalis) and Lavender (Lavandula angustifolia) Essential Oils

ABSTRACT Objective: This study was performed to evaluate the effects of sage (Salvia officinalis) and lavender (Lavandula angustifolia) essential oils (EO) supplementation into drinking water on egg production, quality and eggshell hygiene in laying hens. Material and Methods: A total of 300 Nick Brown laying hens between 30 and 38 of age were used in a completely randomized design in three treatments and ten replicates. The treatments consisted of: control group, sage EO, lavender EO supplementation group. EOs were supplemented into drinking water (0.3 mL/L). Results: A lower value of egg production, egg weight, egg mass and deteriorations in feed efficiency, eggshell breaking strength and thickness were observed in lavender EO group (P

PLA/PCL polymer nanocomposite with silver and copper nanoparticles and lavender essential oil: Synthesis, characterization and application in tissue engineering

The present work aims to synthesize, characterize, and evaluate the cytotoxicity and antimicrobial activity of PLA/PCL polymeric nanocomposite with silver nanoparticles (AgNPs) and copper (CuNPs) and the addition of lavender essential oil (LEO) for application in tissue engineering. For the synthesis of the nanocomposite films, the central composite rotational design (CCRD 2²) was used, where the ideal condition was 0 .5 %wt. of AgNPs and CuNPs (3:1D) with a higher cell viability (196.1 %) after 24 h. After defining the ideal condition, the effect of incorporating LEO into the polymer blend and nanoparticles in the proportions of 0.5 (3:1D0.5), 0.75 (3:1D0.75) and 1 v-1 (3:1D1) was evaluated. All nanocomposite films were characterized structurally, morphologically, thermally, and mechanically by X-ray diffraction (XRD), Field Emission Gun–Scanning Electron Microscopy (FEG-SEM), Thermogravimetric analysis (TGA), contact angle and mechanical Properties (displacement and maximum tension). To evaluate cytotoxicity, an in vitro safety profile was performed in HFF-1 (fibroblasts) and HaCat (keratinocytes) cell lines, where PLA/PCL polymer blend with 0.5 %wt. of AgNPs and CuNPs (3:1D) and PLA/PCL polymer blend with 0.5 %wt. of AgNPs and CuNPs and LEO (0.5 v-1) (3:1D0.5) nanocomposite film showed the best cell viability without the nitric oxide (NO) generation, total levels of reactive oxygen species (ROS) or dsDNA release for the HFF-1 and HaCat cell lines, as well as genoprotective characteristic and without genotoxic profile. Moreover, the tests were carried out on the pH of injured skin at different immersion times (3, 6, 12 and 24 h) and didn´t show cell death or inflammatory reaction. For the antimicrobial activity, the 3:1D, 3:1D0.5, and PLA/PCL polymer blend with 0.5 %wt. of AgNPs and CuNPs and LEO (0.75 v-1) (3:1D0.75) nanocomposite films showed the formation of biofilm for S. aureus, E. coli, P. aeruginosa and K. pneumoniae. Therefore, the PLA/PCL polymer nanocomposite with AgNPs and CuNPs showed potential application as a healing dressing for skin regeneration.

Scented solutions: Harnessing lavender essential oil liposomes for enhanced plywood performance

A wood-based panel that is both healthy and environmentally friendly has been developed utilizing the aromatic odor emitted by lavender essential oil. Liposomes were employed to encapsulate the lavender essential oil, resulting in a favorable loading effect and facilitating the control of odor release. Chitosan was used to encapsulate the lavender essential oil liposomes and then cross-linked with phosphate ions to form hydrogel balls, which improved the antioxidant performance and thermal stability of the lavender essential oil liposomes, achieving a 100 % encapsulation rate at optimal dosages. In order to investigate the effect of composite liposomes on the emission of volatile organic compounds (VOCs) that cause odors, plywood was used as the subtract for their application. Panels treated with essential oil liposome hydrogel spheres exhibited improved mechanical properties, with a 4.3 % increase in average MOR and a 15.7 % increase in average bonding strength compared to control panels. The release of aromatic VOCs was prolonged after plywood had been treated with essential oil liposome hydrogel balls, but the release of phenolic odor VOCs was significantly suppressed. This study provides a new solution for reducing plywood odor emissions.

Structure-property relationship of ultrasound-assisted nanoemulsion-impregnated bioactive polysaccharide films for enhanced shelf life of mushrooms

This study aimed to develop bioactive nanoemulsion (NE)-impregnated polysaccharide films to extend the shelf life of mushrooms. A stable and well-dispersed NE was prepared using 5 wt% soy protein (SP) and 10 % (v/v) lavender essential oil (LEO) through 10 min of ultrasound treatment, resulting in a droplet size of 152.3 nm, a polydispersity index (PDI) of 0.17, and a ζ-potential of −43.4 mV. Two types of films were prepared by incorporating 5 % and 10 % (v/v) SP/LEO NE into a curdlan (CD) and chitosan (CS) composite matrix, forming CD-CS-NE1 and CD-CS-NE2 films, respectively. The CD-CS-NE2 films possessed the highest tensile strength (14.5 MPa) and elongation at break (140 %). FTIR and molecular docking studies confirmed strong intermolecular interactions between the CD, CS, and NE components. The antibacterial activity of the NE-impregnated CD-CS films was significantly enhanced, with inhibition zones of 22 mm and 26 mm for Escherichia coli and Staphylococcus aureus, respectively, in the CD-CS-NE2 film. Growth curve and colony-forming unit (CFU) analyses further supported the superior antibacterial performance of the CD-CS-NE2 film. In mushroom storage tests, the CD-CS-NE2 film extended the shelf life of button mushrooms to 12 days and straw mushrooms to 4 days. Additionally, it reduced weight loss to 3 % and 4 % in button and straw mushrooms after 12 and 4 days, respectively. Mushrooms treated with CD-CS-NE2 film maintained higher firmness, with values of 18 N for button mushrooms and 6 N for straw mushrooms. The films effectively suppressed polyphenol oxidase (PPO) activity and browning. Overall, these findings suggest that SP/LEO NE-impregnated CD-CS films have strong potential for improving food preservation and reducing spoilage, particularly in fresh produce like mushrooms.

Effects of eggshell powder emulsion gel on the oxidative stability and sustained-release effect of lavender essential oil

This study aimed to develop a new type of eggshell powder (EP) emulsion gels for improving the antioxidant ability and sustained release effect of lavender essential oil (LEO). The effects of EP addition on the physicochemical, structural properties, oxidative stability, and sustained-release performance of the emulsion gels were investigated. The results showed that with the increase of EP addition (0–1 %), the gel strength initially increased and then decreased. The emulsion gel with 1 % EP had better freeze-thaw stability (36.77 %), thermal stability (78.63 °C), and water holding capacity (96.57 %). Moreover, the micromorphology results indicated that the EP-ovalbumin (OVA)-konjac glucomannan (KGM) complex showed a connected filamentous network structure, and the emulsion gel with 1 % EP addition had the most uniform and densest network structure. Furthermore, the EP emulsion gel had the highest free sulfhydryl content and hydrophobic interaction, and LEO exhibited the best antioxidant and sustained-release properties at this time. In conclusion, the findings demonstrated the potential of eggshell powder to enhance emulsion gel stability, which could improve the high-value utilization of egg by-products.

Lavender improves sleep through olfactory perception and GABAergic neurons of the central amygdala

Ethnopharmacological relevanceThe use of lavender as sleep aid or hypnotic agent can be traced back as early as ancient Romans and Greeks. Yet, objective experimental data on whether and how lavender enhances sleep duration or/and sleep quality remain lacking. Aim of the studyWe aimed to characterize the sleep-wake regulating effects of lavender in the mouse and to demonstrate the brain targets and neural circuits involved. Materials and methodsA self-made precise odor delivery system combined with chronic polysomnographic recordings was employed to assess the sleep-wake effects of inhalation with lavender essential oil (LEO, extracted from lavender) and its different constituents during the light and dark phases in free-moving C57BL/6J mice. Neuroviral labeling, in situ hybridization and pharmacogenetics were combined to identify the neural circuits and targets involved. Finally, an insomniac model of DL-4-Chlorophenylalanine (PCPA)-treated mice was established to examine the sleep-inducing potential of LEO. ResultsWe found that inhalation of LEO with a concentration at 25.0% during the light (inactive) phase significantly shortened the latency to non-rapid eye movement (NREM) sleep, increased the total amount of NREM sleep at the expense of wakefulness (W), and enhanced cortical EEG slow wave activities, notably delta power spectra density. We further identified linalool, d-limonene, 1,8-cineole, linalyl acetate and terpinene-4-ol as the major effective sleep-promoting monomer components. Importantly, we found that LEO no longer produced any of the above sleep-promoting effect following either nasal injection of zinc sulfate which interrupts the olfactory pathway, or pharmacogenetics silencing of central amygdala GABAergic neurons. Finally, LEO reestablished NREM sleep with short latency in PCPA-treated insomniac mice, effects comparable with those induced by a potent sedative diazepam. ConclusionsWe have characterized the quantitative and qualitative sleep-promoting effects of LEO and its effective components via the olfactory pathway and central amygdala GABA neuronal targets. The hypnotic property of LEO is reinforced by its ability to restore sleep in insomnia. Our study thus establishes a neurobiological basis for aromatherapy of sleep disorders using lavender.

Aromatherapy Using Lavender Oil Effectiveness on Pain and Anxiety After C-Section: A Randomized Controlled Trial.

Managing postoperative setting, regarding pain and anxiety after cesarean delivery is crucial for the mother's recovery, her emotional well-being, mother-infant bonding and initiating breastfeeding. Although some research have suggested that aromatherapy with lavender essential oil can be effective in reducing pain and anxiety in various medical settings, the efficacy of lavender aromatherapy in the postoperative setting after cesarean delivery is less well-studied. We aimed to assess the effectiveness of lavender essential oil therapy in the management of pain and anxiety after cesarean delivery. This was a monocentric randomized controlled double-blind trial conducted over a period of five months during 2023. A hundred women undergoing c-sections under spinal anesthesia were enrolled and randomly assigned; using block randomization of 4 items per block with allocation ratio 1:1, into two groups: The aromatherapy group (receiving inhaled Lavender essential oil) versus the placebo group (receiving distilled water instead). The primary outcomes were pain (at rest and after mobilization) and anxiety levels and after the intervention. This trial was registered on clinical-trials.org (NCT06387849). A total of 100 women were included (50 women in each group aromatherapy and the placebo group). The two groups were comparable regarding baseline characteristics and pre-intervention parameters with no statistically significant difference. After the intervention, the pain at rest (38,76 ± 22,9 vs. 23,84 ± 18,01; p < 0.001), the pain after mobilization (60,28 ± 23,72 vs. 40,12 ± 22,18; p < 0.001), and degree of anxiety (46,76 ± 6,59 vs. 44,3 ± 5,17; p = 0.03) were all significantly lower in the aromatherapy group. No adverse effects were reported by participants in both groups. Aromatherapy using Lavender essential oil is effective in reducing pain and anxiety after cesarean delivery without adverse effects.

Lavender essential oil market integrity: A comprehensive study of commercial Lavandula angustifolia essential oils adulteration and assessment of industrial standards

Adulteration of essential oils (EOs) is a common and unethical practice that affects both consumers and honest suppliers and harms market integrity. Despite the awareness of this problem, scarce scientific studies are described in the scientific literature. Therefore, 55 samples of lavender EOs were purchased and extensively analyzed to the trace levels, including chromatographic profile, quantitative analysis, and chiral profile. Of the 51 samples labeled as Lavandula angustifolia, 51 % were genuine, 6 % were cheaper lavandin EO, 14 % were fortified with synthetic additives and over 29 % of the samples were adulterated with both lavandin EO and synthetics. Usually, adulterated EOs were cheaper than genuine products, still some expensive products were also falsified. The most common synthetic adulterants were synthetic linalool and linalyl acetate, 3,5,5-trimethylhexyl acetate, α-terpinyl acetate, and dipropylene glycol. Only four of the studied samples were diluted with a medium not fully visible in the recorded GC profile. Industry standards were assessed to eliminate adulterated EOs and ISO 3515 was found to be impractical and too strict, but Ph. Eur. demonstrated its efficiency in eliminating adulterated samples without rejecting many genuine ones.PCA enabled the differentiation of lavender EOs containing synthetics from those of purely natural origin, and in the latter group, to distinguish L. angustifolia from lavandin. Some samples had an unusual composition suggesting that they were artificial blends of synthetics and some terpene fractions of non-lavender origin.This is the first such extensive study of adulteration of lavender EOs, regarding both the number of commercial samples as well as implications on their biological activity. The adulteration via dilution influenced the antimicrobial activity of the essential oils. In conclusion, adulteration is a significant problem in the market, and a large share of products on the market is somehow counterfeited, not only the cheapest products.

Application of Multivariate Data Analysis Methods for Rapid Detection and Quantification of Adulterants in Lavender Essential Oil Using Infrared Spectroscopy

Application of Multivariate Data Analysis Methods for Rapid Detection and Quantification of Adulterants in Lavender Essential Oil Using Infrared Spectroscopy

In vitro and Silico Exploration of the Insecticidal Properties of Lavandula multifida L. Essential Oil and its Binary Combinations with Cyantraniliprole and Emamectin benzoate on Spodoptera frugiperda (Lepidoptera: Noctuidae)

Control methods have faced challenges in effectively managing the spread and damage caused by the fall armyworm (FAW), Spodoptera frugiperda, across various crops worldwide, highlighting the need for more sustainable and integrated approaches. This study explored the insecticidal effect of the essential oil (EO) of lavender (LV) (Lavandula multifida L.), cyantraniliprole (CY), and emamectin benzoate (EM) insecticides on FAW larvae. Toxicity, biological, and biochemical assays were employed to elucidate the impact of the two insecticides individually or combined with LV EO. Additionally, in silico molecular docking investigations were performed for eucalyptol (the major component of LV EO) and for CY against the acetylcholine esterase (AChE) enzyme (PDB ID: 6xyu) and cytochrome P450 (PDB ID: 2q6n). EM was the most toxic compound to FAW larvae with an LC50 of 0.0073 mg L−1, followed by CY and LV EO. The chi-square (χ2) test confirmed the synergistic effect of the LV EO/CY combination and the antagonistic effect LV EO/EM combination on FAW larvae. Biological development studies revealed that both LV EO/CY and LV EO/EM combinations impacted the larval and pupal durations. The biochemical assays indicated that the P450-specific activity was activated by LV EO (at LC25), CY (at LC25 & LC50), and their binary combination (at LC25:LC25). In addition, the LV EO/CY combination significantly activated the AChE and GST-specific activity, and the LV EO/CY combination and CY (at LC50) significantly activated α-esterase- specific activity. Molecular docking investigations revealed energy scores (S) of −6.7729 and −7.7644 kcal/mol for eucalyptol and CY, compared to −7.0993 kcal/mol for PDB ID: 6xyu ligand. The current results can serve as baseline data for utilizing the LV EO/CY combination in the integrated pest management (IPM) of FAW.

Meta-analysis of the Effect Size of Lavender Essential Oil and Lavender Blended Essential Oils on Psychological Factors in Adults

Purpose: This study analyzed the effect size of lavender essential oil and lavender blended essential oils on adult psychological factors. A meta-analysis was conducted to recommend an effective application strategy for improving psychological factors in adults.Methods: To analyze the effect size of lavender essential oil and lavender blended essential oils on psychological factors in adults, studies published over the last 10 years (January 2013 to December 2023) were collected. Studies were selected based on the population, intervention, comparison, outcomes, and study-format focusing on those that compared the pre and post psychological health of experimental group and control group and presented the mean and standard deviation. Data were analyzed using the version 4 software by Biostat (Englewood, USA).Results: Treatment with lavender essential oil alone showed highly positive effect on anxiety (0.731) and stress (0.730), followed by positive effects on sleep quality (0.673) and fatigue (0.601). Furthermore, treatment with lavender blended essential oils showed the most positive effects on sleep quality (1.383), followed by fatigue (1.159), stress (0.789), and anxiety (0.638).Conclusion: This study, discovered that lavender essential is effective in relieving anxiety and stress when used to improve adult psychological factors (anxiety, sleep quality, stress, and fatigue), and lavender blended essential oils are particularly effective in improving sleep quality and reducing fatigue. These results are expected to be valuable in prescribing treatments for individuals of various ages and lifestyles suffering from various psychological factors.

Fabrication and characterization of bioactive curdlan and sodium alginate films for enhancing the shelf life of Volvariella volvacea

This study aimed to develop bioactive films based on curdlan (CD) and sodium alginate (SA) to enhance the shelf life of the Volvariella volvacea mushroom. A stable nanoemulsion of droplet size of 150.1 ± 5 nm was first formulated using 5% soy protein (Sp) and 10% lavender essential oil (LEO), achieved by ultrasound treatment for 10 min, resulting in small droplet sizes. In parallel, a CD-SA film was prepared by mixing them in a 1:1 ratio. The SpLEO nanoemulsion was then ex situ added to the CD-SA film at varying concentrations (4%, 6%, 8%, and 10%). The resulting bioactive film exhibited desirable properties, including water vapor permeability (1.15 ± 0.05 × 10−10 g m−1 Pa−1 s−1), swelling rate (547%), and tensile strength (10.1 ± 1.3 MPa). Docking and structural analyses suggested that ultrasound treatment enhanced the intermolecular hydrogen bonding, creating a uniform and regular surface and reduced crystallinity. The CD-SA film with ultrasound-treated 8% SpLEO nanoemulsion [i.e., (CD-SA/SpLEO-8)US] showed antibacterial activity against Escherichia coli and Staphylococcus aureus and extended the freshness of straw mushrooms prevention of spoilage during storage. Additionally, the film reduced respiration rate (975 mg CO₂/kg/h at 96 h) and ethylene production (160 ng/kg/s by 96 h) while effectively inhibiting straw mushroom autolysis. This led to a reduction in browning (2.91), total soluble solids (7.5%), weight loss (13.9%), and polyphenol oxidase activity (0.08 ΔOD420/min⋅g), thereby extending the shelf life of the mushrooms to 96 h. These findings highlight the potential of incorporating different molecules using ultrasound treatment to develop innovative edible films for food preservation.

Sustainable antimicrobial functionalization of cotton with lavender oil and jackfruit latex

In recent years, functional antimicrobial fabric materials have been in high demand in the health sector due to the impact of COVID-19. Considering the increasing demand, the availability of natural, environmentally friendly, and non-toxic products is limited. In this study, a facile, eco-friendly method for the preparation of antimicrobial functional cotton fabric is proposed. At first, scoured and bleached cotton fabric is treated with chitosan, followed by encapsulation of lavender essential oil (LEO) with the addition of Artocarpus heterophyllus Lam. (jackfruit) latex gum as a binder. For the encapsulation and optimization of LEO and jackfruit latex gum (JLG) performance, four variations of these material’s quantity were utilized. Among all the studied samples, we found that the most efficient inhibition of bacterial growth was induced in both gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) cultures. Among the samples, the chitosan-treated fabric with LEO and JLG added, named TG-5 (refers to LEO of 3 mL and JLG of 5 mL), showed the most impactful bacteria reduction. It demonstrates the most effective antibacterial reduction of 92.5% and 56.8% for E. coli and S. aureus bacterium cultures, respectively. The field emission scanning electron microscope illustrates and validates the morphology and addition of the prepared samples, while Fourier transform infrared is employed to identify the chemical bonding and chemical compounds of the functionalized materials. Therefore, the new combination of lavender oil and latex gum of jackfruit as an antimicrobial finishing agent can be the replacement of synthetic chemicals for cotton fabric functionalization in medical textiles.

Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity.

According to data in the literature, natural products and essential oils are often used in dental practice. To develop a new oromucosal spray for the treatment of infectious and inflammatory diseases of the oral cavity, clove CO2 extract and essential oils of lavender and grapefruit were used as active pharmaceutical ingredients. Clove extract was obtained by the method of subcritical extraction from various raw materials, the choice of which was based on the yield of the CO2 extract and the study of its phytochemical and microbiological properties. Based on the results of microscopic and diffraction analyses, the rational time of ultrasonic exposure for the emulsion of active pharmaceutical ingredients was established. Mucoadhesive polymers were used as stabilizers of the two-phase system and prolongators. This article discusses the impact of the type and concentration of mucoadhesive polymers on the stability of the emulsion system; the viscous, textural, adhesive, and film characteristics of oromucosal spray; and the parameters determining sprayability.

Sustained-release effect of eggshell powder microcapsules on lavender essential oil

Eggshells are rich in Ca2+ and organic compounds, which can be taken as coupling agents for sustained-release materials. Essential oils are widely applied due to their excellent volatility, but poor sustained-release stability has limited their development. The study aimed to develop a novel eggshell powder (EP) sustained-release microcapsule, providing a new approach to protect the active ingredients of Lavender essential oil (LEO), and investigated the reasons for EP to regulate protein-polysaccharide microcapsule structure. Experimental results showed when the addition ratio of EP and Whey protein (WPI) was 1: 3, the dosage of LEO was 25%, the microcapsule displayed smooth and porous spherical structure. XRD and FT-IR indicated that a dense and orderly network structure was formed via the cross-linking reaction between eggshell powder and wall materials, which induced protein and polysaccharide to form special spherical hollow sustained-release shell structure through the calcium bridge (-COO-Ca-COO-), then achieved the sustained-release effect on LEO.